Supports Cardiovascular and Antioxidant Health*
HOW PATIENTS MAY BENEFIT
- Supports cells and mitochondrial DNA from the harmful effects of reactive oxygen species*
PhysioLogics Coenzyme Q-10 Q-SorbÃ¢â€žÂ¢ 200 mg provides an essential component of the mitochondrial electron transport chain, vital for the production of adenosine triphosphate (ATP) required for virtually all cellular processes. Co Q-10 is a lipophilic antioxidant that neutralizes the formation of reactive oxygen species in the mitochondria, which is important for cardiovascular health.*
Endogenous levels of Co Q-10 may diminish with age, strenuous exercise, and environmental stressors. In addition, certain regularly prescribed drugs, including statins, may deplete the body's supply of Co Q-10. (Note: Coenzyme Q-10 is not intended to serve as a replacement for statin therapy, nor should patients discontinue taking any prescribed medications while supplementing with Coenzyme Q-10.)
STRUCTURE AND FUNCTION
Coenzyme Q-10 is a vitamin-like molecule naturally found in the inner mitochondrial membrane of every cell in the human body. In the mitochondrial respiratory chain, Co Q-10 is the electron acceptor for mitochondrial complex I and complex II, and donates electrons to complex III during oxidative phosphorylation. Each pair of electrons in the electron transport chain must interact with Co Q-10, the rate-limiting component of the mitochondrial respiratory cycle.
Co Q-10 is also a component of extra-mitochondrial redox chains, whose function is to remove excess reducing power formed during glycolysis when mitochondrial respiration is decreased. In its reduced form, Co Q-10 is a lipid-soluble antioxidant that readily provides electrons to neutralize superoxide and lipid radicals. Mitochondria are the primary sources of intracellular reactive oxygen species (ROS), which are capable of mitochondrial DNA damage. Co Q-10 scavenges these species to support the cell and DNA and fight oxidative stress, neutralizing both the initiation and propagation of lipid peroxidation.
By supporting the normal physiological function of the heart, Co Q-10 promotes healthy circulation through myocardial tissue. Co Q-10 also has membrane stabilizing properties thought to be involved in the phospholipidprotein interaction that aids in the metabolism of prostaglandins. Myocardial calcium-dependent ion channels are stabilized by Co Q-10, which supports molecules essential for ATP synthesis. In addition, Co Q-10 seems to play a role in supporting the fluidity of membranes, important for physiological functions of receptors, carriers and membrane-bound enzymes.
- In a double-blind, placebo-controlled, randomized study conducted by Berman et al, subjects consuming Co Q-10 showed significant improvement in a 6-minute walk test, in breathing parameters, New York Heart Association (NYHA) classification, and fatigue. The administration of Co Q-10 to subjects led to a significant improvement in functional status, and quality of life. Coenzyme Q-10 was shown to effectively support overall well being including heart health. (Berman et al, 2004)
- In another randomized, double-blind, controlled trial, the effects of oral treatment with Co Q-10 (120 mg/day) were compared over one year in 144 subjects. Co Q-10 significantly increased the level of vitamin E in the blood, supported healthy HDL levels, and reduced molecules that cause oxidative stress. There was a significantly lower effect in the control group. (Singh et al, 2003)
Coenzyme Q-10 plays an essential role in the production of cellular ATP.* Its role as an antioxidant supports cardiovascular tissue from oxidative damage.* Supplementing a patient's nutritional regimen with PhysioLogics Coenzyme Q-10 Q-SorbÃ¢â€žÂ¢ 200 mg softgels will support their cellular energy production and also help promote cardiovascular health.
For adults, take one (1) softgel daily, preferably with a meal, or follow the advice of a health care professional.
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