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Best L-Tryptophan 500mg 90 Veggie caps
Best L-Tryptophan featuring TryptoPure™
• TryptoPure™, which is unsurpassed in purity by any other l-tryptophan in the world today, is a trademark of Ajinomoto Company, Inc.
• Ajinomoto in Japan is the word's foremost producer of pharmaceutical-grade amino acids, including TryptoPure.
• TryptoPure surpasses all testing criteria established by the U.S. Pharmacopeia (USP), Japan Pharmacopeia (JP), and European Pharmacopeia (EP) standards.
• U.S. importation of Ajinomoto's l-tryptophan has proceeded uninterrupted for over 25 years.
• Best L-Tryptophan featuring TryptoPure is packaged in veggie caps and suitable for vegetarians.
• TryptoPure is used in hospitals and pharmacies all over the world.
• It is additive-free, solvent-free, 100% fermented, and GMP certified.
Suggested Use:
Take 1 or 2 capsules daily, or as directed by a health practitioner. For optimum absorption, take separately from protein-containing foods and dietary supplements containing protein or amino acids.
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Best 5-HTP 100 mg 60 Capsules
5-HTP (5-hydroxytryptophan) is a naturally-occurring metabolite of the essential amino acid tryptophan. 5-HTP for use in dietary supplements is derived from the seeds of the Griffonia simplicifolia plant. Metabolism and absorption of 5-HTP5-HTP (5-hydroxytryptophan) is formed by the addition of a hydroxyl group (-OH) to the 5 carbon of the indole ring of tryptophan. Conversion of tryptophan to 5-hydroxytryptophan is catalyzed by the enzyme tryptophan hydroxylase. 5-HTP functions as the precursor for serotonin, and is converted to serotonin in a pyridoxal phosphate (vitamin B6) dependent reaction catalyzed by the enzyme L-amino acid decarboxylase.Synthesis of serotonin in the brain requires an adequate supply of either tryptophan or 5-HTP as precursors. The supply of tryptophan available for conversion to 5-HTP depends on a number of factors, including nutritional status and competition between tryptophan and other amino acids for transport across the blood brain barrier.Disturbances in the serotonin metabolic pathway may disrupt central nervous system functions which utilize serotonin as a neurotransmitter. Administration of 5-HTP bypasses the conversion of tryptophan to 5-HTP. 5-HTP readily crosses the blood brain barrier and becomes available for serotonin synthesis. Serotonergic neurons (nerve cells stimulated by serotonin) regulate sleep, appetite, nociception (the perception of pain), and aggressive behavior.Serotonin is metabolized to 5-HIAA (5-hydroxyindolacetic acid) which is its primary breakdown product. The concentration of 5-HIAA in cerebrospinal fluid is used as an indicator of serotonin turnover in the CNS serotonin level. Psychiatric patients have been found to have low levels of 5-HIAA in the CNS fluid, suggesting serotonin deficiency.5-HTP is readily absorbed by the mucosal cells of the gastrointestinal tract. In one study using five subjects, systemic absorption of 5-HTP in combination with carbidopa averaged 69.2 percent. Another absorption study found that carbidopa enhanced the increase in serum 5-HTP concentration 5 to 15 fold. In this study, a single dose of 5-HTP increased the plasma level of 5-HTP only slightly, whereas 5-HIAA increased 9-20 fold. This suggests that the gut mucosa has a storage capacity for 5-HTP, and that plasma increases occur after maximum capacity is reached.BenefitsImproves Well-Being in Depressed PersonsSerotonin in the central nervous system is recognized as a causative factor in some depressed persons. A comprehensive review of seven open and seven controlled clinical studies found that oral consumption of 5-HTP improved mental and emotional status in 60 to 70 percent of depressed people. The results varied from "modest" to "marked."8 Dosages ranged from 50 to 300 mg daily. The accumulated evidence is inconclusive as to whether 5-HTP is more effective combined with decarboxylase inhibitors than when taken alone. Many of the early trials used the combination, and this has been a frequently used therapeutic strategy for reducing conversion of 5-HTP to serotonin outside the CNS. It is generally accepted that a large portion of absorbed 5-HTP is metabolized to serotonin in peripheral tissues before it can enter the brain.Peripheral conversion of 5-HTP to serotonin would theoretically limit the usefulness of oral 5-HTP for improving CNS functions and mental health. However, trials in which 5-HTP was given alone do show benefits. A small open trial in which 25 people were given 5-HTP either alone or with a decarboxylase inhibitor found no difference in effectiveness. Thirteen of the patients had "very good" or "good" improvement, 8 had "moderate," and in 4 out of the twenty-five the results were judged to be "poor."A more recent randomized double-blind study compared the efficacy of oral 5-HTP (100 mg T.I.D., without a decarboxylase inhibitor) to that of fluvoxamine, a selective serotonin reuptake inhibitor. (SSRIs block the reabsorption of serotonin by postsynaptic receptors, thus increasing the available supply of serotonin in the synaptic cleft.) The two were found to be equally effective, and 5-HTP was better tolerated. It should be noted that 5-HTP was given in the form of enteric-coated pH-sensitive capsules which dissolve in the small intestine, thus preventing conversion of 5-HTP to serotonin in the stomach.In contrast to MAO inhibitors and SSRIs, medications which act by blocking normal physiologic functions, 5-HTP supports normal function in its role as a serotonin precursor. Correcting serotonin deficiency has been called a "functional-dimensional approach" in the treatment of depression.Improves Sleep Quality Studies have shown that 5-HTP influences the quality of sleep by increasing REM (rapid eye movement) sleep. Administration of 5-HTP in the evening prior to bedtime has been shown to increase the duration of REM sleep and decrease the amount of non-REM sleep.5-HTP–A Free-radical ScavengerThe OH group which is added to tryptophan in the formation of 5-HTP gives 5-HTP antioxidant properties. (Compounds such as vitamin E and flavonoids derive their free-radical quenching ability from OH groups, which donate electrons to oxidants.) 5-HTP quenches a variety of free-radicals. This is in contrast to tryptophan, which is sensitive to oxidation.Adverse effects of 5-HTP Oral administration of 5-HTP in clinical studies has resulted in gastrointestinal disturbances such as nausea, vomiting and diarrhea. According to a review by Byerley, et. al. these effects are tolerated by most patients and tend to lessen over time.8 Side effects are more marked with higher doses, and may be reduced by the use of enteric-coated, pH sensitive capsules or tablets. |
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Best Acetyl L-Carnitine 60 Capsules
Acetyl-L-Carnitine (ALC) is a naturally occurring form of L-Carnitine, a vitamin-like nutrient synthesized in the body from the amino acids lysine and methionine. ALC serves as a transport molecule for "active acetate," which is a source of fuel for metabolic processes that take place in cells. ALC carries active acetate (the "Acetyl" portion) directly into the mitochondrion, the cell's energy-generating structure. Active acetate is used to produce cellular energy in the form of ATP. Both L-Carnitine and ALC serve as fat carriers. Unlike L-Carnitine, ALC readily crosses the blood-brain barrier, where it has specific benefits for brain neurons. When taken orally, ALC has been shown to increase ALC levels in both blood and cerebrospinal fluid, demonstrating its uptake in the brain.Best Acetyl-L-Carnitine consists of Biosint™ Acetyl-L-Carnitine, which is manufactured in Italy by the Sigma Tau company. It is derived from a base of pharmaceutical-grade L-Carnitine manufactured using an FDA-approved process that fully complies with international monograph standards for carnitine production. Known as a global leader in L-Carnitine research, Sigma Tau holds numerous patents for production of L-Carnitine, and its L-Carnitine derivatives, such as ALC, which are used in clinical trials.BenefitsSupports cognitive functionALC has been studied for its effect on cognitive performance and emotional health in the elderly. In a single-blind, placebo-controlled trial, 481 elderly subjects exhibiting mild memory impairment improved their scores on a memory test after taking 1500 mg of ALC a day for 90 days. Hospitalized elderly people taking ALC have shown improvements in mental outlook.While ALC is not a treatment or cure for Alzheimer's disease, double-blind studies suggest it may help slow the rate at which early-stage Alzheimer's patients deteriorate. In particular, ALC seems to benefit short-term memory in these patients.Supports biosynthesis of acetylcholine, a key neurotransmitter for brain and nerve functionBrain function requires coordinated communication between brain cells. Brain and nerve cells ("neurons") communicate across tiny cell-to-cell gaps called "synapses." The passage of an electrical impulse from one neuron to the next requires a "neurotransmitter." When an electrical signal arrives at the synaptic junction, the neuron releases a neurotransmitter into the synapse. The neuron on the other side of the synapse contains receptors for the neurotransmitter; these receptors bind the neurotransmitter, triggering a series of chemical events that sends a new electrical signal down the membrane of the receiving neuron. Neurotransmitters work together like an orchestra to transmit information throughout the brain and nervous system. Acetylcholine is the most abundant neurotransmitter in the body, regulating activities of vital organs, blood vessels and communication between nerves and muscles. In the brain, acetylcholine helps facilitate memory and learning as well as influence emotions. ALC is structurally similar to acetylcholine, and brain neurons stimulated by acetylcholine are receptive to stimulation by ALC. It has been shown experimentally that ALC supplies acetyl groups for the biosynthesis of acetylcholine. ALC's hypothesized cholinomimetic (acts like acetylcholine) activity has led researchers to investigate its effects on mental function and emotional health.Helps supply the brain with energy by improving energetics in the mitochondrionThe acetyl groups donated by ALC can be used to synthesize acetyl-CoA, the key substrate for energy metabolism in the mitochondrion. Acetyl-CoA enters the Krebs cycle, the mitochondrial mechanism that generates cellular energy in the form of ATP. ALC easily crosses the blood-brain barrier, allowing it to play various roles in maintaining brain neuron (nerve cell) function. When given by oral administration, the concentration of ALC is increased in the blood and cerebrospinal fluid.Stabilizes intracellular membranesALC was found to improve membrane phospholipid metabolism in early-stage Alzheimer's patients. Phospholipids are structural components of brain cell membranes that regulate neuron function. ALC donates acetyl groups that can be used to modify the functional activity of proteins in neuronal membranes. ALC thus plays a role in maintaining membrane function. ALC also increases membrane stability and structural integrity.Increases nerve growth factor productionThe body produces various specialized proteins called "growth factors" which are essential to growth and repair of tissue. Nerve Growth Factor (NGF) protects neurons from death, prolonging survival of neurons in both the central and peripheral nervous systems. It is theorized that aging of the central nervous system is associated with a loss of NGF. ALC has shown the ability to reverse age-related decrease in the binding of NGF to its receptors in neuron membranes. Given to aged rats, ALC increases the level and utilization of NGF in the rats. ALC protects cholinergic neurons (nerve cells stimulated by acetylcholine) in rats from degeneration due to lack of NGF. These results, together with other data from animal studies, suggest that ALC positively influences NGF activity.Has a protective influence on brain neuronsSeveral animal studies have revealed that ALC exerts a protective effect on neurons. In one experiment, brain cells from rats exposed to NMDA, a known neurotoxin, were protected by being simultaneously exposed to ALC. Rats injected with ALC were protected from mortality caused by the neurotoxin MPP+. ALC has been shown to raise levels of glutathione, a highly valuable antioxidant, in isolated mouse brain tissue. ALC prevents buildup of malondyhaldeyde, a marker of lipid peroxidation. ALC is also a chelator of iron, which can generate free radicals. It also reinforces antioxidant mechanisms in the brain.As a whole, data from test tube and animal studies, showing that ALC has a protective, restorative effect on brain neurons and neuronal energetic processes, suggest that ALC is an anti-aging nutrient for the brain. This hypothesis is supported by human studies demonstrating measurable benefits for brain function in elderly persons taking ALC by oral consumption. |
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Best Agaricus Blazei 90 Veggie Capsules
Agaricus blazei is a medicinal mushroom that contains a special class of polysaccharides known as "beta glucans." Studies show beta glucans stimulate activity of natural killer (NK) cells, which are an important part of the immune system. The Agaricus blazei in this product is extracted with the preferred hot water/alcohol method to increase its digestibility and enhance bioavailability of the polysaccharides.Originally discovered in Brazil, Agaricus blazei is widely consumed in many countries, where it is regarded as a health food, due to its medicinal properties. The mushroom is used both in tea form and as a food. Since 1965, strains of Agaricus blazei have been imported to Japan, where it is now widely cultivated and researched.Folk Use The folk use of this herb encompasses a broad profile of reported effects, including:__1) Fighting physical and emotional stress. __2) Immune support. __3) Maintaining normal blood sugar levels. __4) Maintaining already normal cholesterol levels. __5) Digestive support. __6) Bone health. __7) Liver supportAmong the above properties attributed to Agaricus, immune support is the major focus of usage scientific research to date. Like other medicinal mushrooms, Agaricus contains complex polysaccharides that stimulate the immune system. It is reported that Agaricus is utilized for this purpose by 300,000 to 500,000 people in Japan annually, where yearly production of the dried mushroom ranges from 100,000 to 300,000 kg.BenefitsSupports immune functionAgaricus blazei has been the subject of research in Japan, where investigations have focused on the role of mushroom polysaccharides as "biological response modifiers that can stimulate immune function. Studies have shown that beta glucans extracted from Agaricus are the active polysaccharides, with beta-glucan as the most potent immunomodulator. Fungi-derived beta glucans have been found to stimulate the release of tumor necrosis factor from immune cells called "macrophages." While activating the immune response to abnormal cells, beta glucans have no effect on normal cells. Additional experiments have shown that Agaricus blazei activates the alternative complement pathway, which is an important part of the body’s immune defense against foreign organisms. Agaricus extracts have demonstrated an ability to help maintain cellular health through an antimutagenic effect on cells. In the test tube, isolated fractions of Agaricus blazei have been found to inhibit proliferation of white blood cells and cytokines that can cause inflammation if over expressed. These results suggest Agaricus may help regulate immune over-activity.Liver protection against toxinsA water extract of Agaricus blazei was tested on rat liver cells exposed to the toxic chemical diethylnitrosamine (DEN). Rats were administered the mushroom extract for two weeks and then injected with the toxin. Compared to control rats that did not receive the extract, the rats given Agaricus showed markedly less liver damage. Different doses of the toxin where used to gauge the level of protection exerted by the mushroom. Liver enzymes were lower in rats that received moderate, but not high, doses of the toxin, leading researchers to conclude that Agaricus protects against moderate, but not severe, chemical-induced liver toxicity. No adverse effects were seen.A group of medical researchers in China has reported that 10 hepatitis patients given Agaricus blazei showed improvements in liver function and hematology tests. |
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Best Alpha Lipoic Acid 150mg 120 Capsules
Alpha-lipoic acid (ALA) is a sulfur-containing fatty acid that performs vitamin-like roles in the body. Also known as "lipoic acid" or "thioctic acid," ALA functions, in a similar way to B complex vitamins, as a co-enzyme in the metabolism of carbohydrates that produces energy inside cells for the body’s metabolic needs. ALA is required for synthesis of "acetyl CoA," a key metabolite in the cellular process that turns glucose (blood sugar) into energy. Because the body produces ALA on its own, it is not classified as a true vitamin. As with other so-called "non-essential" nutrients, however, internal ALA production may not always be optimal. Alpha-lipoic acid functions as both a water-soluble and fat-soluble antioxidant. (Antioxidants neutralize free-radicals, normal by-products of metabolism that, while necessary at normal levels, may damage tissues over time if not properly kept in check by antioxidants.) ALA’s ability to act upon free radicals in both a watery and fatty environment makes it a highly versatile antioxidant. In the body, alpha-lipoic acid can be converted (reduced) to DHLA, or dihydrolipoic acid. Together, these two forms of ALA make up a "redox couple," which means that each form can chemically change into the other and back again. DHLA also functions as an antioxidant.How “about R-Lipoic” Acid ?Alpha Lipoic Acid occurs in two forms, designated "R" and "S". Studies suggest that R-alpha lipoic acid, the natural form, is more biologically active than the S form. Like ALA, RLA recycles antioxidant nutrients, such as vitamin C and E, and helps maintain healthy blood sugar levels when used as part of the diet.BenefitsSupports the Body’s Defense Against Free RadicalsRecycles Antioxidant Nutrients such as Vitamin C and Vitamin EHelps Maintain a Healthy Blood Sugar Level when used as part of the dietAlpha-lipoic Acid––the "Ideal Antioxidant"The antioxidant potential of a substance is based on a number of criteria, including: 1) Ability to quench specific free-radicals. 2) Ability to bind or "chelate" metal ions that can generate free radicals. 3) Supports function of other antioxidants. 4) Absorption/bioavailability. 5) Concentration in tissues, cells and extra cellular fluids. 6) Ability to function as an antioxidant in fatty and watery environments.The "ideal antioxidant" would meet all the above criteria. Very few antioxidants do, yet a particular antioxidant with but a few of the characteristics is still valuable and effective. Vitamin E, for example, is one of the most important dietary antioxidants, yet it only works in fatty environments such as cell membranes. As a team, ALA and DHLA come close to the ideal, for the following reasons: 1) ALA is easily absorbed when consumed orally. 2) ALA is readily converted to DHLA in various tissues. 3) As a pair, ALA and DHLA neutralize superoxide, hydroxyl, peroxyl, and hypochlorus radicals. 4) ALA and DHLA form stable complexes with metal ions such as iron, manganese, copper and zinc ions. 5) ALA and DHLA scavenge free radicals in fatty environments and watery environments.6) DHLA recycles other important antioxidants.DHLA-regenerates vitamin C, vitamin E and glutathioneWithin the cell, antioxidants work as a team to keep free radicals from damaging cell structures. In order to neutralize a free radical, an antioxidant such as vitamin C must give up an electron, which mean it becomes oxidized. Before it can function as an antioxidant once again, it must be regenerated back to its "reduced" form, by gaining an electron to replace the donated electron. For this, it needs the help of other antioxidants. Vitamin C, vitamin E and glutathione are key antioxidants that can be generated by cycling between their oxidized and reduce forms. This is necessary to maintain the balance between oxidation and its reverse––the neutralization of free radicals by antioxidants. DHLA is an essential component in the interaction between these antioxidants. Studies show that addition of alpha-lipoic acid to liver tissues results in increased vitamin C levels. It has been found that DHLA is responsible for regenerating vitamin C, which in turn regenerates vitamin E.3 DHLA also converts glutathione from its oxidized form back into its free radical scavenging reduced form. The ALA/DHLA pair is thus vital for prevention of "oxidative stress," which occurs which the balance is tipped in favor of oxidation in cells. DHLA helps preserve antioxidants in both the watery cell interior and the fatty structure of cell membranes. Evidence from animal studies suggests that DHLA protects the brain against free radical damage.Alpha-lipoic Acid and Blood SugarAlpha-lipoic acid is a key factor in the cellular process that metabolizes glucose to produce energy for cellular functions. The importance of ALA’s role in blood sugar metabolism is evidenced in studies on ALA and type-2 diabetes. In a small pilot study, 13 people with type-2 diabetes showed improved utilization of glucose in muscle tissue in response to intravenous administration of ALA. In a four week controlled multicenter trial, 74 people with type-2 diabetes took ALA in oral doses of 600, 1200 or 1800 mg per day. After 4 weeks, the normal lowering of blood sugar levels in response to insulin improved. In vitro studies have shown that ALA has a positive effect on insulin-stimulated uptake of glucose by muscle cells. |
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Best Alpha Lipoic Acid 600mg 60 Veggie Capsules
Alpha-lipoic acid (ALA) is a sulfur-containing fatty acid that performs vitamin-like roles in the body. Also known as "lipoic acid" or "thioctic acid," ALA functions, in a similar way to B complex vitamins, as a co-enzyme in the metabolism of carbohydrates that produces energy inside cells for the body’s metabolic needs. ALA is required for synthesis of "acetyl CoA," a key metabolite in the cellular process that turns glucose (blood sugar) into energy. Because the body produces ALA on its own, it is not classified as a true vitamin. As with other so-called "non-essential" nutrients, however, internal ALA production may not always be optimal. Alpha-lipoic acid functions as both a water-soluble and fat-soluble antioxidant. (Antioxidants neutralize free-radicals, normal by-products of metabolism that, while necessary at normal levels, may damage tissues over time if not properly kept in check by antioxidants.) ALA’s ability to act upon free radicals in both a watery and fatty environment makes it a highly versatile antioxidant. In the body, alpha-lipoic acid can be converted (reduced) to DHLA, or dihydrolipoic acid. Together, these two forms of ALA make up a "redox couple," which means that each form can chemically change into the other and back again. DHLA also functions as an antioxidant.Alpha Lipoic Acid occurs in two forms, designated "R" and "S". Studies suggest that R-alpha lipoic acid, the natural form, is more biologically active than the S form. Like ALA, RLA recycles antioxidant nutrients, such as vitamin C and E, and helps maintain healthy blood sugar levels when used as part of the diet.BenefitsSupports the Body’s Defense Against Free RadicalsRecycles Antioxidant Nutrients such as Vitamin C and Vitamin EHelps Maintain a Healthy Blood Sugar Level when used as part of the dietAlpha-lipoic Acid––the "Ideal Antioxidant"The antioxidant potential of a substance is based on a number of criteria, including: 1) Ability to quench specific free-radicals. 2) Ability to bind or "chelate" metal ions that can generate free radicals. 3) Supports function of other antioxidants. 4) Absorption/bioavailability. 5) Concentration in tissues, cells and extra cellular fluids. 6) Ability to function as an antioxidant in fatty and watery environments.The "ideal antioxidant" would meet all the above criteria. Very few antioxidants do, yet a particular antioxidant with but a few of the characteristics is still valuable and effective. Vitamin E, for example, is one of the most important dietary antioxidants, yet it only works in fatty environments such as cell membranes. As a team, ALA and DHLA come close to the ideal, for the following reasons: 1) ALA is easily absorbed when consumed orally. 2) ALA is readily converted to DHLA in various tissues. 3) As a pair, ALA and DHLA neutralize superoxide, hydroxyl, peroxyl, and hypochlorus radicals. 4) ALA and DHLA form stable complexes with metal ions such as iron, manganese, copper and zinc ions. 5) ALA and DHLA scavenge free radicals in fatty environments and watery environments.6) DHLA recycles other important antioxidants.DHLA-regenerates vitamin C, vitamin E and glutathioneWithin the cell, antioxidants work as a team to keep free radicals from damaging cell structures. In order to neutralize a free radical, an antioxidant such as vitamin C must give up an electron, which mean it becomes oxidized. Before it can function as an antioxidant once again, it must be regenerated back to its "reduced" form, by gaining an electron to replace the donated electron. For this, it needs the help of other antioxidants. Vitamin C, vitamin E and glutathione are key antioxidants that can be generated by cycling between their oxidized and reduce forms. This is necessary to maintain the balance between oxidation and its reverse––the neutralization of free radicals by antioxidants. DHLA is an essential component in the interaction between these antioxidants. Studies show that addition of alpha-lipoic acid to liver tissues results in increased vitamin C levels. It has been found that DHLA is responsible for regenerating vitamin C, which in turn regenerates vitamin E. DHLA also converts glutathione from its oxidized form back into its free radical scavenging reduced form. The ALA/DHLA pair is thus vital for prevention of "oxidative stress," which occurs which the balance is tipped in favor of oxidation in cells. DHLA helps preserve antioxidants in both the watery cell interior and the fatty structure of cell membranes. Evidence from animal studies suggests that DHLA protects the brain against free radical damage.Alpha-lipoic Acid and Blood SugarAlpha-lipoic acid is a key factor in the cellular process that metabolizes glucose to produce energy for cellular functions. The importance of ALA’s role in blood sugar metabolism is evidenced in studies on ALA and type-2 diabetes. In a small pilot study, 13 people with type-2 diabetes showed improved utilization of glucose in muscle tissue in response to intravenous administration of ALA. In a four week controlled multicenter trial, 74 people with type-2 diabetes took ALA in oral doses of 600, 1200 or 1800 mg per day. After 4 weeks, the normal lowering of blood sugar levels in response to insulin improved. In vitro studies have shown that ALA has a positive effect on insulin-stimulated uptake of glucose by muscle cells. |
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Best Benfotiamine 80mg 120 Veggie Capsules
Benfotiamine (S-benzyolthiamine-O-monophosphate) is a synthetic derivative of thiamin, belonging to the family of compounds known as "allithiamines." Benfotiamine is fat-soluble and thus more bioavailable and physiologically active than thiamin.* Characteristic of the allithiamines is an open thiazole ring within the chemical structure of these thiamine-related compounds, making them fat (lipid) soluble. In contrast, thiamine, which is water soluble, has a closed thiazole ring. The lipid solubility of benfotiamine, conferred by this open ring, increases its bioavailablity. Benfotiamine is readily absorbed at higher doses, in contrast to absorption of water-soluble thiamin salts, which decreases at higher doses, due to saturation of absorption sites in the intestines. In a double-blind, cross-over trial, comparing bioavailability of benfotiamine to that of thiamine in 12 subjects, benfotiamine caused an average 5-fold greater increase in blood thiamine levels than thiamin mononitrate, with a concomitant greater thiamine concentration in erythrocytes (red blood cells). Benfotiamine readily passes through intestinal mucosal cells, where it is converted into physiologically active thiamine. Benfotiamine inceases blood levels of thiamine pyrophosphate (TPP), the primary thiamin co-enzyme.BenefitsBenfotiamine raises the blood level of thiamine pyrophosphate (TPP), the biologically active co-enzyme of thiamine.Thiamine and its Co-enzyme, TPP Thiamine (vitamin B1) plays an essential part in the metabolism of glucose, through actions of it co-enzyme TPP (thiamine pyrophosphate). TPP is formed by the enzymatically-catalyzed addition of two phosphate groups donated by ATP to thiamine. TPP also goes by the name "thiamine diphosphate." In the cytoplasm of the cell, glucose, a 6-carbon sugar, is metabolized to pyruvic acid, which is converted into acetyl-CoA, otherwise known as "active acetate." Acetyl CoA enters the mitochondrion, where it serves as the starting substrate in the Kreb’s cycle (citric acid cycle). The Krebs cycle is the primary source of cellular metabolic energy. TPP, along with other co-enzymes, is essential for the removal of CO2 from pyruvic acid, which in turn is a key step in the conversion of pyruvic acid to acetyl CoA. CO2 removal from pyruvic acid is called "oxidative decarboxylation," and for this reason, TPP was originally referred to as "cocarboxylase." TPP is thus vital to the cell’s energy supply.Benfotiamine helps maintain healthy cells in the presence of blood glucose. Acting as a biochemical "super-thiamin," it does this through several different cellular mechanisms, as discussed below.Benfotiamine and Glucose Metabolism Benfotiamine normalizes cellular processes fueled by glucose metabolites. As long as glucose remains at normal levels, excess glucose metabolites do not accumulate within the cell. The bulk of the cell’s glucose supply is converted to pyruvic acid, which serves as substrate for production of acetyl CoA, the primary fuel for the Krebs cycle. Of the total amount of metabolic energy (in the form of ATP) released from food, the Krebs cycle generates about 90 percent. In the presence of elevated glucose levels, the electron transport chain, the final ATP-generating system in the mitochondrion, produces larger than normal amounts of the oxygen free radical "superoxide." This excess superoxide inhibits glyceraldehyde phosphate dehydrogenase (GAPDH), as key enzyme in the conversion of glucose to pyruvic acid, resulting in an excess of intermediate metabolites known as "triosephosphates." Increase triosephophate levels trigger several cellular mechanisms that result in potential damage to vascular tissue. Cells particularly vulnerable to this biochemical dysfunction are found in the retina, kidneys and nerves. Benfotiamine has been shown to block three of these mechanisms: the hexosamine pathway, the diaglycerol-protein kinease C pathway and the formation of Advanced Glycation End-poducts. As discussed below, benfotiamine does this by activating transketolase, a key thiamin-dependent enzyme. Benfotiamine stimulates tranketolase, a cellular enzyme essential for maintenance of normal glucose metabolic pathways. Transketolase diverts the excess fructose-6-phosphate and glyceraldehydes-3-phosphate, (formed by the inhibition of GAPDH, as mentioned above), into production of pentose-5-phosphates and erythrose-4-phosphate and away from the damaging pathways. Benfotiamine activates transketolase activity in bovine aortic endothelial cells incubated in glucose. To test benfotiamine’s ability to counteract these metabolic abnormalities caused by elevated blood glucose, studies have been done in diabetic rats. Benfotiamine increases transketolase activity in the retinas of diabetic rats, while concomitantly decreasing hexosamine pathway activity, protein kinase C activity and AGE formation. Benfotiamine and Protein glycation Benfotiamine controls formation of Advanced Glycation End-products (AGEs). AGEs have an affinity for proteins such as collagen, the major structural protein in connective tissue. AGEs are formed through abnormal linkages between proteins and glucose. This occurs via a non-enzymatic glycosylation reaction similar to the "browning reaction" that takes place in stored food. At high glucose concentrations, glucose attaches to lysine, forming a Schiff base, which in turn forms "early glycosylation products." Once blood glucose levels return to normal levels, the amount of these early glycosylation products decreases, and they are not particularly harmful to most tissue proteins. On long-lived proteins such as collagen, however, early glycosylation products are chemically rearranged into the damaging Advanced Glycation End-products. AGE formation on the collagen in coronary arteries causes increased vascular permeability. This vessel "leakiness" allows for abnormal cross-linking between plasma proteins and other proteins in the vessel wall, comprising vascular function and potentially occluding the vessel lumen. A number of other potentially harmful events may also occur, including production of cytokines that further increase vascular permeability. Endothelin-1, a strong vasoconstrictor, is over produced, increasing the possibility of thrombosis and generation of oxygen free radicals is stimulated. It is vitally important to support normal glucose metabolic pathways so that formation of AGEs is minimized. Benfotiamine, in the test tube (in vitro) prevents AGE formation in endothelial cells cultured in high glucose by decreasing the glucose metabolites that produce AGEs. Endothelial cells make up the membranes that line the inner walls of organs and blood vessels. In a rat study comparing the effects of Benfotiamine with water-soluble thiamin, Benfotiamine inhibited AGE formation in diabetic rats while completely preventing formation of "glycooxidation products," which are toxic by products of chronic elevated blood glucose. AGE levels were not significantly altered by thiamin. Benfotiamine also normalized nerve function in the animals. After three months of administration, "nerve conduction velocity (NCV)," a measure of nerve function, was increased by both benfotiamine and thiamin; at six months, NCV was normalized by benfotiamine, whereas thiamin produced no further increases in this parameter. Dysfunctional glucose metabolic pathways leading to AGE formation occurs in endothelial cells of the kidneys. In a recent animal study, benfotiamine was administered to rats with elevated glucose levels. Benfotiamine increased transketolase activity in the kidney filtration system of these rats, while at the same time shifting triosephophates into the pentose pathway and preventing protein leakage. |
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Best Benfotiamine 150mg 120 Veggie Capsules
Benfotiamine (S-benzyolthiamine-O-monophosphate) is a synthetic derivative of thiamin, belonging to the family of compounds known as "allithiamines." Benfotiamine is fat-soluble and thus more bioavailable and physiologically active than thiamin.* Characteristic of the allithiamines is an open thiazole ring within the chemical structure of these thiamine-related compounds, making them fat (lipid) soluble. In contrast, thiamine, which is water soluble, has a closed thiazole ring. The lipid solubility of benfotiamine, conferred by this open ring, increases its bioavailablity. Benfotiamine is readily absorbed at higher doses, in contrast to absorption of water-soluble thiamin salts, which decreases at higher doses, due to saturation of absorption sites in the intestines. In a double-blind, cross-over trial, comparing bioavailability of benfotiamine to that of thiamine in 12 subjects, benfotiamine caused an average 5-fold greater increase in blood thiamine levels than thiamin mononitrate, with a concomitant greater thiamine concentration in erythrocytes (red blood cells). Benfotiamine readily passes through intestinal mucosal cells, where it is converted into physiologically active thiamine. Benfotiamine inceases blood levels of thiamine pyrophosphate (TPP), the primary thiamin co-enzyme.BenefitsBenfotiamine raises the blood level of thiamine pyrophosphate (TPP), the biologically active co-enzyme of thiamine.Thiamine and its Co-enzyme, TPP Thiamine (vitamin B1) plays an essential part in the metabolism of glucose, through actions of it co-enzyme TPP (thiamine pyrophosphate). TPP is formed by the enzymatically-catalyzed addition of two phosphate groups donated by ATP to thiamine. TPP also goes by the name "thiamine diphosphate." In the cytoplasm of the cell, glucose, a 6-carbon sugar, is metabolized to pyruvic acid, which is converted into acetyl-CoA, otherwise known as "active acetate." Acetyl CoA enters the mitochondrion, where it serves as the starting substrate in the Kreb’s cycle (citric acid cycle). The Krebs cycle is the primary source of cellular metabolic energy. TPP, along with other co-enzymes, is essential for the removal of CO2 from pyruvic acid, which in turn is a key step in the conversion of pyruvic acid to acetyl CoA. CO2 removal from pyruvic acid is called "oxidative decarboxylation," and for this reason, TPP was originally referred to as "cocarboxylase." TPP is thus vital to the cell’s energy supply.Benfotiamine helps maintain healthy cells in the presence of blood glucose. Acting as a biochemical "super-thiamin," it does this through several different cellular mechanisms, as discussed below.Benfotiamine and Glucose Metabolism Benfotiamine normalizes cellular processes fueled by glucose metabolites. As long as glucose remains at normal levels, excess glucose metabolites do not accumulate within the cell. The bulk of the cell’s glucose supply is converted to pyruvic acid, which serves as substrate for production of acetyl CoA, the primary fuel for the Krebs cycle. Of the total amount of metabolic energy (in the form of ATP) released from food, the Krebs cycle generates about 90 percent. In the presence of elevated glucose levels, the electron transport chain, the final ATP-generating system in the mitochondrion, produces larger than normal amounts of the oxygen free radical "superoxide." This excess superoxide inhibits glyceraldehyde phosphate dehydrogenase (GAPDH), as key enzyme in the conversion of glucose to pyruvic acid, resulting in an excess of intermediate metabolites known as "triosephosphates." Increase triosephophate levels trigger several cellular mechanisms that result in potential damage to vascular tissue. Cells particularly vulnerable to this biochemical dysfunction are found in the retina, kidneys and nerves. Benfotiamine has been shown to block three of these mechanisms: the hexosamine pathway, the diaglycerol-protein kinease C pathway and the formation of Advanced Glycation End-poducts. As discussed below, benfotiamine does this by activating transketolase, a key thiamin-dependent enzyme. Benfotiamine stimulates tranketolase, a cellular enzyme essential for maintenance of normal glucose metabolic pathways. Transketolase diverts the excess fructose-6-phosphate and glyceraldehydes-3-phosphate, (formed by the inhibition of GAPDH, as mentioned above), into production of pentose-5-phosphates and erythrose-4-phosphate and away from the damaging pathways. Benfotiamine activates transketolase activity in bovine aortic endothelial cells incubated in glucose. To test benfotiamine’s ability to counteract these metabolic abnormalities caused by elevated blood glucose, studies have been done in diabetic rats. Benfotiamine increases transketolase activity in the retinas of diabetic rats, while concomitantly decreasing hexosamine pathway activity, protein kinase C activity and AGE formation. Benfotiamine and Protein glycation Benfotiamine controls formation of Advanced Glycation End-products (AGEs). AGEs have an affinity for proteins such as collagen, the major structural protein in connective tissue. AGEs are formed through abnormal linkages between proteins and glucose. This occurs via a non-enzymatic glycosylation reaction similar to the "browning reaction" that takes place in stored food. At high glucose concentrations, glucose attaches to lysine, forming a Schiff base, which in turn forms "early glycosylation products." Once blood glucose levels return to normal levels, the amount of these early glycosylation products decreases, and they are not particularly harmful to most tissue proteins. On long-lived proteins such as collagen, however, early glycosylation products are chemically rearranged into the damaging Advanced Glycation End-products. AGE formation on the collagen in coronary arteries causes increased vascular permeability. This vessel "leakiness" allows for abnormal cross-linking between plasma proteins and other proteins in the vessel wall, comprising vascular function and potentially occluding the vessel lumen. A number of other potentially harmful events may also occur, including production of cytokines that further increase vascular permeability. Endothelin-1, a strong vasoconstrictor, is over produced, increasing the possibility of thrombosis and generation of oxygen free radicals is stimulated. It is vitally important to support normal glucose metabolic pathways so that formation of AGEs is minimized. Benfotiamine, in the test tube (in vitro) prevents AGE formation in endothelial cells cultured in high glucose by decreasing the glucose metabolites that produce AGEs. Endothelial cells make up the membranes that line the inner walls of organs and blood vessels. In a rat study comparing the effects of Benfotiamine with water-soluble thiamin, Benfotiamine inhibited AGE formation in diabetic rats while completely preventing formation of "glycooxidation products," which are toxic by products of chronic elevated blood glucose. AGE levels were not significantly altered by thiamin. Benfotiamine also normalized nerve function in the animals. After three months of administration, "nerve conduction velocity (NCV)," a measure of nerve function, was increased by both benfotiamine and thiamin; at six months, NCV was normalized by benfotiamine, whereas thiamin produced no further increases in this parameter. Dysfunctional glucose metabolic pathways leading to AGE formation occurs in endothelial cells of the kidneys. In a recent animal study, benfotiamine was administered to rats with elevated glucose levels. Benfotiamine increased transketolase activity in the kidney filtration system of these rats, while at the same time shifting triosephophates into the pentose pathway and preventing protein leakage. |
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Best Cinnamon Extract 60 Veggie Capsules
Cinnamon, a staple ingredient in apple pie, has remained one of the world’s favorite spices throughout recorded history. The evergreen cinnamon tree (Cinnamomum verum), considered to be true cinnamon, is native to Sri Lanka. Chinese cinnamon (Cinnamomum cassia or Cinnamomum aromaticum), the cinnamon most commonly sold in the U.S., goes by the name “Cassia.” Usage of cinnamon in Chinese medicine is said to date back over 4,000 years. Mentioned in the Bible, cinnamon was imported to Egypt and Europe from the Far East by 500 B.C. In addition to its value as culinary spice, cinnamon has traditionally been utilized as a folk medicine for colds and minor digestive complaints. True cinnamon and cassia are very similar; cassia has a more pungent flavor. Cassia buds can be found in potpourri and used as a flavoring agent in sweets and beverages. Recent research has revealed that constituents in cinnamon bark called procyanidin Type-A polymers help maintain the body’s ability to metabolize glucose in a healthy way. Best Cinnamon Extract is Cinnulin PF®, a patented, water extract of Cinnamon that contains Type-A polymers. Cinnulin PF® is a registered trademark of Integrity Nutraceuticals International and is manufactured under US Patent # 6,200,569. BenefitsUse as Part of Your Diet to Help Maintain a Healthy Blood Sugar Level In Vitro and Animal StudiesResearch has revealed that a number of herbs and spices have insulin-like activity. In a study published in 2000 by the U.S. Department of Agriculture (USDA), cinnamon demonstrated the greatest ability to stimulate cellular glucose metabolism among 49 botanicals tested. In a 2001 study, researchers at the USDA’s Human Nutrition Research Center showed that bioactive compounds in cinnamon trigger an insulin-like response in fat cells. These compounds stimulated glucose uptake into cells and increased glycogen (stored glucose) production via activation of the enzyme, glycogen synthase.The bioactive compounds in cinnamon appear to potentiate insulin activity at the level of the cell receptor for insulin. It has been shown that insulin resistance involves downregulation of “insulin signaling” characterized by dephosphorylation of the receptor. Enzymes called “protein tyrosine kinases” (PTPases) are believed to decrease receptor phosphorylation, and increased PTPase activity has been observed in insulin resistant rats. Cinnamon compounds have demonstrated the in vitro ability to inhibit PTP-1 and increase autophosphorylation of the insulin receptor. In a recent animal study, cinnamon (cassia) extract was administered to rats for three weeks. Following this, the rats were infused with insulin and glucose to assess their insulin response. Increased phosphorylation of the insulin receptor was observed in skeletal muscle of these rats, suggesting that cinnamon has the ability to potentiate insulin function by normalizing insulin signaling, leading to improved uptake of glucose into skeletal muscle. Until recently, the precise molecular structure of the bioactive compounds in cinnamon had not been clearly defined. The USDA has now determined that the bioactive compounds in cinnamon are water-soluble procyanidin Type-A polymers of catechin and epicatechin. In a 2004 study, type-A polymers were isolated from cinnamon and characterized by nuclear magnetic resonance and mass spectroscopy. Type-A polymers were found to increase in vitro insulin activity by a factor of 20. Type-A polymers also exhibited antioxidant activity, as measured by inhibition of free radical production in platelets. These results suggest that, in addition to regulating glucose metabolism, cinnamon may help protect cell membranes by controlling the lipid peroxidation associated with disruptions in insulin function. Human Clinical TrialThe effect of cinnamon on glucose and blood lipids levels on people with type 2 diabetes was tested in a recent randomized, placebo-controlled trial. A total of 60 subjects were divided into six groups administered 1, 3, or 6 grams of cinnamon daily, in 500 mg capsules, or equal numbers of placebo capsules. The cinnamon or placebo capsules were consumed for two periods of 20 days each. Serum glucose, triglyceride, cholesterol, LDL cholesterol and HDL cholesterol were measured after 20 days, 40 days and again at the end of a 20-day wash-out period, during which neither cinnamon nor placebo was consumed. In all three cinnamon groups, statistically significant reductions in blood glucose levels occurred, with decreases ranging from 18 to 29 percent. Interestingly, glucose levels remained significantly lower after the 20-day wash-out period (60 days from the study start) only in the group that took the lowest cinnamon dose (1 gram daily). The placebo groups showed no significant changes.Decreases in triglyceride levels ranging from 23 to 30% were observed in all three cinnamon groups after 40 days. When the study ended at 60 days, triglyceride levels remained lower than at the study start in the 1 and 3 gram cinnamon groups, but not in the group taking 6 grams daily. Cholesterol reductions also occurred with the three cinnamon doses, with decreases ranging from 13 to 25% that were maintained at the study end. For LDL, the 3 and 6 gram cinnamon groups showed significant reductions from 10 to 24%, while in the 1 gram cinnamon group, non-significant reductions occurred after 40 days; LDL levels continued to decrease, reaching statistical significance at 60 days. With respect to HDL, significant increases were seen only in the 3 gram cinnamon group after 20 days; non-significant changes occurred in the 1 and 6 gram groups after 40 days. The overall results of this trial demonstrate that cinnamon exerts a beneficial effect on blood glucose and lipid levels in people with type 2 diabetes, at daily intakes of 1 gram, and that this low dose is equally efficacious as are the higher doses of 3 and 6 grams. |
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Best Curcumin with Bioperine 120 Capsules
Best Curcumin w/Bioperine contains a standardized extract of Curcuma longa root, commonly known as “Turmeric.” Turmeric is a yellow spice used in curried dishes. In the Far East, turmeric is valued for more than just its culinary applications. The herb has been employed in the Ayurvedic healing tradition for centuries , and is a common household remedy in India. The active ingredients in Curcuma longa are a group of plant substances called curcuminoids. Known collectively as “curcumin,” curcuminoids have demonstrated potent antioxidant properties in scientific studies. Curcuminoids benefit joints and other tissues by helping to neutralize free-radicals. Curcuminoids are responsible for turmeric’s distinctive yellow color. Curcuma C3 Complex supplies 95% total curcuminoids, including curcumin, bisdemethoxy curcumin and demethoxy curcumin. Bioperine is an extract of Black Pepper fruit that contains 95-98% piperine. Bioperine is added as a natural bioenhancer to promote absorption of the product.Turmeric- History and Traditional Usage Native to Southeast Asia, Curcuma longa is a tall tropical shrub with large oblong leaves and pale yellow flowers. The genus “Curcuma” belongs to the Zingiberaceae family, which includes ginger. The plant possesses a large root structure with fleshy, bulbous underground parts called “rhizomes.” These rhizomes, known as turmeric root, are harvested at maturity, dried and cured for commercial use. Chemical analysis shows that dried turmeric contains essential and volatile oils, with a curcuminoid content of 2.5 to 5.0 %. In addition to its popularity as a spice, turmeric is used as a dye for cloth and coloring agent in foods and cosmetics, thanks to its rich yellow color. Turmeric also serves as a preservative, probably owing to the antioxidant and antimicrobial properties of curcumin. Extracts of Curcuma longa have demonstrated in vitro antibacterial and anti-fungal effects. Turmeric is named in ancient Ayurvedic and Chinese herbal texts as a traditional folk remedy. Historically, turmeric was used externally for wounds, and sprains, and internally for digestive complaints, rheumatism, liver disorders, coughs and colds.BenefitsProtects cells and tissues by fighting free radicals. Supports joint functionThe numerous beneficial effects attributed to turmeric stem in large measure from the antioxidant properties of curcumin. Antioxidants neutralize free radicals, which are highly unstable molecules that can damage cellular structures through abnormal oxidative reactions. Curcumin is a potent “scavenger” of the superoxide radical, a free radical that initiates potentially harmful oxidative processes such as lipid peroxidation. Through this activity, curcumin has been shown to protect skin cells from the injurious effect of nitroblue tetrazolium, a toxin that generates superoxide radicals. Curcumin also increases survival of cells exposed in vitro to the enzyme hypoxanthine/xanthine oxidase, which stimulates superoxide and hydrogen peroxide production. Curcumin itself is not toxic to cells, even at high concentrations. Pure curcumin was shown to be less protective than a mixture of curcuminoids, indicating a possible synergism among curcuminoids. Because free radicals are involved in aging and exert harmful effects on skin, these results suggest curcumin may help slow skin aging. Curcumin demonstrates several other in vitro effects linked to free radical scavenging. Curcumin scavenges nitric oxide, a compound associated with the body’s inflammatory response. Pure curcumin and turmeric extracts protect red blood cells from lipid peroxidation induced by hydrogen peroxide. Curcumin has been shown to protect DNA from oxidative damage, inhibit binding of toxic metabolites to DNA, and reduce DNA mutations in the Ames’ test. Although additional studies suggest an anticarcinogenic effect of curcumin, through protection of DNA, one in vitro study found that curcumin induced DNA damage in human gastric mucosal cells. It is speculated that curcumin may act as a pro-oxidant in the presence of transition metal ions such as copper and iron. (This is true for other antioxidants, including vitamin C.) Curcumin also demonstrates in vitro inhibition of COX-I and COX-II enzymes, which are involved in the inflammatory reaction. Together these results strongly suggest that curcumin is a potent bioprotectant with a potentially wide range of therapeutic applications.Animal studies- In vivo protective effectsThrough its free radical scavenging properties, curcumin has shown bioprotective effects in animals. In one study, rats were treated with isoproterenol, a chemical that causes cardiac hypertrophy (enlargement of the heart) due to abnormal collagen metabolism. Co-treatment with curcumin reversed the degradation of collagen and cardiac hypertrophy induced by isoproterenol. Curcumin protects mice from detrimental effects of radiation, by stabilizing the glyoxalase system, a biological system that regulates cell division. Curcumin protects livers of rats from the damaging effects of carbon tetrachloride (CCl4), a potent hepatoxin that injures the liver via its free radical metabolite, CCl3. Curcumin protected rats from alcohol-induced brain damage, in a study in which oral administration of curcumin reversed lipid peroxidation, reduced levels of free-radical metabolites and increased levels of glutathione, a major physiologic antioxidant. Curcuma longa extracts have shown anti-inflammatory effects in rats. Human TrialsCurcumin exhibits free-radical scavenging ability when administered to humans. In an open trial (uncontrolled), 18 healthy individuals ranging in age from 27 to 67 years consumed a Curcuma longa extract, at a dose supplying 20 mg curcuminoids, for 45 days. Before and after blood tests showed a statistically significant decrease in lipid peroxides. Preliminary trials have tested the anti-inflammatory action of curcumin, with results that verify the traditional use of turmeric as an anti-rheumatic herb. In a short-term double-blind, cross-over, comparative study, 18 people received curcumin (1200 mg daily) or phenylbutazone for two week periods. Both curcumin and phenylbutazone produced measurable improvements in joint flexibility and walking time. The subjects reported results only with phenylbutazone, which may be explained by the short duration of the trial.20 In a small placebo-controlled trial comparing curcumin to phenylbutazone, 45 patients with post-operative inflammation received curcumin, phenylbutazone or placebo. The anti-inflammatory effects of curcumin and phenylbutazone were comparable and superior to placebo. Curcumin has not been found to produce an analgesic (pain relieving) effect. Bioperine-Nature’s Absorption Enhancer Boosts Curcumin AbsorptionTraditional Ayurvedic herbal formulas often include black pepper and long pepper as synergistic herbs. The active ingredient in both black pepper and long pepper is the alkaloid, piperine. Experiments carried out to evaluate the scientific basis for the use of peppers have shown that piperine significantly enhances bioavailability when consumed with other substances. Several double-blind clinical studies have confirmed that Bioperine® increases absorption of nutrients. Curcumin is poorly absorbed in the intestinal tract, limiting its therapeutic effectiveness. Oral doses are largely excreted in feces, and only trace amounts appear in the blood. Concomitant administration of 20 mg of piperine with 2 grams of curcumin increases the bioavailability of curcumin by 2000% |
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Best French Red Wine (60 mg) 90 VCapsules
Best French Grape Extract is a whole grape extract produced from premium wine grapes. Processed without chemical solvents and using a low-temperature extraction method, Best French Grape Extract contains proanthocyanidins, polyphenols, flavonoids and resveratrol.Made from the whole grape, including seed, skin, and stem Best French Grape Extract is a full-spectrum product extracted from the seeds, skins, and stems of select hybrid grapes. The unique extraction process is done in France using locally grown grapes. The final product is purely extracted with water and grain alcohol only. This ensures a product free of chemical residues, and absorption is optimized because the extract is water soluble. Best French Grape Extract retains the natural deep purple grape color.Quality Guaranteed Best French Grape Extract is continually analyzed by an independent laboratory using the Porter Method, an industry-accepted test of grape-extract quality. The Porter Value of Best French Grape Extract ranges from 290 to 320. These are exceptionally high measurements indicative of a product rich in beneficial active ingredients.Benefits Rich in Natural Antioxidants, including resveratrolBest French Grape Extract delivers a wide profile of natural constituents present in wine grapes, including polyphenols, proanthocyanidins (OPCs), gallic acid, ellagic acid, quercetin, catechin, epicatechin and other valuable components. Many of these substances are powerful antioxidants, which are under investigation for their potential health benefits.Best French Grape Extract also contains resveratrol, a potent antioxidant present in the grape skin. In a study recently conducted at the University of Chicago, resveratrol demonstrated significant in vitro free-radical inhibiting ability and antimutagenic activity, as well as anti-inflammatory activity in test animals.Protects health of capillaries OPCs derived from grapes have been investigated for their protective effect on capillaries, the small blood vessels subject to free-radical-induced injury. OPCs show the ability to prevent the formation of lipid peroxides, a type of free-radical that can attack lipid molecules in epithelial tissue, which forms the lining of capillary walls. OPCs also protect capillary tissues from breakdown by enzymes such as collagenase, elastase and hyaluronidase.Protects Heart Health There is growing interest in the ability of wine grape polyphenols to protect LDL cholesterol from oxidation. In a 1993 study published in The Lancet, Frankel, et al found that phenolic substances present in wine acted as electron donors to inhibit copper-catalyzed oxidation of LDL. It is now believed that oxidized LDL is a major factor in the buildup of plaque deposits in blood vessels. In its unoxidized or “native” state, LDL cholesterol accumulates in blood-vessel walls only to a limited degree. On the other hand, oxidized LDL is readily absorbed by macrophages present in arterial walls, forming “foam cells.” This is the initial stage in plaque formation. Much of the value of dietary antioxidants may center around mitigating LDL oxidation. It has been suggested that the benefits of polyphenols may help explain the so-called “French Paradox,” the relatively low mortality rate from heart disease found in regions with high consumption of red wine. In summary, the broad range of natural grape antioxidants in Best French Grape Extract may protect overall cardiovascular health in several ways: 1) Reduction of oxidative stress (free radicals), 2) Protection of LDL cholesterol against oxidation, 3) Preventing formation of lipid peroxides which can attack capillary cell membranes, and 4) Inhibition of enzymes that break down capillary tissues. |
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Best Glucosamine Sulfate (500 mg) 300 Capsules
Best Glucosamine Sulfate contains pure glucosamine sulfate, as confirmed by HPLC testing. Glucosamine sulfate consists of glucosamine, an amino sugar extracted from shellfish skeletons. "Chitin", the resilient polysaccharide that forms the structural framework of animal shells, is a long-chain polymer consisting of many glucosamine molecules linked together. The purified glucosamine is then sulfated and stabilized with potassium chloride. Note: Best Glucosamine Sulfate is sodium-free. It contains 24-26% potassium chloride. Benefits Supplies the body with building material for cartilage Cartilage, a “connective tissue,” is composed of cells (chondrocytes), protein fibers (chiefly collagen) and clusters of complex molecules called “proteoglycans.” A proteoglycan consists of a long protein (polypeptide) with many side chains attached to it. (The structure of proteoglycan looks somewhat like a test-tube brush.) The attached side chains are polysaccharides-chiefly chondroitin sulfate and keratin sulfate. Glucosamine is a key component of keratin sulfate.2 Glucosamine is also a component of hyaluronic acid, another glycosaminoglycan found in cartilage and other connective tissues. Hyaluronic acid forms the backbone for the proteoglycan clusters.2 Glycosaminoglycans have a strong attraction for water. The water-holding ability of proteoglycan clusters to hold water gives cartilage its strong, sponge-like quality. It also allows nutrients to flow into cartilage and wastes to flow out. Supports Joint Structure and Function Glucosamine sulfate is one the most important nutritional supplements for joint health ever developed. Glucosamine sulfate provides significant benefits for both the structure and function of joints. Many years of research have produced unequivocal evidence that glucosamine sulfate normalizes cartilage metabolism, slows breakdown of cartilage, and improves joint function. Glucosamine sulfate has been thoroughly researched over the last 20 years. Experimental studies and human clinical trials convincingly demonstrate that orally consumed glucosamine sulfate improves joint function. In one large open trial, over 1200 people took oral glucosamine sulfate for periods ranging from 36 to 64 days. 252 physicians participated in this multi-center study. 95% of the subjects experienced greater joint comfort and increased mobility. The physicians reported “good” results in 59%, and “sufficient” results in 36%. The improvements lasted for up to three months after the glucosamine sulfate was discontinued. The effectiveness of glucosamine sulfate for joint health has been shown in double-blind, placebo-controlled research. One study compared glucosamine sulfate to “ibuprofen,” a commonly used pain medication, over an eight week period. During the first two weeks, better results were seen with ibuprofen, but by the eighth week, glucosamine sulfate produced greater improvements in pain scores.Provides Sulfur, the Key Structural Mineral in Cartilage Sulfur, one of the body’s essential structural minerals, is incorporated into the structure of glycosaminoglycans such as chondroitin sulfate and keratin sulfate.Why Potassium-Stabilized Glucosamine Sulfate is Preferable In order for glucosamine sulfate to be processed for oral consumption as a supplement, it must be stabilized with either sodium or potassium. Either mineral works for this purpose. Potassium is preferable for numerous reasons; many people are on sodium-restricted diets, and the Standard American Diet tends to be high in sodium and low in potassium. Moreover, studies have found people needing joint support to be low in both salivary potassium and total body potassium. |
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Best Glucosamine Sulfate (750 mg) 180 Capsules
Best Glucosamine Sulfate contains pure glucosamine sulfate, as confirmed by HPLC testing. Glucosamine sulfate consists of glucosamine, an amino sugar extracted from shellfish skeletons. "Chitin", the resilient polysaccharide that forms the structural framework of animal shells, is a long-chain polymer consisting of many glucosamine molecules linked together. The purified glucosamine is then sulfated and stabilized with potassium chloride. Note: Best Glucosamine Sulfate is sodium-free. It contains 24-26% potassium chloride. Benefits Supplies the body with building material for cartilage Cartilage, a “connective tissue,” is composed of cells (chondrocytes), protein fibers (chiefly collagen) and clusters of complex molecules called “proteoglycans.” A proteoglycan consists of a long protein (polypeptide) with many side chains attached to it. (The structure of proteoglycan looks somewhat like a test-tube brush.) The attached side chains are polysaccharides-chiefly chondroitin sulfate and keratin sulfate. Glucosamine is a key component of keratin sulfate.2 Glucosamine is also a component of hyaluronic acid, another glycosaminoglycan found in cartilage and other connective tissues. Hyaluronic acid forms the backbone for the proteoglycan clusters.2 Glycosaminoglycans have a strong attraction for water. The water-holding ability of proteoglycan clusters to hold water gives cartilage its strong, sponge-like quality. It also allows nutrients to flow into cartilage and wastes to flow out. Supports Joint Structure and Function Glucosamine sulfate is one the most important nutritional supplements for joint health ever developed. Glucosamine sulfate provides significant benefits for both the structure and function of joints. Many years of research have produced unequivocal evidence that glucosamine sulfate normalizes cartilage metabolism, slows breakdown of cartilage, and improves joint function. Glucosamine sulfate has been thoroughly researched over the last 20 years. Experimental studies and human clinical trials convincingly demonstrate that orally consumed glucosamine sulfate improves joint function. In one large open trial, over 1200 people took oral glucosamine sulfate for periods ranging from 36 to 64 days. 252 physicians participated in this multi-center study. 95% of the subjects experienced greater joint comfort and increased mobility. The physicians reported “good” results in 59%, and “sufficient” results in 36%. The improvements lasted for up to three months after the glucosamine sulfate was discontinued. The effectiveness of glucosamine sulfate for joint health has been shown in double-blind, placebo-controlled research. One study compared glucosamine sulfate to “ibuprofen,” a commonly used pain medication, over an eight week period. During the first two weeks, better results were seen with ibuprofen, but by the eighth week, glucosamine sulfate produced greater improvements in pain scores.Provides Sulfur, the Key Structural Mineral in Cartilage Sulfur, one of the body’s essential structural minerals, is incorporated into the structure of glycosaminoglycans such as chondroitin sulfate and keratin sulfate.Why Potassium-Stabilized Glucosamine Sulfate is Preferable In order for glucosamine sulfate to be processed for oral consumption as a supplement, it must be stabilized with either sodium or potassium. Either mineral works for this purpose. Potassium is preferable for numerous reasons; many people are on sodium-restricted diets, and the Standard American Diet tends to be high in sodium and low in potassium. Moreover, studies have found people needing joint support to be low in both salivary potassium and total body potassium. |
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Best L-Carnitine Fumarate (855 mg) 60 Capsules
L-Carnitine is a vitamin-like nutrient that is synthesized in the body, using the amino acids lysine and methionine as precursors. Because the body produces L-Carnitine on its own, it cannot be classified as a vitamin, even though it has functions similar to B vitamins. Fumarate is also a natural compound found in the body. Fumarate serves as an intermediate in the Krebs cycle, a key cellular energy-producing process. L-Carnitine and Fumarate both play important roles in energy metabolism.Best L-Carnitine contains BIOSINT™ L-Carnitine Fumarate, which is made in Italy by Sigma Tau Health Science. It is derived from a base of pharmaceutical-grade L-Carnitine manufactured using an FDA-approved process that fully complies with international monograph standards for carnitine production. No biotechnology or genetically modified organisms are involved. L-Carnitine Fumarate is certified GMO free, BSE safe, pesticide free and Kosher. It is also ISO 9002 certified and NNFA GMP certified. L-Carnitine Fumarate is highly stable and bioavailable.Known as a global leader in L-Carnitine research, Sigma Tau holds numerous patents for production of L-Carnitine, and its L-Carnitine derivatives are used in clinical trials. Sigma Tau Health Science has the only FDA-approved (1984) pharmaceutical batch process system for consistent L-Carnitine quality, and has been manufacturing L-Carnitine derivatives for 30 years.BenefitsHelps the body burn fat for energyL-Carnitine promotes energy production in cells by transporting fatty acids into the mitochondrion. Its primary function is to transfer long-chain fatty acids across the inner mitochondrial membrane. Fatty acid molecules are activated to coenzyme A (CoA) esters in the cytoplasm of the cell, and then esterified to L-Carnitine. The combination of a fatty acid molecule and L-Carnitine is called “acyl-carnitine.” Much of the body's L-Carnitine content is stored in the form of acyl-carnitine.The mitochondrion is the cell’s energy-generating furnace. Called an “organelle,” the mitochondrion is a self-contained structure inside the cell. Like all cellular structures, the mitochondrion is surrounded by a membrane. This membrane is an impenetrable barrier to acyl-CoA esters; passage across the membrane requires L-Carnitine as a transporter. On the inside of the mitochondrial membrane, the acyl-CoA esters are made available to be metabolized through the process of beta oxidation. One of the key metabolic byproducts of this process is acetyl-CoA, also called “active acetate,” which enters the Krebs cycle (also known as the “citric acid cycle”) to supply fuel for production of ATP, the cell’s primary energy “currency.” L-Carnitine shuttles excess fatty acid residues out of the mitochondrion, and in this role is essential for preventing toxic buildup of fatty acids inside the mitochondrion.Evidence suggests that L-Carnitine and short chain acyl-carnitine esters can protect the mitochondrion from adverse effects of drugs and toxic chemicals. L-Carnitine has been shown to protect animals form cardiotoxins and decrease mortality rate in animals with diphtheria, due to this cardioprotective effect.Helps maintain a healthy heart and cardiovascular systemMuscle tissue contains a high concentration of L-Carnitine. With its constant energy needs, heart muscle tissue is especially rich in L-Carnitine. If the body’s ability to biosynthesize L-Carnitine is compromised, energy production in muscle tissue is impaired, and a toxic buildup of fatty acids can occur. Defective production of L-Carnitine by the body can result from a variety of factors, including kidney or liver malfunction, increased catabolism or the inability of tissues to extract and retain L-Carnitine from the blood.Along with glucose and lactate, fatty acids are the primary oxidation fuel for the heart. A considerable amount of scientific data from animal experiments indicates that L-Carnitine protects the heart under conditions of hypoxia, or low oxygen. In addition to the oxidation of fat for energy in the cell, L-Carnitine is involved in the metabolism of glucose. Evidence of L-Carnitine’s role in glucose metabolism was uncovered in a small trial on 9 diabetic individuals. Given intravenously, L-Carnitine improved insulin-mediated glucose utilization and insulin sensitivity.Depletion of the body’s L-Carnitine supply is linked to various abnormal states, especially of the heart muscle. The effect of L-Carnitine on hypoxic (oxygen-starved) isolated heart muscle tissue has been studied. At high concentrations, L-Carnitine demonstrates a clear-cut ability to potentiate the contractility of isolated heart muscle tissue, indicating the L-Carnitine has a strengthening effect on the heart. L-Carnitine has been shown to improve the performance of rats subjected to fatigue test.Research has revealed that in animals and humans with defective heart muscle, the amount of free L-Carnitine (not bound to fatty acids) is reduced. Administration of L-Carnitine to hamsters prevents damage to the heart muscle. Given to humans with angina, L-Carnitine was found to improve exercise tolerance. In a small study, patients with congestive heart failure showed gains in heart function with oral consumption of L-Carnitine, reportedly by restoring normal oxidation of fatty acids. In heart valve replacement patients, L-Carnitine has been shown to increase the valve tissue levels of ATP, pyruvate and creatine phosphate, which are key cellular energy substrates. In a controlled study, L-Carnitine was administered to 38 patients prior to open heart surgery. Prior to surgery, heart circulatory function, as assessed by measurements of hemodynamics, was “good” in all 38. While there was evidence of a “preserving” effect of L-Carnitine on heart cells, no differences in cardiac performance were observed. These results suggest that noticeable improvements in heart muscle performance with L-Carnitine are most likely to occur in people with compromised hearts.It has been suggested that L-Carnitine favorably influences blood lipids. Preliminary evidence of this was seen in a small open trial on 26 patients who took 3 grams of L-Carnitine daily for 40 days. Blood levels of cholesterol and triglycerides dropped substantially, while the ratio of total to HDL cholesterol–– a known marker of cardiovascular health––markedly improved.While L-Carnitine is not a treatment for heart disease, (nor should it be used as a substitute for medical treatment) the results of these and other studies suggest that oral consumption of L-Carnitine has a beneficial influence on maintaining a healthy heart and cardiovascular system. |
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Best MSM (1000 mg) 180 Capsules
Best MSM and Best MSM Powder contain pure MSM (methylsulfonylmethane), a white crystalline substance that occurs in the human body and in some foods. MSM is an excellent dietary source of bioavailable organic sulfur.The MSM Story-One of Nature's Primary Sources of Organic Dietary Sulfur! The human body requires a continuous supply of usable sulfur, and MSM is one of the primary organic sulfur-containing molecules for use by living organisms. From life's earliest beginnings, primitive marine organisms (blue-green algae and phytoplankton) have absorbed inorganic sulfur from ocean waters and produced organic sulfur molecules, primarily dimethyl sulfonium salts. These salts are released back into the sea, where they are converted to dimethyl sulfide, which readily evaporates, ending up in the upper atmosphere. Dimethyl sulfide is then oxidized by UV light, forming DMSO and MSM. The two compounds are delivered to land masses in rain water, and absorbed by plants. MSM is a stable end-product of this process, and thus serves as a primary source of sulfur in the food chain.Though present on earth since before life appeared on dry land, and known to science since the 1950's, MSM has only recently been recognized as having importance in human nutrition.Why the Human Body Needs MSM MSM occurs naturally in the blood, body fluids and tissues. It is now believed that a minimum MSM concentration of 0.2 parts per million is necessary for the body to function normally. MSM may be the most easily absorbed and non-toxic source of nutritional sulfur occurring in nature.Sulfur is a structural mineral that maintains the strength of various tissues by forming sulfur "tie-bars" (sulfhydryl bonds) between connective tissue proteins. MSM serves as a readily available source of sulfur for this function, and thus helps maintain the pliancy of tissues and cell membranes. Repair of damaged tissue depends upon a supply of sulfur for continuation of reactions involving sulfhydryl groups (-SH). Sulfur is required for the maintenance of healthy hair, skin and nails. In view of the presence of MSM in biological systems since the beginning of evolution, it is logical to assume that all higher life forms, including humans and animals, are well adapted to use MSM as a sulfur donor.Benefits Clinical research on the role of MSM in the human body has culminated in the filing of several patents covering numerous uses for MSM as a dietary ingredient for both humans and animals. As a result of these investigations, it is believed that physical and psychological stress increases in the human body when the MSM concentration falls below minimum levels, resulting in a loss of normal organ function.Based on observations, ingestion of MSM by humans has the following beneficial effects:• MSM supports maintenance of strong, healthy body tissues by donating sulfur for formation of sulfur tie-bars between connective tissue proteins. • MSM supports normal gastrointestinal function. • MSM improves the body's resistance to adverse physical stress. • MSM supports mental alertness and maintenance of healthy mood. • MSM promotes the body's processes that heal tissue. • MSM helps modify the physiologic response to allergens. • MSM supports normal lung function. • MSM supports normal relaxation of muscles. • MSM supports normal joint function.• MSM helps maintain healthy skin.Supplementation is Needed to Realize the Benefits of MSM Widespread in nature, MSM is found in a variety of foods, including fresh fruits and vegetables, raw milk, raw meat and raw fish. However, MSM is a volatile substance easily lost during cooking, pasteurization, food processing and storage. The average American diet thus supplies at best a marginal MSM intake, which may be inadequate to maintain the optimum MSM concentration in the body. The body's MSM concentration is also believed to decline with increasing age. |
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Best MSM (1500 mg) 120 Tablets
Best MSM and Best MSM Powder contain pure MSM (methylsulfonylmethane), a white crystalline substance that occurs in the human body and in some foods. MSM is an excellent dietary source of bioavailable organic sulfur.The MSM Story-One of Nature's Primary Sources of Organic Dietary Sulfur! The human body requires a continuous supply of usable sulfur, and MSM is one of the primary organic sulfur-containing molecules for use by living organisms. From life's earliest beginnings, primitive marine organisms (blue-green algae and phytoplankton) have absorbed inorganic sulfur from ocean waters and produced organic sulfur molecules, primarily dimethyl sulfonium salts. These salts are released back into the sea, where they are converted to dimethyl sulfide, which readily evaporates, ending up in the upper atmosphere. Dimethyl sulfide is then oxidized by UV light, forming DMSO and MSM. The two compounds are delivered to land masses in rain water, and absorbed by plants. MSM is a stable end-product of this process, and thus serves as a primary source of sulfur in the food chain.Though present on earth since before life appeared on dry land, and known to science since the 1950's, MSM has only recently been recognized as having importance in human nutrition.Why the Human Body Needs MSM MSM occurs naturally in the blood, body fluids and tissues. It is now believed that a minimum MSM concentration of 0.2 parts per million is necessary for the body to function normally. MSM may be the most easily absorbed and non-toxic source of nutritional sulfur occurring in nature.Sulfur is a structural mineral that maintains the strength of various tissues by forming sulfur "tie-bars" (sulfhydryl bonds) between connective tissue proteins. MSM serves as a readily available source of sulfur for this function, and thus helps maintain the pliancy of tissues and cell membranes. Repair of damaged tissue depends upon a supply of sulfur for continuation of reactions involving sulfhydryl groups (-SH). Sulfur is required for the maintenance of healthy hair, skin and nails. In view of the presence of MSM in biological systems since the beginning of evolution, it is logical to assume that all higher life forms, including humans and animals, are well adapted to use MSM as a sulfur donor.Benefits Clinical research on the role of MSM in the human body has culminated in the filing of several patents covering numerous uses for MSM as a dietary ingredient for both humans and animals. As a result of these investigations, it is believed that physical and psychological stress increases in the human body when the MSM concentration falls below minimum levels, resulting in a loss of normal organ function.Based on observations, ingestion of MSM by humans has the following beneficial effects:• MSM supports maintenance of strong, healthy body tissues by donating sulfur for formation of sulfur tie-bars between connective tissue proteins. • MSM supports normal gastrointestinal function. • MSM improves the body's resistance to adverse physical stress. • MSM supports mental alertness and maintenance of healthy mood. • MSM promotes the body's processes that heal tissue. • MSM helps modify the physiologic response to allergens. • MSM supports normal lung function. • MSM supports normal relaxation of muscles. • MSM supports normal joint function.• MSM helps maintain healthy skin.Supplementation is Needed to Realize the Benefits of MSM Widespread in nature, MSM is found in a variety of foods, including fresh fruits and vegetables, raw milk, raw meat and raw fish. However, MSM is a volatile substance easily lost during cooking, pasteurization, food processing and storage. The average American diet thus supplies at best a marginal MSM intake, which may be inadequate to maintain the optimum MSM concentration in the body. The body's MSM concentration is also believed to decline with increasing age. |
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Best MSM Powder 250 grams
Best MSM and Best MSM Powder contain pure MSM (methylsulfonylmethane), a white crystalline substance that occurs in the human body and in some foods. MSM is an excellent dietary source of bioavailable organic sulfur.The MSM Story-One of Nature's Primary Sources of Organic Dietary Sulfur! The human body requires a continuous supply of usable sulfur, and MSM is one of the primary organic sulfur-containing molecules for use by living organisms. From life's earliest beginnings, primitive marine organisms (blue-green algae and phytoplankton) have absorbed inorganic sulfur from ocean waters and produced organic sulfur molecules, primarily dimethyl sulfonium salts. These salts are released back into the sea, where they are converted to dimethyl sulfide, which readily evaporates, ending up in the upper atmosphere. Dimethyl sulfide is then oxidized by UV light, forming DMSO and MSM. The two compounds are delivered to land masses in rain water, and absorbed by plants. MSM is a stable end-product of this process, and thus serves as a primary source of sulfur in the food chain.Though present on earth since before life appeared on dry land, and known to science since the 1950's, MSM has only recently been recognized as having importance in human nutrition.Why the Human Body Needs MSM MSM occurs naturally in the blood, body fluids and tissues. It is now believed that a minimum MSM concentration of 0.2 parts per million is necessary for the body to function normally. MSM may be the most easily absorbed and non-toxic source of nutritional sulfur occurring in nature.Sulfur is a structural mineral that maintains the strength of various tissues by forming sulfur "tie-bars" (sulfhydryl bonds) between connective tissue proteins. MSM serves as a readily available source of sulfur for this function, and thus helps maintain the pliancy of tissues and cell membranes. Repair of damaged tissue depends upon a supply of sulfur for continuation of reactions involving sulfhydryl groups (-SH). Sulfur is required for the maintenance of healthy hair, skin and nails. In view of the presence of MSM in biological systems since the beginning of evolution, it is logical to assume that all higher life forms, including humans and animals, are well adapted to use MSM as a sulfur donor.Benefits Clinical research on the role of MSM in the human body has culminated in the filing of several patents covering numerous uses for MSM as a dietary ingredient for both humans and animals. As a result of these investigations, it is believed that physical and psychological stress increases in the human body when the MSM concentration falls below minimum levels, resulting in a loss of normal organ function.Based on observations, ingestion of MSM by humans has the following beneficial effects:• MSM supports maintenance of strong, healthy body tissues by donating sulfur for formation of sulfur tie-bars between connective tissue proteins. • MSM supports normal gastrointestinal function. • MSM improves the body's resistance to adverse physical stress. • MSM supports mental alertness and maintenance of healthy mood. • MSM promotes the body's processes that heal tissue. • MSM helps modify the physiologic response to allergens. • MSM supports normal lung function. • MSM supports normal relaxation of muscles. • MSM supports normal joint function.• MSM helps maintain healthy skin.Supplementation is Needed to Realize the Benefits of MSM Widespread in nature, MSM is found in a variety of foods, including fresh fruits and vegetables, raw milk, raw meat and raw fish. However, MSM is a volatile substance easily lost during cooking, pasteurization, food processing and storage. The average American diet thus supplies at best a marginal MSM intake, which may be inadequate to maintain the optimum MSM concentration in the body. The body's MSM concentration is also believed to decline with increasing age. |
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Best Nattokinase 100mg (2,000 Fibrin Units) 90 Veggie Caps
Nattokinase is an enzyme derived from "natto", a traditional fermented soy food popular in Japan. During the natto production process B. subtilis natto, a friendly bacteria, ferments boiled soybeans, releasing nattokinase. Best Nattokinase contains pure nattokinase enzyme in a lactose base.*Nattokinase from Doctor's Best is an unbeatable value at this sale price. |
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Best Noni Concentrate (650 mg) 150 Capsules
Best Noni contains pure dried Morinda citrifolia fruit, commonly known as “Noni.” The Morinda citrifolia plant has a long herbal history in Southeast Asia and the South Pacific, and is considered beneficial for a wide variety of uses. Noni fruit, recognized as a valuable food source and approved by the U.S. government since World War II, contains vitamin C1 and other nutritious substances.NONI: Traditional Folk Remedy Morinda citrifolia is well known throughout tropical regions of Asia, the South Pacific and the Caribbean. There are no fewer than 40 common names for this remarkable plant. In the South Pacific, the fruit of Morinda citrifolia goes by the name “Noni.” Highly esteemed for its nutritional value, Noni was approved by the U.S. government during World War II as a food for American soldiers in the Pacific. Noni is also a prized traditional folk remedy among Pacific island cultures and is considered useful for a wide variety of ailments. Pharmaceutical research has uncovered a number of active constituents in the roots, leaves and fruit of Morinda citrifolia. Noni fruit, in addition to vitamin C, contains antibacterial compounds and beneficial polysaccharides.Benefits Stimulates Cell Repair Noni fruit has recently been found to contain a substance given the name “proxeronine” which is believed to increase levels in the body of an alkaloid called “xeronine.” Preliminary unpublished investigations indicate that xeronine is vital for the regeneration of cell structures and maintenance of cellular functions. This intriguing discovery may in large measure explain Noni’s wide range of reported beneficial effects.Supports Immune Function Anecdotal clinical reports on the use of Noni fruit include improvement in the body’s resistance to viruses, yeast, fungi, and bacteria. These observations are supported by current research studies performed at the University of Hawaii. Noni fruit extracts showed an ability to enhance the immune response in mice.Additional reports on the current uses on Noni which coincide with the traditional uses include: 1) Effective against fatigue, 2) Support for joint function and control of the inflammatory response, 3) Maintenance of normal blood-sugar levels. Noni is safe and free of side effects. As a supplement, it should be taken on an empty stomach to prevent breakdown by stomach acid of the natural enzymes present in Noni fruit. |
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Best Red Yeast Rice 120 Veggie Capsules
Best Red Yeast Rice contains rice that has been naturally fermented with red yeast (Monascus purpureus) according to traditional methods. Produced in the U.S., this product is similar to red yeast rice that has been used in culinary applications in Asia since at least 800 A.D. It is considered beneficial for adult men and women when taken as part of a lifestyle program that includes regular exercise and a healthy diet. |
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Best Red Yeast Rice 1200mg 60 Tablets
Best Red Yeast Rice contains rice that has been naturally fermented with red yeast (Monascus purpureus) according to traditional methods. Produced in the U.S., this product is similar to red yeast rice that has been used in culinary applications in Asia since at least 800 A.D. It is considered beneficial for adult men and women when taken as part of a lifestyle program that includes regular exercise and a healthy diet. |
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Best Red Yeast Rice 1200mg w/ CoQ10 60 Tablets
Best Red Yeast Rice contains rice that has been naturally fermented with red yeast (Monascus purpureus) according to traditional methods. Produced in the U.S., this product is similar to red yeast rice that has been used in culinary applications in Asia since at least 800 A.D. It is considered beneficial for adult men and women when taken as part of a lifestyle program that includes regular exercise and a healthy diet. |
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Best Saw Palmetto 320 mg 60 Softgel Capsules
Standardized Saw palmetto berry extract, guaranteed to contain 90 percent fatty acids and sterols.Benefits Effective Prostate Support. Saw palmetto extract is one of the world's leading herbal products for prostate support. Widely-cited clinical studies conducted over the last fifteen years have clearly established the ability of Saw palmetto extract to produce major improvements in prostate-related urinary function. Saw Palmetto's key active ingredients help to normalize prostate gland structure. Discussion As men pass through and beyond middle age, hormonal changes occur which can impact the prostate gland. Levels of dihydrotestoterone (DHT), a normal metabolite of testosterone, increase. This, plus an increased binding of DHT to nuclear receptors in the prostate cell, results in growth of prostate tissue. This tissue growth takes place in the part of the prostate which surrounds the urethra, the tube for urine excretion. This can constrict the urethra, resulting in urinary disturbances.Saw palmetto extract has been shown to inhibit 5 alpha-reductase, an enzyme that controls conversion of testosterone to DHT. Saw palmetto extract also blocks the binding of DHT to prostate cells. These mechanisms are believed to account for Saw palmetto extract's positive effect on prostate gland structure.In clinical studies, Saw palmetto extract has produced measurable improvements in urinary functions and prostate size. Quality of life scores have also improved.The results with Saw palmetto extract have been duplicated in open trials and controlled, double-blind studies.Saw palmetto extract is safe and virtually free of side-effects.Saw palmetto’s effectiveness comes from its content of natural fatty acids and sterols. These include oleic acid, lauric acid, campasterol, stigmasterol, beta-sitosterol and others. The standard of quality for Saw palmetto extract products is a high concentration of fatty acids and sterols, equaling 90%. |
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Celadrin Complex with Glucosamine 90 Tablets
Celadrin® is a unique formulation of esterified (stable) fatty acids that has been shown to reduce certain effects related to pronounced inflammatory processes that can occur in the body. Being a complex molecule consisting of various fatty acids, it is able to penetrate cell membranes, which enhances membrane permeability and cell-to-cell signaling. In doing so, Celadrin® may reduce the level of inflammatory components of the immune system from binding to cells and thus causing occasional inflammation in different parts of the body. Glucosamine SulfateGlucosamine sulfate is the most completely studied form of glucosamine. It is commonly derived from the exoskeleton of shellfish and is a critical nutrient needed for the synthesis and repair of joint cartilage. Glucosamine sulfate has the ability to stimulate the synthesis of glycosaminoglycans and other components of the structural matrix of joint tissue. Because of the comprehensive nature of glucosamine sulfate's effects, it may play a role in maintaining the health of joint tissues.BenefitsIncreased Range of Motion in JointsResearch has shown that Celadrin® can have an impact on improving the range of motion in the joints. A placebo-controlled trial conducted in 2002 showed that those individuals taking a complex containing Celadrin® for 2 months had a significant improvement in knee flexion (ability to bend the knee) over those taking a placebo.Another study conducted on Celadrin® published in 2004 concluded that treatment “significantly increased physical performance (as measured by a variety of orthopedic tests)” in patients with compromised knee mobility. The study found that the subjects given Celadrin® showed improvement in their ability to climb stairs, rise from a chair and walk, along with an improved sense of balance, strength and endurance.Helps Maintain Healthy Joint CartilageGlucosamine sulfate plays a fundamental role as a building block for joint cartilage. Evidence to date suggests it may reduce the severity of the symptoms in individuals with joint problems.Glucosamine sulfate has been shown in some studies to stimulate the regeneration of damaged cartilage, while also having anti-inflammatory effects. Research has found that glucosamine sulfate may have a stimulatory effect on proteoglycan production from human cartilage cells.A specific 3-year placebo-controlled, randomized study was conducted to assess the impact of taking oral glucosamine sulfate on the progression of joint space narrowing. Joint space narrowing may be associated with certain degenerative conditions of articular tissue. The study found that those individuals taking the oral glucosamine at the recommended intake had no space narrowing on average over the time period versus significant space narrowing in the placebo group. Glucosamine sulfate may further play a role in enhancing joint lubrication by acting to form the protective agent mucin, a necessary component of healthy joints.Maintains Joint ComfortThe anti-inflammatory actions of Celadrin® have been demonstrated by one double-blind, placebo controlled trial that showed Celadrin®, when taken orally at recommended intake levels, decreased pain scores and increased walking distance compared to the group receiving placebo. The authors theorize that Celadrin® may work by down-regulating the effect of certain precursors of the body's inflammatory response.In one large open trial, over 1200 people took oral glucosamine sulfate for periods ranging from 36 to 64 days. Over 252 physicians participated in this multicenter study. 95% of the subjects experienced greater joint comfort and increased mobility. The physicians reported "good" results in 59%, and "sufficient" results in 36%. The improvements lasted for up to three months after the glucosamine sulfate was discontinued. |
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Comprehensive Prostate Formula 90 Tablets
Comprehensive Prostate Formula is a complete nutritional program for supporting prostate health with herbs, vitamins, minerals and other nutrients known to benefit the prostate gland.Herbs: Saw palmetto extract -- The Saw palmetto in Comprehensive Prostate Formula is standardized to contain 85 to 90% fatty acids, which are the active ingredients in the Saw palmetto berry that promote prostate health. Three tablets supplies 320 mg, the daily dose used for prostate therapy in clinical studies.Pygeum extract -- Pygeum is an evergreen tree native to the high plateaus of southern Africa. Pygeum bark contains phytosterols, beta sitosterol and other sitosterols, natural sterols that have been shown to normalize the prostate.2 Clinical trials establish 100 mg per as a highly effective dose of Pygeum extract, especially in combination with Nettle root.Nettle root extract -- Nettle, also known as "Stinging Nettle," grows wild in forests and fields throughout North America and Europe. Nettle root has been researched in European studies and shown to benefit the prostate and urinary tract. While the specific active ingredients in Nettle for prostate support have not been positively identified, Nettle's effect on the prostate may stem from its content of polysaccharides and isolectin.4 300 mg per day is a clinically effective dose of Nettle root extract.Amino acids -- The combination of L-alanine, glutamic acid and glycine were first used for prostate support in 1958. Two medical doctors administered the amino acids to allergy patients who reported improvement in urinary function.Lycopene -- Tomatoes are rich in carotenes, natural pigments responsible for the rich variety of colors in fruits and vegetables. Lycopene gives the tomato fruit its red color. Recent research suggests that lycopene may help reduce the risk of prostate C. (These findings, however, are strictly preliminary and await confirmation through further research.)Minerals -- The human prostate contains a high concentration of zinc, which is known to be a key mineral for prostate health. Selenium, an essential trace mineral, may play a role in C risk reduction. Recent work by Harvard University researchers showed that men with the highest levels of selenium were less likely to develop prostate C than those with the lowest selenium levels. Copper is added to balance zinc. When supplementing with zinc, it is advised to take a small amount of additional copper to prevent copper deficiency.Vitamins -- Vitamin E is added as an antioxidant and support for the reproductive system. Vitamin B6 may benefit the prostate by reducing excess levels of the hormone prolactin.BenefitsHelps maintain a healthy prostate gland. Supports normal urinary function. Comprehensive Prostate Formula-the Clinical StudiesSaw palmetto ExtractSaw palmetto extract is one of the world's leading herbal products for prostate support. Widely-cited clinical studies conducted over the last fifteen years suggest Saw palmetto extract can produce major improvements in prostate-related urinary function. In clinical studies, Saw palmetto extract has produced measurable improvements in urinary functions and prostate size. Quality of life scores have also improved. The results with Saw palmetto extract have been duplicated in open trials and controlled, double-blind studies.For example, in a large open trial, 505 men took 320 mg of Saw palmetto extract daily for three months. The results were evaluated with various measurements such as the International Prostate Symptom Score, the quality of life score, urinary flow rates, residual urinary volume, and prostate size. After 45 days these parameters improved significantly. After 90 days of treatment nearly ninety percent of both the doctors and patients regarded Saw palmetto extract as effective as therapy for the prostate.The changes in prostate health that accompany middle age are related to the hormone DHT, or dihydrotestosterone, a metabolite of testosterone. DHT levels rise, and DHT binds to prostate cells, accelerating growth of prostate tissue. Saw palmetto extract has been shown to inhibit 5 alpha-reductase, an enzyme that controls conversion of testosterone to DHT. Experimental evidence suggests Saw palmetto extract blocks the binding of DHT to prostate cells. The fatty acids and sterols in Saw palmetto are believed to be responsible for these actions. These include oleic acid, lauric acid, campasterol, stigmasterol, beta-sitoster | | |
