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Best L-Tryptophan 500mg 90 Veggie caps
Best L-Tryptophan featuring TryptoPure™
• TryptoPure™, which is unsurpassed in purity by any other l-tryptophan in the world today, is a trademark of Ajinomoto Company, Inc.
• Ajinomoto in Japan is the word's foremost producer of pharmaceutical-grade amino acids, including TryptoPure.
• TryptoPure surpasses all testing criteria established by the U.S. Pharmacopeia (USP), Japan Pharmacopeia (JP), and European Pharmacopeia (EP) standards.
• U.S. importation of Ajinomoto's l-tryptophan has proceeded uninterrupted for over 25 years.
• Best L-Tryptophan featuring TryptoPure is packaged in veggie caps and suitable for vegetarians.
• TryptoPure is used in hospitals and pharmacies all over the world.
• It is additive-free, solvent-free, 100% fermented, and GMP certified.
Suggested Use:
Take 1 or 2 capsules daily, or as directed by a health practitioner. For optimum absorption, take separately from protein-containing foods and dietary supplements containing protein or amino acids.
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Best 5-HTP 100 mg 60 Capsules
5-HTP (5-hydroxytryptophan) is a naturally-occurring metabolite of the essential amino acid tryptophan. 5-HTP for use in dietary supplements is derived from the seeds of the Griffonia simplicifolia plant. Metabolism and absorption of 5-HTP5-HTP (5-hydroxytryptophan) is formed by the addition of a hydroxyl group (-OH) to the 5 carbon of the indole ring of tryptophan. Conversion of tryptophan to 5-hydroxytryptophan is catalyzed by the enzyme tryptophan hydroxylase. 5-HTP functions as the precursor for serotonin, and is converted to serotonin in a pyridoxal phosphate (vitamin B6) dependent reaction catalyzed by the enzyme L-amino acid decarboxylase.Synthesis of serotonin in the brain requires an adequate supply of either tryptophan or 5-HTP as precursors. The supply of tryptophan available for conversion to 5-HTP depends on a number of factors, including nutritional status and competition between tryptophan and other amino acids for transport across the blood brain barrier.Disturbances in the serotonin metabolic pathway may disrupt central nervous system functions which utilize serotonin as a neurotransmitter. Administration of 5-HTP bypasses the conversion of tryptophan to 5-HTP. 5-HTP readily crosses the blood brain barrier and becomes available for serotonin synthesis. Serotonergic neurons (nerve cells stimulated by serotonin) regulate sleep, appetite, nociception (the perception of pain), and aggressive behavior.Serotonin is metabolized to 5-HIAA (5-hydroxyindolacetic acid) which is its primary breakdown product. The concentration of 5-HIAA in cerebrospinal fluid is used as an indicator of serotonin turnover in the CNS serotonin level. Psychiatric patients have been found to have low levels of 5-HIAA in the CNS fluid, suggesting serotonin deficiency.5-HTP is readily absorbed by the mucosal cells of the gastrointestinal tract. In one study using five subjects, systemic absorption of 5-HTP in combination with carbidopa averaged 69.2 percent. Another absorption study found that carbidopa enhanced the increase in serum 5-HTP concentration 5 to 15 fold. In this study, a single dose of 5-HTP increased the plasma level of 5-HTP only slightly, whereas 5-HIAA increased 9-20 fold. This suggests that the gut mucosa has a storage capacity for 5-HTP, and that plasma increases occur after maximum capacity is reached.BenefitsImproves Well-Being in Depressed PersonsSerotonin in the central nervous system is recognized as a causative factor in some depressed persons. A comprehensive review of seven open and seven controlled clinical studies found that oral consumption of 5-HTP improved mental and emotional status in 60 to 70 percent of depressed people. The results varied from "modest" to "marked."8 Dosages ranged from 50 to 300 mg daily. The accumulated evidence is inconclusive as to whether 5-HTP is more effective combined with decarboxylase inhibitors than when taken alone. Many of the early trials used the combination, and this has been a frequently used therapeutic strategy for reducing conversion of 5-HTP to serotonin outside the CNS. It is generally accepted that a large portion of absorbed 5-HTP is metabolized to serotonin in peripheral tissues before it can enter the brain.Peripheral conversion of 5-HTP to serotonin would theoretically limit the usefulness of oral 5-HTP for improving CNS functions and mental health. However, trials in which 5-HTP was given alone do show benefits. A small open trial in which 25 people were given 5-HTP either alone or with a decarboxylase inhibitor found no difference in effectiveness. Thirteen of the patients had "very good" or "good" improvement, 8 had "moderate," and in 4 out of the twenty-five the results were judged to be "poor."A more recent randomized double-blind study compared the efficacy of oral 5-HTP (100 mg T.I.D., without a decarboxylase inhibitor) to that of fluvoxamine, a selective serotonin reuptake inhibitor. (SSRIs block the reabsorption of serotonin by postsynaptic receptors, thus increasing the available supply of serotonin in the synaptic cleft.) The two were found to be equally effective, and 5-HTP was better tolerated. It should be noted that 5-HTP was given in the form of enteric-coated pH-sensitive capsules which dissolve in the small intestine, thus preventing conversion of 5-HTP to serotonin in the stomach.In contrast to MAO inhibitors and SSRIs, medications which act by blocking normal physiologic functions, 5-HTP supports normal function in its role as a serotonin precursor. Correcting serotonin deficiency has been called a "functional-dimensional approach" in the treatment of depression.Improves Sleep Quality Studies have shown that 5-HTP influences the quality of sleep by increasing REM (rapid eye movement) sleep. Administration of 5-HTP in the evening prior to bedtime has been shown to increase the duration of REM sleep and decrease the amount of non-REM sleep.5-HTP–A Free-radical ScavengerThe OH group which is added to tryptophan in the formation of 5-HTP gives 5-HTP antioxidant properties. (Compounds such as vitamin E and flavonoids derive their free-radical quenching ability from OH groups, which donate electrons to oxidants.) 5-HTP quenches a variety of free-radicals. This is in contrast to tryptophan, which is sensitive to oxidation.Adverse effects of 5-HTP Oral administration of 5-HTP in clinical studies has resulted in gastrointestinal disturbances such as nausea, vomiting and diarrhea. According to a review by Byerley, et. al. these effects are tolerated by most patients and tend to lessen over time.8 Side effects are more marked with higher doses, and may be reduced by the use of enteric-coated, pH sensitive capsules or tablets. |
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Best Acetyl L-Carnitine 60 Capsules
Acetyl-L-Carnitine (ALC) is a naturally occurring form of L-Carnitine, a vitamin-like nutrient synthesized in the body from the amino acids lysine and methionine. ALC serves as a transport molecule for "active acetate," which is a source of fuel for metabolic processes that take place in cells. ALC carries active acetate (the "Acetyl" portion) directly into the mitochondrion, the cell's energy-generating structure. Active acetate is used to produce cellular energy in the form of ATP. Both L-Carnitine and ALC serve as fat carriers. Unlike L-Carnitine, ALC readily crosses the blood-brain barrier, where it has specific benefits for brain neurons. When taken orally, ALC has been shown to increase ALC levels in both blood and cerebrospinal fluid, demonstrating its uptake in the brain.Best Acetyl-L-Carnitine consists of Biosint™ Acetyl-L-Carnitine, which is manufactured in Italy by the Sigma Tau company. It is derived from a base of pharmaceutical-grade L-Carnitine manufactured using an FDA-approved process that fully complies with international monograph standards for carnitine production. Known as a global leader in L-Carnitine research, Sigma Tau holds numerous patents for production of L-Carnitine, and its L-Carnitine derivatives, such as ALC, which are used in clinical trials.BenefitsSupports cognitive functionALC has been studied for its effect on cognitive performance and emotional health in the elderly. In a single-blind, placebo-controlled trial, 481 elderly subjects exhibiting mild memory impairment improved their scores on a memory test after taking 1500 mg of ALC a day for 90 days. Hospitalized elderly people taking ALC have shown improvements in mental outlook.While ALC is not a treatment or cure for Alzheimer's disease, double-blind studies suggest it may help slow the rate at which early-stage Alzheimer's patients deteriorate. In particular, ALC seems to benefit short-term memory in these patients.Supports biosynthesis of acetylcholine, a key neurotransmitter for brain and nerve functionBrain function requires coordinated communication between brain cells. Brain and nerve cells ("neurons") communicate across tiny cell-to-cell gaps called "synapses." The passage of an electrical impulse from one neuron to the next requires a "neurotransmitter." When an electrical signal arrives at the synaptic junction, the neuron releases a neurotransmitter into the synapse. The neuron on the other side of the synapse contains receptors for the neurotransmitter; these receptors bind the neurotransmitter, triggering a series of chemical events that sends a new electrical signal down the membrane of the receiving neuron. Neurotransmitters work together like an orchestra to transmit information throughout the brain and nervous system. Acetylcholine is the most abundant neurotransmitter in the body, regulating activities of vital organs, blood vessels and communication between nerves and muscles. In the brain, acetylcholine helps facilitate memory and learning as well as influence emotions. ALC is structurally similar to acetylcholine, and brain neurons stimulated by acetylcholine are receptive to stimulation by ALC. It has been shown experimentally that ALC supplies acetyl groups for the biosynthesis of acetylcholine. ALC's hypothesized cholinomimetic (acts like acetylcholine) activity has led researchers to investigate its effects on mental function and emotional health.Helps supply the brain with energy by improving energetics in the mitochondrionThe acetyl groups donated by ALC can be used to synthesize acetyl-CoA, the key substrate for energy metabolism in the mitochondrion. Acetyl-CoA enters the Krebs cycle, the mitochondrial mechanism that generates cellular energy in the form of ATP. ALC easily crosses the blood-brain barrier, allowing it to play various roles in maintaining brain neuron (nerve cell) function. When given by oral administration, the concentration of ALC is increased in the blood and cerebrospinal fluid.Stabilizes intracellular membranesALC was found to improve membrane phospholipid metabolism in early-stage Alzheimer's patients. Phospholipids are structural components of brain cell membranes that regulate neuron function. ALC donates acetyl groups that can be used to modify the functional activity of proteins in neuronal membranes. ALC thus plays a role in maintaining membrane function. ALC also increases membrane stability and structural integrity.Increases nerve growth factor productionThe body produces various specialized proteins called "growth factors" which are essential to growth and repair of tissue. Nerve Growth Factor (NGF) protects neurons from death, prolonging survival of neurons in both the central and peripheral nervous systems. It is theorized that aging of the central nervous system is associated with a loss of NGF. ALC has shown the ability to reverse age-related decrease in the binding of NGF to its receptors in neuron membranes. Given to aged rats, ALC increases the level and utilization of NGF in the rats. ALC protects cholinergic neurons (nerve cells stimulated by acetylcholine) in rats from degeneration due to lack of NGF. These results, together with other data from animal studies, suggest that ALC positively influences NGF activity.Has a protective influence on brain neuronsSeveral animal studies have revealed that ALC exerts a protective effect on neurons. In one experiment, brain cells from rats exposed to NMDA, a known neurotoxin, were protected by being simultaneously exposed to ALC. Rats injected with ALC were protected from mortality caused by the neurotoxin MPP+. ALC has been shown to raise levels of glutathione, a highly valuable antioxidant, in isolated mouse brain tissue. ALC prevents buildup of malondyhaldeyde, a marker of lipid peroxidation. ALC is also a chelator of iron, which can generate free radicals. It also reinforces antioxidant mechanisms in the brain.As a whole, data from test tube and animal studies, showing that ALC has a protective, restorative effect on brain neurons and neuronal energetic processes, suggest that ALC is an anti-aging nutrient for the brain. This hypothesis is supported by human studies demonstrating measurable benefits for brain function in elderly persons taking ALC by oral consumption. |
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Best Agaricus Blazei 90 Veggie Capsules
Agaricus blazei is a medicinal mushroom that contains a special class of polysaccharides known as "beta glucans." Studies show beta glucans stimulate activity of natural killer (NK) cells, which are an important part of the immune system. The Agaricus blazei in this product is extracted with the preferred hot water/alcohol method to increase its digestibility and enhance bioavailability of the polysaccharides.Originally discovered in Brazil, Agaricus blazei is widely consumed in many countries, where it is regarded as a health food, due to its medicinal properties. The mushroom is used both in tea form and as a food. Since 1965, strains of Agaricus blazei have been imported to Japan, where it is now widely cultivated and researched.Folk Use The folk use of this herb encompasses a broad profile of reported effects, including:__1) Fighting physical and emotional stress. __2) Immune support. __3) Maintaining normal blood sugar levels. __4) Maintaining already normal cholesterol levels. __5) Digestive support. __6) Bone health. __7) Liver supportAmong the above properties attributed to Agaricus, immune support is the major focus of usage scientific research to date. Like other medicinal mushrooms, Agaricus contains complex polysaccharides that stimulate the immune system. It is reported that Agaricus is utilized for this purpose by 300,000 to 500,000 people in Japan annually, where yearly production of the dried mushroom ranges from 100,000 to 300,000 kg.BenefitsSupports immune functionAgaricus blazei has been the subject of research in Japan, where investigations have focused on the role of mushroom polysaccharides as "biological response modifiers that can stimulate immune function. Studies have shown that beta glucans extracted from Agaricus are the active polysaccharides, with beta-glucan as the most potent immunomodulator. Fungi-derived beta glucans have been found to stimulate the release of tumor necrosis factor from immune cells called "macrophages." While activating the immune response to abnormal cells, beta glucans have no effect on normal cells. Additional experiments have shown that Agaricus blazei activates the alternative complement pathway, which is an important part of the body’s immune defense against foreign organisms. Agaricus extracts have demonstrated an ability to help maintain cellular health through an antimutagenic effect on cells. In the test tube, isolated fractions of Agaricus blazei have been found to inhibit proliferation of white blood cells and cytokines that can cause inflammation if over expressed. These results suggest Agaricus may help regulate immune over-activity.Liver protection against toxinsA water extract of Agaricus blazei was tested on rat liver cells exposed to the toxic chemical diethylnitrosamine (DEN). Rats were administered the mushroom extract for two weeks and then injected with the toxin. Compared to control rats that did not receive the extract, the rats given Agaricus showed markedly less liver damage. Different doses of the toxin where used to gauge the level of protection exerted by the mushroom. Liver enzymes were lower in rats that received moderate, but not high, doses of the toxin, leading researchers to conclude that Agaricus protects against moderate, but not severe, chemical-induced liver toxicity. No adverse effects were seen.A group of medical researchers in China has reported that 10 hepatitis patients given Agaricus blazei showed improvements in liver function and hematology tests. |
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Best Alpha Lipoic Acid 150mg 120 Capsules
Alpha-lipoic acid (ALA) is a sulfur-containing fatty acid that performs vitamin-like roles in the body. Also known as "lipoic acid" or "thioctic acid," ALA functions, in a similar way to B complex vitamins, as a co-enzyme in the metabolism of carbohydrates that produces energy inside cells for the body’s metabolic needs. ALA is required for synthesis of "acetyl CoA," a key metabolite in the cellular process that turns glucose (blood sugar) into energy. Because the body produces ALA on its own, it is not classified as a true vitamin. As with other so-called "non-essential" nutrients, however, internal ALA production may not always be optimal. Alpha-lipoic acid functions as both a water-soluble and fat-soluble antioxidant. (Antioxidants neutralize free-radicals, normal by-products of metabolism that, while necessary at normal levels, may damage tissues over time if not properly kept in check by antioxidants.) ALA’s ability to act upon free radicals in both a watery and fatty environment makes it a highly versatile antioxidant. In the body, alpha-lipoic acid can be converted (reduced) to DHLA, or dihydrolipoic acid. Together, these two forms of ALA make up a "redox couple," which means that each form can chemically change into the other and back again. DHLA also functions as an antioxidant.How “about R-Lipoic” Acid ?Alpha Lipoic Acid occurs in two forms, designated "R" and "S". Studies suggest that R-alpha lipoic acid, the natural form, is more biologically active than the S form. Like ALA, RLA recycles antioxidant nutrients, such as vitamin C and E, and helps maintain healthy blood sugar levels when used as part of the diet.BenefitsSupports the Body’s Defense Against Free RadicalsRecycles Antioxidant Nutrients such as Vitamin C and Vitamin EHelps Maintain a Healthy Blood Sugar Level when used as part of the dietAlpha-lipoic Acid––the "Ideal Antioxidant"The antioxidant potential of a substance is based on a number of criteria, including: 1) Ability to quench specific free-radicals. 2) Ability to bind or "chelate" metal ions that can generate free radicals. 3) Supports function of other antioxidants. 4) Absorption/bioavailability. 5) Concentration in tissues, cells and extra cellular fluids. 6) Ability to function as an antioxidant in fatty and watery environments.The "ideal antioxidant" would meet all the above criteria. Very few antioxidants do, yet a particular antioxidant with but a few of the characteristics is still valuable and effective. Vitamin E, for example, is one of the most important dietary antioxidants, yet it only works in fatty environments such as cell membranes. As a team, ALA and DHLA come close to the ideal, for the following reasons: 1) ALA is easily absorbed when consumed orally. 2) ALA is readily converted to DHLA in various tissues. 3) As a pair, ALA and DHLA neutralize superoxide, hydroxyl, peroxyl, and hypochlorus radicals. 4) ALA and DHLA form stable complexes with metal ions such as iron, manganese, copper and zinc ions. 5) ALA and DHLA scavenge free radicals in fatty environments and watery environments.6) DHLA recycles other important antioxidants.DHLA-regenerates vitamin C, vitamin E and glutathioneWithin the cell, antioxidants work as a team to keep free radicals from damaging cell structures. In order to neutralize a free radical, an antioxidant such as vitamin C must give up an electron, which mean it becomes oxidized. Before it can function as an antioxidant once again, it must be regenerated back to its "reduced" form, by gaining an electron to replace the donated electron. For this, it needs the help of other antioxidants. Vitamin C, vitamin E and glutathione are key antioxidants that can be generated by cycling between their oxidized and reduce forms. This is necessary to maintain the balance between oxidation and its reverse––the neutralization of free radicals by antioxidants. DHLA is an essential component in the interaction between these antioxidants. Studies show that addition of alpha-lipoic acid to liver tissues results in increased vitamin C levels. It has been found that DHLA is responsible for regenerating vitamin C, which in turn regenerates vitamin E.3 DHLA also converts glutathione from its oxidized form back into its free radical scavenging reduced form. The ALA/DHLA pair is thus vital for prevention of "oxidative stress," which occurs which the balance is tipped in favor of oxidation in cells. DHLA helps preserve antioxidants in both the watery cell interior and the fatty structure of cell membranes. Evidence from animal studies suggests that DHLA protects the brain against free radical damage.Alpha-lipoic Acid and Blood SugarAlpha-lipoic acid is a key factor in the cellular process that metabolizes glucose to produce energy for cellular functions. The importance of ALA’s role in blood sugar metabolism is evidenced in studies on ALA and type-2 diabetes. In a small pilot study, 13 people with type-2 diabetes showed improved utilization of glucose in muscle tissue in response to intravenous administration of ALA. In a four week controlled multicenter trial, 74 people with type-2 diabetes took ALA in oral doses of 600, 1200 or 1800 mg per day. After 4 weeks, the normal lowering of blood sugar levels in response to insulin improved. In vitro studies have shown that ALA has a positive effect on insulin-stimulated uptake of glucose by muscle cells. |
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Best Alpha Lipoic Acid 600mg 60 Veggie Capsules
Alpha-lipoic acid (ALA) is a sulfur-containing fatty acid that performs vitamin-like roles in the body. Also known as "lipoic acid" or "thioctic acid," ALA functions, in a similar way to B complex vitamins, as a co-enzyme in the metabolism of carbohydrates that produces energy inside cells for the body’s metabolic needs. ALA is required for synthesis of "acetyl CoA," a key metabolite in the cellular process that turns glucose (blood sugar) into energy. Because the body produces ALA on its own, it is not classified as a true vitamin. As with other so-called "non-essential" nutrients, however, internal ALA production may not always be optimal. Alpha-lipoic acid functions as both a water-soluble and fat-soluble antioxidant. (Antioxidants neutralize free-radicals, normal by-products of metabolism that, while necessary at normal levels, may damage tissues over time if not properly kept in check by antioxidants.) ALA’s ability to act upon free radicals in both a watery and fatty environment makes it a highly versatile antioxidant. In the body, alpha-lipoic acid can be converted (reduced) to DHLA, or dihydrolipoic acid. Together, these two forms of ALA make up a "redox couple," which means that each form can chemically change into the other and back again. DHLA also functions as an antioxidant.Alpha Lipoic Acid occurs in two forms, designated "R" and "S". Studies suggest that R-alpha lipoic acid, the natural form, is more biologically active than the S form. Like ALA, RLA recycles antioxidant nutrients, such as vitamin C and E, and helps maintain healthy blood sugar levels when used as part of the diet.BenefitsSupports the Body’s Defense Against Free RadicalsRecycles Antioxidant Nutrients such as Vitamin C and Vitamin EHelps Maintain a Healthy Blood Sugar Level when used as part of the dietAlpha-lipoic Acid––the "Ideal Antioxidant"The antioxidant potential of a substance is based on a number of criteria, including: 1) Ability to quench specific free-radicals. 2) Ability to bind or "chelate" metal ions that can generate free radicals. 3) Supports function of other antioxidants. 4) Absorption/bioavailability. 5) Concentration in tissues, cells and extra cellular fluids. 6) Ability to function as an antioxidant in fatty and watery environments.The "ideal antioxidant" would meet all the above criteria. Very few antioxidants do, yet a particular antioxidant with but a few of the characteristics is still valuable and effective. Vitamin E, for example, is one of the most important dietary antioxidants, yet it only works in fatty environments such as cell membranes. As a team, ALA and DHLA come close to the ideal, for the following reasons: 1) ALA is easily absorbed when consumed orally. 2) ALA is readily converted to DHLA in various tissues. 3) As a pair, ALA and DHLA neutralize superoxide, hydroxyl, peroxyl, and hypochlorus radicals. 4) ALA and DHLA form stable complexes with metal ions such as iron, manganese, copper and zinc ions. 5) ALA and DHLA scavenge free radicals in fatty environments and watery environments.6) DHLA recycles other important antioxidants.DHLA-regenerates vitamin C, vitamin E and glutathioneWithin the cell, antioxidants work as a team to keep free radicals from damaging cell structures. In order to neutralize a free radical, an antioxidant such as vitamin C must give up an electron, which mean it becomes oxidized. Before it can function as an antioxidant once again, it must be regenerated back to its "reduced" form, by gaining an electron to replace the donated electron. For this, it needs the help of other antioxidants. Vitamin C, vitamin E and glutathione are key antioxidants that can be generated by cycling between their oxidized and reduce forms. This is necessary to maintain the balance between oxidation and its reverse––the neutralization of free radicals by antioxidants. DHLA is an essential component in the interaction between these antioxidants. Studies show that addition of alpha-lipoic acid to liver tissues results in increased vitamin C levels. It has been found that DHLA is responsible for regenerating vitamin C, which in turn regenerates vitamin E. DHLA also converts glutathione from its oxidized form back into its free radical scavenging reduced form. The ALA/DHLA pair is thus vital for prevention of "oxidative stress," which occurs which the balance is tipped in favor of oxidation in cells. DHLA helps preserve antioxidants in both the watery cell interior and the fatty structure of cell membranes. Evidence from animal studies suggests that DHLA protects the brain against free radical damage.Alpha-lipoic Acid and Blood SugarAlpha-lipoic acid is a key factor in the cellular process that metabolizes glucose to produce energy for cellular functions. The importance of ALA’s role in blood sugar metabolism is evidenced in studies on ALA and type-2 diabetes. In a small pilot study, 13 people with type-2 diabetes showed improved utilization of glucose in muscle tissue in response to intravenous administration of ALA. In a four week controlled multicenter trial, 74 people with type-2 diabetes took ALA in oral doses of 600, 1200 or 1800 mg per day. After 4 weeks, the normal lowering of blood sugar levels in response to insulin improved. In vitro studies have shown that ALA has a positive effect on insulin-stimulated uptake of glucose by muscle cells. |
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Best Benfotiamine 80mg 120 Veggie Capsules
Benfotiamine (S-benzyolthiamine-O-monophosphate) is a synthetic derivative of thiamin, belonging to the family of compounds known as "allithiamines." Benfotiamine is fat-soluble and thus more bioavailable and physiologically active than thiamin.* Characteristic of the allithiamines is an open thiazole ring within the chemical structure of these thiamine-related compounds, making them fat (lipid) soluble. In contrast, thiamine, which is water soluble, has a closed thiazole ring. The lipid solubility of benfotiamine, conferred by this open ring, increases its bioavailablity. Benfotiamine is readily absorbed at higher doses, in contrast to absorption of water-soluble thiamin salts, which decreases at higher doses, due to saturation of absorption sites in the intestines. In a double-blind, cross-over trial, comparing bioavailability of benfotiamine to that of thiamine in 12 subjects, benfotiamine caused an average 5-fold greater increase in blood thiamine levels than thiamin mononitrate, with a concomitant greater thiamine concentration in erythrocytes (red blood cells). Benfotiamine readily passes through intestinal mucosal cells, where it is converted into physiologically active thiamine. Benfotiamine inceases blood levels of thiamine pyrophosphate (TPP), the primary thiamin co-enzyme.BenefitsBenfotiamine raises the blood level of thiamine pyrophosphate (TPP), the biologically active co-enzyme of thiamine.Thiamine and its Co-enzyme, TPP Thiamine (vitamin B1) plays an essential part in the metabolism of glucose, through actions of it co-enzyme TPP (thiamine pyrophosphate). TPP is formed by the enzymatically-catalyzed addition of two phosphate groups donated by ATP to thiamine. TPP also goes by the name "thiamine diphosphate." In the cytoplasm of the cell, glucose, a 6-carbon sugar, is metabolized to pyruvic acid, which is converted into acetyl-CoA, otherwise known as "active acetate." Acetyl CoA enters the mitochondrion, where it serves as the starting substrate in the Kreb’s cycle (citric acid cycle). The Krebs cycle is the primary source of cellular metabolic energy. TPP, along with other co-enzymes, is essential for the removal of CO2 from pyruvic acid, which in turn is a key step in the conversion of pyruvic acid to acetyl CoA. CO2 removal from pyruvic acid is called "oxidative decarboxylation," and for this reason, TPP was originally referred to as "cocarboxylase." TPP is thus vital to the cell’s energy supply.Benfotiamine helps maintain healthy cells in the presence of blood glucose. Acting as a biochemical "super-thiamin," it does this through several different cellular mechanisms, as discussed below.Benfotiamine and Glucose Metabolism Benfotiamine normalizes cellular processes fueled by glucose metabolites. As long as glucose remains at normal levels, excess glucose metabolites do not accumulate within the cell. The bulk of the cell’s glucose supply is converted to pyruvic acid, which serves as substrate for production of acetyl CoA, the primary fuel for the Krebs cycle. Of the total amount of metabolic energy (in the form of ATP) released from food, the Krebs cycle generates about 90 percent. In the presence of elevated glucose levels, the electron transport chain, the final ATP-generating system in the mitochondrion, produces larger than normal amounts of the oxygen free radical "superoxide." This excess superoxide inhibits glyceraldehyde phosphate dehydrogenase (GAPDH), as key enzyme in the conversion of glucose to pyruvic acid, resulting in an excess of intermediate metabolites known as "triosephosphates." Increase triosephophate levels trigger several cellular mechanisms that result in potential damage to vascular tissue. Cells particularly vulnerable to this biochemical dysfunction are found in the retina, kidneys and nerves. Benfotiamine has been shown to block three of these mechanisms: the hexosamine pathway, the diaglycerol-protein kinease C pathway and the formation of Advanced Glycation End-poducts. As discussed below, benfotiamine does this by activating transketolase, a key thiamin-dependent enzyme. Benfotiamine stimulates tranketolase, a cellular enzyme essential for maintenance of normal glucose metabolic pathways. Transketolase diverts the excess fructose-6-phosphate and glyceraldehydes-3-phosphate, (formed by the inhibition of GAPDH, as mentioned above), into production of pentose-5-phosphates and erythrose-4-phosphate and away from the damaging pathways. Benfotiamine activates transketolase activity in bovine aortic endothelial cells incubated in glucose. To test benfotiamine’s ability to counteract these metabolic abnormalities caused by elevated blood glucose, studies have been done in diabetic rats. Benfotiamine increases transketolase activity in the retinas of diabetic rats, while concomitantly decreasing hexosamine pathway activity, protein kinase C activity and AGE formation. Benfotiamine and Protein glycation Benfotiamine controls formation of Advanced Glycation End-products (AGEs). AGEs have an affinity for proteins such as collagen, the major structural protein in connective tissue. AGEs are formed through abnormal linkages between proteins and glucose. This occurs via a non-enzymatic glycosylation reaction similar to the "browning reaction" that takes place in stored food. At high glucose concentrations, glucose attaches to lysine, forming a Schiff base, which in turn forms "early glycosylation products." Once blood glucose levels return to normal levels, the amount of these early glycosylation products decreases, and they are not particularly harmful to most tissue proteins. On long-lived proteins such as collagen, however, early glycosylation products are chemically rearranged into the damaging Advanced Glycation End-products. AGE formation on the collagen in coronary arteries causes increased vascular permeability. This vessel "leakiness" allows for abnormal cross-linking between plasma proteins and other proteins in the vessel wall, comprising vascular function and potentially occluding the vessel lumen. A number of other potentially harmful events may also occur, including production of cytokines that further increase vascular permeability. Endothelin-1, a strong vasoconstrictor, is over produced, increasing the possibility of thrombosis and generation of oxygen free radicals is stimulated. It is vitally important to support normal glucose metabolic pathways so that formation of AGEs is minimized. Benfotiamine, in the test tube (in vitro) prevents AGE formation in endothelial cells cultured in high glucose by decreasing the glucose metabolites that produce AGEs. Endothelial cells make up the membranes that line the inner walls of organs and blood vessels. In a rat study comparing the effects of Benfotiamine with water-soluble thiamin, Benfotiamine inhibited AGE formation in diabetic rats while completely preventing formation of "glycooxidation products," which are toxic by products of chronic elevated blood glucose. AGE levels were not significantly altered by thiamin. Benfotiamine also normalized nerve function in the animals. After three months of administration, "nerve conduction velocity (NCV)," a measure of nerve function, was increased by both benfotiamine and thiamin; at six months, NCV was normalized by benfotiamine, whereas thiamin produced no further increases in this parameter. Dysfunctional glucose metabolic pathways leading to AGE formation occurs in endothelial cells of the kidneys. In a recent animal study, benfotiamine was administered to rats with elevated glucose levels. Benfotiamine increased transketolase activity in the kidney filtration system of these rats, while at the same time shifting triosephophates into the pentose pathway and preventing protein leakage. |
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Best Benfotiamine 150mg 120 Veggie Capsules
Benfotiamine (S-benzyolthiamine-O-monophosphate) is a synthetic derivative of thiamin, belonging to the family of compounds known as "allithiamines." Benfotiamine is fat-soluble and thus more bioavailable and physiologically active than thiamin.* Characteristic of the allithiamines is an open thiazole ring within the chemical structure of these thiamine-related compounds, making them fat (lipid) soluble. In contrast, thiamine, which is water soluble, has a closed thiazole ring. The lipid solubility of benfotiamine, conferred by this open ring, increases its bioavailablity. Benfotiamine is readily absorbed at higher doses, in contrast to absorption of water-soluble thiamin salts, which decreases at higher doses, due to saturation of absorption sites in the intestines. In a double-blind, cross-over trial, comparing bioavailability of benfotiamine to that of thiamine in 12 subjects, benfotiamine caused an average 5-fold greater increase in blood thiamine levels than thiamin mononitrate, with a concomitant greater thiamine concentration in erythrocytes (red blood cells). Benfotiamine readily passes through intestinal mucosal cells, where it is converted into physiologically active thiamine. Benfotiamine inceases blood levels of thiamine pyrophosphate (TPP), the primary thiamin co-enzyme.BenefitsBenfotiamine raises the blood level of thiamine pyrophosphate (TPP), the biologically active co-enzyme of thiamine.Thiamine and its Co-enzyme, TPP Thiamine (vitamin B1) plays an essential part in the metabolism of glucose, through actions of it co-enzyme TPP (thiamine pyrophosphate). TPP is formed by the enzymatically-catalyzed addition of two phosphate groups donated by ATP to thiamine. TPP also goes by the name "thiamine diphosphate." In the cytoplasm of the cell, glucose, a 6-carbon sugar, is metabolized to pyruvic acid, which is converted into acetyl-CoA, otherwise known as "active acetate." Acetyl CoA enters the mitochondrion, where it serves as the starting substrate in the Kreb’s cycle (citric acid cycle). The Krebs cycle is the primary source of cellular metabolic energy. TPP, along with other co-enzymes, is essential for the removal of CO2 from pyruvic acid, which in turn is a key step in the conversion of pyruvic acid to acetyl CoA. CO2 removal from pyruvic acid is called "oxidative decarboxylation," and for this reason, TPP was originally referred to as "cocarboxylase." TPP is thus vital to the cell’s energy supply.Benfotiamine helps maintain healthy cells in the presence of blood glucose. Acting as a biochemical "super-thiamin," it does this through several different cellular mechanisms, as discussed below.Benfotiamine and Glucose Metabolism Benfotiamine normalizes cellular processes fueled by glucose metabolites. As long as glucose remains at normal levels, excess glucose metabolites do not accumulate within the cell. The bulk of the cell’s glucose supply is converted to pyruvic acid, which serves as substrate for production of acetyl CoA, the primary fuel for the Krebs cycle. Of the total amount of metabolic energy (in the form of ATP) released from food, the Krebs cycle generates about 90 percent. In the presence of elevated glucose levels, the electron transport chain, the final ATP-generating system in the mitochondrion, produces larger than normal amounts of the oxygen free radical "superoxide." This excess superoxide inhibits glyceraldehyde phosphate dehydrogenase (GAPDH), as key enzyme in the conversion of glucose to pyruvic acid, resulting in an excess of intermediate metabolites known as "triosephosphates." Increase triosephophate levels trigger several cellular mechanisms that result in potential damage to vascular tissue. Cells particularly vulnerable to this biochemical dysfunction are found in the retina, kidneys and nerves. Benfotiamine has been shown to block three of these mechanisms: the hexosamine pathway, the diaglycerol-protein kinease C pathway and the formation of Advanced Glycation End-poducts. As discussed below, benfotiamine does this by activating transketolase, a key thiamin-dependent enzyme. Benfotiamine stimulates tranketolase, a cellular enzyme essential for maintenance of normal glucose metabolic pathways. Transketolase diverts the excess fructose-6-phosphate and glyceraldehydes-3-phosphate, (formed by the inhibition of GAPDH, as mentioned above), into production of pentose-5-phosphates and erythrose-4-phosphate and away from the damaging pathways. Benfotiamine activates transketolase activity in bovine aortic endothelial cells incubated in glucose. To test benfotiamine’s ability to counteract these metabolic abnormalities caused by elevated blood glucose, studies have been done in diabetic rats. Benfotiamine increases transketolase activity in the retinas of diabetic rats, while concomitantly decreasing hexosamine pathway activity, protein kinase C activity and AGE formation. Benfotiamine and Protein glycation Benfotiamine controls formation of Advanced Glycation End-products (AGEs). AGEs have an affinity for proteins such as collagen, the major structural protein in connective tissue. AGEs are formed through abnormal linkages between proteins and glucose. This occurs via a non-enzymatic glycosylation reaction similar to the "browning reaction" that takes place in stored food. At high glucose concentrations, glucose attaches to lysine, forming a Schiff base, which in turn forms "early glycosylation products." Once blood glucose levels return to normal levels, the amount of these early glycosylation products decreases, and they are not particularly harmful to most tissue proteins. On long-lived proteins such as collagen, however, early glycosylation products are chemically rearranged into the damaging Advanced Glycation End-products. AGE formation on the collagen in coronary arteries causes increased vascular permeability. This vessel "leakiness" allows for abnormal cross-linking between plasma proteins and other proteins in the vessel wall, comprising vascular function and potentially occluding the vessel lumen. A number of other potentially harmful events may also occur, including production of cytokines that further increase vascular permeability. Endothelin-1, a strong vasoconstrictor, is over produced, increasing the possibility of thrombosis and generation of oxygen free radicals is stimulated. It is vitally important to support normal glucose metabolic pathways so that formation of AGEs is minimized. Benfotiamine, in the test tube (in vitro) prevents AGE formation in endothelial cells cultured in high glucose by decreasing the glucose metabolites that produce AGEs. Endothelial cells make up the membranes that line the inner walls of organs and blood vessels. In a rat study comparing the effects of Benfotiamine with water-soluble thiamin, Benfotiamine inhibited AGE formation in diabetic rats while completely preventing formation of "glycooxidation products," which are toxic by products of chronic elevated blood glucose. AGE levels were not significantly altered by thiamin. Benfotiamine also normalized nerve function in the animals. After three months of administration, "nerve conduction velocity (NCV)," a measure of nerve function, was increased by both benfotiamine and thiamin; at six months, NCV was normalized by benfotiamine, whereas thiamin produced no further increases in this parameter. Dysfunctional glucose metabolic pathways leading to AGE formation occurs in endothelial cells of the kidneys. In a recent animal study, benfotiamine was administered to rats with elevated glucose levels. Benfotiamine increased transketolase activity in the kidney filtration system of these rats, while at the same time shifting triosephophates into the pentose pathway and preventing protein leakage. |
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Best Cinnamon Extract 60 Veggie Capsules
Cinnamon, a staple ingredient in apple pie, has remained one of the world’s favorite spices throughout recorded history. The evergreen cinnamon tree (Cinnamomum verum), considered to be true cinnamon, is native to Sri Lanka. Chinese cinnamon (Cinnamomum cassia or Cinnamomum aromaticum), the cinnamon most commonly sold in the U.S., goes by the name “Cassia.” Usage of cinnamon in Chinese medicine is said to date back over 4,000 years. Mentioned in the Bible, cinnamon was imported to Egypt and Europe from the Far East by 500 B.C. In addition to its value as culinary spice, cinnamon has traditionally been utilized as a folk medicine for colds and minor digestive complaints. True cinnamon and cassia are very similar; cassia has a more pungent flavor. Cassia buds can be found in potpourri and used as a flavoring agent in sweets and beverages. Recent research has revealed that constituents in cinnamon bark called procyanidin Type-A polymers help maintain the body’s ability to metabolize glucose in a healthy way. Best Cinnamon Extract is Cinnulin PF®, a patented, water extract of Cinnamon that contains Type-A polymers. Cinnulin PF® is a registered trademark of Integrity Nutraceuticals International and is manufactured under US Patent # 6,200,569. BenefitsUse as Part of Your Diet to Help Maintain a Healthy Blood Sugar Level In Vitro and Animal StudiesResearch has revealed that a number of herbs and spices have insulin-like activity. In a study published in 2000 by the U.S. Department of Agriculture (USDA), cinnamon demonstrated the greatest ability to stimulate cellular glucose metabolism among 49 botanicals tested. In a 2001 study, researchers at the USDA’s Human Nutrition Research Center showed that bioactive compounds in cinnamon trigger an insulin-like response in fat cells. These compounds stimulated glucose uptake into cells and increased glycogen (stored glucose) production via activation of the enzyme, glycogen synthase.The bioactive compounds in cinnamon appear to potentiate insulin activity at the level of the cell receptor for insulin. It has been shown that insulin resistance involves downregulation of “insulin signaling” characterized by dephosphorylation of the receptor. Enzymes called “protein tyrosine kinases” (PTPases) are believed to decrease receptor phosphorylation, and increased PTPase activity has been observed in insulin resistant rats. Cinnamon compounds have demonstrated the in vitro ability to inhibit PTP-1 and increase autophosphorylation of the insulin receptor. In a recent animal study, cinnamon (cassia) extract was administered to rats for three weeks. Following this, the rats were infused with insulin and glucose to assess their insulin response. Increased phosphorylation of the insulin receptor was observed in skeletal muscle of these rats, suggesting that cinnamon has the ability to potentiate insulin function by normalizing insulin signaling, leading to improved uptake of glucose into skeletal muscle. Until recently, the precise molecular structure of the bioactive compounds in cinnamon had not been clearly defined. The USDA has now determined that the bioactive compounds in cinnamon are water-soluble procyanidin Type-A polymers of catechin and epicatechin. In a 2004 study, type-A polymers were isolated from cinnamon and characterized by nuclear magnetic resonance and mass spectroscopy. Type-A polymers were found to increase in vitro insulin activity by a factor of 20. Type-A polymers also exhibited antioxidant activity, as measured by inhibition of free radical production in platelets. These results suggest that, in addition to regulating glucose metabolism, cinnamon may help protect cell membranes by controlling the lipid peroxidation associated with disruptions in insulin function. Human Clinical TrialThe effect of cinnamon on glucose and blood lipids levels on people with type 2 diabetes was tested in a recent randomized, placebo-controlled trial. A total of 60 subjects were divided into six groups administered 1, 3, or 6 grams of cinnamon daily, in 500 mg capsules, or equal numbers of placebo capsules. The cinnamon or placebo capsules were consumed for two periods of 20 days each. Serum glucose, triglyceride, cholesterol, LDL cholesterol and HDL cholesterol were measured after 20 days, 40 days and again at the end of a 20-day wash-out period, during which neither cinnamon nor placebo was consumed. In all three cinnamon groups, statistically significant reductions in blood glucose levels occurred, with decreases ranging from 18 to 29 percent. Interestingly, glucose levels remained significantly lower after the 20-day wash-out period (60 days from the study start) only in the group that took the lowest cinnamon dose (1 gram daily). The placebo groups showed no significant changes.Decreases in triglyceride levels ranging from 23 to 30% were observed in all three cinnamon groups after 40 days. When the study ended at 60 days, triglyceride levels remained lower than at the study start in the 1 and 3 gram cinnamon groups, but not in the group taking 6 grams daily. Cholesterol reductions also occurred with the three cinnamon doses, with decreases ranging from 13 to 25% that were maintained at the study end. For LDL, the 3 and 6 gram cinnamon groups showed significant reductions from 10 to 24%, while in the 1 gram cinnamon group, non-significant reductions occurred after 40 days; LDL levels continued to decrease, reaching statistical significance at 60 days. With respect to HDL, significant increases were seen only in the 3 gram cinnamon group after 20 days; non-significant changes occurred in the 1 and 6 gram groups after 40 days. The overall results of this trial demonstrate that cinnamon exerts a beneficial effect on blood glucose and lipid levels in people with type 2 diabetes, at daily intakes of 1 gram, and that this low dose is equally efficacious as are the higher doses of 3 and 6 grams. |
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Best Curcumin with Bioperine 120 Capsules
Best Curcumin w/Bioperine contains a standardized extract of Curcuma longa root, commonly known as “Turmeric.” Turmeric is a yellow spice used in curried dishes. In the Far East, turmeric is valued for more than just its culinary applications. The herb has been employed in the Ayurvedic healing tradition for centuries , and is a common household remedy in India. The active ingredients in Curcuma longa are a group of plant substances called curcuminoids. Known collectively as “curcumin,” curcuminoids have demonstrated potent antioxidant properties in scientific studies. Curcuminoids benefit joints and other tissues by helping to neutralize free-radicals. Curcuminoids are responsible for turmeric’s distinctive yellow color. Curcuma C3 Complex supplies 95% total curcuminoids, including curcumin, bisdemethoxy curcumin and demethoxy curcumin. Bioperine is an extract of Black Pepper fruit that contains 95-98% piperine. Bioperine is added as a natural bioenhancer to promote absorption of the product.Turmeric- History and Traditional Usage Native to Southeast Asia, Curcuma longa is a tall tropical shrub with large oblong leaves and pale yellow flowers. The genus “Curcuma” belongs to the Zingiberaceae family, which includes ginger. The plant possesses a large root structure with fleshy, bulbous underground parts called “rhizomes.” These rhizomes, known as turmeric root, are harvested at maturity, dried and cured for commercial use. Chemical analysis shows that dried turmeric contains essential and volatile oils, with a curcuminoid content of 2.5 to 5.0 %. In addition to its popularity as a spice, turmeric is used as a dye for cloth and coloring agent in foods and cosmetics, thanks to its rich yellow color. Turmeric also serves as a preservative, probably owing to the antioxidant and antimicrobial properties of curcumin. Extracts of Curcuma longa have demonstrated in vitro antibacterial and anti-fungal effects. Turmeric is named in ancient Ayurvedic and Chinese herbal texts as a traditional folk remedy. Historically, turmeric was used externally for wounds, and sprains, and internally for digestive complaints, rheumatism, liver disorders, coughs and colds.BenefitsProtects cells and tissues by fighting free radicals. Supports joint functionThe numerous beneficial effects attributed to turmeric stem in large measure from the antioxidant properties of curcumin. Antioxidants neutralize free radicals, which are highly unstable molecules that can damage cellular structures through abnormal oxidative reactions. Curcumin is a potent “scavenger” of the superoxide radical, a free radical that initiates potentially harmful oxidative processes such as lipid peroxidation. Through this activity, curcumin has been shown to protect skin cells from the injurious effect of nitroblue tetrazolium, a toxin that generates superoxide radicals. Curcumin also increases survival of cells exposed in vitro to the enzyme hypoxanthine/xanthine oxidase, which stimulates superoxide and hydrogen peroxide production. Curcumin itself is not toxic to cells, even at high concentrations. Pure curcumin was shown to be less protective than a mixture of curcuminoids, indicating a possible synergism among curcuminoids. Because free radicals are involved in aging and exert harmful effects on skin, these results suggest curcumin may help slow skin aging. Curcumin demonstrates several other in vitro effects linked to free radical scavenging. Curcumin scavenges nitric oxide, a compound associated with the body’s inflammatory response. Pure curcumin and turmeric extracts protect red blood cells from lipid peroxidation induced by hydrogen peroxide. Curcumin has been shown to protect DNA from oxidative damage, inhibit binding of toxic metabolites to DNA, and reduce DNA mutations in the Ames’ test. Although additional studies suggest an anticarcinogenic effect of curcumin, through protection of DNA, one in vitro study found that curcumin induced DNA damage in human gastric mucosal cells. It is speculated that curcumin may act as a pro-oxidant in the presence of transition metal ions such as copper and iron. (This is true for other antioxidants, including vitamin C.) Curcumin also demonstrates in vitro inhibition of COX-I and COX-II enzymes, which are involved in the inflammatory reaction. Together these results strongly suggest that curcumin is a potent bioprotectant with a potentially wide range of therapeutic applications.Animal studies- In vivo protective effectsThrough its free radical scavenging properties, curcumin has shown bioprotective effects in animals. In one study, rats were treated with isoproterenol, a chemical that causes cardiac hypertrophy (enlargement of the heart) due to abnormal collagen metabolism. Co-treatment with curcumin reversed the degradation of collagen and cardiac hypertrophy induced by isoproterenol. Curcumin protects mice from detrimental effects of radiation, by stabilizing the glyoxalase system, a biological system that regulates cell division. Curcumin protects livers of rats from the damaging effects of carbon tetrachloride (CCl4), a potent hepatoxin that injures the liver via its free radical metabolite, CCl3. Curcumin protected rats from alcohol-induced brain damage, in a study in which oral administration of curcumin reversed lipid peroxidation, reduced levels of free-radical metabolites and increased levels of glutathione, a major physiologic antioxidant. Curcuma longa extracts have shown anti-inflammatory effects in rats. Human TrialsCurcumin exhibits free-radical scavenging ability when administered to humans. In an open trial (uncontrolled), 18 healthy individuals ranging in age from 27 to 67 years consumed a Curcuma longa extract, at a dose supplying 20 mg curcuminoids, for 45 days. Before and after blood tests showed a statistically significant decrease in lipid peroxides. Preliminary trials have tested the anti-inflammatory action of curcumin, with results that verify the traditional use of turmeric as an anti-rheumatic herb. In a short-term double-blind, cross-over, comparative study, 18 people received curcumin (1200 mg daily) or phenylbutazone for two week periods. Both curcumin and phenylbutazone produced measurable improvements in joint flexibility and walking time. The subjects reported results only with phenylbutazone, which may be explained by the short duration of the trial.20 In a small placebo-controlled trial comparing curcumin to phenylbutazone, 45 patients with post-operative inflammation received curcumin, phenylbutazone or placebo. The anti-inflammatory effects of curcumin and phenylbutazone were comparable and superior to placebo. Curcumin has not been found to produce an analgesic (pain relieving) effect. Bioperine-Nature’s Absorption Enhancer Boosts Curcumin AbsorptionTraditional Ayurvedic herbal formulas often include black pepper and long pepper as synergistic herbs. The active ingredient in both black pepper and long pepper is the alkaloid, piperine. Experiments carried out to evaluate the scientific basis for the use of peppers have shown that piperine significantly enhances bioavailability when consumed with other substances. Several double-blind clinical studies have confirmed that Bioperine® increases absorption of nutrients. Curcumin is poorly absorbed in the intestinal tract, limiting its therapeutic effectiveness. Oral doses are largely excreted in feces, and only trace amounts appear in the blood. Concomitant administration of 20 mg of piperine with 2 grams of curcumin increases the bioavailability of curcumin by 2000% |
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Best French Red Wine (60 mg) 90 VCapsules
Best French Grape Extract is a whole grape extract produced from premium wine grapes. Processed without chemical solvents and using a low-temperature extraction method, Best French Grape Extract contains proanthocyanidins, polyphenols, flavonoids and resveratrol.Made from the whole grape, including seed, skin, and stem Best French Grape Extract is a full-spectrum product extracted from the seeds, skins, and stems of select hybrid grapes. The unique extraction process is done in France using locally grown grapes. The final product is purely extracted with water and grain alcohol only. This ensures a product free of chemical residues, and absorption is optimized because the extract is water soluble. Best French Grape Extract retains the natural deep purple grape color.Quality Guaranteed Best French Grape Extract is continually analyzed by an independent laboratory using the Porter Method, an industry-accepted test of grape-extract quality. The Porter Value of Best French Grape Extract ranges from 290 to 320. These are exceptionally high measurements indicative of a product rich in beneficial active ingredients.Benefits Rich in Natural Antioxidants, including resveratrolBest French Grape Extract delivers a wide profile of natural constituents present in wine grapes, including polyphenols, proanthocyanidins (OPCs), gallic acid, ellagic acid, quercetin, catechin, epicatechin and other valuable components. Many of these substances are powerful antioxidants, which are under investigation for their potential health benefits.Best French Grape Extract also contains resveratrol, a potent antioxidant present in the grape skin. In a study recently conducted at the University of Chicago, resveratrol demonstrated significant in vitro free-radical inhibiting ability and antimutagenic activity, as well as anti-inflammatory activity in test animals.Protects health of capillaries OPCs derived from grapes have been investigated for their protective effect on capillaries, the small blood vessels subject to free-radical-induced injury. OPCs show the ability to prevent the formation of lipid peroxides, a type of free-radical that can attack lipid molecules in epithelial tissue, which forms the lining of capillary walls. OPCs also protect capillary tissues from breakdown by enzymes such as collagenase, elastase and hyaluronidase.Protects Heart Health There is growing interest in the ability of wine grape polyphenols to protect LDL cholesterol from oxidation. In a 1993 study published in The Lancet, Frankel, et al found that phenolic substances present in wine acted as electron donors to inhibit copper-catalyzed oxidation of LDL. It is now believed that oxidized LDL is a major factor in the buildup of plaque deposits in blood vessels. In its unoxidized or “native” state, LDL cholesterol accumulates in blood-vessel walls only to a limited degree. On the other hand, oxidized LDL is readily absorbed by macrophages present in arterial walls, forming “foam cells.” This is the initial stage in plaque formation. Much of the value of dietary antioxidants may center around mitigating LDL oxidation. It has been suggested that the benefits of polyphenols may help explain the so-called “French Paradox,” the relatively low mortality rate from heart disease found in regions with high consumption of red wine. In summary, the broad range of natural grape antioxidants in Best French Grape Extract may protect overall cardiovascular health in several ways: 1) Reduction of oxidative stress (free radicals), 2) Protection of LDL cholesterol against oxidation, 3) Preventing formation of lipid peroxides which can attack capillary cell membranes, and 4) Inhibition of enzymes that break down capillary tissues. |
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Best Glucosamine Sulfate (500 mg) 300 Capsules
Best Glucosamine Sulfate contains pure glucosamine sulfate, as confirmed by HPLC testing. Glucosamine sulfate consists of glucosamine, an amino sugar extracted from shellfish skeletons. "Chitin", the resilient polysaccharide that forms the structural framework of animal shells, is a long-chain polymer consisting of many glucosamine molecules linked together. The purified glucosamine is then sulfated and stabilized with potassium chloride. Note: Best Glucosamine Sulfate is sodium-free. It contains 24-26% potassium chloride. Benefits Supplies the body with building material for cartilage Cartilage, a “connective tissue,” is composed of cells (chondrocytes), protein fibers (chiefly collagen) and clusters of complex molecules called “proteoglycans.” A proteoglycan consists of a long protein (polypeptide) with many side chains attached to it. (The structure of proteoglycan looks somewhat like a test-tube brush.) The attached side chains are polysaccharides-chiefly chondroitin sulfate and keratin sulfate. Glucosamine is a key component of keratin sulfate.2 Glucosamine is also a component of hyaluronic acid, another glycosaminoglycan found in cartilage and other connective tissues. Hyaluronic acid forms the backbone for the proteoglycan clusters.2 Glycosaminoglycans have a strong attraction for water. The water-holding ability of proteoglycan clusters to hold water gives cartilage its strong, sponge-like quality. It also allows nutrients to flow into cartilage and wastes to flow out. Supports Joint Structure and Function Glucosamine sulfate is one the most important nutritional supplements for joint health ever developed. Glucosamine sulfate provides significant benefits for both the structure and function of joints. Many years of research have produced unequivocal evidence that glucosamine sulfate normalizes cartilage metabolism, slows breakdown of cartilage, and improves joint function. Glucosamine sulfate has been thoroughly researched over the last 20 years. Experimental studies and human clinical trials convincingly demonstrate that orally consumed glucosamine sulfate improves joint function. In one large open trial, over 1200 people took oral glucosamine sulfate for periods ranging from 36 to 64 days. 252 physicians participated in this multi-center study. 95% of the subjects experienced greater joint comfort and increased mobility. The physicians reported “good” results in 59%, and “sufficient” results in 36%. The improvements lasted for up to three months after the glucosamine sulfate was discontinued. The effectiveness of glucosamine sulfate for joint health has been shown in double-blind, placebo-controlled research. One study compared glucosamine sulfate to “ibuprofen,” a commonly used pain medication, over an eight week period. During the first two weeks, better results were seen with ibuprofen, but by the eighth week, glucosamine sulfate produced greater improvements in pain scores.Provides Sulfur, the Key Structural Mineral in Cartilage Sulfur, one of the body’s essential structural minerals, is incorporated into the structure of glycosaminoglycans such as chondroitin sulfate and keratin sulfate.Why Potassium-Stabilized Glucosamine Sulfate is Preferable In order for glucosamine sulfate to be processed for oral consumption as a supplement, it must be stabilized with either sodium or potassium. Either mineral works for this purpose. Potassium is preferable for numerous reasons; many people are on sodium-restricted diets, and the Standard American Diet tends to be high in sodium and low in potassium. Moreover, studies have found people needing joint support to be low in both salivary potassium and total body potassium. |
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Best Glucosamine Sulfate (750 mg) 180 Capsules
Best Glucosamine Sulfate contains pure glucosamine sulfate, as confirmed by HPLC testing. Glucosamine sulfate consists of glucosamine, an amino sugar extracted from shellfish skeletons. "Chitin", the resilient polysaccharide that forms the structural framework of animal shells, is a long-chain polymer consisting of many glucosamine molecules linked together. The purified glucosamine is then sulfated and stabilized with potassium chloride. Note: Best Glucosamine Sulfate is sodium-free. It contains 24-26% potassium chloride. Benefits Supplies the body with building material for cartilage Cartilage, a “connective tissue,” is composed of cells (chondrocytes), protein fibers (chiefly collagen) and clusters of complex molecules called “proteoglycans.” A proteoglycan consists of a long protein (polypeptide) with many side chains attached to it. (The structure of proteoglycan looks somewhat like a test-tube brush.) The attached side chains are polysaccharides-chiefly chondroitin sulfate and keratin sulfate. Glucosamine is a key component of keratin sulfate.2 Glucosamine is also a component of hyaluronic acid, another glycosaminoglycan found in cartilage and other connective tissues. Hyaluronic acid forms the backbone for the proteoglycan clusters.2 Glycosaminoglycans have a strong attraction for water. The water-holding ability of proteoglycan clusters to hold water gives cartilage its strong, sponge-like quality. It also allows nutrients to flow into cartilage and wastes to flow out. Supports Joint Structure and Function Glucosamine sulfate is one the most important nutritional supplements for joint health ever developed. Glucosamine sulfate provides significant benefits for both the structure and function of joints. Many years of research have produced unequivocal evidence that glucosamine sulfate normalizes cartilage metabolism, slows breakdown of cartilage, and improves joint function. Glucosamine sulfate has been thoroughly researched over the last 20 years. Experimental studies and human clinical trials convincingly demonstrate that orally consumed glucosamine sulfate improves joint function. In one large open trial, over 1200 people took oral glucosamine sulfate for periods ranging from 36 to 64 days. 252 physicians participated in this multi-center study. 95% of the subjects experienced greater joint comfort and increased mobility. The physicians reported “good” results in 59%, and “sufficient” results in 36%. The improvements lasted for up to three months after the glucosamine sulfate was discontinued. The effectiveness of glucosamine sulfate for joint health has been shown in double-blind, placebo-controlled research. One study compared glucosamine sulfate to “ibuprofen,” a commonly used pain medication, over an eight week period. During the first two weeks, better results were seen with ibuprofen, but by the eighth week, glucosamine sulfate produced greater improvements in pain scores.Provides Sulfur, the Key Structural Mineral in Cartilage Sulfur, one of the body’s essential structural minerals, is incorporated into the structure of glycosaminoglycans such as chondroitin sulfate and keratin sulfate.Why Potassium-Stabilized Glucosamine Sulfate is Preferable In order for glucosamine sulfate to be processed for oral consumption as a supplement, it must be stabilized with either sodium or potassium. Either mineral works for this purpose. Potassium is preferable for numerous reasons; many people are on sodium-restricted diets, and the Standard American Diet tends to be high in sodium and low in potassium. Moreover, studies have found people needing joint support to be low in both salivary potassium and total body potassium. |
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Best L-Carnitine Fumarate (855 mg) 60 Capsules
L-Carnitine is a vitamin-like nutrient that is synthesized in the body, using the amino acids lysine and methionine as precursors. Because the body produces L-Carnitine on its own, it cannot be classified as a vitamin, even though it has functions similar to B vitamins. Fumarate is also a natural compound found in the body. Fumarate serves as an intermediate in the Krebs cycle, a key cellular energy-producing process. L-Carnitine and Fumarate both play important roles in energy metabolism.Best L-Carnitine contains BIOSINT™ L-Carnitine Fumarate, which is made in Italy by Sigma Tau Health Science. It is derived from a base of pharmaceutical-grade L-Carnitine manufactured using an FDA-approved process that fully complies with international monograph standards for carnitine production. No biotechnology or genetically modified organisms are involved. L-Carnitine Fumarate is certified GMO free, BSE safe, pesticide free and Kosher. It is also ISO 9002 certified and NNFA GMP certified. L-Carnitine Fumarate is highly stable and bioavailable.Known as a global leader in L-Carnitine research, Sigma Tau holds numerous patents for production of L-Carnitine, and its L-Carnitine derivatives are used in clinical trials. Sigma Tau Health Science has the only FDA-approved (1984) pharmaceutical batch process system for consistent L-Carnitine quality, and has been manufacturing L-Carnitine derivatives for 30 years.BenefitsHelps the body burn fat for energyL-Carnitine promotes energy production in cells by transporting fatty acids into the mitochondrion. Its primary function is to transfer long-chain fatty acids across the inner mitochondrial membrane. Fatty acid molecules are activated to coenzyme A (CoA) esters in the cytoplasm of the cell, and then esterified to L-Carnitine. The combination of a fatty acid molecule and L-Carnitine is called “acyl-carnitine.” Much of the body's L-Carnitine content is stored in the form of acyl-carnitine.The mitochondrion is the cell’s energy-generating furnace. Called an “organelle,” the mitochondrion is a self-contained structure inside the cell. Like all cellular structures, the mitochondrion is surrounded by a membrane. This membrane is an impenetrable barrier to acyl-CoA esters; passage across the membrane requires L-Carnitine as a transporter. On the inside of the mitochondrial membrane, the acyl-CoA esters are made available to be metabolized through the process of beta oxidation. One of the key metabolic byproducts of this process is acetyl-CoA, also called “active acetate,” which enters the Krebs cycle (also known as the “citric acid cycle”) to supply fuel for production of ATP, the cell’s primary energy “currency.” L-Carnitine shuttles excess fatty acid residues out of the mitochondrion, and in this role is essential for preventing toxic buildup of fatty acids inside the mitochondrion.Evidence suggests that L-Carnitine and short chain acyl-carnitine esters can protect the mitochondrion from adverse effects of drugs and toxic chemicals. L-Carnitine has been shown to protect animals form cardiotoxins and decrease mortality rate in animals with diphtheria, due to this cardioprotective effect.Helps maintain a healthy heart and cardiovascular systemMuscle tissue contains a high concentration of L-Carnitine. With its constant energy needs, heart muscle tissue is especially rich in L-Carnitine. If the body’s ability to biosynthesize L-Carnitine is compromised, energy production in muscle tissue is impaired, and a toxic buildup of fatty acids can occur. Defective production of L-Carnitine by the body can result from a variety of factors, including kidney or liver malfunction, increased catabolism or the inability of tissues to extract and retain L-Carnitine from the blood.Along with glucose and lactate, fatty acids are the primary oxidation fuel for the heart. A considerable amount of scientific data from animal experiments indicates that L-Carnitine protects the heart under conditions of hypoxia, or low oxygen. In addition to the oxidation of fat for energy in the cell, L-Carnitine is involved in the metabolism of glucose. Evidence of L-Carnitine’s role in glucose metabolism was uncovered in a small trial on 9 diabetic individuals. Given intravenously, L-Carnitine improved insulin-mediated glucose utilization and insulin sensitivity.Depletion of the body’s L-Carnitine supply is linked to various abnormal states, especially of the heart muscle. The effect of L-Carnitine on hypoxic (oxygen-starved) isolated heart muscle tissue has been studied. At high concentrations, L-Carnitine demonstrates a clear-cut ability to potentiate the contractility of isolated heart muscle tissue, indicating the L-Carnitine has a strengthening effect on the heart. L-Carnitine has been shown to improve the performance of rats subjected to fatigue test.Research has revealed that in animals and humans with defective heart muscle, the amount of free L-Carnitine (not bound to fatty acids) is reduced. Administration of L-Carnitine to hamsters prevents damage to the heart muscle. Given to humans with angina, L-Carnitine was found to improve exercise tolerance. In a small study, patients with congestive heart failure showed gains in heart function with oral consumption of L-Carnitine, reportedly by restoring normal oxidation of fatty acids. In heart valve replacement patients, L-Carnitine has been shown to increase the valve tissue levels of ATP, pyruvate and creatine phosphate, which are key cellular energy substrates. In a controlled study, L-Carnitine was administered to 38 patients prior to open heart surgery. Prior to surgery, heart circulatory function, as assessed by measurements of hemodynamics, was “good” in all 38. While there was evidence of a “preserving” effect of L-Carnitine on heart cells, no differences in cardiac performance were observed. These results suggest that noticeable improvements in heart muscle performance with L-Carnitine are most likely to occur in people with compromised hearts.It has been suggested that L-Carnitine favorably influences blood lipids. Preliminary evidence of this was seen in a small open trial on 26 patients who took 3 grams of L-Carnitine daily for 40 days. Blood levels of cholesterol and triglycerides dropped substantially, while the ratio of total to HDL cholesterol–– a known marker of cardiovascular health––markedly improved.While L-Carnitine is not a treatment for heart disease, (nor should it be used as a substitute for medical treatment) the results of these and other studies suggest that oral consumption of L-Carnitine has a beneficial influence on maintaining a healthy heart and cardiovascular system. |
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Best MSM (1000 mg) 180 Capsules
Best MSM and Best MSM Powder contain pure MSM (methylsulfonylmethane), a white crystalline substance that occurs in the human body and in some foods. MSM is an excellent dietary source of bioavailable organic sulfur.The MSM Story-One of Nature's Primary Sources of Organic Dietary Sulfur! The human body requires a continuous supply of usable sulfur, and MSM is one of the primary organic sulfur-containing molecules for use by living organisms. From life's earliest beginnings, primitive marine organisms (blue-green algae and phytoplankton) have absorbed inorganic sulfur from ocean waters and produced organic sulfur molecules, primarily dimethyl sulfonium salts. These salts are released back into the sea, where they are converted to dimethyl sulfide, which readily evaporates, ending up in the upper atmosphere. Dimethyl sulfide is then oxidized by UV light, forming DMSO and MSM. The two compounds are delivered to land masses in rain water, and absorbed by plants. MSM is a stable end-product of this process, and thus serves as a primary source of sulfur in the food chain.Though present on earth since before life appeared on dry land, and known to science since the 1950's, MSM has only recently been recognized as having importance in human nutrition.Why the Human Body Needs MSM MSM occurs naturally in the blood, body fluids and tissues. It is now believed that a minimum MSM concentration of 0.2 parts per million is necessary for the body to function normally. MSM may be the most easily absorbed and non-toxic source of nutritional sulfur occurring in nature.Sulfur is a structural mineral that maintains the strength of various tissues by forming sulfur "tie-bars" (sulfhydryl bonds) between connective tissue proteins. MSM serves as a readily available source of sulfur for this function, and thus helps maintain the pliancy of tissues and cell membranes. Repair of damaged tissue depends upon a supply of sulfur for continuation of reactions involving sulfhydryl groups (-SH). Sulfur is required for the maintenance of healthy hair, skin and nails. In view of the presence of MSM in biological systems since the beginning of evolution, it is logical to assume that all higher life forms, including humans and animals, are well adapted to use MSM as a sulfur donor.Benefits Clinical research on the role of MSM in the human body has culminated in the filing of several patents covering numerous uses for MSM as a dietary ingredient for both humans and animals. As a result of these investigations, it is believed that physical and psychological stress increases in the human body when the MSM concentration falls below minimum levels, resulting in a loss of normal organ function.Based on observations, ingestion of MSM by humans has the following beneficial effects:• MSM supports maintenance of strong, healthy body tissues by donating sulfur for formation of sulfur tie-bars between connective tissue proteins. • MSM supports normal gastrointestinal function. • MSM improves the body's resistance to adverse physical stress. • MSM supports mental alertness and maintenance of healthy mood. • MSM promotes the body's processes that heal tissue. • MSM helps modify the physiologic response to allergens. • MSM supports normal lung function. • MSM supports normal relaxation of muscles. • MSM supports normal joint function.• MSM helps maintain healthy skin.Supplementation is Needed to Realize the Benefits of MSM Widespread in nature, MSM is found in a variety of foods, including fresh fruits and vegetables, raw milk, raw meat and raw fish. However, MSM is a volatile substance easily lost during cooking, pasteurization, food processing and storage. The average American diet thus supplies at best a marginal MSM intake, which may be inadequate to maintain the optimum MSM concentration in the body. The body's MSM concentration is also believed to decline with increasing age. |
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Best MSM (1500 mg) 120 Tablets
Best MSM and Best MSM Powder contain pure MSM (methylsulfonylmethane), a white crystalline substance that occurs in the human body and in some foods. MSM is an excellent dietary source of bioavailable organic sulfur.The MSM Story-One of Nature's Primary Sources of Organic Dietary Sulfur! The human body requires a continuous supply of usable sulfur, and MSM is one of the primary organic sulfur-containing molecules for use by living organisms. From life's earliest beginnings, primitive marine organisms (blue-green algae and phytoplankton) have absorbed inorganic sulfur from ocean waters and produced organic sulfur molecules, primarily dimethyl sulfonium salts. These salts are released back into the sea, where they are converted to dimethyl sulfide, which readily evaporates, ending up in the upper atmosphere. Dimethyl sulfide is then oxidized by UV light, forming DMSO and MSM. The two compounds are delivered to land masses in rain water, and absorbed by plants. MSM is a stable end-product of this process, and thus serves as a primary source of sulfur in the food chain.Though present on earth since before life appeared on dry land, and known to science since the 1950's, MSM has only recently been recognized as having importance in human nutrition.Why the Human Body Needs MSM MSM occurs naturally in the blood, body fluids and tissues. It is now believed that a minimum MSM concentration of 0.2 parts per million is necessary for the body to function normally. MSM may be the most easily absorbed and non-toxic source of nutritional sulfur occurring in nature.Sulfur is a structural mineral that maintains the strength of various tissues by forming sulfur "tie-bars" (sulfhydryl bonds) between connective tissue proteins. MSM serves as a readily available source of sulfur for this function, and thus helps maintain the pliancy of tissues and cell membranes. Repair of damaged tissue depends upon a supply of sulfur for continuation of reactions involving sulfhydryl groups (-SH). Sulfur is required for the maintenance of healthy hair, skin and nails. In view of the presence of MSM in biological systems since the beginning of evolution, it is logical to assume that all higher life forms, including humans and animals, are well adapted to use MSM as a sulfur donor.Benefits Clinical research on the role of MSM in the human body has culminated in the filing of several patents covering numerous uses for MSM as a dietary ingredient for both humans and animals. As a result of these investigations, it is believed that physical and psychological stress increases in the human body when the MSM concentration falls below minimum levels, resulting in a loss of normal organ function.Based on observations, ingestion of MSM by humans has the following beneficial effects:• MSM supports maintenance of strong, healthy body tissues by donating sulfur for formation of sulfur tie-bars between connective tissue proteins. • MSM supports normal gastrointestinal function. • MSM improves the body's resistance to adverse physical stress. • MSM supports mental alertness and maintenance of healthy mood. • MSM promotes the body's processes that heal tissue. • MSM helps modify the physiologic response to allergens. • MSM supports normal lung function. • MSM supports normal relaxation of muscles. • MSM supports normal joint function.• MSM helps maintain healthy skin.Supplementation is Needed to Realize the Benefits of MSM Widespread in nature, MSM is found in a variety of foods, including fresh fruits and vegetables, raw milk, raw meat and raw fish. However, MSM is a volatile substance easily lost during cooking, pasteurization, food processing and storage. The average American diet thus supplies at best a marginal MSM intake, which may be inadequate to maintain the optimum MSM concentration in the body. The body's MSM concentration is also believed to decline with increasing age. |
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Best MSM Powder 250 grams
Best MSM and Best MSM Powder contain pure MSM (methylsulfonylmethane), a white crystalline substance that occurs in the human body and in some foods. MSM is an excellent dietary source of bioavailable organic sulfur.The MSM Story-One of Nature's Primary Sources of Organic Dietary Sulfur! The human body requires a continuous supply of usable sulfur, and MSM is one of the primary organic sulfur-containing molecules for use by living organisms. From life's earliest beginnings, primitive marine organisms (blue-green algae and phytoplankton) have absorbed inorganic sulfur from ocean waters and produced organic sulfur molecules, primarily dimethyl sulfonium salts. These salts are released back into the sea, where they are converted to dimethyl sulfide, which readily evaporates, ending up in the upper atmosphere. Dimethyl sulfide is then oxidized by UV light, forming DMSO and MSM. The two compounds are delivered to land masses in rain water, and absorbed by plants. MSM is a stable end-product of this process, and thus serves as a primary source of sulfur in the food chain.Though present on earth since before life appeared on dry land, and known to science since the 1950's, MSM has only recently been recognized as having importance in human nutrition.Why the Human Body Needs MSM MSM occurs naturally in the blood, body fluids and tissues. It is now believed that a minimum MSM concentration of 0.2 parts per million is necessary for the body to function normally. MSM may be the most easily absorbed and non-toxic source of nutritional sulfur occurring in nature.Sulfur is a structural mineral that maintains the strength of various tissues by forming sulfur "tie-bars" (sulfhydryl bonds) between connective tissue proteins. MSM serves as a readily available source of sulfur for this function, and thus helps maintain the pliancy of tissues and cell membranes. Repair of damaged tissue depends upon a supply of sulfur for continuation of reactions involving sulfhydryl groups (-SH). Sulfur is required for the maintenance of healthy hair, skin and nails. In view of the presence of MSM in biological systems since the beginning of evolution, it is logical to assume that all higher life forms, including humans and animals, are well adapted to use MSM as a sulfur donor.Benefits Clinical research on the role of MSM in the human body has culminated in the filing of several patents covering numerous uses for MSM as a dietary ingredient for both humans and animals. As a result of these investigations, it is believed that physical and psychological stress increases in the human body when the MSM concentration falls below minimum levels, resulting in a loss of normal organ function.Based on observations, ingestion of MSM by humans has the following beneficial effects:• MSM supports maintenance of strong, healthy body tissues by donating sulfur for formation of sulfur tie-bars between connective tissue proteins. • MSM supports normal gastrointestinal function. • MSM improves the body's resistance to adverse physical stress. • MSM supports mental alertness and maintenance of healthy mood. • MSM promotes the body's processes that heal tissue. • MSM helps modify the physiologic response to allergens. • MSM supports normal lung function. • MSM supports normal relaxation of muscles. • MSM supports normal joint function.• MSM helps maintain healthy skin.Supplementation is Needed to Realize the Benefits of MSM Widespread in nature, MSM is found in a variety of foods, including fresh fruits and vegetables, raw milk, raw meat and raw fish. However, MSM is a volatile substance easily lost during cooking, pasteurization, food processing and storage. The average American diet thus supplies at best a marginal MSM intake, which may be inadequate to maintain the optimum MSM concentration in the body. The body's MSM concentration is also believed to decline with increasing age. |
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Best Nattokinase 100mg (2,000 Fibrin Units) 90 Veggie Caps
Nattokinase is an enzyme derived from "natto", a traditional fermented soy food popular in Japan. During the natto production process B. subtilis natto, a friendly bacteria, ferments boiled soybeans, releasing nattokinase. Best Nattokinase contains pure nattokinase enzyme in a lactose base.*Nattokinase from Doctor's Best is an unbeatable value at this sale price. |
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Best Noni Concentrate (650 mg) 150 Capsules
Best Noni contains pure dried Morinda citrifolia fruit, commonly known as “Noni.” The Morinda citrifolia plant has a long herbal history in Southeast Asia and the South Pacific, and is considered beneficial for a wide variety of uses. Noni fruit, recognized as a valuable food source and approved by the U.S. government since World War II, contains vitamin C1 and other nutritious substances.NONI: Traditional Folk Remedy Morinda citrifolia is well known throughout tropical regions of Asia, the South Pacific and the Caribbean. There are no fewer than 40 common names for this remarkable plant. In the South Pacific, the fruit of Morinda citrifolia goes by the name “Noni.” Highly esteemed for its nutritional value, Noni was approved by the U.S. government during World War II as a food for American soldiers in the Pacific. Noni is also a prized traditional folk remedy among Pacific island cultures and is considered useful for a wide variety of ailments. Pharmaceutical research has uncovered a number of active constituents in the roots, leaves and fruit of Morinda citrifolia. Noni fruit, in addition to vitamin C, contains antibacterial compounds and beneficial polysaccharides.Benefits Stimulates Cell Repair Noni fruit has recently been found to contain a substance given the name “proxeronine” which is believed to increase levels in the body of an alkaloid called “xeronine.” Preliminary unpublished investigations indicate that xeronine is vital for the regeneration of cell structures and maintenance of cellular functions. This intriguing discovery may in large measure explain Noni’s wide range of reported beneficial effects.Supports Immune Function Anecdotal clinical reports on the use of Noni fruit include improvement in the body’s resistance to viruses, yeast, fungi, and bacteria. These observations are supported by current research studies performed at the University of Hawaii. Noni fruit extracts showed an ability to enhance the immune response in mice.Additional reports on the current uses on Noni which coincide with the traditional uses include: 1) Effective against fatigue, 2) Support for joint function and control of the inflammatory response, 3) Maintenance of normal blood-sugar levels. Noni is safe and free of side effects. As a supplement, it should be taken on an empty stomach to prevent breakdown by stomach acid of the natural enzymes present in Noni fruit. |
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Best Red Yeast Rice 120 Veggie Capsules
Best Red Yeast Rice contains rice that has been naturally fermented with red yeast (Monascus purpureus) according to traditional methods. Produced in the U.S., this product is similar to red yeast rice that has been used in culinary applications in Asia since at least 800 A.D. It is considered beneficial for adult men and women when taken as part of a lifestyle program that includes regular exercise and a healthy diet. |
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Best Red Yeast Rice 1200mg 60 Tablets
Best Red Yeast Rice contains rice that has been naturally fermented with red yeast (Monascus purpureus) according to traditional methods. Produced in the U.S., this product is similar to red yeast rice that has been used in culinary applications in Asia since at least 800 A.D. It is considered beneficial for adult men and women when taken as part of a lifestyle program that includes regular exercise and a healthy diet. |
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Best Red Yeast Rice 1200mg w/ CoQ10 60 Tablets
Best Red Yeast Rice contains rice that has been naturally fermented with red yeast (Monascus purpureus) according to traditional methods. Produced in the U.S., this product is similar to red yeast rice that has been used in culinary applications in Asia since at least 800 A.D. It is considered beneficial for adult men and women when taken as part of a lifestyle program that includes regular exercise and a healthy diet. |
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Best Saw Palmetto 320 mg 60 Softgel Capsules
Standardized Saw palmetto berry extract, guaranteed to contain 90 percent fatty acids and sterols.Benefits Effective Prostate Support. Saw palmetto extract is one of the world's leading herbal products for prostate support. Widely-cited clinical studies conducted over the last fifteen years have clearly established the ability of Saw palmetto extract to produce major improvements in prostate-related urinary function. Saw Palmetto's key active ingredients help to normalize prostate gland structure. Discussion As men pass through and beyond middle age, hormonal changes occur which can impact the prostate gland. Levels of dihydrotestoterone (DHT), a normal metabolite of testosterone, increase. This, plus an increased binding of DHT to nuclear receptors in the prostate cell, results in growth of prostate tissue. This tissue growth takes place in the part of the prostate which surrounds the urethra, the tube for urine excretion. This can constrict the urethra, resulting in urinary disturbances.Saw palmetto extract has been shown to inhibit 5 alpha-reductase, an enzyme that controls conversion of testosterone to DHT. Saw palmetto extract also blocks the binding of DHT to prostate cells. These mechanisms are believed to account for Saw palmetto extract's positive effect on prostate gland structure.In clinical studies, Saw palmetto extract has produced measurable improvements in urinary functions and prostate size. Quality of life scores have also improved.The results with Saw palmetto extract have been duplicated in open trials and controlled, double-blind studies.Saw palmetto extract is safe and virtually free of side-effects.Saw palmetto’s effectiveness comes from its content of natural fatty acids and sterols. These include oleic acid, lauric acid, campasterol, stigmasterol, beta-sitosterol and others. The standard of quality for Saw palmetto extract products is a high concentration of fatty acids and sterols, equaling 90%. |
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Celadrin Complex with Glucosamine 90 Tablets
Celadrin® is a unique formulation of esterified (stable) fatty acids that has been shown to reduce certain effects related to pronounced inflammatory processes that can occur in the body. Being a complex molecule consisting of various fatty acids, it is able to penetrate cell membranes, which enhances membrane permeability and cell-to-cell signaling. In doing so, Celadrin® may reduce the level of inflammatory components of the immune system from binding to cells and thus causing occasional inflammation in different parts of the body. Glucosamine SulfateGlucosamine sulfate is the most completely studied form of glucosamine. It is commonly derived from the exoskeleton of shellfish and is a critical nutrient needed for the synthesis and repair of joint cartilage. Glucosamine sulfate has the ability to stimulate the synthesis of glycosaminoglycans and other components of the structural matrix of joint tissue. Because of the comprehensive nature of glucosamine sulfate's effects, it may play a role in maintaining the health of joint tissues.BenefitsIncreased Range of Motion in JointsResearch has shown that Celadrin® can have an impact on improving the range of motion in the joints. A placebo-controlled trial conducted in 2002 showed that those individuals taking a complex containing Celadrin® for 2 months had a significant improvement in knee flexion (ability to bend the knee) over those taking a placebo.Another study conducted on Celadrin® published in 2004 concluded that treatment “significantly increased physical performance (as measured by a variety of orthopedic tests)” in patients with compromised knee mobility. The study found that the subjects given Celadrin® showed improvement in their ability to climb stairs, rise from a chair and walk, along with an improved sense of balance, strength and endurance.Helps Maintain Healthy Joint CartilageGlucosamine sulfate plays a fundamental role as a building block for joint cartilage. Evidence to date suggests it may reduce the severity of the symptoms in individuals with joint problems.Glucosamine sulfate has been shown in some studies to stimulate the regeneration of damaged cartilage, while also having anti-inflammatory effects. Research has found that glucosamine sulfate may have a stimulatory effect on proteoglycan production from human cartilage cells.A specific 3-year placebo-controlled, randomized study was conducted to assess the impact of taking oral glucosamine sulfate on the progression of joint space narrowing. Joint space narrowing may be associated with certain degenerative conditions of articular tissue. The study found that those individuals taking the oral glucosamine at the recommended intake had no space narrowing on average over the time period versus significant space narrowing in the placebo group. Glucosamine sulfate may further play a role in enhancing joint lubrication by acting to form the protective agent mucin, a necessary component of healthy joints.Maintains Joint ComfortThe anti-inflammatory actions of Celadrin® have been demonstrated by one double-blind, placebo controlled trial that showed Celadrin®, when taken orally at recommended intake levels, decreased pain scores and increased walking distance compared to the group receiving placebo. The authors theorize that Celadrin® may work by down-regulating the effect of certain precursors of the body's inflammatory response.In one large open trial, over 1200 people took oral glucosamine sulfate for periods ranging from 36 to 64 days. Over 252 physicians participated in this multicenter study. 95% of the subjects experienced greater joint comfort and increased mobility. The physicians reported "good" results in 59%, and "sufficient" results in 36%. The improvements lasted for up to three months after the glucosamine sulfate was discontinued. |
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Comprehensive Prostate Formula 90 Tablets
Comprehensive Prostate Formula is a complete nutritional program for supporting prostate health with herbs, vitamins, minerals and other nutrients known to benefit the prostate gland.Herbs: Saw palmetto extract -- The Saw palmetto in Comprehensive Prostate Formula is standardized to contain 85 to 90% fatty acids, which are the active ingredients in the Saw palmetto berry that promote prostate health. Three tablets supplies 320 mg, the daily dose used for prostate therapy in clinical studies.Pygeum extract -- Pygeum is an evergreen tree native to the high plateaus of southern Africa. Pygeum bark contains phytosterols, beta sitosterol and other sitosterols, natural sterols that have been shown to normalize the prostate.2 Clinical trials establish 100 mg per as a highly effective dose of Pygeum extract, especially in combination with Nettle root.Nettle root extract -- Nettle, also known as "Stinging Nettle," grows wild in forests and fields throughout North America and Europe. Nettle root has been researched in European studies and shown to benefit the prostate and urinary tract. While the specific active ingredients in Nettle for prostate support have not been positively identified, Nettle's effect on the prostate may stem from its content of polysaccharides and isolectin.4 300 mg per day is a clinically effective dose of Nettle root extract.Amino acids -- The combination of L-alanine, glutamic acid and glycine were first used for prostate support in 1958. Two medical doctors administered the amino acids to allergy patients who reported improvement in urinary function.Lycopene -- Tomatoes are rich in carotenes, natural pigments responsible for the rich variety of colors in fruits and vegetables. Lycopene gives the tomato fruit its red color. Recent research suggests that lycopene may help reduce the risk of prostate C. (These findings, however, are strictly preliminary and await confirmation through further research.)Minerals -- The human prostate contains a high concentration of zinc, which is known to be a key mineral for prostate health. Selenium, an essential trace mineral, may play a role in C risk reduction. Recent work by Harvard University researchers showed that men with the highest levels of selenium were less likely to develop prostate C than those with the lowest selenium levels. Copper is added to balance zinc. When supplementing with zinc, it is advised to take a small amount of additional copper to prevent copper deficiency.Vitamins -- Vitamin E is added as an antioxidant and support for the reproductive system. Vitamin B6 may benefit the prostate by reducing excess levels of the hormone prolactin.BenefitsHelps maintain a healthy prostate gland. Supports normal urinary function. Comprehensive Prostate Formula-the Clinical StudiesSaw palmetto ExtractSaw palmetto extract is one of the world's leading herbal products for prostate support. Widely-cited clinical studies conducted over the last fifteen years suggest Saw palmetto extract can produce major improvements in prostate-related urinary function. In clinical studies, Saw palmetto extract has produced measurable improvements in urinary functions and prostate size. Quality of life scores have also improved. The results with Saw palmetto extract have been duplicated in open trials and controlled, double-blind studies.For example, in a large open trial, 505 men took 320 mg of Saw palmetto extract daily for three months. The results were evaluated with various measurements such as the International Prostate Symptom Score, the quality of life score, urinary flow rates, residual urinary volume, and prostate size. After 45 days these parameters improved significantly. After 90 days of treatment nearly ninety percent of both the doctors and patients regarded Saw palmetto extract as effective as therapy for the prostate.The changes in prostate health that accompany middle age are related to the hormone DHT, or dihydrotestosterone, a metabolite of testosterone. DHT levels rise, and DHT binds to prostate cells, accelerating growth of prostate tissue. Saw palmetto extract has been shown to inhibit 5 alpha-reductase, an enzyme that controls conversion of testosterone to DHT. Experimental evidence suggests Saw palmetto extract blocks the binding of DHT to prostate cells. The fatty acids and sterols in Saw palmetto are believed to be responsible for these actions. These include oleic acid, lauric acid, campasterol, stigmasterol, beta-sitosterol and others. Clinical studies have used extracts containing 85 to 90 percent fatty acids and sterols.Pygeum Extract Like Saw palmetto, Pygeum contains natural sterols and fatty acids. Although the mechanisms for its effect have not been clearly established, animal experiments suggest Pygeum may work by inhibiting prostate cell proliferation and reducing inflammation. In several European trials, Pygeum has successfully improved urinary function. In a large double-blind, placebo-controlled study, 263 men were given 100 mg of Pygeum extract a day for 60 days. Urination improved in 66 percent of the men taking Pygeum, compared with 31 percent on placebo, based on subjective and objective tests.Nettle Root Extract Nettles are approved by the German Commission E as effective for relieving inflammation in the urinary tract. As far back as 1950, German investigators have observed favorable effects on the prostate with the use of Nettle root. These initial findings have been confirmed through case studies, as well as double-blind studies, published mainly in German medical journals. In a recent double blind study published in the journal Clinical Therapeutics, 134 men took a combination of Nettle root extract and Pygeum extract over a period of 56 days. Urination was significantly improved.L-Alanine, Glutamic Acid and Glycine As noted above, Drs. Feinblatt and Gant discovered that a combination of the amino acids L-alanine, glutamic acid and glycine has a positive effect on prostate-related urinary function. A controlled study of 45 men was conducted to follow up on these initial observations. The majority of subjects experienced complete or partial relief in urinary complaints such as nighttime urination and urgency. |
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Extra Strength Ginkgo 120 Capsules
Ginkgo biloba extract is derived from the Ginkgo biloba tree leaf. Thriving on Earth for more than 200 million years, the Ginkgo tree is the world’s oldest living plant. Considered sacred in the Orient, Ginkgo was the only surviving tree near the epicenter of the Hiroshima atomic bomb blast. One specimen, planted near a Japanese monastery more than 1,000 years ago, is still alive today.Rich and Concentrated The Ginkgo biloba leaf is rich in phytonutrients, chiefly flavonglycosides and terpene lactones (ginkgolides.) In the extract, these bioflavonoid-like active ingredients are highly concentrated. Fifty pounds of Ginkgo leaves are used to yield one pound of extract.Benefits Brain and Mental FunctionNumerous clinical studies have been published on Ginkgo biloba extract. Much of this extensive research deals with Ginkgo’s beneficial effects on the brain and mental function.Supports Circulation Foremost among its actions, Ginkgo biloba extract supports circulatory function in the brain and also in the extremities. Enhanced blood flow to the brain means better delivery of oxygen and nutrients.Many Observed Benefits The clinically observed benefits of Ginkgo biloba extract include improved short-term memory, and a positive effect on mood, sociability, thinking ability and hearing.Powerful Antioxidant Ginkgo biloba extract is a powerful antioxidant. Acting as free-radical scavengers, Ginkgo’s flavonglysosides help prevent damaging peroxidation of cell membrane lipid components.Platelet Activating Factor (PAF) The ginkgolides have been shown to inhibit Platelet Activating Factor (PAF). Controlling PAF reduces clumping of blood platelets and improves circulatory health.Oxygen Delivery By maintaining blood flow in the extremities, Ginkgo biloba extract supports oxygen delivery to tissues and promotes ability to walk without discomfort.Discussion Ginkgo biloba extracts rank high among the most popular herbal products in Europe, where sales exceed $500 million annually. Ginkgo biloba extract is non-toxic, free of side effects, and safe for continuous use at the recommended intake level. Best Ginkgo Extract should be taken for four weeks or more before results can be expected. |
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Glucosamine /Chondroitin /MSM 240 Capsules
Glucosamine/Chondroitin/MSM• Best Glucosamine Sulfate contains pure glucosamine sulfate, as confirmed by HPLC testing. Glucosamine sulfate consists of glucosamine, an amino sugar extracted from "chitin," a component of shellfish skeletons. ("Chitin," the resilient polysaccharide that forms the structural framework of animal shells, is a long-chain polymer consisting of many glucosamine molecules linked together.) The purified glucosamine is then sulfated and stabilized with potassium chloride.Note: Glucosamine sulfate is derived from the shells of ocean-growing shellfish. It is processed to remove all residues of protein and impurities, yielding pure glucosamine sulfate as the final material.• Glucosamine/Chondrotin/MSM contains chondroitin sulfate with a purity of 90 percent or greater. Quality assurance testing is performed using two sophisticated laboratory analysis methods: 1) HPLC and 2) C.P.C. Titration, a newly developed method now accepted as the most definitive test for chondroitin sulfate.• Glucosamine/Chondrotin/MSM contains pure LIGNISUL MSM (methylsulfonylmethane). LIGNISUL™ MSM is natural-source MSM derived from trees. A biological compound that occurs in the human body and in some foods, MSM is an excellent dietary source of bioavailable organic sulfur.Understanding Glucosamine Sulfate and Chondroitin Sulfate and Their Roles in Joints Cartilage contains connective tissue composed of cells (chondrocytes), protein fibers (chiefly collagen) and clusters of complex molecules called "proteoglycans." Proteoglycan molecules are formed from long proteins (polypeptides) with numerous side chains. (The proteoglycan structure looks like a bottle brush.) The attached side chains, chiefly chondroitin sulfate and keratin sulfate, are long polysaccharide molecules called "glycosaminoglycans." Glucosamine is a key component of keratin sulfate, and it can be converted to galactosamine, which, along with glucuronic acid, forms chondroitin sulfate.Cartilage contains collagen fibers embedded within a gel-like matrix known as "intracellular cement." Proteoglycans are the key structural component within this matrix. Chondroitin sulfate and the other glycosaminoglycans have a strong attraction for water, due to negative charges on their sulfate groups. These negative charges also repel each other, creating spaces between glycosaminoglycan side-chains in the proteoglycan molecule. Water enters the spaces, giving cartilage a sponge-like quality that allows it to function as a shock absorber for joints. The movement of water in and out of cartilage allows nutrients to flow in and wastes to flow out.Glucosamine is also a component of hyaluronic acid, another glycosaminoglycan found in cartilage and other connective tissues. Hyaluronic acid forms the backbone for the proteoglycan clusters. As essential components of cartilage, glucosamine and chondroitin sulfate are therefore critically important for the health and function of joints.The MSM Story-One of Nature's Primary Sources of Organic Dietary Sulfur! The human body requires a continuous supply of usable sulfur, and MSM is one of the primary organic sulfur-containing molecules for use by living organisms. From life's earliest beginnings, primitive marine organisms (blue-green algae and phytoplankton) have absorbed inorganic sulfur from ocean waters and produced organic sulfur molecules, primarily dimethyl sulfonium salts. These salts are released back into the sea, where they are converted to dimethyl sulfide, which readily evaporates into the upper atmosphere. Dimethyl sulfide is then oxidized by UV light, forming DMSO and MSM. The two compounds are delivered to land masses in rain water, and absorbed by plants. MSM is a stable end-product of this process, serving as a primary source of sulfur in the food chain.Benefits Supports Joint Structure and FunctionGlucosamine Sulfate Glucosamine sulfate is one of the most important nutritional supplements for joint health ever developed. Glucosamine sulfate provides significant benefits for both the structure and function of joints. Many years of research have produced unequivocal evidence that glucosamine sulfate normalizes cartilage metabolism, slows breakdown of cartilage, and improves joint function. Glucosamine sulfate has been thoroughly researched over the last twenty years. Experimental studies and human clinical trials convincingly demonstrate that orally consumed glucosamine sulfate improves joint function. In one large open trial, over 1200 people took oral glucosamine sulfate for periods ranging from 36 to 64 days. 252 physicians participated in this multicenter study. 95% of the subjects experienced greater joint comfort and increased mobility. The physicians reported "good" results in 59%, and "sufficient" results in 36%. The improvements lasted for up to three months after the glucosamine sulfate was discontinued.Chondroitin Sulfate In a 1996 controlled, double-blind multicenter clinical trial published in the Journal of Rheumatology, 146 volunteers consumed 1200 mg of chondroitin sulfate every day for 6 months. Changes in joint function were measured according to several clinical parameters and carefully analyzed. After the first month, significant improvements were noted and maintained for three months after the subjects stopped taking the chondroitin sulfate. In an earlier double-blind study subjects taking chondroitin sulfate had improvements in joint function after three months of use, as determined by both objective and subjective measurements.8 In both studies, the benefits lasted for weeks after subjects stopped taking chondroitin sulfate.In another controlled multicenter study, 192 subjects took 1200 mg of chondroitin sulfate or a placebo daily for one year. At the end of the trial, chondroitin sulfate produced substantial increases in joint cartilage thickness, while those on placebo had decreases. Improvements in joint function also occurred. The researchers reported that "we clearly demonstrated that (chondroitin sulfate) exerts a chondroprotective activity."New Clinical Evidence of MSM’s Joint Benefits A small pilot study recently conducted at the U.C.L.A. School of Medicine is the first controlled double-blind trial to test the effects of MSM on joints. Sixteen subjects demonstrating need for joint support took either MSM or a placebo daily for six weeks. As measured by a Visual Analog Scale, those taking MSM registered an 82 percent improvement compared to 20 percent with placebo. Though preliminary due to the small number of subjects, these results suggest potential for MSM as a joint support nutrient that warrants further investigation in larger double-blind trials.Additional Benefits of MSM Sulfur is a structural mineral that maintains the strength of various tissues by forming sulfur "tie-bars" (sulfhydryl bonds) between connective tissue proteins. MSM serves as a readily available source of sulfur for this function, and thus helps maintain the pliancy of tissues and cell membranes. Based on anecdotal clinical reports, as outlined in MSM patents, ingestion of MSM by humans appears to have the following beneficial effects: 1) Supports normal gastrointestinal function; 2) Improves the body's resistance to adverse physical stress; 3) Supports mental alertness and maintenance of healthy mood; 4) Helps regulate body's inflammatory function; 5) Helps modify the physiologic response to allergens; 6) Supports normal lung function; 7) Helps maintain healthy skin.Supplementation is Needed to Realize the Benefits of MSM Widespread in nature, MSM is found in a variety of foods, including fresh fruits and vegetables, raw milk, raw meat and raw fish. However, MSM is a volatile substance easily lost during cooking, pasteurization, food processing and storage. The average American diet thus supplies at best a marginal MSM intake which may be inadequate to maintain the optimum MSM concentration in the body. The average body's MSM concentration is also believed to decline with increasing age. |
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Glucosamine /Chondroitin /MSM 120 Capsules
Glucosamine/Chondroitin/MSM• Best Glucosamine Sulfate contains pure glucosamine sulfate, as confirmed by HPLC testing. Glucosamine sulfate consists of glucosamine, an amino sugar extracted from "chitin," a component of shellfish skeletons. ("Chitin," the resilient polysaccharide that forms the structural framework of animal shells, is a long-chain polymer consisting of many glucosamine molecules linked together.) The purified glucosamine is then sulfated and stabilized with potassium chloride.Note: Glucosamine sulfate is derived from the shells of ocean-growing shellfish. It is processed to remove all residues of protein and impurities, yielding pure glucosamine sulfate as the final material.• Glucosamine/Chondrotin/MSM contains chondroitin sulfate with a purity of 90 percent or greater. Quality assurance testing is performed using two sophisticated laboratory analysis methods: 1) HPLC and 2) C.P.C. Titration, a newly developed method now accepted as the most definitive test for chondroitin sulfate.• Glucosamine/Chondrotin/MSM contains pure LIGNISUL MSM (methylsulfonylmethane). LIGNISUL™ MSM is natural-source MSM derived from trees. A biological compound that occurs in the human body and in some foods, MSM is an excellent dietary source of bioavailable organic sulfur.Understanding Glucosamine Sulfate and Chondroitin Sulfate and Their Roles in Joints Cartilage contains connective tissue composed of cells (chondrocytes), protein fibers (chiefly collagen) and clusters of complex molecules called "proteoglycans." Proteoglycan molecules are formed from long proteins (polypeptides) with numerous side chains. (The proteoglycan structure looks like a bottle brush.) The attached side chains, chiefly chondroitin sulfate and keratin sulfate, are long polysaccharide molecules called "glycosaminoglycans." Glucosamine is a key component of keratin sulfate, and it can be converted to galactosamine, which, along with glucuronic acid, forms chondroitin sulfate.Cartilage contains collagen fibers embedded within a gel-like matrix known as "intracellular cement." Proteoglycans are the key structural component within this matrix. Chondroitin sulfate and the other glycosaminoglycans have a strong attraction for water, due to negative charges on their sulfate groups. These negative charges also repel each other, creating spaces between glycosaminoglycan side-chains in the proteoglycan molecule. Water enters the spaces, giving cartilage a sponge-like quality that allows it to function as a shock absorber for joints. The movement of water in and out of cartilage allows nutrients to flow in and wastes to flow out.Glucosamine is also a component of hyaluronic acid, another glycosaminoglycan found in cartilage and other connective tissues. Hyaluronic acid forms the backbone for the proteoglycan clusters. As essential components of cartilage, glucosamine and chondroitin sulfate are therefore critically important for the health and function of joints.The MSM Story-One of Nature's Primary Sources of Organic Dietary Sulfur! The human body requires a continuous supply of usable sulfur, and MSM is one of the primary organic sulfur-containing molecules for use by living organisms. From life's earliest beginnings, primitive marine organisms (blue-green algae and phytoplankton) have absorbed inorganic sulfur from ocean waters and produced organic sulfur molecules, primarily dimethyl sulfonium salts. These salts are released back into the sea, where they are converted to dimethyl sulfide, which readily evaporates into the upper atmosphere. Dimethyl sulfide is then oxidized by UV light, forming DMSO and MSM. The two compounds are delivered to land masses in rain water, and absorbed by plants. MSM is a stable end-product of this process, serving as a primary source of sulfur in the food chain.Benefits Supports Joint Structure and FunctionGlucosamine Sulfate Glucosamine sulfate is one of the most important nutritional supplements for joint health ever developed. Glucosamine sulfate provides significant benefits for both the structure and function of joints. Many years of research have produced unequivocal evidence that glucosamine sulfate normalizes cartilage metabolism, slows breakdown of cartilage, and improves joint function. Glucosamine sulfate has been thoroughly researched over the last twenty years. Experimental studies and human clinical trials convincingly demonstrate that orally consumed glucosamine sulfate improves joint function. In one large open trial, over 1200 people took oral glucosamine sulfate for periods ranging from 36 to 64 days. 252 physicians participated in this multicenter study. 95% of the subjects experienced greater joint comfort and increased mobility. The physicians reported "good" results in 59%, and "sufficient" results in 36%. The improvements lasted for up to three months after the glucosamine sulfate was discontinued.Chondroitin Sulfate In a 1996 controlled, double-blind multicenter clinical trial published in the Journal of Rheumatology, 146 volunteers consumed 1200 mg of chondroitin sulfate every day for 6 months. Changes in joint function were measured according to several clinical parameters and carefully analyzed. After the first month, significant improvements were noted and maintained for three months after the subjects stopped taking the chondroitin sulfate. In an earlier double-blind study subjects taking chondroitin sulfate had improvements in joint function after three months of use, as determined by both objective and subjective measurements.8 In both studies, the benefits lasted for weeks after subjects stopped taking chondroitin sulfate.In another controlled multicenter study, 192 subjects took 1200 mg of chondroitin sulfate or a placebo daily for one year. At the end of the trial, chondroitin sulfate produced substantial increases in joint cartilage thickness, while those on placebo had decreases. Improvements in joint function also occurred. The researchers reported that "we clearly demonstrated that (chondroitin sulfate) exerts a chondroprotective activity."New Clinical Evidence of MSM’s Joint Benefits A small pilot study recently conducted at the U.C.L.A. School of Medicine is the first controlled double-blind trial to test the effects of MSM on joints. Sixteen subjects demonstrating need for joint support took either MSM or a placebo daily for six weeks. As measured by a Visual Analog Scale, those taking MSM registered an 82 percent improvement compared to 20 percent with placebo. Though preliminary due to the small number of subjects, these results suggest potential for MSM as a joint support nutrient that warrants further investigation in larger double-blind trials.Additional Benefits of MSM Sulfur is a structural mineral that maintains the strength of various tissues by forming sulfur "tie-bars" (sulfhydryl bonds) between connective tissue proteins. MSM serves as a readily available source of sulfur for this function, and thus helps maintain the pliancy of tissues and cell membranes. Based on anecdotal clinical reports, as outlined in MSM patents, ingestion of MSM by humans appears to have the following beneficial effects: 1) Supports normal gastrointestinal function; 2) Improves the body's resistance to adverse physical stress; 3) Supports mental alertness and maintenance of healthy mood; 4) Helps regulate body's inflammatory function; 5) Helps modify the physiologic response to allergens; 6) Supports normal lung function; 7) Helps maintain healthy skin.Supplementation is Needed to Realize the Benefits of MSM Widespread in nature, MSM is found in a variety of foods, including fresh fruits and vegetables, raw milk, raw meat and raw fish. However, MSM is a volatile substance easily lost during cooking, pasteurization, food processing and storage. The average American diet thus supplies at best a marginal MSM intake which may be inadequate to maintain the optimum MSM concentration in the body. The average body's MSM concentration is also believed to decline with increasing age. |
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High Absorption CoQ10 w/ Bioperine 100mg 60 soft gels
High Absorption CoQ10 contains pure, vegetarian source Coenzyme Q10 in a base of rice powder, plus Bioperine®, an herbal extract that enhances CoQ10 absorption.
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High Absorption CoQ10 w/ Bioperine 100mg 30 soft gels
High Absorption CoQ10 contains pure, vegetarian source Coenzyme Q10 in a base of rice powder, plus Bioperine®, an herbal extract that enhances CoQ10 absorption.
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High Absorption CoQ10 100mg 60 Veggie Caps
High Absorption CoQ10 contains pure, vegetarian source Coenzyme Q10 in a base of rice powder, plus Bioperine®, an herbal extract that enhances CoQ10 absorption. Benefits Boosts Cellular Energy Production Coenzyme Q10 is a vitamin-like nutrient found in the human body. Essential to life, CoQ10 works at the cellular level to produce metabolic energy in the form of ATP. CoQ10 serves as a vital link in the “electron transport chain,” which is the final step in the production of ATP inside cells. Lacking adequate CoQ10, cells become energy-deficient. When cells are nourished with optimal levels of CoQ10, tissues, organs and systems function optimally. Strengthens and Protects the HeartThe heart is the hardest-working muscle in the body. Because of its high energy requirements, the heart needs to be well supplied with CoQ10 at all times. The body’s highest concentration of CoQ10 occurs in heart muscle tissue. (Heart muscle cells contain large numbers of mitochondria.) Numerous clinical studies have demonstrated significant improvements in heart function with oral administration of CoQ10.Supports Immune FunctionWhen the immune system goes into battle for us, immune cells need large amounts of energy to carry out their defensive functions. CoQ10 is required for this energy to be available. Experimental research on animals has shown that CoQ10 enhances immune functions such as the activity of phagocytes, and antibody production. Age-related immune suppression has been observed in mice given CoQ10.Antioxidant Protection CoQ10 is a versatile antioxidant. The reduced form of CoQ10, ubiquinol-10, has been found to protect LDL against peroxidation by free radicals more effectively than vitamin E. CoQ10 stabilizes membranes, thus protecting them from free-radical damage.Benefits the GumsA number of studies have shown that CoQ10 supports repair of gingival (gum) tissue. Gingival tissues in people with periodontal disease have been found deficient in CoQ10. In several double-blind clinical trials, oral administration of CoQ10 has resulted in significant improvements.Many Clinical Benefits Research studies and clinical reports suggest CoQ10 has a broad range of applications stemming from its ability to support the heart and cardiovascular system, the immune system, cellular energy production, liver function, nerves, and muscles.CoQ10 — Vitamin E’s Partner In vitro studies suggest CoQ10 in combination with vitamin E protects LDL cholesterol from oxidation more effectively than vitamin E alone. Protecting LDL from being oxidized by free radicals is now thought to be important for cardiovascular health.Bioperine® — A Bioavailability-Enhancing Phytonutrient Bioperine® is a natural extract derived from black pepper that enhances nutrient absorption. Preliminary trials on humans have shown significant increases in the absorption of nutrients consumed along with Bioperine®. In a recent study (publication pending), the administration of 5 mg of Bioperine® together with 120 mg of CoQ10 per day resulted in a 32% increase in CoQ10 absorption after 21 days. (This is especially important for individuals who have impaired absorption of fat-soluble nutrients such as CoQ10.) |
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High Absorption CoQ10 100mg 30 Veggie Capsules
High Absorption CoQ10 contains pure, vegetarian source Coenzyme Q10 in a base of rice powder, plus Bioperine®, an herbal extract that enhances CoQ10 absorption. Benefits Boosts Cellular Energy Production Coenzyme Q10 is a vitamin-like nutrient found in the human body. Essential to life, CoQ10 works at the cellular level to produce metabolic energy in the form of ATP. CoQ10 serves as a vital link in the “electron transport chain,” which is the final step in the production of ATP inside cells. Lacking adequate CoQ10, cells become energy-deficient. When cells are nourished with optimal levels of CoQ10, tissues, organs and systems function optimally. Strengthens and Protects the HeartThe heart is the hardest-working muscle in the body. Because of its high energy requirements, the heart needs to be well supplied with CoQ10 at all times. The body’s highest concentration of CoQ10 occurs in heart muscle tissue. (Heart muscle cells contain large numbers of mitochondria.) Numerous clinical studies have demonstrated significant improvements in heart function with oral administration of CoQ10.Supports Immune FunctionWhen the immune system goes into battle for us, immune cells need large amounts of energy to carry out their defensive functions. CoQ10 is required for this energy to be available. Experimental research on animals has shown that CoQ10 enhances immune functions such as the activity of phagocytes, and antibody production. Age-related immune suppression has been observed in mice given CoQ10.Antioxidant Protection CoQ10 is a versatile antioxidant. The reduced form of CoQ10, ubiquinol-10, has been found to protect LDL against peroxidation by free radicals more effectively than vitamin E. CoQ10 stabilizes membranes, thus protecting them from free-radical damage.Benefits the GumsA number of studies have shown that CoQ10 supports repair of gingival (gum) tissue. Gingival tissues in people with periodontal disease have been found deficient in CoQ10. In several double-blind clinical trials, oral administration of CoQ10 has resulted in significant improvements.Many Clinical Benefits Research studies and clinical reports suggest CoQ10 has a broad range of applications stemming from its ability to support the heart and cardiovascular system, the immune system, cellular energy production, liver function, nerves, and muscles.CoQ10 — Vitamin E’s Partner In vitro studies suggest CoQ10 in combination with vitamin E protects LDL cholesterol from oxidation more effectively than vitamin E alone. Protecting LDL from being oxidized by free radicals is now thought to be important for cardiovascular health.Bioperine® — A Bioavailability-Enhancing Phytonutrient Bioperine® is a natural extract derived from black pepper that enhances nutrient absorption. Preliminary trials on humans have shown significant increases in the absorption of nutrients consumed along with Bioperine®. In a recent study (publication pending), the administration of 5 mg of Bioperine® together with 120 mg of CoQ10 per day resulted in a 32% increase in CoQ10 absorption after 21 days. (This is especially important for individuals who have impaired absorption of fat-soluble nutrients such as CoQ10.) |
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High Absorption Magnesium 240 Tablets
High Absorption Magnesium contains elemental magnesium chelated with the amino acids glycine and lysine. It is a "di-peptide" chelate, which means that each magnesium atom is chelated with two amino acid molecules. It has a low molecular weight of 324 daltons, which is ideal for optimum absorption. Bioperine® is a patented herbal extract that enhances nutrient absorption. Benefits As an essential dietary mineral, magnesium plays many important roles, including: • Acts as a co-factor for metabolic enzymes. • Assists energy production in cells. • Supports nerve and muscle function. • Helps maintain a normal, regular heartbeat.• Supports bone density.Magnesium is a dietary mineral with a wide array of biological activities in the body. Magnesium participates in numerous life-essential processes that occur both inside and outside cells. Magnesium deficiency impacts normal physiologic function on many levels. Adequate magnesium is a fundamental requirement for optimum function of the cardiovascular system, the nervous system and skeletal muscle, as well as the uterus and GI tract. Magnesium deficiency can affect health of the heart, bones and blood vessels and alter blood sugar balance.Magnesium–Important for Everyone, Deficient in Many The average person living in a modern country today very likely consumes less than the optimum amount of magnesium. An abundance of data collected over the last two decades shows a consistent pattern of low magnesium intake in the U.S. This pattern cuts a wide swath across various age-sex groups. The USDA’s Nationwide Food Consumption Survey found that a majority of Americans consumed less than the recommended daily magnesium intake. Twelve age-sex groups were studied and this low magnesium intake was true for all groups except 0 to 5 year olds.An analysis of the nutrient content of the diets of 7,810 individuals age four and above included magnesium among several nutrients where the amounts supplied by the average diet "were not sufficient to meet recommended standards". The FDA’s Total Diet study examined the intakes of eleven minerals, including magnesium, among eight age-sex groups. Data was collected four times yearly from 1982 to 1984. Levels of magnesium, calcium, iron, zinc and copper were low for most age-sex groups. Surveys conducted in Europe and in other parts of North America paint a similar picture. Loss of magnesium during food processing is one explanation for this global lack of adequate dietary magnesium.In particular, the elderly may be susceptible to magnesium deficiency for a variety of reasons, including inadequate magnesium intake, poor absorption due to impaired gastrointestinal function and use of drugs such as diuretics that deplete magnesium from the body. It has recently been theorized that magnesium deficiency may contribute to accelerated aging, through effects on the cardiovascular and nervous systems, as well as muscles and the kidneys. Women who take both synthetic estrogen and calcium supplements may be at risk for low blood levels of magnesium. Estrogen promotes the transfer of magnesium from blood to soft–tissues. Low blood magnesium may result if the ratio of calcium to magnesium intake exceeds 4 to 1. Magnesium supplementation is thus advisable for women taking estrogen and calcium.Young adults are not immune to magnesium deficiency. The University of California’s Bogalusa Heart Study collected nutritional data from a cross-sectional sample of 504 young adults between age 19 and 28.10 The reported intake of magnesium, along with several other minerals and vitamins, was below the RDA.Glycine is a highly effective mineral chelator. This is because it is a low-molecular-weight amino acid, hence is easily transported across the intestinal membrane. A study conducted at Weber State University found this particular magnesium glycinate was absorbed up to four times more effectively than typical magnesium supplements.Magnesium-the Versatile MineralThe average adult body contains anywhere from about 21 to 28 grams of magnesium. Approximately 60 percent of the body’s magnesium supply is stored in bone. Soft tissue, such as skeletal muscle, contains 38%, leaving only about 1 to 2% of the total body magnesium content in blood plasma and red blood cells. Magnesium in the body may be bound either to proteins or "anions" (negatively charged substances.) About 55% of the body’s magnesium content is in the "ionic" form, which means it carries an electrical charge. Magnesium ions are "cations," ions that carry a positive charge. In its charged state, magnesium functions as one of the mineral "electrolytes."Magnesium works as a "co-factor" for over 300 enzymatic reactions in the body. Metabolism uses a phosphate containing molecule called "ATP" as its energy source. Magnesium is required for all reactions involving ATP.11 ATP supplies the energy for physical activity, by releasing energy stored in "phosphate bonds".Skeletal and heart muscle use up large amounts of ATP. The energy for muscle contraction is released when one of ATP’s phosphate bonds is broken, in a reaction that produces ADP. Phosphate is added back to ADP, re-forming ATP. ATP also powers the cellular "calcium pump" which allows muscle cells to relax. Because it participates in these ATP-controlled processes, magnesium is vitally important for muscle contraction and relaxation. By controlling the flow of sodium, potassium and calcium in and out of cells, magnesium regulates the function of nerves as well as muscles.Magnesium’s importance for heart health is widely recognized. The heart is the only muscle in the body that generates its own electrical impulses. Through its influence on the heart’s electrical conduction system, magnesium is essential for maintenance of a smooth, regular heartbeat.13 Magnesium appears to help the heart resist the effects of systemic stress. Magnesium deficiency aggravates cardiac damage due to acute systemic stress (such as caused by infection or trauma), while magnesium supplementation protects the heart against stress.14 This has been found true even in the absence of an actual magnesium deficit in the body. Evidence suggests that magnesium may help support mineral bone density in elderly women. In a two-year open, controlled trial, 22 out of a group of 31 postmenopausal women who took daily magnesium supplements showed gains in bone density. A control group of 23 women who declined taking the supplements had decreases in bone density. The dietary intakes of magnesium, potassium, fruit and vegetables are associated with increased bone density in elderly women and men.16 In an interesting animal study, rats were fed diets with either high or low levels of magnesium. Compared to the high magnesium-fed rats, bone strength and magnesium content of bone decreased in the low-magnesium rats, even though these rats showed no visible signs of magnesium deficiency. While this finding may or may not apply to humans, it raises the possibility that diets supplying low magnesium intakes may contribute to weakening of bone in the elderly.Maximizing Absorption––Chelated Minerals Explained Mineral absorption occurs mainly in the small intestine. Like any mineral, magnesium may be absorbed as an "ion," a mineral in its elemental state that carries an electric charge. Mineral ions cross the intestinal membrane either through "active transport" by a protein carrier imbedded in the cells lining the membrane inner wall, or by simple diffusion. The magnesium in mineral salts is absorbed in ionic form. However, absorption of ionic minerals can be compromised by any number of factors, including: 1) Low solubility of the starting salt, which inhibits release of the mineral ion, and 2) Binding of the released ion to naturally occurring dietary factors such as phytates, fats and other minerals that form indigestible mineral complexes.A second absorption mechanism has been discovered for minerals. Experiments have shown that minerals chemically bonded to amino acids (building blocks of protein) are absorbed differently from mineral ions. This has given rise to the introduction of "chelated" minerals as dietary supplements. Mineral amino acid chelates consist of a single atom of elemental mineral that is surrounded by two or more amino acid molecules in a stable, ring-like structure.Unlike mineral salts, which must be digested by stomach acid before the desired mineral portion can be released and absorbed, mineral chelates are not broken down in the stomach or intestines. Instead, chelates cross the intestinal wall intact, carrying the mineral tightly bound and hidden within the amino acid ring. The mineral is then released into the bloodstream for use by the body. Research by pioneers in the field of mineral chelation and human nutrition indicates that the best-absorbed chelates consist of one mineral atom chelated with two amino acids. This form of chelate is called a "di-peptide." Compared to other chelates, di-peptides have the ideal chemical attributes for optimum absorption. Dipeptide chelates demonstrate superior absorption compared to mineral salts. For example, a magnesium di-peptide chelate was shown to be four times better absorbed than magnesium oxide.Consumer Alert! Not all "amino acid chelates" are true chelates. In order for a mineral supplement to qualify as a genuine chelate, it must be carefully processed to ensure the mineral is chemically bonded to the amino acids in a stable molecule with the right characteristics. The magnesium bis-glycinate/lysinate in High Absorption Magnesium is a genuine di-peptide chelate ("bis" means "two"). It has a molecular weight of 324 daltons, considerably lower than the upper limit of 800 daltons stated in the definition of "mineral amino acid chelates" adopted by the National Nutritional Foods Association in 1996.Bioperine® For Enhanced Absorption Bioperine® is a natural extract derived from black pepper that increases nutrient absorption. Preliminary trials on humans have shown significant increases in the absorption of nutrients consumed along with Bioperine®. |
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High Absorption Magnesium 120 Tablets
High Absorption Magnesium contains elemental magnesium chelated with the amino acids glycine and lysine. It is a "di-peptide" chelate, which means that each magnesium atom is chelated with two amino acid molecules. It has a low molecular weight of 324 daltons, which is ideal for optimum absorption. Bioperine® is a patented herbal extract that enhances nutrient absorption. Benefits As an essential dietary mineral, magnesium plays many important roles, including: • Acts as a co-factor for metabolic enzymes. • Assists energy production in cells. • Supports nerve and muscle function. • Helps maintain a normal, regular heartbeat.• Supports bone density.Magnesium is a dietary mineral with a wide array of biological activities in the body. Magnesium participates in numerous life-essential processes that occur both inside and outside cells. Magnesium deficiency impacts normal physiologic function on many levels. Adequate magnesium is a fundamental requirement for optimum function of the cardiovascular system, the nervous system and skeletal muscle, as well as the uterus and GI tract. Magnesium deficiency can affect health of the heart, bones and blood vessels and alter blood sugar balance.Magnesium–Important for Everyone, Deficient in Many The average person living in a modern country today very likely consumes less than the optimum amount of magnesium. An abundance of data collected over the last two decades shows a consistent pattern of low magnesium intake in the U.S. This pattern cuts a wide swath across various age-sex groups. The USDA’s Nationwide Food Consumption Survey found that a majority of Americans consumed less than the recommended daily magnesium intake. Twelve age-sex groups were studied and this low magnesium intake was true for all groups except 0 to 5 year olds.An analysis of the nutrient content of the diets of 7,810 individuals age four and above included magnesium among several nutrients where the amounts supplied by the average diet "were not sufficient to meet recommended standards". The FDA’s Total Diet study examined the intakes of eleven minerals, including magnesium, among eight age-sex groups. Data was collected four times yearly from 1982 to 1984. Levels of magnesium, calcium, iron, zinc and copper were low for most age-sex groups. Surveys conducted in Europe and in other parts of North America paint a similar picture. Loss of magnesium during food processing is one explanation for this global lack of adequate dietary magnesium.In particular, the elderly may be susceptible to magnesium deficiency for a variety of reasons, including inadequate magnesium intake, poor absorption due to impaired gastrointestinal function and use of drugs such as diuretics that deplete magnesium from the body. It has recently been theorized that magnesium deficiency may contribute to accelerated aging, through effects on the cardiovascular and nervous systems, as well as muscles and the kidneys. Women who take both synthetic estrogen and calcium supplements may be at risk for low blood levels of magnesium. Estrogen promotes the transfer of magnesium from blood to soft–tissues. Low blood magnesium may result if the ratio of calcium to magnesium intake exceeds 4 to 1. Magnesium supplementation is thus advisable for women taking estrogen and calcium.Young adults are not immune to magnesium deficiency. The University of California’s Bogalusa Heart Study collected nutritional data from a cross-sectional sample of 504 young adults between age 19 and 28.10 The reported intake of magnesium, along with several other minerals and vitamins, was below the RDA.Glycine is a highly effective mineral chelator. This is because it is a low-molecular-weight amino acid, hence is easily transported across the intestinal membrane. A study conducted at Weber State University found this particular magnesium glycinate was absorbed up to four times more effectively than typical magnesium supplements.Magnesium-the Versatile MineralThe average adult body contains anywhere from about 21 to 28 grams of magnesium. Approximately 60 percent of the body’s magnesium supply is stored in bone. Soft tissue, such as skeletal muscle, contains 38%, leaving only about 1 to 2% of the total body magnesium content in blood plasma and red blood cells. Magnesium in the body may be bound either to proteins or "anions" (negatively charged substances.) About 55% of the body’s magnesium content is in the "ionic" form, which means it carries an electrical charge. Magnesium ions are "cations," ions that carry a positive charge. In its charged state, magnesium functions as one of the mineral "electrolytes."Magnesium works as a "co-factor" for over 300 enzymatic reactions in the body. Metabolism uses a phosphate containing molecule called "ATP" as its energy source. Magnesium is required for all reactions involving ATP.11 ATP supplies the energy for physical activity, by releasing energy stored in "phosphate bonds".Skeletal and heart muscle use up large amounts of ATP. The energy for muscle contraction is released when one of ATP’s phosphate bonds is broken, in a reaction that produces ADP. Phosphate is added back to ADP, re-forming ATP. ATP also powers the cellular "calcium pump" which allows muscle cells to relax. Because it participates in these ATP-controlled processes, magnesium is vitally important for muscle contraction and relaxation. By controlling the flow of sodium, potassium and calcium in and out of cells, magnesium regulates the function of nerves as well as muscles.Magnesium’s importance for heart health is widely recognized. The heart is the only muscle in the body that generates its own electrical impulses. Through its influence on the heart’s electrical conduction system, magnesium is essential for maintenance of a smooth, regular heartbeat.13 Magnesium appears to help the heart resist the effects of systemic stress. Magnesium deficiency aggravates cardiac damage due to acute systemic stress (such as caused by infection or trauma), while magnesium supplementation protects the heart against stress.14 This has been found true even in the absence of an actual magnesium deficit in the body. Evidence suggests that magnesium may help support mineral bone density in elderly women. In a two-year open, controlled trial, 22 out of a group of 31 postmenopausal women who took daily magnesium supplements showed gains in bone density. A control group of 23 women who declined taking the supplements had decreases in bone density. The dietary intakes of magnesium, potassium, fruit and vegetables are associated with increased bone density in elderly women and men.16 In an interesting animal study, rats were fed diets with either high or low levels of magnesium. Compared to the high magnesium-fed rats, bone strength and magnesium content of bone decreased in the low-magnesium rats, even though these rats showed no visible signs of magnesium deficiency. While this finding may or may not apply to humans, it raises the possibility that diets supplying low magnesium intakes may contribute to weakening of bone in the elderly.Maximizing Absorption––Chelated Minerals Explained Mineral absorption occurs mainly in the small intestine. Like any mineral, magnesium may be absorbed as an "ion," a mineral in its elemental state that carries an electric charge. Mineral ions cross the intestinal membrane either through "active transport" by a protein carrier imbedded in the cells lining the membrane inner wall, or by simple diffusion. The magnesium in mineral salts is absorbed in ionic form. However, absorption of ionic minerals can be compromised by any number of factors, including: 1) Low solubility of the starting salt, which inhibits release of the mineral ion, and 2) Binding of the released ion to naturally occurring dietary factors such as phytates, fats and other minerals that form indigestible mineral complexes.A second absorption mechanism has been discovered for minerals. Experiments have shown that minerals chemically bonded to amino acids (building blocks of protein) are absorbed differently from mineral ions. This has given rise to the introduction of "chelated" minerals as dietary supplements. Mineral amino acid chelates consist of a single atom of elemental mineral that is surrounded by two or more amino acid molecules in a stable, ring-like structure.Unlike mineral salts, which must be digested by stomach acid before the desired mineral portion can be released and absorbed, mineral chelates are not broken down in the stomach or intestines. Instead, chelates cross the intestinal wall intact, carrying the mineral tightly bound and hidden within the amino acid ring. The mineral is then released into the bloodstream for use by the body. Research by pioneers in the field of mineral chelation and human nutrition indicates that the best-absorbed chelates consist of one mineral atom chelated with two amino acids. This form of chelate is called a "di-peptide." Compared to other chelates, di-peptides have the ideal chemical attributes for optimum absorption. Dipeptide chelates demonstrate superior absorption compared to mineral salts. For example, a magnesium di-peptide chelate was shown to be four times better absorbed than magnesium oxide.Consumer Alert! Not all "amino acid chelates" are true chelates. In order for a mineral supplement to qualify as a genuine chelate, it must be carefully processed to ensure the mineral is chemically bonded to the amino acids in a stable molecule with the right characteristics. The magnesium bis-glycinate/lysinate in High Absorption Magnesium is a genuine di-peptide chelate ("bis" means "two"). It has a molecular weight of 324 daltons, considerably lower than the upper limit of 800 daltons stated in the definition of "mineral amino acid chelates" adopted by the National Nutritional Foods Association in 1996.Bioperine® For Enhanced Absorption Bioperine® is a natural extract derived from black pepper that increases nutrient absorption. Preliminary trials on humans have shown significant increases in the absorption of nutrients consumed along with Bioperine®. |
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Quercetin/Bromelain 180 Capsules
Quercetin is a potent and versatile flavonoid and phytonutrient. Bromelain is an enzyme complex derived from the pineapple stem. (Note: G.D.U. stands for “Gelatin-Digesting Units,” a commonly accepted measure of enzyme activity.) Benefits Down-regulates the Body’s Response to Environmental Challenges Quercetin is a member of the flavonoid family, a diverse group of low molecular-weight compounds found throughout the plant kingdom. Flavonoids exhibit numerous biological activities, many of which are directly beneficial to human health. Quercetin, which belongs to the “flavonol” subgroup, is one of the most versatile and important flavonoids. Quercetin has a broad range of activity, much of which stems from its interaction with calmodulin, a calcium-regulatory protein. Calmodulin transports calcium ions across cellular membranes, initiating numerous cellular processes. Quercetin appears to act as a calmodulin antagonist. Through this mechanism, quercetin functions at the cell-membrane level with a membrane-stabilizing action. Quercetin inhibits calmodulin-dependent enzymes present at cell membranes such as ATPases and phospholipase, thereby influencing membrane permeability. Quercetin affects other calmodulin-dependent enzymes that control various cellular functions, including the secretion of histamine from mast cells. A number of investigations have corroborated quercetin’s ability to reduce histamine secretion from mast cells in various tissues, and also from basophils. Quercetin modifies the body’s response to antigenic substances. Suppression of histamine secretion from mast cells is one of quercetin’s most clinically important effects. Quercetin acts on ATPase at the membranes of histamine-containing granules in mast cells. Mast-cell degranulation and subsequent release of histamine into the bloodstream is an integral part of the body’s response to environmental challenges. Maintains Tissue Comfort by Regulating Enzymes Quercetin’s enzyme-inhibiting action extends to enzymes such as phospholipase, which catalyzes the release of arachidonic acid from phospholipids stored in cell membranes. Arachidonic acid serves as the key substrate for substances such as thromboxanes, inflammatory prostaglandins and leukotrienes. In addition, quercetin inhibits the enzymes cyclooxygenase and lipoxygenase, which catalyze the conversion of arachidonic acid into its metabolites. Reducing levels of these metabolites, as well as histamine levels, is beneficial in maintaining the normal comfort level of body tissues and structures. Quercetin has also been shown to limit the function of adhesion molecules on endothelial cells. Adhesion molecules are involved in physiologic processes that influence tissue comfort. Bromelain is a complex substance derived from the pineapple stem largely composed of proteolytic (protein-digesting) enzymes. Bromelain acts by a variety of mechanisms to help maintain tissues in a normal state of comfort. Several investigators, including Taussig and Ako, et. al., have presented evidence that bromelain is a fibrinolytic agent, i.e., it induces the breakdown of fibrin, a plasma protein that blocks tissue drainage. The generally accepted mechanisms involve direct proteolysis of fibrin by bromelain and activation of plasmin, a serum protease. Plasmin acts on fibrinogen (the precursor to fibrin), forming peptides which stimulate PGE1, a prostaglandin that helps maintain tissue comfort. Helps Maintain Health of Blood Vessels by Modifying Oxidation of LDL Cholesterol — Quercetin’s Antioxidant Action Quercetin is a versatile and effective antioxidant that scavenges a variety of free-radicals such as hydroxyl and lipid peroxy radicals. Quercetin also chelates ions of transition metals such as iron, which can initiate formation of oxygen free radicals. LDL cholesterol is vulnerable to oxidation by lipid peroxides. Oxidized LDL is absorbed by macrophages and arterial endothelial cells, leading to the formation of “foam cells,” and eventually plaque deposits, in arterial walls. Quercetin has been shown to protect LDL from oxidation, both by lipid peroxides and transition metal ions. Helps Maintain Normal Blood Viscosity Quercetin inhibits blood platelet aggregation (clumping), by potentiating PGI2, an anti-aggregatory prostaglandin, and by raising platelet cyclic AMP levels. Human studies have revealed that bromelain also reduces platelet aggregation. These properties qualify both quercetin and bromelain as valuable dietary ingredients for maintaining cardiovascular health. Bromelain May Enhance Quercetin Absorption In addition to the actions described above that support the effects of quercetin, bromelain may also assist the absorption of quercetin in the G.I. tract. (Quercetin is generally believed to be poorly absorbed, although a recent study by Hollman et. al., which concluded that humans do in fact absorb appreciable amounts of quercetin, contradicts this assumption.) Studies have shown that bromelain enhances absorption of antibiotics, presumably by increasing permeability of the gut wall. Given that quercetin is a low molecular-weight compound, it is plausible that simultaneously ingested bromelain likewise enhances quercetin absorption. |
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Strontium Bone Maker 340mg 60 Veggie Capsules
Strontium is a naturally occurring mineral present in water and food. Trace amounts of strontium are found in the human skeleton. Strontium has an affinity for bone and is taken up at the bone matrix crystal surface. The influence of strontium on bone metabolism has been researched since the 1950’s. Studies show that strontium positively affects bone metabolism to promote bone formation and decrease bone resorption, leading to normalized bone density. Strontium citrate is a naturally occurring compound supplying stable strontium that is safe and suitable for consumption as a dietary supplement. (This form strontium is entirely different from the radioactive and unstable “strontium-90” formed by nuclear fission.)
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Synergistic Glucosamine/MSM Formula 180 Capsules
Synergistic Glucosamine/MSM Formula contains pure, sodium-free, potassium-stabilized glucosamine sulfate, as confirmed by HPLC testing. Note: Glucosamine sulfate is derived from the shells of ocean-growing shellfish. It is processed to remove all residues of protein and impurities, yielding pure glucosamine sulfate as the final material. Synergistic Glucosamine/MSM Formula contains pure LIGNISUL™ MSM (methylsulfonylmethane). LIGNISUL™ MSM is natural-source MSM derived from trees. A biological compound that occurs in the human body and in some foods, MSM is an excellent dietary source of bioavailable organic sulfur. Synergistic Glucosamine/MSM Formula contains pure, corn-free ascorbic acid. BenefitsGlucosamine sulfate supports joint function by supplying the body with dietary ingredients (glucosamine and sulfur) for building joint cartilage. Glucosamine, an amino sugar normally manufactured in cartilage, stimulates the production of cartilage components known as “glycosaminoglycans.” These substances are essential to the maintenance of sound joint structure, which in turn allows for normal joint function. MSM, organic sulfur is a structural mineral that maintains the strength of various tissues by forming sulfur “tie-bars” (sulfhydryl bonds) between connective tissue proteins. MSM supplies the body with nature’s original source of organic bioavailable sulfur.Vitamin C is essential for the formation of collagen, the protein fiber that gives cartilage its structural strength.MSM MSM, organic sulfur is a structural mineral that maintains the strength of various tissues by forming sulfur “tie-bars” (sulfhydryl bonds) between connective tissue proteins. MSM supplies the body with nature’s original source of organic bioavailable sulfur.Vitamin C Vitamin C is essential for the formation of collagen, the protein fiber that gives cartilage its structural strength.Why is potassium-stabilized glucosamine sulfate preferable? In order for glucosamine sulfate to be processed for oral intake as a supplement, it must be stabilized with either sodium or potassium. Either mineral works for this purpose. Potassium is preferable. Many people are on sodium-restricted diets, and the Standard American Diet tends to be high in sodium and low in potassium. What’s more, studies have found that people needing joint support are low in both salivary potassium and total body potassium.Glucosamine Sulfate: A solid foundation of clinical evidence Glucosamine sulfate has been thoroughly researched over the last 20 years. Double-blind and open clinical trials convincingly demonstrate that oral glucosamine sulfate improves joint function. In one large open trial, more than 1,200 people took oral glucosamine sulfate for periods ranging from 36 to 64 days. 252 physicians participated in this multi-center study. 95% of the subjects experienced greater joint comfort and increased mobility. The physicians reported “good” results in 59%, and “sufficient” results in 36%. The improvements lasted for up to three months after the glucosamine sulfate was discontinued.Why the human body needs MSM The human body requires a continuous supply of bioavailable sulfur, and MSM is one of the primary, organic, sulfur-containing molecules for use by living organisms. MSM occurs normally in tissues and body fluids. Scientists who have studied MSM in detail believe MSM is an absolute requirement for maintenance of healthy tissues and organ functions. The research on MSM has led to the filing of several patents that cover numerous uses of MSM as a dietary ingredient for both humans and animals. Through these studies, it has been found that physical and psychological stress increases in the body when its MSM supply falls below minimum levels, resulting in a loss of normal organ function. MSM supports joint and organ function by donating sulfur for formation of sulfur tie-bars that maintain the integrity of cartilage and other tissues. Based on clinical observations, MSM benefits the body in many ways, which include maintenance of healthy skin, hair, and nails, digestive system support, and immune support. MSM is as nontoxic to the body as water, and is therefore completely safe, even at high dosage levels.Supplementation is Needed to Realize the Benefits of MSM Widespread in nature, MSM is found in a variety of foods, including fresh fruits and vegetables, raw milk, raw meat and raw fish. However, MSM is a volatile substance easily lost during cooking, pasteurization, food processing and storage. The average American diet thus supplies at best a marginal MSM intake, which may be inadequate to maintain the optimum MSM concentration in the body. The body’s MSM concentration is also believed to decline with increasing age. |
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Sytrinol®(150mg) NEW 60 Softgel Capsules
Sytrinol is a patented formula (US Patent # 6,239114 and # 6,251,400) derived from citrus and palm fruit extracts. It is a combination of citrus flavonoids and palm-sourced tocotrienols that can exert potent antioxidant effects. The polymethoxylated flavones (PMFs) are a group of compounds that are derived from the peels of citrus fruits. These are the predominant flavonoids found in Sytrinol . The two most common are tangeretin and nobiletin. These compounds, on their own or in combination with other nutrients, have an ability to affect the metabolism of lipids. The second major component of Sytrinol is a class of compounds known as tocotrienols. Tocotrienols are fat-soluble vitamins related to the family of tocopherols, derivatives of vitamin E. They are potent free radical scavengers that may have the ability to modify certain cardiovascular risk factors.BenefitsHelps Maintain Normal Cholesterol Levels in Healthy Individuals PMFs: In Vitro and Animal ResearchResearch into the way in which PMFs modulate the production of cholesterol has revealed potential mechanisms of action. One such in vitro trial looked at the effect of tangeretin on human HepG2 cells, a model commonly used to study the metabolism of lipids. This study found that when these cells are exposed to tangeretin, the rate of Apoprotein B production rapidly decreases. Apoprotein B is a structural protein that controls the synthesis of LDL cholesterol from the cells. The study showed that tangeretin inhibited apoprotein B secretion in a dose-dependant manner.Another interesting component that was measured in this study was tangeretin's effectiveness in a lipid-rich environment. The cells were bathed in the tangeretin solution in the presence of a high amount of fat. In this environment, tangeretin possessed the same ability to decrease apoprotein B secretion. It was thus shown that tangeretin can be effective at modulating the production of cholesterol in a variety of cellular environments.The researchers also showed that tangeretin may modulate the production of triglycerides on an enzymatic level. Triglycerides are an important component of the body's lipid profile, and play a role in human health similar to other cholesterol components. Microsomal triglyceride transfer protein (MTP) and diacylglycerol acyltransferase (DGAT) are two components of triglyceride synthesis and transport within the cells. Tangeretin displayed inhibitory effects on MTP and suppressed the activity of DGAT, thereby affecting triglyceride metabolism.A 2005 in vitro study looked at the effects of the second major PMF present in Sytrinol , nobiletin. The results of this study showed that nobiletin, in addition to being able to modulate the production of cholesterol, has important free radical scavenging effects in the bloodstream.It is well known that the levels of cholesterol in the bloodstream are not the only factor in determining cardiovascular risk. Just as important, if not more important, is the state of oxidation of LDL cholesterol molecules. Oxidized LDL may deposit in blood vessels and increase cardiovascular risk factors. Nobiletin was shown to prevent oxidative damage to LDL molecules in this study.2 In purveying its potent antioxidant effect, it keeps the LDL molecules healthy and prevents them from causing potential harm.A recent trial was conducted in hamsters to measure the effectiveness of a combination of tangeretin and nobiletin on serum cholesterol levels. This controlled trial investigated the effect of including these PMFs into the diet for 5 weeks. The control group received a normal, standardized diet free of PMFs. Blood parameters were measured and at the end of the experimental period, the animals fed the tangeretin/nobiletin combination showed significantly favorable results in a number of lipid parameters. This research highlights the ability of these PMFs to have beneficial effects on the maintenance of cardiovascular health.Tocotrienols: Research SummaryA number of studies have highlighted the cardiovascular health benefits of tocotrienols. Animal studies have shown important serum lipid modulating functions of various tocotrienols. A study conducted in rats found that supplementation of their diets with gamma-tocotrienol resulted in significant effects on total and LDL cholesterol levels after 6 weeks. A second study assessed the impact of feeding tocotrienol-rich rice bran oil to chickens. The results also showed significant decreases in total and LDL cholesterol levels. Additional in vitro and animal research has documented the far-reaching benefits of tocotrienols on a number of cardiovascular markers. Some of the most interesting research shows amazing antioxidant abilities of these compounds, including an ability to protect LDL cholesterol molecules from lipid peroxidation, thus preventing them from becoming harmful. This is also a noted effect of PMFs. According to in vitro trials, tocotrienols work to modulate cholesterol synthesis at the enzymatic level. This action is unique to these compounds and researchers believe that this mechanism is responsible for the positive results seen in the animal studies.Two human trials with tocotrienols have also shown positive results on lipid profiles. Tocotrienol-rich palm oil or rice bran oil was used in these studies and they both showed significant effects on plasma cholesterol levels. The various mechanisms of action of tocotrienols make them an ideal choice for promoting heart health.Sytrinol : Human Clinical TrialsSytrinol combines the benefits of PMFs and tocotrienols in one convenient formula to promote cardiovascular health. Two initial small clinical trials were conducted to determine the effectiveness of this product at maintaining healthy cholesterol levels already in the normal range. Both showed very positive results evidenced by a healthy impact on plasma cholesterol, LDL and triglyceride levels. Based on these results a larger clinical trial of 120 people was conducted with highly favorable results. This trial is due for publication soon. The promising results of this trial and prior research place Sytrinol as a safe and effective cornerstone of cardiovascular health maintenance and wellness protocols. |
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Ultra Cordyceps 60 Capsules
Ultra Cordyceps contains a strain of pure cultivated Cordyceps sinensis recognized by the Chinese government as very similar to wild Cordyceps sinensis. Highly valued in China as a food and tonic herb, wild Cordyceps is a black, blade-shaped fungus found mainly above 13,000 feet in a mountainous region of China known as the Qinghai-Tibetan Highlands. Also called "Chinese caterpillar fungus," wild Cordyceps grows on, and derives nutrients from, several species of caterpillars. Because wild Cordyceps is rare and difficult to harvest, due to its harsh growing environment, efforts have been made to cultivate Cordyceps mycelia for commercial application. Ultra Cordyceps contains an award-winning strain of cultivated Cordyceps mycelia standardized by HPLC for consistent potency. It contains a minimum level of 8% cordycepic acid, a polysaccharide considered to be the major active component. Cordyceps naturally contains many other ingredients, including proteins, peptides, polysaccharides, nucleic acids such as adenosine, fatty acids, sterols, vitamins and minerals. Benefits Boosts energy and stamina Improves general vitality Supports sexual health Benefits the heart Supports the lungs and improves respiratory function Benefits the kidneys and liver Supports the immune system Scavenges free radicals (antioxidant) Cordyceps-History and ScienceThe historical use of Cordyceps as an anti-aging herb in traditional Chinese medicine (TCM) dates back to 1700 BCE. During China's Chin Dynasty, one emperor is said to have paid an ounce of gold for a three days supply of the precious fungus. Tibetan scholars wrote detailed descriptions of Cordyceps in 15th and 18th century texts. Cordyceps was introduced to Europe at a scientific meeting in Paris in 1726, and first imported to Japan in 1728.The traditional use of Cordyceps includes improving circulation, as well as health of the lungs, heart, kidneys and liver. Cordyceps was also used to boost general vitality, increase longevity and improve sexual health. Cordyceps is known as a "kidney tonic" in traditional Chinese medicine. In the terminology of TCM theory, "the kidneys" refer to a functional organ system that stores vital energy and governs reproduction/sexual ability. Cordyceps promotes both the "yin and yang" aspect of the body, thus it has a very balancing, normalizing effect on many facets of human physiology.Commercial cultivation of Cordyceps sinensis began in the early 1980s, making the herb readily available for clinical research. More than 2000 patients have been enrolled in clinical trials in China. The results of this research show that cultivated Cordyceps has the same effects as wild Cordyceps on energy, vitality and numerous other parameters of health.Pre-clinical Animal Studies: Higher biochemical energy levels; more efficient use of oxygen Animal experiments suggest Cordyceps may increase the body's supply of ATP, which is the primary form of biochemical energy used by cells to produce metabolic energy. Mice given Cordyceps show substantial increases in liver stores of ATP. Cordyceps increased survival time of mice kept in a low oxygen environment, suggesting that Cordyceps helps the body use oxygen more efficiently. Studies are underway in China to determine if these findings explain the energy enhancing, anti-fatigue effects of Cordyceps observed in humans. Animal experiments indicate Cordyceps may improve blood supply to the brain and heart by increasing arterial blood flow to these organs.Human Clinical Trials The various effects of Cordyceps on humans have been seen in both open (uncontrolled) and placebo-controlled human trials. Cordyceps was given to a group of elderly persons experiencing fatigue and other age-related complaints. Compared to subjects on placebo, those taking Cordyceps reported better energy, greater tolerance to cold, better memory and improved libido. Similar improvements in energy, mental health and sexual function, along with improvements in heart function, were seen in a long-term study giving Cordyceps to patients with chronic heart failure. Further evidence that Cordyceps benefits the cardiovascular system is shown in trials where the herb has improved heart rhythm as seen on ECG.Clinical trials appear to validate the traditional uses of Cordyceps as a beneficial herb for the lungs, respiratory system, kidneys, liver and immune system. At a dose of 3 grams per day, Cordyceps improved respiratory function and lung health by as much as 92 % after 12 weeks. In several trials, Cordyceps has improved various parameters of kidney function such as increased creatinine clearance, reduced BUN and decreased in urinary protein excretion. Cordyceps also protects the kidneys from the toxic effects of potent antibiotics, as seen in both human and animal studies. Cordyceps has successfully improved liver health, as measured by liver function tests, in patients with hepatitis and liver cirrhosis. Numerous in vitro and in vivo animal studies have shown that Cordyceps influences various aspects of immune function, including phagocytosis, natural killer cells, interleukin-2 and T lymphocytes. Positive changes in T cells have been observed in human trials, as well.Antioxidant effects Extracts of Cordyceps exhibit strong free radical scavenging properties. Cordyceps has increased red blood cell SOD activity in humans, while at the same time reducing blood levels of MDA (monodialdehyde), a free radical by-product. Cordyceps shows an ability to inhibit both oxidation of LDL by free radicals and the accumulation of oxidized LDL in macrophages. Cordyceps has also decreased cholesterol deposition in the aortas of atherosclerotic mice. |
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Ultra Cordyceps Plus 60 Capsules
Cordyceps sinensisUltra Cordyceps Plus contains a strain of pure cultivated Cordyceps sinensis recognized by the Chinese government as very similar to wild Cordyceps sinensis. Highly valued in China as a food and tonic herb, wild Cordyceps is a black, blade-shaped fungus found mainly above 13,000 feet in a mountainous region of China known as the Qinghai-Tibetan Highlands. Also called "Chinese caterpillar fungus," wild Cordyceps grows on, and derives nutrients from, several species of caterpillars. Because wild Cordyceps is rare and difficult to harvest, due to its harsh growing environment, efforts have been made to cultivate Cordyceps mycelia for commercial application. Ultra Cordyceps Plus contains an award-winning strain of Cordyceps mycelia standardized by HPLC for consistent potency. It contains a minimum level of 8% cordycepic acid, a polysaccharide considered to be the major active component. Cordyceps contains many other ingredients, including proteins, peptides, polysaccharides, nucleic acids such as adenosine, fatty acids, sterols, vitamins and minerals.Ginkgo biloba extractGinkgo biloba extract is derived from the Ginkgo biloba leaf. Considered to be the oldest living plant species, Ginkgo is a large tree that has thrived on the earth since before the last Ice Age. Ginkgo leaves contain flavonoid-like substances called "flavonglycosides," which, along with other constituents known as "terpene lactones," give Ginkgo its beneficial properties. The Ginkgo biloba extract in Ultra Cordyceps Plus is guaranteed to contain no less than 24% flavonglycosides and 6% terpene lactones.Artichoke leaf extract Artichoke leaf contains various organic acids, including cynarin. The artichoke leaf extract in Ultra Cordyceps Plus supplies 2% to 5% cynarin.Benefits Cordyceps-History and ScienceThe historical use of Cordyceps as an anti-aging herb in traditional Chinese medicine (TCM) dates back to 1700 BCE. During China’s Chin Dynasty, one emperor is said to have paid an ounce of gold for a mere three days supply of the precious fungus. Tibetan scholars wrote detailed descriptions of Cordyceps in 15th and 18th century texts. Cordyceps was introduced to Europe at a scientific meeting in Paris in 1726, and first imported to Japan in 1728.The traditional uses of Cordyceps include improving circulation, function of the lungs, heart, kidneys and liver. Cordyceps was also used to boost general vitality, increase longevity and improve sexual health. Cordyceps is known as a tonic for the "kidney," which includes the reproductive system in traditional Chinese medicine. Cordyceps promotes both the "yin and yang" function of the body, thus it has a very balancing, normalizing effect on many aspects of human physiology.Commercial cultivation of Cordyceps sinensis began in the early 1980s, making the herb readily available for clinical research. More than 2000 patients have been enrolled in trials in China. The results of this research show that cultivated Cordyceps has the same effects as wild Cordyceps on energy, vitality and numerous other parameters of health.Pre-clinical Animal Studies: Higher Biochemical Energy Levels; More Efficient Use of Oxygen Animal experiments suggest Cordyceps may increase the body’s supply of ATP, which is the primary form of biochemical energy used by cells to produce metabolic energy. Mice given Cordyceps show substantial increases in liver stores of ATP. Cordyceps increased survival time of mice kept in a low oxygen environment, suggesting that Cordyceps helps the body use oxygen more efficiently. Studies are underway in China to determine if these findings explain the energy enhancing, anti-fatigue effects of Cordyceps observed in humans. Animal experiments indicate Cordyceps may improve blood supply to the brain and heart by increasing arterial blood flow to these organs.Human Clinical Trials The various effects of Cordyceps on humans have been seen in both open (uncontrolled) and placebo-controlled human trials. Cordyceps was given to a group of elderly persons experiencing fatigue and other age-related complaints. Compared to subjects on placebo, those taking Cordyceps reported better energy, greater tolerance to cold, better memory and improved libido. Similar improvements in energy, mental health and sexual function, along with improvements in heart function, were seen in a long-term study in which Cordyceps was given to patients with chronic heart failure. Further evidence that Cordyceps benefits the cardiovascular system is shown in trials where the herb has improved heart rhythm as seen on ECG. Clinical trials appear to validate the traditional uses of Cordyceps as a beneficial herb for the lungs, respiratory system, kidneys, liver and immune system. At a dose of 3 grams per day, Cordyceps improved respiratory function and lung health by as much as 92 % after 12 weeks. In several trials, Cordyceps has improved various parameters of kidney function such as increased creatinine clearance, reduced BUN and decreased urinary protein excretion. Cordyceps also protects the kidneys from the toxic effects of potent antibiotics, as seen in both human and animal studies. Cordyceps has successfully improved liver health, as measured by liver function tests, in patients with hepatitis and liver cirrhosis. Numerous in vitro and in vivo animal studies have shown that Cordyceps influences various aspects of immune function, including phagocytosis, natural killer cells, interleukin-2 and T lymphocytes. Positive changes in T cells have been observed in human trials, as well.Antioxidant Effects Extracts of Cordyceps exhibit strong free radical scavenging properties. Cordyceps has increased red blood cell SOD activity in humans, while at the same time reducing blood levels of MDA (monodialdehyde), a free radical by-product. Cordyceps shows an ability to inhibit both oxidation of LDL by free radicals and the accumulation of oxidized LDL in macrophages. Cordyceps has also decreased cholesterol deposition in the aortas of atherosclerotic mice.Ginkgo Biloba Extract- Herbal Tonic for the Brain and Circulation An abundance of scientific evidence supports the use of Ginkgo biloba extract for improving circulation, both to the brain and extremities. Ginkgo biloba is approved by the German Commission E for treatment of memory loss, reduced concentration and other signs of impaired mental function in the aging population. Uses of Ginkgo biloba include increasing brain tolerance to low oxygen, improvement of blood flow to the brain and extremities, improving mental function and learning capacity, improving equilibrium, inactivation of free radicals and inhibiting platelet activating factor. Numerous clinical trials, using standardized Ginkgo biloba extract, have demonstrated these effects in humans.Artichoke Extract-Herbal Protection for the Liver Artichoke leaf (Cynara scolymus) is not only a popular food, it has been used as an herb for the liver since the time of the Roman Empire. Artichoke is known to stimulate bile flow and protect the liver against toxins. Evidence that confirms the traditional use of Artichoke for improving liver health was seen in experiments where artichoke extracts protected cultured rat cells from the damaging effect of highly toxic oxidizing agents. Artichoke exhibited an antioxidant effect by preventing the formation of MDA that occurs when cells are exposed to these agents. Normalizing bile flow may lead to improved digestion, as demonstrated in a large clinical trial that tested artichoke extract on 553 people with poor digestion. |
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Ultra Guggulow 90 Tablets
Gugulipid® is the leading extract of gum guggul resin. Gum guggul is harvested from Commiphora mukul, a shrub-like tree indigenous to arid regions of northern India.Gum Guggul Gum guggul is related to myrrh gum and also to Boswellia serrata, another resinous herb prominent in the Ayurvedic materia medica. Gum guggul, often referred to simply as “guggul,” has been used in the Ayurvedic herbal tradition since at least 600 B.C. The herb is mentioned in the Vedas, the Holy Scriptures of India, which are estimated to date back anywhere from 3,000 to 10,000 years. Modern investigation into gum guggul began in 1964, with a series of tests conducted by G.V. Satyavati. The inspiration for this research is a Ayurvedic treatise written in Sanskrit that describes in detail a condition called “coating and obstruction of channels.” Impressed by the apparent analogy to the cardiovascular system, Satyavati and others initiated a series of tests to determine if gum guggul, which was mentioned in the treatise, would have any effect on blood lipid levels. This set the stage for an extensive series of studies on gum guggul’s pharmacology and clinical effects.GuggulsteronesSystematic analysis of gum guggul resin carried out by Indian researchers in the 1980s identified the active ingredients as a group of lipid-based compounds called guggulsterols and guggulsterones. It was determined that two members of this group, Z-guggulsterone and E-guggulsterone, are largely responsible for the herb’s effect on cholesterol and blood fats. An extract standardized for guggulsterone content of gum guggul was then developed by the CDRI in Lucknow, India. This extract, called “Gugulipid®,” is now the preferred form of gum guggul for use in clinical studies. Ultra Guggulow contains Gugulipid® standardized to supply 25 mg of guggulsterones per 1000 mg of extract.Bioperine® Traditional Ayurvedic herbal formulas often include black pepper and long pepper as synergistic herbs. The active ingredient in both black pepper and long pepper is piperine, an alkaloid. Experiments carried out to evaluate the scientific basis for the use of peppers have shown that piperine significantly enhances bioavailability when consumed with other substances.Bioperine® contains 95% piperine extracted from the fruits of black pepper. Several double-blind clinical studies have confirmed that Bioperine® increases absorption of nutrients. Benefits Helps Maintain Normal Healthy Cholesterol Levels The research of gum guggul over the last 30 years has produced a wealth of evidence establishing this herb’s beneficial effect on cholesterol and blood fats. The preliminary studies carried out by Satyavati and her colleagues were done on rabbits fed hydrogenated vegetable oil to artificially elevate cholesterol levels. In contrast to non-treated test subjects, rabbits given gum guggul had normal cholesterol and blood lipid levels and healthy blood vessels.A number of multicentric clinical trials have tested the efficacy of Gugulipid® for maintaining normal cholesterol. The CDRI has conducted Phase 1 trials to establish the safety of the extract. Gugulipid® has been found safe and free of unwanted effects on blood chemistry, liver function and the heart. Phase II trials confirmed Gugulipid®’s effectiveness in normalizing total cholesterol, LDL, HDL and triglycerides.SOD-Protecting, Antioxidant ActionIn an animal study carried out by the CDRI, guggulsterones reversed the decrease in SOD (superoxide dismutase) activity that results from reduced blood flow to the heart. The researchers reported that “SOD was significantly protected by guggulsterone.” Increases in lipid peroxides (free-radical byproducts) and xanthine oxidase, an enzyme that produces oxygen free radicals, were also reversed. Although preliminary, these findings lend additional support to the use of Gugulipid® for sustaining cardiovascular health. |
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CoQsol-CF 100mg 30 Softgels
CoQsol-CF is a patent pending formulation of crystal-free Coenzyme Q10 in d-limonene oil. The formula also includes mixed tocopherols. Co Q10 is a nutrient that supports heart function and promotes energy production in cells. Co Q10 is a versatile antioxidant, which stabilizes cell membranes, protecting them from free radical damage. Co Q10 can also powerfully support immune function.
CoQsol-CF provides the well-known benefits of coenzyme Q10 in a formula designed for enhanced bioavailability. CoQ10 is itself a highly unstable molecule that is prone to crystallization upon exposure to heat, light and air. Many CoQ10 products are, therefore, highly crystallized. This crystallization process decreases absorption and bioavailability of the CoQ10. CoQsol-CF solves this problem by providing crystal-free CoQ10 that is highly soluble and has enhanced bioavailability. CoQsol-CF also provides the added antioxidant protection of mixed tocopherols. The end result of using CoQsol-CF is that more of the CoQ10 is actually available for use by the body in performing its critical functions.
Benefits
• Boosts Cellular Energy Production
Coenzyme Q10 is a vitamin-like nutrient found in the human body. Essential to life, Co Q10 works at the cellular level to produce energy for metabolism in the form of ATP.1,2 Co Q10 serves as a vital link in the "electron transport chain," which is the final step in the production of ATP in the mitochondria of cells.
Without an adequate supply of Co Q10, cells can become energy-deficient, slowing down a number of critical cellular processes. When cells are nourished with optimal levels of Co Q10, tissues, organs and systems function properly.
• Strengthens and Protects the Heart
The heart is the hardest working muscle in the body. Because of its high energy requirements, the heart needs Co Q10 at all times. The highest concentration of Co Q10 in the human body occurs in heart muscle tissue. Numerous clinical studies have demonstrated significant improvements in heart function with oral administration of Co Q10.3,4,5 Studies are increasingly showing an ability of Co Q10 to improve energy production in heart cell mitochondria by bypassing defective components in the respiratory chain, as well as to protect heart tissue from the effects of chronic oxidative stress.14
• Supports Immune Function
When the immune system goes into battle for us, immune cells need large amounts of energy to carry out their defensive functions. Co Q10 is required for this energy to be available. Experimental research on animals has shown that Co Q10 enhances immune functions such as the activity of phagocytes, and antibody production.6
• Antioxidant protection
Co Q10 is a versatile antioxidant. The reduced form of Co Q10, ubiquinol-10, has been found to protect LDL against peroxidation by free radicals more effectively than vitamin E. Co Q10 stabilizes membranes, thus protecting them from free radical damage.7,8,9 In addition, studies have shown that CoQ10’s potent free radical scavenging properties extend to brain tissue, where CoQ10 may protect neurons from the ravages of oxidative damage.13 Along with conferring protection to heart and brain tissues, CoQ10 has also been shown to enhance the levels of other antioxidant vitamins in the circulation, such as vitamins, A, C and E.13
• Benefits the Gums
A number of studies have shown that Co Q10 supports repair of gingival (gum) tissue. Gingival tissues in people with periodontal disease have been found deficient in Co Q10. In several double-blind clinical trials, oral administration of Co Q10 has resulted in significant improvements.10,11
• Co Q10 – Vitamin E's Partner
In vitro studies suggest Co Q10 in combination with vitamin E protects LDL cholesterol from oxidation more effectively than vitamin E alone. Protecting LDL from being oxidized by free radicals is a major factor in maintaining cardiovascular health.9,12
• Diverse clinical benefits
A number of research studies and clinical reports suggest a broad range of potential benefits from Co Q10 supplementation, stemming from its ability to support the heart and cardiovascular system, the immune system, cellular energy production, liver function, nerves, and muscles. |
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High Absorption CoQ10, 200 mg/60 veggie Caps
High Absorption CoQ10 contains pure, vegetarian source Coenzyme Q10 in a base of rice powder, plus Bioperine®, an herbal extract that enhances CoQ10 absorption.
Supplement Facts
Serving Size: 1 capsule
Servings Per Container : 60 servings
Amount Per Serving
%DV
Coenzyme Q10
200 mg
†
Black Pepper ext.(fruit)(Bioperine)
5 mg
†
† Daily Value (DV) not established
Other ingredients: rice powder,modified cellulose (vegetarian capsule), magnesium stearate.
Suggested Use: As a dietary supplement, take 1 capsule daily with food. For maximum absorption, take with a fat-containing meal.
The black pepper fruit extract used in this product is Bioperine,a patented standardized extract containing 95% piperine.
Benefits:
Boosts Cellular Energy Production*
Coenzyme Q10 is a vitamin-like nutrient found in the human body. Essential to life, CoQ10 works at the cellular level to produce metabolic energy in the form of ATP.* 1,2 CoQ10 serves as a vital link in the “electron transport chain,” which is the final step in the production of ATP inside cells. Lacking adequate CoQ10, cells become energy-deficient. When cells are nourished with optimal levels of CoQ10, tissues, organs and systems function optimally.
Strengthens and Protects the Heart*
The heart is the hardest-working muscle in the body. Because of its high energy requirements, the heart needs to be well supplied with CoQ10 at all times. The body's highest concentration of CoQ10 occurs in heart muscle tissue. (Heart muscle cells contain large numbers of mitochondria.) Numerous clinical studies have demonstrated significant improvements in heart function with oral administration of CoQ10. 3,4,5
Supports Immune Function*
When the immune system goes into battle for us, immune cells need large amounts of energy to carry out their defensive functions. CoQ10 is required for this energy to be available. Experimental research on animals has shown that CoQ10 enhances immune functions such as the activity of phagocytes, and antibody production.* Age-related immune suppression has been observed in mice given CoQ10. 6
Antioxidant Protection
CoQ10 is a versatile antioxidant.* The reduced form of CoQ10, ubiquinol-10, has been found to protect LDL against peroxidation by free radicals more effectively than vitamin E.* CoQ10 stabilizes membranes,* thus protecting them from free-radical damage. 7,8,9
Benefits the Gums*
A number of studies have shown that CoQ10 supports repair of gingival (gum) tissue. Gingival tissues in people with periodontal disease have been found deficient in CoQ10. In several double-blind clinical trials, oral administration of CoQ10 has resulted in significant improvements. 10,11
Many Clinical Benefits
Research studies and clinical reports suggest CoQ10 has a broad range of applications stemming from its ability to support the heart and cardiovascular system, the immune system, cellular energy production, liver function, nerves, and muscles.*
CoQ10 — Vitamin E's Partner
In vitro studies suggest CoQ10 in combination with vitamin E protects LDL cholesterol from oxidation more effectively than vitamin E alone. Protecting LDL from being oxidized by free radicals is now thought to be important for cardiovascular health. 9,12
Bioperine® — A Bioavailability-Enhancing Phytonutrient
Bioperine® is a natural extract derived from black pepper that enhances nutrient absorption.* Preliminary trials on humans have shown significant increases in the absorption of nutrients consumed along with Bioperine®. In a recent study (publication pending), the administration of 5 mg of Bioperine® together with 120 mg of CoQ10 per day resulted in a 32% increase in CoQ10 absorption after 21 days. 13 (This is especially important for individuals who have impaired absorption of fat-soluble nutrients such as CoQ10.) |
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High Absorption CoQ10, 400 mg/60 veggie Caps
High Absorption CoQ10 contains pure, vegetarian source Coenzyme Q10 in a base of rice powder, plus Bioperine®, an herbal extract that enhances CoQ10 absorption.
Supplement Facts
Serving Size: 1 capsule
Servings Per Container : 60 servings
Amount Per Serving
%DV
Coenzyme Q10
400 mg
†
Black Pepper ext.(fruit)(Bioperine)
5 mg
†
† Daily Value (DV) not established
Other ingredients: rice powder,modified cellulose (vegetarian capsule), magnesium stearate.
Suggested Use: As a dietary supplement, take 1 capsule daily with food. For maximum absorption, take with a fat-containing meal.
The black pepper fruit extract used in this product is Bioperine,a patented standardized extract containing 95% piperine.
Benefits:
Boosts Cellular Energy Production*
Coenzyme Q10 is a vitamin-like nutrient found in the human body. Essential to life, CoQ10 works at the cellular level to produce metabolic energy in the form of ATP.* 1,2 CoQ10 serves as a vital link in the “electron transport chain,” which is the final step in the production of ATP inside cells. Lacking adequate CoQ10, cells become energy-deficient. When cells are nourished with optimal levels of CoQ10, tissues, organs and systems function optimally.
Strengthens and Protects the Heart*
The heart is the hardest-working muscle in the body. Because of its high energy requirements, the heart needs to be well supplied with CoQ10 at all times. The body's highest concentration of CoQ10 occurs in heart muscle tissue. (Heart muscle cells contain large numbers of mitochondria.) Numerous clinical studies have demonstrated significant improvements in heart function with oral administration of CoQ10. 3,4,5
Supports Immune Function*
When the immune system goes into battle for us, immune cells need large amounts of energy to carry out their defensive functions. CoQ10 is required for this energy to be available. Experimental research on animals has shown that CoQ10 enhances immune functions such as the activity of phagocytes, and antibody production.* Age-related immune suppression has been observed in mice given CoQ10. 6
Antioxidant Protection
CoQ10 is a versatile antioxidant.* The reduced form of CoQ10, ubiquinol-10, has been found to protect LDL against peroxidation by free radicals more effectively than vitamin E.* CoQ10 stabilizes membranes,* thus protecting them from free-radical damage. 7,8,9
Benefits the Gums*
A number of studies have shown that CoQ10 supports repair of gingival (gum) tissue. Gingival tissues in people with periodontal disease have been found deficient in CoQ10. In several double-blind clinical trials, oral administration of CoQ10 has resulted in significant improvements. 10,11
Many Clinical Benefits
Research studies and clinical reports suggest CoQ10 has a broad range of applications stemming from its ability to support the heart and cardiovascular system, the immune system, cellular energy production, liver function, nerves, and muscles.*
CoQ10 — Vitamin E's Partner
In vitro studies suggest CoQ10 in combination with vitamin E protects LDL cholesterol from oxidation more effectively than vitamin E alone. Protecting LDL from being oxidized by free radicals is now thought to be important for cardiovascular health. 9,12
Bioperine® — A Bioavailability-Enhancing Phytonutrient
Bioperine® is a natural extract derived from black pepper that enhances nutrient absorption.* Preliminary trials on humans have shown significant increases in the absorption of nutrients consumed along with Bioperine®. In a recent study (publication pending), the administration of 5 mg of Bioperine® together with 120 mg of CoQ10 per day resulted in a 32% increase in CoQ10 absorption after 21 days. 13 (This is especially important for individuals who have impaired absorption of fat-soluble nutrients such as CoQ10.) |
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Best 5-HTP Enhanced with Vitamins B6 and C 120 veggie caps
5-HTP (5-hydroxytryptophan) is a naturally-occurring metabolite of the essential amino acid tryptophan. 5-HTP for use in dietary supplements is derived from the seeds of the Griffonia simplicifolia plant.
Metabolism and absorption of 5-HTP
5-HTP (5-hydroxytryptophan) is formed by the addition of a hydroxyl group (-OH) to the 5 carbon of the indole ring of tryptophan. Conversion of tryptophan to 5-hydroxytryptophan is catalyzed by the enzyme tryptophan hydroxylase. 5-HTP functions as the precursor for serotonin, and is converted to serotonin in a pyridoxal phosphate (vitamin B6) dependent reaction catalyzed by the enzyme L-amino acid decarboxylase.
Synthesis of serotonin in the brain requires an adequate supply of either tryptophan or 5-HTP as precursors. The supply of tryptophan available for conversion to 5-HTP depends on a number of factors, including nutritional status and competition between tryptophan and other amino acids for transport across the blood brain barrier.
Disturbances in the serotonin metabolic pathway may disrupt central nervous system functions which utilize serotonin as a neurotransmitter. Administration of 5-HTP bypasses the conversion of tryptophan to 5-HTP. 5-HTP readily crosses the blood brain barrier and becomes available for serotonin synthesis. Serotonergic neurons (nerve cells stimulated by serotonin) regulate sleep, appetite, nociception (the perception of pain), and aggressive behavior.
Serotonin is metabolized to 5-HIAA (5-hydroxyindolacetic acid) which is its primary breakdown product.3 The concentration of 5-HIAA in cerebrospinal fluid is used as an indicator of serotonin turnover in the CNS serotonin level. Psychiatric patients have been found to have low levels of 5-HIAA in the CNS fluid, suggesting serotonin deficiency.
5-HTP is readily absorbed by the mucosal cells of the gastrointestinal tract. In one study using five subjects, systemic absorption of 5-HTP in combination with carbidopa averaged 69.2 percent. Another absorption study found that carbidopa enhanced the increase in serum 5-HTP concentration 5 to 15 fold. In this study, a single dose of 5-HTP increased the plasma level of 5-HTP only slightly, whereas 5-HIAA increased 9-20 fold. This suggests that the gut mucosa has a storage capacity for 5-HTP, and that plasma increases occur after maximum capacity is reached.
Benefits
Improves Well-Being in Depressed Persons
Serotonin in the central nervous system is recognized as a causative factor in some depressed persons. A comprehensive review of seven open and seven controlled clinical studies found that oral consumption of 5-HTP improved mental and emotional status in 60 to 70 percent of depressed people. The results varied from "modest" to "marked." Dosages ranged from 50 to 300 mg daily.
The accumulated evidence is inconclusive as to whether 5-HTP is more effective combined with decarboxylase inhibitors than when taken alone. Many of the early trials used the combination, and this has been a frequently used therapeutic strategy for reducing conversion of 5-HTP to serotonin outside the CNS. It is generally accepted that a large portion of absorbed 5-HTP is metabolized to serotonin in peripheral tissues before it can enter the brain.
Peripheral conversion of 5-HTP to serotonin would theoretically limit the usefulness of oral 5-HTP for improving CNS functions and mental health. However, trials in which 5-HTP was given alone do show benefits. A small open trial in which 25 people were given 5-HTP either alone or with a decarboxylase inhibitor found no difference in effectiveness. Thirteen of the patients had "very good" or "good" improvement, 8 had "moderate," and in 4 out of the twenty-five the results were judged to be "poor."
A more recent randomized double-blind study compared the efficacy of oral 5-HTP (100 mg T.I.D., without a decarboxylase inhibitor) to that of fluvoxamine, a selective serotonin reuptake inhibitor. (SSRIs block the reabsorption of serotonin by postsynaptic receptors, thus increasing the available supply of serotonin in the synaptic cleft.) The two were found to be equally effective, and 5-HTP was better tolerated. It should be noted that 5-HTP was given in the form of enteric-coated pH-sensitive capsules which dissolve in the small intestine, thus preventing conversion of 5-HTP to serotonin in the stomach.
In contrast to MAO inhibitors and SSRIs, medications which act by blocking normal physiologic functions, 5-HTP supports normal function in its role as a serotonin precursor. Correcting serotonin deficiency has been called a "functional-dimensional approach" in the treatment of depression.
Improves Sleep Quality
Studies have shown that 5-HTP influences the quality of sleep by increasing REM (rapid eye movement) sleep. Administration of 5-HTP in the evening prior to bedtime has been shown to increase the duration of REM sleep and decrease the amount of non-REM sleep.
5-HTP–A Free-radical Scavenger
The OH group which is added to tryptophan in the formation of 5-HTP gives 5-HTP antioxidant properties. (Compounds such as vitamin E and flavonoids derive their free-radical quenching ability from OH groups, which donate electrons to oxidants.) 5-HTP quenches a variety of free-radicals. This is in contrast to tryptophan, which is sensitive to oxidation.
Adverse effects of 5-HTP
Oral administration of 5-HTP in clinical studies has resulted in gastrointestinal disturbances such as nausea, vomiting and diarrhea. According to a review by Byerley, et. al. these effects are tolerated by most patients and tend to lessen over time. Side effects are more marked with higher doses, and may be reduced by the use of enteric-coated, pH sensitive capsules or tablets
Supplement Facts
Serving size: 1 Capsule
Servings Per Container: 120 servings
Amount Per Serving
% Daily Value
Vitamin C
200 mg
333%
Vitamin B6 (Pyridoxine hydrochloride)
15 mg
750%
5-hydroxy L-tryptophan
100 mg
†
** Daily Value not established.
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NP Nutra Organic Freeze Dried Extract (500mg) 120 Veggie Caps
Acai is an exotic palm fruit from the Amazonian rain forest. The story of acai dates back hundreds of years to its use by the peoples of the Orinoco basin area of Brazil. The fruit was treasured as a source of sustenance for the people. Scientific research has confirmed the high nutritional value of acai fruit and uncovered its potent antioxidant benefits. Analyses have shown that acai is one of the richest sources of anthocyanins in the world, substances known to be powerful free radical scavengers.
Best Acai features OptiAcai™, a potent, freeze-dried form of acai fruit. Ripe acai fruits that grow wild in the Amazon are harvested at their peak. The skin and pulp are separated from their seeds and dried in a unique freeze-drying process that preserves the wholesome goodness of the entire fruit, including the important anthocyanins. This ensures that OptiAcai™ retains powerful, beneficial antioxidant properties, which serve to promote cellular health.
Supplement Facts
Serving Size: 1 capsule
Servings Per Container: 120
Amount Per Serving
% Daily Value
OptiAcai freeze-dried Acai extract
500 mg
†
† Percent Daily Values not established.
Acai, one of the latest, hot new health food discoveries from the Amazon rainforest boasts some impressive credentials as a source of omega-6 and omega-9 fatty acids, vitamins A, C and E and more than 50 other antioxidants, especially anthocyanin—the powerhouse pigment found in red wine and blueberries.
Proponents of acai, which is actually the purplish fruit of Euterpe oleracea, a short palm found in abundance in Brazil, claim this superfood promotes healthy cholesterol, supports the immune system and protects the heart. With the publication of a new study in the Journal of Agricultural and Food Chemistry, they might be able to add “fights cancer” to that list as well.
The study, conducted at the University of Florida, tested the effect of pure acai juice-stripped of any lipids (EFAs) and cellulose material on HL-60 human leukemia cells in vitro. Researchers also evaluated five other extracts or “fractions” of the fruit, which contained different mixtures of antioxidants, for their effect on leukemia cells. They found that the extracts “reduce cell proliferation from 56% to 86%, most likely by damaging the cells enough to cause them to self-destruct.
Journal of Agricultural and Food Chemistry 54(4):1222-1229, 2006
Beneficial Antioxidant Protection
Our body produces free radicals as a byproduct of many metabolic processes. Free radicals are molecules with unpaired electrons that have the potential of causing harm if not adequately neutralized by the body’s antioxidant system. While some free radical production is necessary for metabolism and detoxification, excessive amounts of free radicals may lead to compromised health.
Acai is a rich source of anthocyanins and other phenolics. Anthocyanins are compounds that have potent antioxidant activity, allowing for the neutralization of potentially harmful free radicals. By neutralizing these free radicals, anthocyanins from acai may serve to maintain the healthy function of numerous systems and organs. Some of the anthocyanins that have been found in acai include cyanidin-3-glucoside and cyanidin-3-glucoside-coumarate. Other phenolics include catechin and epi-catechin (the same compounds in green tea), quercetin derivatives and other flavonoids.1 It is likely that the synergistic effects of these compounds as present in acai fruit are responsible for its potent antioxidant activities.
OptiAcai™ freeze-dried acai fruit powder has undergone numerous assays to assess its in vitro antioxidant capacity. One of the assays considered to be a standard measure of antioxidant capacity is known as the ORAC (Oxygen Radical Absorbance Capacity). This test measures how much a particular food can inhibit free radical activity. Numerous foods have been tested using this assay by the USDA Agricultural Research Service to develop standard in vitro measures of antioxidant capacity. Of the foods USDA tested, the results show that cranberries had the highest ORAC values per gram. The units are given as Trolox Equivalents (TE). Trolox is a water-soluble analogue of vitamin E. When whole cranberries were tested, the results indicate that their ORAC value was 94 TE per gram. When OptiAcai™ freeze-dried acai fruit powder underwent ORAC testing, the results showed that it had the ORAC activity of 610 TE per gram, the highest of any fruit or vegetable. What is truly amazing is that these numbers represent the ORAC value of the unaltered freeze-dried fruit, as OptiAcai is pure freeze-dried acai. There are no added preservatives or antioxidants that would artificially inflate the ORAC value of this product. The process of freeze-drying helps to strongly preserve the antioxidant compounds in the fruit, contributing to its remarkable ORAC activity.2
Other assays performed on acai pulp include the in vitro TOSC (Total Oxidant Scavenging Capacity) assay. In a Brazilian study, eleven commercially available acai pulp samples were analyzed for antioxidant potential using this assay. It was found that all eleven of the samples performed very well for the ability to scavenge peroxyl and peroxynitrite radicals. The researchers also concluded that the activity of the anthocyanins alone could not account for the free radical scavenging actions of the acai fruit pulp. Other compounds, many of which are possibly yet to be identified, make significant contributions to the remarkable oxidant scavenging capacity seen with the fruit.3
Maintains Cellular Health
Acai’s deep purple coloration makes it a rich source of beneficial polyphenols. While these compounds are potent antioxidants as outlined above, they also confer benefits beyond their free radical scavenging activity. A number of these phytochemicals are known to have beneficial effects on cellular health. Some mechanisms employed by polyphenols include the induction or inhibition of enzyme function and alteration of signal transduction, enhancing the ability of cells to communicate more effectively with each other. Many polyphenols are considered “biological response modifiers”, since they possess multiple effects, including the ability to decrease oxidative stress to cells. Since polyphenols are water soluble, they are also well-absorbed and assimilated, allowing them to efficiently promote cellular health.4
Safety
Because of the health benefits associated with a high intake of polyphenols it is crucial to get an adequate number of servings of fresh fruits and vegetables on a daily basis. Best Acai featuring OptiAcai™ freeze-dried acai fruit powder with its high polyphenol content can provide an invaluable supplemental source of these health-promoting compounds to a normal diet. |
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Best Acetyl L-Carnitine (588mg) 120 Capsules
Acetyl-L-Carnitine (ALC) is a naturally occurring form of L-Carnitine, a vitamin-like nutrient synthesized in the body from the amino acids lysine and methionine. ALC serves as a transport molecule for "active acetate," which is a source of fuel for metabolic processes that take place in cells. ALC carries active acetate (the "Acetyl" portion) directly into the mitochondrion, the cell's energy-generating structure. Active acetate is used to produce cellular energy in the form of ATP. Both L-Carnitine and ALC serve as fat carriers. Unlike L-Carnitine, ALC readily crosses the blood-brain barrier, where it has specific benefits for brain neurons. When taken orally, ALC has been shown to increase ALC levels in both blood and cerebrospinal fluid, demonstrating its uptake in the brain.1
Best Acetyl-L-Carnitine consists of Biosint™ Acetyl-L-Carnitine, which is manufactured in Italy by the Sigma Tau company. It is derived from a base of pharmaceutical-grade L-Carnitine manufactured using an FDA-approved process that fully complies with international monograph standards for carnitine production. Known as a global leader in L-Carnitine research, Sigma Tau holds numerous patents for production of L-Carnitine, and its L-Carnitine derivatives, such as ALC, which are used in clinical trials.
Benefits
Supports cognitive function
ALC has been studied for its effect on cognitive performance and emotional health in the elderly. In a single-blind, placebo-controlled trial, 481 elderly subjects exhibiting mild memory impairment improved their scores on a memory test after taking 1500 mg of ALC a day for 90 days.2 Hospitalized elderly people taking ALC have shown improvements in mental outlook.3
While ALC is not a treatment or cure for Alzheimer's disease, double-blind studies suggest it may help slow the rate at which early-stage Alzheimer's patients deteriorate.4 In particular, ALC seems to benefit short-term memory in these patients.5
Supports biosynthesis of acetylcholine, a key neurotransmitter for brain and nerve function
Brain function requires coordinated communication between brain cells. Brain and nerve cells ("neurons") communicate across tiny cell-to-cell gaps called "synapses." The passage of an electrical impulse from one neuron to the next requires a "neurotransmitter." When an electrical signal arrives at the synaptic junction, the neuron releases a neurotransmitter into the synapse. The neuron on the other side of the synapse contains receptors for the neurotransmitter; these receptors bind the neurotransmitter, triggering a series of chemical events that sends a new electrical signal down the membrane of the receiving neuron. Neurotransmitters work together like an orchestra to transmit information throughout the brain and nervous system.
Acetylcholine is the most abundant neurotransmitter in the body, regulating activities of vital organs, blood vessels and communication between nerves and muscles. In the brain, acetylcholine helps facilitate memory and learning as well as influence emotions. ALC is structurally similar to acetylcholine, and brain neurons stimulated by acetylcholine are receptive to stimulation by ALC.6 It has been shown experimentally that ALC supplies acetyl groups for the biosynthesis of acetylcholine.7 ALC's hypothesized cholinomimetic (acts like acetylcholine) activity has led researchers to investigate its effects on mental function and emotional health.8
Helps supply the brain with energy by improving energetics in the mitochondrion
The acetyl groups donated by ALC can be used to synthesize acetyl-CoA, the key substrate for energy metabolism in the mitochondrion. 9 Acetyl-CoA enters the Krebs cycle, the mitochondrial mechanism that generates cellular energy in the form of ATP. ALC easily crosses the blood-brain barrier, allowing it to play various roles in maintaining brain neuron (nerve cell) function. When given by oral administration, the concentration of ALC is increased in the blood and cerebrospinal fluid.10
Stabilizes intracellular membranes
ALC was found to improve membrane phospholipid metabolism in early-stage Alzheimer's patients.11 Phospholipids are structural components of brain cell membranes that regulate neuron function. ALC donates acetyl groups that can be used to modify the functional activity of proteins in neuronal membranes.12 ALC thus plays a role in maintaining membrane function. ALC also increases membrane stability and structural integrity.13
Increases nerve growth factor production
The body produces various specialized proteins called "growth factors" which are essential to growth and repair of tissue. Nerve Growth Factor (NGF) protects neurons from death, prolonging survival of neurons in both the central and peripheral nervous systems. It is theorized that aging of the central nervous system is associated with a loss of NGF. ALC has shown the ability to reverse age-related decrease in the binding of NGF to its receptors in neuron membranes.14 Given to aged rats, ALC increases the level and utilization of NGF in the rats. ALC protects cholinergic neurons (nerve cells stimulated by acetylcholine) in rats from degeneration due to lack of NGF.15 These results, together with other data from animal studies, suggest that ALC positively influences NGF activity.16
Has a protective influence on brain neurons
Several animal studies have revealed that ALC exerts a protective effect on neurons. In one experiment, brain cells from rats exposed to NMDA, a known neurotoxin, were protected by being simultaneously exposed to ALC.17 Rats injected with ALC were protected from mortality caused by the neurotoxin MPP+.18 ALC has been shown to raise levels of glutathione, a highly valuable antioxidant, in isolated mouse brain tissue.19 ALC prevents buildup of malondyhaldeyde, a marker of lipid peroxidation.20 ALC is also a chelator of iron, which can generate free radicals. It also reinforces antioxidant mechanisms in the brain.21
As a whole, data from test tube and animal studies, showing that ALC has a protective, restorative effect on brain neurons and neuronal energetic processes, suggest that ALC is an anti-aging nutrient for the brain. This hypothesis is supported by human studies demonstrating measurable benefits for brain function in elderly persons taking ALC by oral consumption.
Supplement Facts
Serving size: 1 Capsule
Servings Per Container: 120
Amount Per Serving
% Daily Value
Acetyl-L-Carnitine (From 588 mg acetyl l-carnitine hydrochloride)
500 mg
†
† Daily Value not established.
Other Ingredients: stearic acid, cellulose, magnesium silicate, silicon dioxide, gelatin capsule.
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Best Bladder Support featuring UroLogic 60 Veggie Caps
Best Bladder Support featuring UroLogic™ (Patent Pending) is a proprietary blend of synergistic herbs and nutrients designed to promote and maintain healthy bladder function. Crateva nurvala and Horsetail (Equisetum arvense) extract have an extensive history of use in traditional medicine for promoting optimal urinary health. Research suggests that Horsetail may promote healthy urinary tract function and Crateva nurvala can enhance bladder tone. Blended together with a complex of minerals to support proper nerve transmission, UroLogic™ is an effective formulation to promote a healthy bladder.* UroLogic™ and Opteva™ are trademarks of BioLogic Health Solutions Pty Ltd.
Benefits
• Supports healthy bladder function*
• Maintains normal urinary sphincter tone*
Crateva Nurvala
Crateva nurvala is an ancient herb used for generations in the traditional Indian sys tem of medicine known as Ayurveda. Ancient Ayurvedic practitioners used it as an internal purifier that helped maintain homeostasis and balance. This herb has a long history of use as the herb of choice to maintain healthy urinary tract and bladder function. The tree that is the source of this herb is often found growing along the banks of rivers in the sub-Himalayan regions of India. The stem bark is the part used to benefit urinary health.
Studies with Crateva nurvala have been conducted in India demonstrating the herb's efficacy in maintaining healthy urinary bladder function. Animal studies with the water extract of Crateva have shown that the herb has the ability to increase the tone of smooth muscle and skeletal muscle. In a rat model of kidney stones, researchers were able to show that rats given Crateva extract had significantly smaller stones than in the untreated group. In addition, a study conducted in dogs showed that the animals receiving Crateva extract for 40 days had significantly higher maintenance of bladder tone than control animals.
A tea prepared from the bark of the plant was given to 30 individuals (50 ml twice daily). Baseline measures of urinary function and bladder tone were assessed at the beginning of the study. It was found that when compared to baseline, the Crateva tea showed a high ability to promote healthy urinary function and enhance bladder tone in these individuals after 3 months of use.
Equisetum Arvense
Equisetum arvense, also known as horsetail, is a traditional plant that is especially rich in silica and other essential minerals. It is a member of a prehistoric family of plants that is now one of the most common species in northern temperate climates. In addition to being extremely rich in the mineral silica, horsetail also contains saponins and flavonoids. The combination of these constituents is thought to be responsible for its beneficial pro perties.
Traditional cultures have used horsetail over the years for its various healing properties. Traditional herbalists re co m m e n d e d horsetail for healing wounds be cause of its noticeably astringent effects. Internally, horsetail was used to promote healthy digestive function.
Because of its flavonoid, saponin and mineral content, horsetail has a special affinity for the urinary tract. Its tonic and astringent properties we re used to promote healthy urinary bladder function and to strengthen urinary sphincter control. The German Commission E monograph on horsetail also supports its use for maintaining the health of the urinary tract.
Calcium and Magnesium
Best Bladder Support featuring UroLogic ™ is also fortified with the essential synergistic minerals calcium and magnesium. These minerals play a critical part in the conduction of electrical impulses through nerves. This process is important for proper bladder tone and sphincter function. The brain sends signals down these nerves to the urinary sphincter, commanding it to contract or relax. A deficit in neural transmission can predispose an individual to improper bladder control.
Calcium and magnesium are also essential to the proper function of all muscles, as these minerals are directly involved in the process of muscle contraction. A double-blind trial found that women who were given magnesium supplements daily had better bladder control than women given a placebo. Calcium and magnesium can work together, therefore, to enhance urinary bladder function and overall health.
Research on UroLogic ™
A study published in August 2002 showed that the combination of nutrients contained in Best Bladder Support featuring UroLogic ™, when given to eight women, had a significant positive effect in enhancing urinary bladder health and sphincter tone compared to baseline measures.
In this trial,women with an average age of 50 years old were given the combination as two tablets twice daily over a period of 12 weeks. Two separate validated questionnaires were used to assess baseline urinary and bladder function. A 50% or greater enhancement in urinary parameters was noted in these otherwise healthy women after 3 months of treatment. The results were highly significant. A second similar study was completed in July 2005. A total of 34 subjects (28 women and 6 men) were recruited to participate in this trial of the UroLogic™ formula. Urinary parameters were assessed before the start of the trial and each month thereafter using the same two urinary function questionnaires. It was shown that the formula was effective at supporting normal bladder and sphincter function in both men and women based on the urinary parameters measured. The formula was also deemed extremely safe, as no major adverse events were reported during the trial. Maximal effects were seen with prolonged use of the product over the entire 3-month timeframe of the study. The potent combination of a unique extract of the Ayurvedic herb Crateva nurvala, the traditional healing herb Equisetum arvense and the minerals calcium and magnesium works synergistically to provide essential support for urinary tract health. Best Bladder Support featuring UroLogic ™ can be a safe and effective option for maintaining healthy urinary bladder function and promoting optimal urinary sphincter tone.
Supplement Facts
Serving Size: 2 Vegetarian capsules
Servings Per Container: 30
Amount Per Serving
% Daily Value*
Calcium (as calcium hydrogen phosphate)
33 mg
3%
Phosphorus (as calcium hydrogen phosphate & magnesium phosphate)
50 mg
5%
Magnesium (as magnesium phosphate)
29 mg
7%
UroLogic™ proprietary blend
Three-Leaf caper (Opteva™) (Crateva nurvala)(stem bark)
Horsetail (Equisetum arvense)(herb)
Silica (as colloidal anhydrous)
1300 mg
†
* Percent Daily Values are based on 2,000 calorie diet
† Daily Value not established.
Other Ingredients: Maltodextrin, hypromellose, magnesium stearate (vegetable source).
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Best CoQ10 (100mg) 30 Soft Gels
Supports Heart Function, Enhances Energy Production in Cells, Antioxdant Protection
Supplement Facts:
Serving size 1 softgel
Servings per container 30
Vitamin E (as d-alpha tocopherol) 5IU 17%
Coenzyme Q10 100mg
Other ingredients: rice bran oil, gelatin, glycerin, soy lecithin, titanium dioxide (color), annatto (color) |
12.99 |
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Best CoQ10 (100mg) 60 Soft Gels
product description coming soon |
22.99 |
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Best CoQ10 (30mg) 60 Soft Gels
product description coming soon |
10.99 |
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Best Goji Berry Extract (600mg) 120 Veggie Caps
Goji berry is an ancient fruit found growing in the wild in the Himalayan regions of Asia. For centuries, traditional herbalists have recognized the various health benefits of Goji berry in addition to its status as a highly nutritious food. Goji berry is a rich source of vitamin C and also contains many other health-promoting vitamins and minerals.
Goji berries have long been revered as a universal tonic for their longevity-enhancing effects. Goji berry may support the health of the eyes, the skin, and the cardiovascular system. The latest scientific research suggests that Goji berry is a potentially potent antioxidant that contains compounds with immune-enhancing properties.
Benefits
Potent Antioxidant Protection
Goji berry possesses a unique combination of flavonoids, vitamins, minerals and polysaccharides that are thought to be responsible for the antioxidant and anti-aging properties attributed to Goji. Studies have been conducted which characterize some of these antioxidant nutrients and show possible beneficial effects of the berry and its extracts on various systems and organs.
In a study published in 2004, scientists undertook an experiment to assess whether Goji berries contained compounds that would be known to exert potential beneficial effects on skin complexion and anti-aging properties. After analyzing the berry, leaf and roots of the Goji plant, they found that the Goji berry contained a unique analog of vitamin C known as 2-O-(beta-D-glucopyranosyl) ascorbic acid. They determined that this compound was unique to the berry and not found in the other parts of the plant. Furthermore, the vitamin C compound was present in levels equivalent to those found in citrus fruits such as lemons. However, the question remained as to whether this vitamin C analog served as a precursor to vitamin C when ingested in the body. A further experiment in rats was performed to determine the intestinal absorption and tissue uptake of this vitamin C analog. The results showed that some of the compound was indeed metabolized into vitamin C in the blood, while the rest was absorbed intact. These studies suggested that the compound was easily transported from the blood into cells and tissues, where it is activated to active vitamin C. Therefore, the vitamin C from Goji berries seems to be highly absorbable and targeted for delivery to the cells that utilize it.
Zeaxanthin is a carotenoid that is widely distributed in fruits and vegetables and, along with lutein, is present in significant amounts in the macula of the human eye. Studies suggest that the presence of zeaxanthin is highly desirable for healthy visual function. Goji berries are used in traditional Chinese herbalism to support eye health and are also known to contain a high level of zeaxanthin dipalmitate. Researchers compared the bioavailability of this naturally esterified zeaxanthin to that of an unesterified form in 12 individuals who underwent a 23-day study in which they received one form or the other, and then switched. Administration was done on day one followed by a three-week washout period. The individuals were then crossed over to get the other form on day 23 in a single administration. Analysis revealed that the esterified zeaxanthin from Goji berry caused a higher increase in plasma levels than the non-esterified form, indicating higher bioavailability.
A second study confirmed these findings. In this study, fourteen individuals consumed 15 grams of whole Goji berries daily for 28 days. These individuals were compared to thirteen age and sex-matched controls who did not consume the berries. Fasting blood samples were taken for all individuals before and after the 28-day period. Results indicated that zeaxanthin plasma levels increased 2.5-fold in the group who consumed the berries daily, suggesting the high bioavailability of zeaxanthin from the berries.
Goji berry was also studied on various measures of antioxidant activity. Researchers subjected three Chinese herbs, one of which was Goji berry, to various assays of reactive oxygen scavenging potential. The results indicated that all of the herbs had significant free radical scavenging properties, however, Goji berries showed the most potent scavenging effect in the assays. Goji berry was especially strong at inhibiting the formation of superoxide anion and scavenging free radicals. The researchers concluded that among these herbs, Goji could be considered the best antioxidant to promote healthy aging.
An interesting study was performed in human skin cultures to determine the mechanism of the potentially protective effect of Goji berry extracts. Researchers found that bathing human skin cultures with an extract from Goji berry impacted the function of several enzymes that promote skin aging. This provides evidence of an anti-aging and antioxidant effect of Goji berry extract in these human skin cultures. Researchers also noted that when these skin cultures were subjected to suboptimal growth conditions (lack of adequate nutrients), supplementing the medium with this Goji berry extract allowed the skin to maintain normal metabolic functions.5 Goji berry extract contains numerous compounds that confer potent antioxidant protection to various tissues.
Maintains Healthy Immune Function
Goji berries contain a unique profile of polysaccharides that work together to impact cell-signaling functions, thereby facilitating immune cell communication. Along with its antioxidant activity, Goji berry extract has the ability to maintain healthy immune function.
The polysaccharide complex of Goji berry seems to be a powerful immune stimulator. Preliminary studies indicate that these polysaccharides may have wide-ranging benefits to immune health. One such study showed that certain polysaccharide components of Goji berry had the ability to influence cytokine production in human PMN cells (a class of white blood cells) when the extract was exposed to human blood samples. These effects suggest an immune-enhancing action of the polysaccharide fraction tested.
A second study conducted in mice tested the immune-modulating effects of the same polysaccharide fraction of Goji berry in these animals. Goji berry extract, given orally once daily for ten days, was shown to influence a wide variety of immune parameters, favoring both humoral and cellular immune responses in a beneficial fashion. This was accomplished, in part, through up-regulation of cytokine and antibody production in these animals after administration of the polysaccharide extract. These changes were not seen in the control group.
Goji berry extract has the ability to promote health through its immune-enhancing and antioxidant qualities. Research into mechanisms of action are revealing that this ancient food, revered as a health tonic for centuries, may hold great importance for supporting the health and function of a number of bodily organs and systems.
Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 120 VCaps
Amount Per Serving
% Daily Value
Goji berry extract (4:1)
600 mg
†
* Daily Value not established.
Other Ingredients: Brown rice powder, modified cellulose (vegetarian capsule).
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Best Hyaluronic Acid 100mg w/Chondroitin Sulfate 60 Capsules
BioCell Collagen IIÒ
Best Hyaluronic Acid with Chondroitin Sulfate contains patented BioCell Collagen IIÒ (US patents 6,025,327; 6,323,319; & 6,780,841). BioCell Collagen IIÒ is sourced from chicken sternal cartilage and provides highly bioavailable, low molecular weight glycosaminoglycans (GAGs). It is standardized to contain 20% Chondroitin Sulfate, 10% Hyaluronic Acid and 60% Collagen Type II.
BioCell Collagen IIÒ is hydrolyzed and denatured to low molecular weight compounds that increase the bioavailability and absorption of its components. Undenatured products have a lower absorption rate due to their larger molecule size.
Hyaluronic Acid and Collagen are vital structural components of skin that decline as we age, and are responsible for the skin’s moisture, suppleness and elasticity. BioCell Collagen IIÒ contains key components that can help support healthy skin and joint function.
• Supports Healthy Joint Structure and Function
Components of BioCell Collagen IIÒ including collagen type II, chondroitin sulfate and hyaluronic acid (HA) can enhance proteoglycans in the joint matrix, thereby providing support for healthy joint function and maintaining joint shock absorption and cushioning.
Chondroitin Sulfate
Chondroitin has been well studied for its effects on joint health. In a 1996 controlled, double-blind trial published in the Journal of Rheumatology, 146 volunteers consumed chondroitin sulfate daily for 6 months. Changes in joint function were measured according to several clinical parameters and carefully analyzed. After the first month, significant improvements were noted and maintained for three months after the subjects stopped taking the chondroitin sulfate.1 In an earlier double-blind study subjects taking chondroitin sulfate had improvements in joint function after three months of use, as determined by both objective and subjective measurements.2 In both studies, the benefits lasted for weeks after subjects stopped taking chondroitin sulfate.
In another controlled study, 192 subjects took chondroitin sulfate or a placebo daily for one year. At the end of the trial, chondroitin sulfate maintained healthy joint cartilage thickness, while those on placebo had decreased cartilage. Improvements in joint function also occurred. The researchers reported that chondroitin exerted a clear chondroprotective effect.3
Collagen Type II
A number of studies have also been conducted on the administration of collagen type II to individuals that have various joint issues. Much of this research has been conducted on animal models of joint conditions while there are also studies showing the effectiveness of oral collagen type II preparations in humans for maintenance of healthy joints.
A randomized controlled trial conducted on 60 patients with joint health issues in 1993 found that oral administration of chicken collagen type II for 3 months led to a significant decrease in swollen and tender joints in this group, as compared to no measurable improvement in the placebo group. There were also no side effects seen with the treatment.4 A second multicenter, double-blind, placebo-controlled trial in 274 individuals with joint issues was published in 1998. The participants were given collagen type II orally for 24 weeks. Positive effects of the treatment were noted while no adverse effects were seen.5
A paper published in 2000 reviewed the literature to assess the role of hydrolyzed collagen in joint and bone health. It was found that hydrolyzed collagen when administered orally was able to support joint health in most of the trials reviewed while the author concluded that, “Its high level of safety makes it attractive as an agent for long-term use.”6
Hyaluronic Acid (HA)
Most of the literature on hyaluronic acid and joint health deals with its intra-articular use, or injections of HA directly into the joints. In this realm, there is good evidence for the effects of HA on joint function.
A study was conducted with injectable HA in individuals with TMJ (temporomandibular joint) conditions. Participants received two injections, each one week apart, or placebo injections with saline. In the HA group, the researchers found decreased clicking sounds and increased function of the joint at 1 month (90% of patients showed improvement) and 6 months (63%) of follow-up, compared to about 26% of the placebo group showing improvement at 6 months.7
A pair of researchers also conducted a literature review of the trials using HA for improving joint health that was published in 2005. Their findings indicate a positive role for HA in modifying the structure of the joint and slowing progressive deterioration of joint function and mobility.8 Hyaluronic acid seems to have a natural affinity for joint tissue, and is therefore able to help support healthy joint structure and function.
• Supports Healthy Joint Structure and Function
Hyaluronic Acid and Collagen are both vital components of skin tissue. Both compounds are known to decline with aging. Collagen is a vital structural component of the skin. It is also one of the most important substances required for proper skin barrier function and health. Collagen, as a major component of the connective tissue, provides structural support, increasing elasticity and tone of the skin.
In 1994, researchers performed comparative measurements of hyaluronic acid levels in the skin of young and elderly individuals. The researchers had hypothesized that a major reason for the aged appearance of skin in the elderly is a reduction of hyaluronic acid levels. What they found using their methods is that there is a progressive reduction in the number of hyaluronic acid granules in human skin with age, until a complete absence of these granules was seen in individuals 60 years or older. These variations in HA levels with age could, according to the researchers, account for the decreased turgidity, wrinkled appearance and altered elasticity of skin tissue.9 Further research was needed to determine the effect of exogenously administered HA on the suppleness of human skin.
In a laboratory study conducted in 1998, researchers analyzed the effects of HA given to live human skin cells. Whereas the cells on their own had a low rate of renewal, hyaluronic acid added to the cells resulted in increased proliferation of skin cells in the collagen matrix. This showed that supplementing skin cells with HA caused a significant increase in the ability of cells to go through the cell cycle.10 One of the major benefits of this may be hyaluronic acid’s ability to continually renew skin tissue to help maintain a youthful appearance of the skin.
Supplement Facts
Serving Size: 2 capsules
Servings Per Container: 30 Servings
Amount Per Serving
% Daily Value
BioCell Collagen II, providing
1000 mg
†
Hyaluronic Acid
100 mg
†
Chondroitin Sulfate
200 mg
†
Hydrolyzed Collagen Type II
600 mg
†
† Daily Value not established.
Other Ingredients: Rice powder, gelatin (capsule), magnesium stearate (vegetable source).
Suggested Adult Use: Take 2 capsules daily, or as directed by a health care practitioner. Take with 8-10 ounces of water, with or without food.
Contains nothing other than listed ingredients. |
21.99 |
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Best Nattokinase 100mg (2,000 Fibrin Units) 30 Veggie Caps
Best Nattokinase is an enzyme derived from "natto" a traditional fermented soy food popular in Japan. During the natto production process B. subtilis natto, a friendly bacteria, ferments boiled, non-GMO soybeans, releasing nattokinase. Best Nattokinase contains pure nattokinase enzyme with all Vitamin K removed.
Suggested Use: Take 1-2 capsules daily, between meals.
Warning: Do not take this product if you are pregnant or nursing, are allergic to soy, or if you have a blood coagulation disorder. If you are taking an anticoagulant (blood-thinning medication) or vitamin K, consult a physician before taking this product.
Contains Nothing Other Than Listed Ingredients.
Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 30 Caps
Amount Per Serving
% Daily Value
Nattokinase ( fibrinolytic units ) enzyme activity
2,000 FU
†
* Daily Value not established.
Other Ingredients: cellulose, vegetarian capsule, maltodextrin, magnesium stearate (vegetable source).
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Best Serrapeptase 90 veggie caps
Serrapeptase is a proteolytic enzyme isolated from the non-pathogenic bacteria Serratia species found in the digestive tract of the Japanese silkworm. The enzyme is used by the worms to digest their cocoons. Serrapeptase has been used as a nutritional supplement in Europe and Asia for nearly three decades. Each vegetarian capsule of Best Serrapeptase contains enteric-coated, acid stable granules of pure serrapeptase designed for optimal absorption in the intestinal tract.
Suggested Use: Take 1 to 3 capsules daily, away from food. |
29.99 |
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Celadrin (500mg) 90 Capsules
Celadrin® is a unique formulation of esterified (stable) fatty acids that has been shown to reduce certain effects related to pronounced inflammatory processes that can occur in the body. Being a complex molecule consisting of various fatty acids, it is able to penetrate cell membranes, which enhances membrane permeability and cell-to-cell signaling. In doing so, Celadrin® may reduce the level of inflammatory components of the immune system from binding to cells and thus causing occasional inflammation in different parts of the body.
Increased Range of Motion in Joints
Research has shown that Celadrin can have an impact on improving the range of motion in joints. A placebo-controlled trial conducted in 2002 showed that those individuals taking a complex containing Celadrin for months had a significant improvement in knee flexion (ability to bend the knee) over those taking a placebo.
Another study conducted on Celadrin published in 2004 concluded that treatment “significantly increased physical performance (as measured by a variety of orthopedic tests)” in patients with compromised knee mobility. The study found that the subjects given Celadrin showed improvement in their ability to climb stairs, rise from a chair and walk, along with an improved sense of balance, strength and endurance.
Maintains Joint Comfort
The anti-inflammatory actions of Celadrin have been demonstrated by one double-blind, placebo controlled trial that showed Celadrin, when taken orally at recommended intake levels, decreased pain scores and increased walking distance compared to the group receiving placebo. The authors theorize that Celadrin may work by down-regulating the effect of certain precursors of the body’s inflammatory response.
Suggested Adult Use: One capsule three times daily, with or without food. |
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Celadrin (350mg) 90 Soft Gels
Celadrin® is a unique formulation of esterified (stable) fatty acids that has been shown to reduce certain effects related to pronounced inflammatory processes that can occur in the body. Being a complex molecule consisting of various fatty acids, it is able to penetrate cell membranes, which enhances membrane permeability and cell-to-cell signaling. In doing so, Celadrin® may reduce the level of inflammatory components of the immune system from binding to cells and thus causing occasional inflammation in different parts of the body.
Increased Range of Motion in Joints
Research has shown that Celadrin can have an impact on improving the range of motion in joints. A placebo-controlled trial conducted in 2002 showed that those individuals taking a complex containing Celadrin for months had a significant improvement in knee flexion (ability to bend the knee) over those taking a placebo.
Another study conducted on Celadrin published in 2004 concluded that treatment “significantly increased physical performance (as measured by a variety of orthopedic tests)” in patients with compromised knee mobility. The study found that the subjects given Celadrin showed improvement in their ability to climb stairs, rise from a chair and walk, along with an improved sense of balance, strength and endurance.
Maintains Joint Comfort
The anti-inflammatory actions of Celadrin have been demonstrated by one double-blind, placebo controlled trial that showed Celadrin, when taken orally at recommended intake levels, decreased pain scores and increased walking distance compared to the group receiving placebo. The authors theorize that Celadrin may work by down-regulating the effect of certain precursors of the body’s inflammatory response.
Suggested Adult Use: One capsule three times daily, with or without food. |
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Celadrin Cream 2 oz
Celadrin® is a unique formulation of esterified (stable) fatty acids that has been shown to reduce certain effects related to pronounced inflammatory processes that can occur in the body. Being a complex molecule consisting of various fatty acids, it is able to penetrate cell membranes, which enhances membrane permeability and cell-to-cell signaling. In doing so, Celadrin® may reduce the level of inflammatory components of the immune system from binding to cells and thus causing occasional inflammation in different parts of the body.
Benefits of Topical Celadrin Cream
Celadrin Cream can also be an effective option for topical joint pain relief. Celadrin fatty acid esters combined with 1.25% USP grade natural menthol provides minor pain relief for sore muscles and joints and the surrounding areas. When applied topically, Celadrin is well-absorbed and can act locally to help maintain joint comfort and increase the range of motion of joints.
Studies have confirmed the benefits of topical applications of the cream directly to sore joints. In a double-blind placebo-controlled trial published in the Journal of Rheumatology in 2004, forty individual with sore knee joints participated.Twenty patients were given Celadrin Cream and 20 others were assigned a placebo cream to be applied topically twice daily for 30 days. Participants were assessed on various orthopedic measures of improvement. At the end of the study, the researchers noted that the Celadrin Cream was an effective treatment for improving knee ROM, ability to ascend/descend stairs, ability to rise from sitting, walk and sit down, and unilateral balance. No changes were seen in the placebo group.
A second study was conducted by the same group of researchers using a cream consisting of Celadrin and menthol. In this trial, participants who had significant functional performance deficiencies of elbow, knee or wrist joints were given the cream and asked to apply it twice daily for one week.
Measure of comfort and performance we reassessed before the treatment and again after one week. The researchers found significant improvement with the use of the cream. Overall, there was a significant improvement in joint range of motion, comfort levels, muscular endurance and joint function. Even in the relatively short period of this trial (only 1 week), the cream was deemed to be effective for enhancing joint function in these participants. |
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PepZin GI 120 Veggie Caps
PepZin GI™ is an exclusive, patented complex of zinc and L-carnosine that was first developed in Japan and has been in use since 1994. This special chelated form of the mineral zinc has a unique ability to exert its effects directly on the cells of the stomach lining. When zinc is complexed to L-carnosine, it dissociates in the stomach at a slower rate. This prolonged existence allows it to maintain its gastric healing effect over a longer period of time. The proprietary chelation process along with excellent scientific research make PepZin GI™ your best choice for supporting gastric health.
PepZin GI™ helps relieve occasional discomfort.
In a randomized, multi-center, placebo-controlled double blind study, 299 patients suffering with symptoms of gastric discomfort were randomly allocated to receive either a zinc-L-carnosine complex or a placebo, or a control drug or its placebo for 8 weeks. Improvement ratings for a range of symptoms were taken at various points during the trial and compared with before treatment data. Of the 258 people who completed the trial, 136 were in the zinc-Lcarnosine group. Of the group, 92% of the participants were rated as “moderately improved” or better on an improvement scale across the category of symptoms including heartburn, tenderness, epigastric pain, diarrhea and constipation after 8 weeks.
In another study, 28 patients with gastric discomfort were given a zinc-L-carnosine compound and monitored for 8 weeks. Improvement was rated on a scale of subjective and objective symptoms. After 4 weeks, the rate of those cases that were considered to be “significantly improved” was 68.4%. After eight weeks, the “significantly improved” number was 68.8%. Over 60% of these patients remained in the “significantly improved” category well after discontinuation of the treatment, suggesting a lasting effect of the zinc-L-carnosine compound beyond the time it is taken.
Maintains a healthy GI environment.
The mineral zinc in PepZin GI™ is a critical component to a number of physiological processes in our bodies. Some of these functions include growth and metabolism of cells, healing of wounds,and maintenance of carbohydrate and lipid metabolism.
PepZin GI™ may also be able to favorably maintain the bacterial balance of the stomach and GI tract. Studies suggest that the zinc-L-carnosine co m pound may have effects on certain strains of harmful bacteria and, therefore, may be able to help maintain a GI environment that is favorable to health.1 By supporting the bacterial balance in the stomach, PepZin GI™ can help maintain a healthy mucosal lining.
Supports the health of gastric cells.
PepZin GI™ has been studied for its ability to prevent free radical damage to gastric cells. In one such study, rat gastric cells were exposed to ethanol and hydrogen peroxide, two substances known to cause free radical damage to living cells. Cells were bathed in hydrogen peroxide, ethanol, zinc-L-carnosine, or a combination of zinc-L-carnosine with either ethanol or hydrogen peroxide. While the cells bathed in ethanol and hydrogen peroxide solutions all exhibited signs of damage due to free radical production, the cells that were bathed in zinc-L-carnosine were largely protected from the effects of free radical damage. The authors concluded that the zinc compound directly protected gastric mucosal cells from oxidant stress and alcohol induced damage.
Additional research further confirms the gastro-protective effects of PepZin GI™. In another rat study, stomach lesions were induced by administration of the chemical monochloramine, a known pro-oxidant (producer of free radicals). One of the groups of rats was fed the zinc-Lcarnosine compound prior to being exposed to monochloramine. The researchers found that the size of the lesions in the group pre-treated with zinc-L-carnosine was significantly less than the lesions in the control group. The authors concluded that the zinc compound exerted a beneficial protective effect against monochloramine-induced stomach lesions.
The zinc-L-carnosine in PepZin GI™ has also been shown to slow the development of aspirin induced stomach damage in rats. The researchers measurably detected lower levels of TNF-alpha in rats given zinc-L-carnosine as compared to the control rats. TNF-alpha is an inflammatory cytokine that is known to be released in response to gastric damage. These results may suggest a role for PepZin GI™ in protecting gastric cells by occasionally reducing the levels of certain cytokines in minor inflammation of the stomach.
Supplement Facts
Serving Size: 1 capsule
Servings Per Container: 120 servings
Amount Per Serving
% Daily Value
Zinc (from PepZin GI)
8 mg
53%
PepZin GI (Zinc-L-Carnosine Complex)
37.5 mg
†
L-Carnosine (from PepZin Gi)
29.5 mg
†
† Daily Value not established.
** % Daily Values are based on a 2,000 calorie diet.
Other Ingredients: Calcium carbonate, modified cellulose (veggie cap), magnesium stearate, silicon dioxide.
Suggested Adult Use: One capsule two times daily, during or after meals.
Contains nothing other than listed ingredients. |
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SAMe 400mg Double Strength 30 tablets
Best SAM-e 400 contains 400 mg of active SAM-e in each tablet. Doctor’s Best utilizes only the highest quality Italian SAM-e available on the market. This ensures the most potent SAM-e product with the highest percentage of the active S,S form per serving.
S-Adenosyl Methionine (SAM-e) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. Methylation occurs billions of times daily in the many organs of the body. SAM-e is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAM-e is also required for the biosynthesis of critical neurotransmitters and hormones. SAM-e is the methyl donor that catalyzes the production of epinephrine, melatonin, glutathione and the amino acids cysteine and taurine. SAM-e is also known to upregulate the production of critical membrane phospholipids including phosphatidylcholine. SAM-e is also a sulfur donor and, for this reason, is critical for the formation of sulfur-containing proteoglycans in joint connective tissue.
All SAM-e supplements are not created equal
During the manufacture of SAM-e, two forms are produced known as the S,S and the R,S isomers. The S,S isomer is the biologically active form in the human body, whereas the R,S form is considered to be inactive. Best SAM-e 400 utilizes Italian SAM-e to yield the highest available percentage of the active pure S,S form on the market. Best SAM-e 400 contains an average of nearly 74% of the active S,S form. Other SAM-e products contain as little as only 50% of the active form. A higher content of the active form yields a more potent product.
The molecule SAM-e itself is highly unstable. It will degrade quickly in conditions of heat, light and moisture. To increase its stability, it must be formed into a salt. It is important to note that SAM-e used for dietary supplements exists in a number of salt forms. Best SAM-e utilizes the SAM-e tosylate disulfate salt form. This salt has been the most extensively utilized form in clinical trials of SAM-e.
Because of the unstable nature of pure SAM-e it is also highly susceptible to degradation in an acidic environment like the stomach. To be utilized effectively, it must pass through the stomach for absorption in the small intestine. For this reason, only enteric-coated formulas should be used. Best SAM-e tablets are enteric-coated to maximize the utilization and benefit of the SAM-e by the body.
· Enhances Mood and Neural Function
SAM-e has been studied for decades now for its potential role in enhancing mood and supporting healthy neural metabolism. In a double-blind placebo trial published in 1976, 30 individuals were given either SAM-e intramuscular injections (15 mg three times daily) or placebo. Individuals were assessed for improved mood and affect. It was found that 100% of patients in the SAM-e group showed significant improvements in mood, while only 30% of the placebo group showed any improvement. The improvement seen with SAM-e in this trial was rapid, with a response time of between 4 and 7 days.
A second Italian double-blind placebo controlled study was published in 1987. Again, individuals showing signs of decreased affect and mood were administered 200 mg SAM-e as daily intramuscular injections, or a placebo, for four weeks. Each group consisted of 20 patients, with all medial and laboratory results being normal. Rating scales were used to monitor changes and the authors found that the treatment with SAM-e was significantly superior to placebo and was very well tolerated.
Researchers had known that SAM-e injections showed benefit in mood enhancement based on the results of multiple clinical trials. However, with injections, chronic administration is always challenging. For this reason, oral doses are superior in terms of ease of administration. Studies were conducted to assess the efficacy of oral SAM-e preparations. One such study was published in 1990. In this double-blind placebo-controlled trial, individuals were given increasing doses of SAM-e from 200 mg to 800 mg twice daily, or placebo, over the 21 day period of the trial. In the placebo group, one of the six individuals showed an enhancement of mood of 50% according to the rating scales, whereas 6 of the 9 individuals given the oral SAM-e showed a 50% or greater improvement in mood and affect. It was concluded that oral SAM-e, like SAM-e injections, can significantly enhance mood without significant side effects.
Another double-blind placebo controlled trial looked at the effects of administering 1600 mg of SAM-e, or placebo, daily to 80 women aged between 45 and 59. The administration took place for 30 days, after which the women were assessed for improvements. Rating scales were administered at 10 and 30 days. SAM-e supplementation significantly enhanced mood and affect in the women compared to placebo administration. SAM-e was also seen to be well tolerated, as three women in the placebo group and two women in the SAM-e group complained of minor side effects which did not interfere with continuation of treatment.
Two groups of researchers have conducted analyses of trials that utilized SAM-e for mood enhancement. One meta-analysis was published in 1994. The researchers analyzed the efficacy of SAM-e in oral or injection forms based on published trials dated between 1973 and 1992. The authors concluded that there was a significant improvement of 17 to 38% seen in trials of SAM-e compared to placebo response. They state that the efficacy of SAM-e was superior to placebo and its administration caused few side effects. A second review was published in 2002. The authors analyzed studies in which SAM-e doses ranged from 200 to 1600 mg daily. They also found a significant effect of SAM-e in comparison to placebo, with an evident rapid onset of effect at enhancing mood.
· Promotes Joint Comfort and Mobility
As a sulfur donor to connective tissue, SAM-e plays a major role in protecting the integrity of cartilage tissue. An in vitro trial assessed the actions of SAM-e in cultured human articular chondrocytes. At a concentration of 10 micrograms/ml, proteoglycan synthesis and sulfate residue incorporation in chondrocytes was shown to be 60% higher than control levels. Based on these results, it was shown that SAM-e has a positive influence on the growth and health of cartilaginous connective tissue.
In a double-blind trial with 734 individuals with compromised joint health. SAM-e given orally at a dose of 1200 mg daily for 30 days was shown to significantly promote joint comfort compared to placebo, with a high level of tolerability and low incidence of side effects. The researchers concluded that SAM-e is a highly effective supplement for enhancing joint comfort.
Another trial evaluated the response of individuals experiencing discomfort in the joints to a regimen of 1200 mg SAM-e for 1 week followed by 800 mg for the second week, and then 400 mg for weeks 3 through 8. This open trial of 20, 641 people showed a strong ability of SAM-e to enhance feelings of comfort within the joints. The treatment was rated as “very good” or “good” in 71% of the participants, with an additional 21% rating the treatment effect as “moderate”.
In a long-term trial lasting 24 months, SAM-e was given to 108 participants with compromised joint function. Individuals were given 600 mg orally per day for the first two weeks followed by 400 mg daily for the remainder of the trial. Individuals experienced significant enhancements in joint comfort, with dramatic improvements noted after 2-4 weeks of treatment. Improvements continued to 6 months and beyond.
In addition to the above studies, a review was conducted in 1987 to assess the results of SAM-e supplementation in clinical trials for enhancing joint mobility and function. Over 22,000 individuals had participated in the clinical trials that were the subject of this review. The author concluded from his analysis that SAM-e was shown to be highly efficacious, rivaling or surpassing the effectiveness of other treatments, and also possessing a high level of safety. Because of this, SAM-e may be the treatment of choice for enhancing joint function.
· Supports Liver Health and Detoxification
SAM-e supplementation can have profound benefits on liver function. These benefits center around its function as the major methyl donor in the liver, as well as its lipotropic activity. SAM-e also enhances the production of the antioxidant glutathione.
A number of trials have been conducted showing the ability of SAM-e to support liver detoxification functions and enhance liver health in individuals susceptible to toxin-induced liver compromise. SAM-e has the ability to normalize liver function by increasing the activity of enzymes needed to upregulate liver detoxification. These effects are comprehensive and rapid. Dosages used in these studies range from 600 mg to 1600 mg daily for 2 months to two years. In these trials, significant benefits of SAM-e supplementation were seen over placebo.
Supplement Facts
Serving Size: 1 tablet
Servings Per Container: 30 servings
Amount Per Serving
% Daily Value
S-Adenosyl Methionine
(from 800 mg of SAMe-tosylate disulfate)
400 mg
†
† Daily Value not established.
Other Ingredients: Cellulose, mannitol, hydroxypropyl methylcellulose phthalate, citric acid, sodium starch glyconate, triacetin, modified cellulose gum, stearic acid, silica, titanium dioxide, yellow ochre.
Suggested Adult Use: Take 1 tablet daily away from food, or as directed by a health care professional. Do not chew or crush tablet.
Contains nothing other than listed ingredients. |
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Best Digestive Enzymes 90 vegetarian capsules
Best Digestive Enzymes – All Vegetarian is a uniquely formulated, full-spectrum high potency digestive enzyme blend created to complement and support the body’s own digestive capacities. Each capsule provides the body with vegetarian microbial-derived enzymes designed to optimally aid the digestion of fats, proteins and carbohydrates present in cooked and raw food. The formula supplies the added support of alpha-galactosidase and beta-glucanase to break down vegetables, beans and grains, and enzymes such as glucoamylase and invertase to assist with the digestion of sugars. In addition, this complete formula contains friendly bacteria and other cofactors to uniquely promote optimal intestinal health.
Benefits
· Provides Optimal Support for Healthy Digestion
· Assists Digestion of Proteins, Carbohydrates and Fats
Digestive enzymes are produced by the pancreas and secreted into the duodenum (upper small intestine), where proteins, carbohydrates and fats are broken down prior to absorption. As we age, the body's capacity to produce enzymes may decline. Moreover, stress and other health difficulties may impact enzyme production.
Overeating sometimes causes incomplete digestion. Occasional heartburn, bloating, belching, discomfort, and a "sour stomach" is often a result of this.
Supplementation with the enzymes in Best Digestive Enzymes – All Vegetarian supports replenishment of the body's enzyme levels, helping to relieve the burden on an overworked pancreas.
• Benefits of Microbial Enzyme Supplementation
Enzyme supplementation promotes enhanced digestion and delivery of vital nutrients to the body. This benefits good health in many ways, including better elimination, support for healthy energy levels and maintenance of healthy body weight . Enzymes also help prevent accumulation of undigested foods in the large intestine, which may disrupt the normal healthy bacterial balance in the bowel.
Best Digestive Enzymes – All Vegetarian contains microbial-derived enzymes that have a long history of research and use in Japan and in Europe. In fact, research on such non-animal source enzymes for therapeutic purposes has been conducted since the 1950s in Europe and Scandinavia. Scientists there were the first to report on the isolation and purification of individual enzymes from microbes such as Aspergillus oryzae and others. They also were the first to publish reports on the use and efficacy of various microbial enzymes for therapeutic purposes in studies on animals and humans.
Microbial-derived enzymes have distinct advantages over animal-sourced enzymes such as pancreatin and have been shown to be more effective at supporting the digestive physiology of the human body when supplemented. Animal-derived standard enzyme preparations are active only in a small pH range and the activity of these enzymes is destroyed by acidic conditions in the stomach. By contrast, microbial-derived enzymes have higher activity levels (less enzyme has to be used for the same purpose) and are active over a wide pH range, with some reports showing activity from pH 2 to 10. This means that while over 90% of animal-derived enzymes may be inactivated in the stomach and be useless for digestive purposes, microbial-derived enzymes would begin digesting food in the acidic conditions of the stomach and continue this process well into the small intestine, increasing the efficiency of the digestive process. |
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Best Camu Camu 4:1 Extract 120 Veggie Capsules
Camu Camu is a round, red to purple colored fruit that grows abundantly in the Amazonian rain forest. Recent research has shown that this fruit contains one of the highest natural vitamin C contents of any food in the world. The fruit is also an extremely rich source of anthocyanins, with a particularly high level of cyanidin-3-glucoside.
Best Camu Camu 4:1 Extract powder is an exclusive wild-crafted, spray-dried concentrate of camu camu fruit. The spray-drying process allows the powder extract to attain four times the nutrient and vitamin C concentration of the whole fruit. Vitamin C and anthocyanin compounds are powerful antioxidants that function as potent free radical scavengers.*
Camu camu’s main growing areas are near the Peruvian border with Brazil, and the fruits are the size of lemons. Due to its high vitamin C content, camu camu is becoming a widely used ingredient in dietary supplements. Camu camu also contains calcium, beta-carotene, protein, leucine, thiamin, valine and serine. The camu camu fruit contains the highest documented quantity of natural vitamin C on Earth. It has up to three times more vitamin C than Acerola. Compared to oranges, camu camu has 30 times more vitamin C, three times more niacin, ten times more iron, double the amount of riboflavin and 50% more phosphorus. Camu camu also contains 711mg of potassium per kilogram, and provides a full complement of minerals and amino acids that can improve the absorption of vitamin C. |
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Best L-Tryptophan Enhanced w Vitamin B6 & Niacinamide 90 veggie Capsules
L-tryptophan is an essential amino acid (protein building block) in human nutrition. Essential amino acids are not synthesized by the body and must be obtained in the diet. The L-tryptophan in this product is manufactured and tested for purity according to United States Pharmacopeia (USP) standards. Vitamin B6 is an essential cofactor in the conversion of tryptophan, while niacinamide plays an important role in allowing our body to properly utilize this essential amino acid.
Suggested Adult Use: 1 or 2 capsules daily, or as directed by a health practitioner. For optimum absorption, take separately from protein-containing foods and dietary supplements containing protein or amino acids. |
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Betaine HCI Pepsin & Gentian Bitters 120 caps
Betaine HCl Pepsin & Gentian Bitters contains three nutritional factors that perform complementary functions designed to support the efficiency of the digestive process. Research suggests that the efficiency of stomach acid production may be altered with the ageing process. Supplementing with Betaine HCl may support the stomach’s digestive capacity. Pepsin is an enzyme produced by the body to digest protein-containing foods in the stomach. Pepsin works in conjunction with stomach acid to support protein digestion. Gentian is an herb used traditionally in many cultures to optimize digestive capacity and tonify the digestive tract. Its bitter nature may help to stimulate the body’s production of digestive enzymes.
For optimal digestive support, use Betaine HCl Pepsin & Gentian Bitters in conjunction with Best Digestive Enzymes – All Vegetarian, a uniquely formulated, full-spectrum high potency digestive enzyme blend.
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Best Artemisinin 90 Veggie Caps
Best Artemisinin contains high quality Artemisinin or Ching-hao-su, an extract from the traditional Chinese herb Artemisia annua (sweet wormwood) or Ching-hao. Sweet wormwood leaves have been consumed over several centuries for promoting general health. The extract Artemisinin has been used for several decades.
The Artemisinin used in Best Artemisinin is extracted from plants grown and harvested in accordance with GAP (Good Agricultural Practice) standards. The extract itself is manufactured to the highest pharmaceutical-grade quality specifications in a certified GMP (Good Manufacturing Practice) facility, ensuring the highest potency.
Take 1 to 2 capsules, once or twice daily on an empty stomach. Sensitive individuals may take with food.
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Best D-Ribose 8.8oz
Ribose is an essential pentose (5-carbon) sugar utilized by the body to synthesize DNA, RNA and produce energy. (Ribose is a “sugar” distinct from glucose. It does not raise blood sugar levels or lead to diabetes.) Ribose is a fundamental building block of adenosine triphosphate (ATP – the substance in which the body stores intracellular energy), the preferential source of energy for skeletal muscle and heart tissue. Studies have shown that ribose supplementation can enhance cardiac energy levels and support cardiovascular metabolism. Further studies suggest that ribose plays a role in supporting energy recovery after exercise. Exercise increases free radical production in muscle tissue. Ribose may strengthen and support the body’s crucial antioxidant defenses.
Research suggests that optimal heart function requires a consistent supply of essential cofactor nutrients including CoQ10, D-ribose, L-carnitine and Magnesium. Consider these other high quality Doctor’s Best products in combination with Best D-Ribose for enhanced cardiovascular support: Best GPLC & CoQ10, High Absorption Magnesium, Best L-Carnitine Fumarate, High Absorption CoQ10, CoQsol-CF.
Caution: Insulin-dependent diabetics and pregnant women should consult their physician before use.
Suggested Adult Use: Take 1 or 2 scoops mixed in water, juice or other beverage two times per day. May be taken with or without food.
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Best GPLC & CoQ10 with GlycoCarn 30VC
Best GPLC & CoQ10 featuring GlycoCarn contains a superior, unique patented nutritional supplemental form of propionyl L-carnitine called Glycine Propionyl L-Carnitine (an AminoCarnitine) combined with the complementary benefits of CoQ10. Propionyl L-carnitine has been well studied for its benefits in promoting the health of energy-intensive muscular tissue, including skeletal muscle and the heart. Propionyl L-carnitine has been shown to increase cellular L-carnitine production. The amino acid L-carnitine facilitates the process of energy production in muscle cells. Propionyl L-carnitine is also known to exhibit significant free radical scavenging activity in the circulatory and cardiovascular systems. Studies have also shown that propionyl L-carnitine may increase exercise capacity and overall energy in athletes and supports the overall metabolism of fat.
CoQ10 is a versatile antioxidant, which stabilizes cell membranes, protecting them from free radical damage. CoQ10 also supports heart function and promotes energy production in cells. Heart muscle is the most energy-intensive tissue in the entire body. Best GPLC & CoQ10 featuring GlycoCarn combines the powerful cardiovascular support of two potent nutrients into one synergistic formulation designed to optimally support heart and muscle function
Suggested Adult Use: Take 1 capsule daily.
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Best Phosphatidyl Serine 60 soft gels
Best Phosphatidyl Serine provides the essential brain nutrient phosphatidylserine in a matrix of other phospholipids and cofactors. Phosphatidylserine and other phospholipids are structural components of brain neurons that can enhance cell-to-cell communication. Studies have shown the ability of supplemental phosphatidylserine to support healthy cognitive function.* It may enhance healthy memory and thinking ability by facilitating neuronal communication. It may also support the body during stressful times. * Best Phosphatidylserine contains phosphatidylserine and other essential nutritional cofactors in a liquid softgel, providing added stability to these key phospholipid molecules.
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Best Prostate & Bladder Support 60 soft gels
more information to follow |
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Best Resveratrol with ResVinol-25 60 veggie caps
Best Resveratrol features ResVinol-25, a proprietary extract providing concentrated levels of polyphenols and trans-resveratrol from red wine matrix and the root of the Japanese knotweed (Polygonum cuspidatum) plant. Resveratrol exists in both trans- and cis-forms. However, published research suggests that only the trans- form has considerable biological activity. ResVinol-25 is a high-quality extract subjected to rigorous ProfileProven analytical and quality assurance procedures designed to ensure potency and purity of the extract from batch to batch. The product is extensively tested for heavy metals, bacterial and fungal contaminants, and pesticides to verify purity and compliance with acceptable standards.
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Decursinol-GS 120 capsules
Decursinol-50 is a whole root extract from the plant Angelica gigas Nakai, commonly known as Korean Angelica. This plant has a history of traditional use dating back over a thousand years. The product is prepared via a proprietary extraction process in which dried whole roots undergo an alcohol-based extraction yielding a high concentration of the major active compounds of the root: decursinol and decursin. Studies suggest that Decursinol-50 may be useful for the treatment and relief of minor pain.
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Decursinol-PN 250mg 60 veggie caps
Decursinol-50 is a whole root extract from the plant Angelica gigas Nakai, commonly known as Korean Angelica. This plant has a history of traditional use dating back over a thousand years. The product is prepared via a proprietary extraction process in which dried whole roots undergo an alcohol-based extraction yielding a high concentration of the major active compounds of the root: decursinol and decursin. Studies suggest that Decursinol-50 may be useful for the treatment and relief of minor pain.
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EpiCor 500mg 60 veggie caps
EpiCor is an all natural, novel immune-supportive compound that fits into the unique category of being a high metabolite immunogen. EpiCor is a nutritive dried yeast fermentate that supports cellular metabolism and modulates immune function. In vitro laboratory data has shown that EpiCor beneficially influences cellular processes that impact immune health.
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Strontium Bone Maker 340mg 120 veggie capsules
Strontium is a naturally occurring mineral present in water and food. Trace amounts of strontium are found in the human skeleton. Strontium has an affinity for bone and is taken up at the bone matrix crystal surface. The influence of strontium on bone metabolism has been researched since the 1950’s. Studies show that strontium positively affects bone metabolism to promote bone formation and decrease bone resorption, leading to normalized bone density. Strontium citrate is a naturally occurring compound supplying stable strontium that is safe and suitable for consumption as a dietary supplement. (This form strontium is entirely different from the radioactive and unstable “strontium-90” formed by nuclear fission.)
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Best Lumbrokinase 60 Veggie Caps
Lumbrokinase is the name of a group of highly stable fibrinolytic enzymes originally derived from the earthworm Lumbricus rubellus. These proteolytic enzymes have been studied and utilized extensively in China for many years. Research suggests that lumbrokinase may have beneficial effects on the cardiovascular system*. Best Lumbrokinase is a highly active form of this enzyme group and may be used to support and maintain healthy cardiovascular function.
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Best Serrapeptase 270 Veggie Caps
Serrapeptase is a proteolytic enzyme isolated from the non-pathogenic bacteria Serratia species found in the digestive tract of the Japanese silkworm. The enzyme is used by the worms to digest their cocoons. Serrapeptase has been used as a nutritional supplement in Europe and Asia for nearly three decades. Each vegetarian capsule of Best Serrapeptase contains enteric-coated pure serrapeptase designed for optimal absorption in the intestinal tract.
Note: Doctor’s Best Serrapeptase 90VC contains 40,000 fibrinolytic units, which refers to the enzyme activity level. Enzymes, like Serrapeptase, are not measured in mg, but in an unassociated measure of units. Even if the enzyme had 1,000mg per capsule but no activity, the enzyme would be worthless. Doctor’s Best Serrapeptase has 40,000FU (units) of activity. This is a very high amount of activity.
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Best Proteolytic Enzymes 90 Veggie Caps
Best Proteolytic Enzymes is a potent formulation containing a broad spectrum of proteolytic enzymes (proteases). Proteolytic enzymes function in the body to digest and break down proteins into their amino acid components. When taken as supplements, studies show that various proteolytic enzymes, including bromelain (from pineapple), papain (from papaya), serratiopeptidase (from bacteria), and fungal protease (from a non-pathogenic fungus medium), are absorbed through the lining of digestive tract and into the circulation [1]. These enzymes, once in the bloodstream, are available to facilitate chemical reactions throughout the body and have a wide range of applications.
Doctor’s Best designed this exceptionally potent, high-quality proteolytic enzyme formula to include a broad spectrum of proteolytic enzymes from a variety of plant, bacterial, and fungal proteases. The goal was to create a blend that works at a variety of pH levels to support the body’s native enzymatic needs. Maintaining optimal enzymatic function is a key factor in supporting the foundation for health and wellness of numerous individuals.
Bromelain – a general name for a family of proteolytic enzymes derived from the pineapple plant. Bromelain effects various systems in the body through a variety of physiological mechanisms, including inhibiting the formation of bradykinin, limiting the generation of fibrin, increasing the breakdown of fibrin, modulating prostaglandins, and decreasing platelet aggregation.
Papain – a proteolytic enzyme derived from the sap (also called latex or milk) of unripe papaya. Traditionally used with bromelain.
Fungal amylase – an enzyme derived from the fungus Aspergillus oryza. Breaks down carbohydrates, such as starch, and glycogen.
Lipase – the main enzyme responsible for breaking down fats. Lipases hydrolyze triglycerides (fats) into their component fatty acid and glycerol molecules.
Protease (bacterial, fungal, neutral) – a group of enzymes whose catalytic function is to hydrolyze (breakdown) peptide bonds of proteins. Proteases differ in their ability to hydrolyze various peptide bonds. Bacterial proteases are optimally active in alkaline conditions, fungal proteases in more acidic conditions, and neutral proteases (from bacteria) are optimally active at a neutral pH.
Rutin – an antioxidant citrus flavonoid consisting of sugar molecules bound to a quercetin backbone. Rutin known to modulate the immune and circulatory systems.
Serratiopeptidase - the “Miracle Enzyme” according to Dr. Han’s Nieper, a legendary medical doctor known for his extensive use of proteolytic enzymes. This proteolytic enzyme has been shown to be more powerful than the pancreatic enzymes proteolytic enzymes chymotrypsin and trypsin.
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