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Chitosan 500mg 120 tablets - Physiologics
A Positive Addition to Your
Diet Program*
All natural Chitosan is a high quality non-digestable
dietary fiber.
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Alpha Lipoic Acid 120MG 60 vcaps - Physiologics
Antioxidant
Enhancer*
Alpha lipoic acid is a vitamin-like antioxidant that helps neutralize cell-damaging free radicals. Free radicals can contribute to oxidative stress, which plays a role in the premature aging of cells. Alpha lipoic acid also supports the regeneration of glutathione, one of the body's primary antioxidants.
Particularly beneficial for vision health
Small in molecular size, so it passes easily through cell membranes
= Vegetarian Formula
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Bilberry Extract 60mg 50 vcaps - Physiologics
Standardized
to contain: 25% Anthocyanidins - Supports Healthy Eye Function*
Bilberry anthocyanidins provide support for
healthy eye function in numerous ways, including supporting the health of
retinal cells, supporting blood vessel walls, and promoting vascular health to
the capillaries in the eyes.* Anthocyanidins also serve as antioxidants, helping
to scavenge free radicals generated by the exposure of the lens to oxygen and
light.*
=
Vegetarian Formula
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Coenzyme Q10 100mg 60 capsules - Physiologics
Supports
Cardiovascular and Antioxidant Health*
The heart has the highest concentration of
Coenzyme Q10 of any organ in the human body.* CoQ10 helps promote the amount of
blood that flows through the heart and the entire body.* Numerous clinical
trials have found that supplemental CoQ10 supports overall cardiac function.*
Cellular energy for the heart*
A fat-soluble antioxidant*
Supports against low density lipoprotein (LDL)
peroxidation*
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Defender FX 100 capsules - Physiologics
Antioxidant
Support Against Free Radicals*
High in antioxidant vitamins C and E, and beta
carotene.
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Garlic HP 650mg 60 tablets - Physiologics
Standardized
to Contain a Minimum:
•6,500 mcg Allicin Yield
•13,000 mcg Alliin Yield
Odor Free
Garlic HP provides 650 mg of standardized garlic
powder in a convenient-to-use tablet. Garlic promotes cardiovascular health and
helps to maintain cholesterol levels that are already within normal range.
Garlic HP contains no odor and is enterically coated for optimal absorption.*
Enterically coated for odor control and
greater activity*
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Grape Seed Extract 100mg 60 vcaps - Physiologics
Powerful
Antioxidant and Helps Support Heart Health*
Grapeseed extract contains oligomeric
proanthocyanidins (OPCs) and other polyphenolic compounds. Proanthocyanidins
are naturally occurring bioflavonoids with antioxidant properties, which help
to neutralize cell-damaging free radicals.*
= Vegetarian Formula
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Hawthorn 150mg 100 capsules - Physiologics
Supports
a Healthy Heart*
Standardized to contain: 2% VITEXIN
Hawthorn delivers antioxidant support for the
heart and supports the blood vessels, which supply the heart with vital oxygen
and nutrients.*
Numerous, positive effects on the circulatory
system*
Primary choice for promoting a strong, healthy
heart*
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Milk Thistle 250mg 100 capsules - Physiologics
Supports
Healthy Liver Function*
Standardized to contain: 80% Silymarin
PRODUCT DISCUSSION
Milk Thistle Extract contains a group of beneficial flavonoids collectively
called Silymarin. PhysioLogics Milk Thistle Extract 250 mg has been standardized
to contain 80% Silymarin, to help support liver health.*
STRUCTURE AND FUNCTION
Free radicals can contribute to oxidative stress, which in turn may contribute
to the premature aging of cells. The flavonoids and antioxidants in Milk Thistle
Extract promote the action of nucleolar polymerase A, for increased ribosomal
protein synthesis.* This promotes healthy liver function and helps support the
outer cell membrane structure of hepatocytes.*
CLINICAL EVIDENCE
Seventeen subjects who received 160 mg of silymarin three times per week
were compared to a control group who received no treatment for four weeks.
The subjects who received silymarin experienced a significant improvement in
liver function compared with the control group. (Torres et al, 2004)
Forty nine subjects received either 150 mg of silymarin three times per
day, or placebo, for six months. Those receiving silymarin experienced a
significant increase in plasma glutathione and antioxidant activity compared
with placebo. (Lucena et al, 2002)
SUMMARY
PhysioLogics Milk Thistle Extract contains beneficial flavonoids that promote
healthy liver function.*
SUGGESTED DOSAGE
For adults, take one (1) capsule three times daily, preferably with meals or
follow the advice of a health care professional. Capsules may be opened and
prepared as a tea.
REFERENCES
Lucena MI, Andrade RJ, de la Cruz JP, et al. Effects of silymarin MZ-80 on
oxidative stress in patients with alcoholic cirrhosis. Results of a
randomized, double-blind, placebo-controlled clinical study. Int J Clin
Pharmacol Ther. 2002;40:2-8.
Torres M, Rodríguez-Serrano F, Rosario DJ, et al. Does Silybum Marianum
play a role in the treatment of chronic hepatitis C? PR Health Sci J.
2004;23:69-74.
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MSM (Methylsulfonylmethane) 500mg 90 capsules - Physiologics
For
Healthy Joint Cartilage*
HOW PATIENTS MAY BENEFIT
Promotes joint and cartilage comfort*
Increases mobility and range of motion*
PRODUCT DISCUSSION
PhysioLogics MSM contains Methylsulfonylmethane (MSM), an organic source of
sulfur, a mineral that is vital in the formation of collagen, connective tissue,
and healthy joint cartilage.* It is one of the top three ingredients found in
popular joint products.
STRUCTURE AND FUNCTION
Sulfur plays an important role in nutrition. It is the eighth most abundant
element, and is an integral component of more than 150 compounds in the body.
Sulfur is fundamental to the structure and integrity of certain tissues,
including hair, skin, nails, and joints.* MSM is a dietary source of sulfur that
is found widely in nature; major sources include milk, eggs, seafood, meats and
plants.
MSM clinical trials have focused on cartilage and
joint support.* Cartilage is a fibrous, elastic connective tissue that functions
as a cushioning layer for joints and is comprised of an extracellular matrix
made of complex proteins known as glycosaminoglycans (GAGs) and proteoglycans.
Sulfur is used in the body as a constituent of certain amino acids, collagen and
disulfide bonds, and provides a raw material for the production of GAGs and
collagen.*
CLINICAL EVIDENCE
118 subjects participated in a clinical trial
in which they received 500 mg of MSM or placebo 3 times per day for 12
weeks. Those receiving MSM experienced a significant increase in joint
comfort compared with the placebo group. Our product provides up to 3 grams
of MSM per day. (Usha and Naidu, 2004)
40 subjects completed a clinical trial in
which they received 3 g of MSM or placebo twice per day for 12 weeks. Those
receiving MSM experienced significant improvements in joint comfort and
function compared with placebo. Our product provides up to 3 grams of MSM.
(Kim et al. 2006)
SUMMARY
Sulfur is one of the building blocks of collagen and GAGs, key structural
components in cartilage.* The compounds play an important role in the integrity
and maintenance of joint cartilage.* MSM is a natural dietary source of sulfur
which helps support the health of joints and cartilage.*
SUGGESTED DOSAGE
For adults, take one (1) capsule two to three times daily (1000 mg) or four to
six times daily (500 mg), preferably with meals, or follow the advice of a
health care professional.
REFERENCES
Beilke MA, Collins-Lech C, Sohnle P. Effects of dimethyl sulfoxide on the
oxidative function of human neutrophils. J Lab Clin Med. 1987;110:91-6.
Jacobs B. MSM packs a sulfuric punch. Nutr Sci
Rev. 1999;4:232-4.
Kim LS et al. Efficacy of methylsulfonylmethane
(MSM) in osteoarthritis pain of the knee: a pilot clinical trial.
Osteoarthritis and Cartilage. 2006. 14(3):286-294.
Oae S, Okuyama T. Organic sulfur chemistry:
biochemical aspects. Boca Raton, FL:CRC Press, 1992.
Parcell S. Sulfur in human nutrition and
applications in medicine. Altern Med Rev. 2002;7:22-44.
Sharif M, Osborne DJ, Meadows K, et al. The
relevance of chondroitin and keratan sulphate markers in normal and arthritic
synovial fluid. Br J Rheumatol. 1996;35:951-7.
Usha PR and Naidu MUR. Randomised,
double-blind, parallel, placebo-controlled study of oral glucosamine,
methylsulfonylmethane and their combination in osteoarthritis. Clinical Drug
Investigation. 2004. 24(6):353-363.
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AminoLogic 90 capsules - Physiologics
Advanced
Amino Acid Formula
PRODUCT DISCUSSION
This unique formula includes highly bioavailable amino acids, which are used to
manufacture structural proteins in the body. Amino acids have numerous other
functions, including hormone, enzyme and neurotransmitter synthesis,
participating in the formation of immune and intestinal cells, providing
structure for the cell's genetic material, and promoting cellular energy
production.*
STRUCTURE AND FUNCTION
Amino acids link together to form over 50,000 different proteins and 20,000
enzymes. The body makes these proteins by breaking down bulk protein from the
food we eat into various amino acids and arranging them into thousands of
different protein combinations that power the body's various activities.
Inadequate availability of amino acids may compromise nitrogen balance, leading
to the catabolism, or breakdown, of existing protein-containing structures, such
as muscle.*
There are twenty amino acids used by the body to
synthesize proteins. Each type of protein is composed of a different combination
of amino acids - each tailored for a specific need.*
Amino acids are classified as
"non-essential", "essential" or "conditionally
essential". The body can manufacture non-essential amino acids, while
essential amino acids must be obtained through dietary sources since they cannot
be endogenously synthesized. Other amino acids are considered conditionally
essential because under certain physiological conditions they are not able to be
produced in the body de novo and must be acquired from the diet.*
Proteins form the basis of many of the body's
structural components. Myosin and actin are contractile proteins found in
skeletal muscle, while collagen, elastin and keratin are fibrous proteins that
compose tendons, ligaments, skin, hair and nails.*
Many hormones are also synthesized from amino
acids. Insulin and glucagon are amino acid-derived hormones responsible for
maintaining healthy blood sugar levels, with their secretion triggered in
response to circulating levels of certain amino acids and carbohydrates. Thyroid
hormone, adrenocorticotrophic hormone and growth hormone are other examples of
peptide hormones synthesized from amino acids.*
The synthesis of many neurotransmitters and
enzymes is dependent upon amino acid availability. The amino acid tyrosine is
the precursor of the catecholamine neurotransmitters dopamine, norepinephrine
and epinephrine, which play numerous roles including regulating the activity of
the sympathetic nervous system. Other amino acids - including glycine and
aspartate (the anion of aspartic acid) - also function as neurotransmitters. In
addition, amino acids are required for the manufacture of the enzymes that
catalyze the body's metabolic processes.*
Amino acids are also necessary in the formation
of small intestine cells (enterocytes) as well as those of the immune system.
For example, glutamine serves as the primary source of fuel for enterocytes, and
glutamine levels can affect cellular health. Other amino acids, such as
methionine and cysteine, are also suggested to be integral to the formation and
preservation of enterocytes. The cells of the immune system are supported by
amino acids, with arginine and cysteine promoting T-cell development and
glutamine serving as an energy source for lymphocytes and macrophages. In
addition, immunoglobins (Ig) and antibodies (Ab) are immunoproteins synthesized
from amino acids.*
Amino acids also are involved in energy
production. Many amino acids are considered "glucogenic", as their
carbon skeletons can be converted to pyruvate or 4- or 5-carbon intermediates of
the Krebs Cycle, leading to a net production of glucose via gluconeogenesis.
Alternatively, "ketogenic" amino acids are converted to acetyl coA,
which can be transformed into energy, through its ability to participate in the
Krebs Cycle.*
The sulfhydryl amino acids, methionine and
cysteine, are primary contributors of sulfur and methyl groups. These compounds
play an integral role in methylation, a metabolic process that fulfills many
important roles including promoting cellular integrity and providing structure
for the cell's genetic material.*
Vitamin B-6 is converted in the liver to
pyridoxal-5-phosphate, a coenzyme involved in amino acid metabolism. Its various
functions and mechanisms of action include transamination, decarboxylation,
transulfhydration, desulfhydration and racemization.*
INDICATIONS
For clients whose diets may not provide them with adequate levels of amino
acids, including those following calorie restricted or vegetarian diets,
AminoLogic® provides a broad range of bioavailable proteinogenic amino acids.
Aging and medication may also cause a reduction in the availability of amino
acids in the body.*
HOW CLIENTS MAY BENEFIT
Provides a functional array of amino acids for
maintaining good health*
Furnishes all of the essential and
conditionally essential amino acids that the body cannot make itself*
Free form amino acids are readily absorbed and
require minimal digestion compared to dietary protein*
Amino acid formulation free of yeast, wheat,
milk or milk derivatives, lactose, sugar, preservatives, soy, artificial
color, artificial flavor, sodium (less than 5 mg per serving)
Provides vitamin B-6, a necessary cofactor for
amino acid metabolism*
SUMMARY
AminoLogic® is designed to provide a balanced spectrum of amino acids that
complement each other and are readily absorbed in the body. Many of these amino
acids cannot be synthesized endogenously and must be acquired through dietary
means. Amino acids have numerous roles supporting the structure and function of
the body including: promoting cellular energy production; the synthesis of
structural proteins, hormones, enzymes and neurotransmitters; and the formation
of immune and intestinal cells. Additionally, sulfhydryl amino acids support
methylation, a metabolic process which promotes cellular integrity and provides
structure for the cell's genetic material.*
SUGGESTED DOSAGE
For adults, take three (3) capsules daily, or follow the advice of your health
care professional. As a reminder, discuss the supplements and medications you
take with your health care providers.
REFERENCES
Barbul A, Dawson H. Arginine and immunity. In: Forse RA, ed. Diet, Nutrition,
and Immunity. CRC Press. Boca Raton, FL, 1994.
Dudrick PS, Alverdy JC, Souba WW. Glutamine and
the immune system. In: Forse RA, ed. Diet, Nutrition, and Immunity. CRC Press.
Boca Raton, FL, 1994.
Grof JL, Gropper SS, Hunt SM. Advanced
Nutrition and Human Metabolism, Second Edition. West Publishing Company. New
York, NY, 1995.
Gundersen RY, Vaagenes P, Breivik T, Fonnum F,
Opstad PK. Glycine - an important neurotransmitter and cytoprotective agent.
Acta Anaesthesiol Scand. 2005 Sep;49(8):1108-16.
Hansen CM, Leklem JE, Miller LT. Vitamin B-6
status of women with a constant intake of vitamin B-6 changes with three
levels of dietary protein. J Nutr. 1996;126(7):1891-1901.
Institute of Medicine. Food and Nutrition
Board. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat,
Protein, and Amino Acids (Macronutrients). National Academy Press. Washington,
DC, 2002. AminoLogic®
Kinscherf R, Fischbach T, Mihm S, Roth S,
Hohenhaus-Sievert E, Weiss C, et al. Effect of glutathione depletion and oral
N-acetyl cysteine treatment on CD4+ and CD8+ cells. FASEB J 1994;8(6):448-451.
Lemon PW. Is increased dietary protein
necessary or beneficial for individuals with a physically active lifestyle?
Nutr Rev. 1996 Apr;54(4 Pt 2):S169-75.
Lu SC. S-Adenosylmethionine. Int J Biochem Cell
Biol. 2000 Apr;32(4):391-5.
Papaconstantinou HT, Hwang KO, Rajaraman S,
Hellmich MR, Townsend CM Jr, Ko TC. Glutamine deprivation induces apoptosis in
intestinal epithelial cells. Surgery. 1998 Aug;124(2):152-9; discussion
159-60.
Reinstein DK, Lehnert H, Wurtman RJ. Dietary
tyrosine suppresses the rise in plasma corticosterone following acute stress
in rats. Life Sci. 1985 Dec 9;37(23):2157-63.
van der Hulst RR, von Meyenfeldt MF, Soeters PB.
Glutamine: an essential amino acid for the gut. Nutrition. 1996
Nov-Dec;12(11-12 Suppl):S78-81.
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Calsorb Calcium/Magnesium Complex 90 vcaplets - Physiologics
Nutritional
Support for Bone Health*
PRODUCT IS A MIXTURE OF
Calcium Citrate, Calcium Carbonate, Calcium Stearate, Magnesium Citrate,
Magnesium Glycinate.
PRODUCT DISCUSSION
Calcium is the major mineral responsible for the health of the body's bones
and teeth. Calcium intake is critical to achieving peak bone mass, maintaining
muscle contractions, nerve impulses and supporting heart health. This unique
formula contains Calcium Citrate, one of the most bioavailable sources of
Calcium, with chelated Magnesium for additional support of bone health.*
STRUCTURE AND FUNCTION
Calcium is an essential nutrient compromising 2% of adult body weight. More
than 99% of the body's Calcium is found in the skeleton, representing 25% of
the dry weight of bones. Calcium reacts with phosphoric acid to form insoluble
salts whose primary function is to provide rigidity to the skeleton. In
addition, the Calcium salts are required to maintain a critical Calcium
concentration in extra-cellular water, which is necessary for support of the
heart, neuromuscular system, and enzymatic reactions.*
Bone is a dynamic tissue, going through a continuous process of formation
and absorption. Calcium accumulates in the skeleton during childhood until
maturity when equilibrium is reached. During midlife the body acquires the
Calcium it needs by slowly absorbing bone. Adequate Calcium intake during
adolescence and adulthood is crucial to achieve optimal bone mass.*
Many factors contribute to the development of osteoporosis including sex,
race, age, and hormonal status. Even your body type, family history, Calcium
intake, and how often you exercise can have an impact. Some populations,
especially Caucasian women of northern European ancestry and Asian women in
their bone forming years (teens and young adults) have a higher risk of
developing osteoporosis. Women going through menopause, those with a family
history of the disease and the elderly are also at a higher risk. American
women of African heritage have the lowest incidence of osteoporotic fracture.
It's important to remember that everyone loses bone mass with age. Regular
exercise, a healthy diet and adequate Calcium intake helps maintain good bone
health and may reduce the high risk of osteoporosis later in life, especially
for teens and young adult Caucasian and Asian women. A total dietary intake
above 2,000 mg has no further known benefit to bone health.
Magnesium also plays an important role in bone health. The human skeleton
utilizes 55% of the body's Magnesium. Magnesium aids in the absorption of
Calcium by promoting the secretion of calcitonin, a hormone that aids in the
influx of calcium into bone. In addition, Magnesium modulates the secretion of
parathyroid hormone, whose function is to draw Calcium out of bones and
deposit it in soft tissue.*
INDICATIONS
Adequate Calcium intake during adolescence, adulthood and menopause is crucial
to achieve and maintain peak bone mass. According to the Third National Health
and Nutrition Examination Survey (NHANES III), more than 50% of children,
adults, and elderly Americans' dietary Calcium intakes fail to meet
recommended levels. In addition, certain regularly prescribed drugs may cause
Calcium and/or Magnesium depletions. PhysioLogics' Calsorb® may be a
desirable dietary supplement for clients who want to promote bone mass and
support overall bone health.*
HOW CLIENTS MAY BENEFIT
Primary support of bone health begins during adolescence when the
skeleton is accruing its peak mass. The Food and Nutrition Board of the
Institute of Medicine issued a Dietary Reference Intake for Calcium to
1,300 mg per day for 9 to 18 year old girls, and 1000 mg for 19 to 50 year
old women. Calcium supplementation during these formative years may
contribute to bone density in the future.*
Optimize peak bone mass during all stages of life for a strong skeletal
system in both men and women.*
Provide extra Calcium normally obtained from bones required for proper
muscle contraction and nerve function.*
Magnesium aids in the absorption of Calcium into bone and is essential
to maintain proper bone mineralization.*
NIAMS, a branch of the National Institutes of Health, recently completed
a placebo-controlled double blind study evaluating the effect of Calcium
supplementation on bone mass accretion over 7 years in a group of 354
prepubescent females. The results will provide data about the efficacy of
Calcium supplementation with regard to bone mass, circulatory health, and
weight control.
A study of 12 young healthy men found that daily supplementation with 15
mmol (365mg) Magnesium supports bone health, as measured by reduced levels
of resorption biochemical markers.
CLINICAL EVIDENCE
A French study shows that Calcium and Vitamin D supplementation may not
only promote bone health, but may also increase bone mass. Over 3,000
women over the age of 69 received 1.2 grams of calcium and 800 IU of
Vitamin D or a placebo every day for 18 months. Not only did 43% of the
supplemented women have stronger bones, but bone density increased
slightly in this group as well.
A meta-analysis of four well-designed intervention studies concludes
that Calcium supplementation of ~1000 mg/d in women can promote bone
health in every bone except the ulna.
A placebo-controlled double-blind study of 389 men and women over 65
years old found a significant positive change in bone density in patients
that consumed 500 mg Calcium and 700 IU Vitamin D for 3 years versus the
placebo group.
SUMMARY
Calcium and Magnesium are essential nutrients for bone formation and
maintenance. PhysioLogics' Calsorb® combines Calcium and Magnesium in a
highly absorbable form for those who want to ensure they obtain adequate
amounts of these minerals to support bone health through all stages of life.*
SUGGESTED DOSAGE
For adults, take three (3) caplets one to two times per day, preferably with a
meal, or follow the advice of your health care professional. As a reminder,
discuss the supplements and medications you take with your health care
providers.
REFERENCES
Alaimo K, McDowell MA, Briefel RR, Bischof AM, Caughman CR, Loria CM,
Johnson CL. Dietary intake of vitamins, minerals, and fiber of persons ages
2 months and over in the United States: Third National Health and Nutrition
Examination Survey, Phase 1, 1988-91. Adv Data. 1994 Nov 14;(258):1-28.
Chapuy MC, Arlot ME, Duboeuf F, Brun J, Crouzet B, Arnaud S, Delmas PD,
Meunier PJ. Vitamin D3 and calcium to prevent hip fractures in the elderly
women. N Engl J Med. 1992 Dec 3;327(23):1637-42
Dawson-Hughs B. Osteoporosis treatment and the calcium requirement. Am J
Clin Nutr. 1998. 67 (1):5-6. Dawson-Hughes B, Harris SS, Krall EA, Dallal
GE. Effect of calcium and vitamin D supplementation on bone density in men
and women 65 years of age or older. N Engl J Med. 1997 Sep 4;337(10):670-6.
Dimai HP, Porta S, Wirnsberger G, Lindschinger M, Pamperl I, Dobnig H,
Wilders-Truschnig M, Lau KH. Daily oral magnesium supplementation suppresses
bone turnover in young adult males. J Clin Endocrinol Metab. 1998
Aug;83(8):2742-8.
DRI for Calcium, Phosphorues, Magnesium, Vitamin D, and Fluoride.
Institute of Medicine. CH 4. Calcium. Pp71-91 Ferment O, Touitou Y.
Magnesium: metabolism and hormonal regulation in different species. Comp
Biochem Physiol A. 1985;82(4):753-8.
Institute of Medicine. Food and Nutrition Board. Dietary Reference
Intakes: Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. National
Academy Press. Washington, DC, 1999.
Matkovic V. Nutrition, genetics and skeletal development. J Am Coll Nutr.
1996. 15(6):556-69
NIH consensus development panel on optimum calcium intake. JAMA. 1994.
272(24):1942-8
Rude RK and Olerich M. Magnesium deficiency: Possible role in
osteoporosis associated with gluten-sensitive enteropathy. Osteoporos Int
1996;6:453-61.
Welten D, Kemper H ,Post G, Van Staveren W. A metaanalysis of the effect
of calcium intake on bone mass in young and middle aged females and males. J
Nutr. 1995 Nov;125(11):2802-13
= Vegetarian Formula
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Iron Plex 28mg 90 capsules - Physiologics
Supports Energy Utilization*
As an important dietary source of iron, Iron Plex® contains iron
bisglycinate, a well tolerated form of iron that is gentle to the system.* Iron
is a necessary component of hemoglobin, the oxygen carrier in the blood.* Iron
is also important for energy utilization.*
Includes folic acid and vitamin B12 (Cyanocobalamin), both necessary for
the healthy formation of red blood cells.*
Supports Cell Growth and Function*
Inositol Hexaphosphate is derived from rice bran. Inositol is an essential
component of cell membranes and plays an important role in cell growth and
function.*
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MultiLogics for Women 90 caplets - Physiologics
Comprehensive
Multivitamin for Women
PRODUCT DISCUSSION
This unique product is a comprehensive formulation with vitamins, herbs,
minerals and nutrients for the specific needs of women. MultiLogics® for Women
includes Daidzein, Dong Quai and Chasteberry to support a women's natural
balance.*
STRUCTURE AND FUNCTION
MultiLogics® for Women delivers an exceptional combination of Bioflavanoids,
Ginkgo Biloba, Black Cohosh, Chasteberry, Dong Quai, Grape Seed and many other
herbs, in addition to essential vitamins and minerals to provide a convenient
source of nutrients traditionally used for women's health.*
Selenium is included to provide immune system
support.*
Copper is essential for collagen formation to
help promote healthy skin, hair, and nails.*
Copper assists Iron in the release of energy
from cells.*
Chromium is an essential mineral required for
normal metabolism of carbohydrates and lipids.*
Vitamin E and Selenium synergistically support
cells from the harmful effects of free radicals, unstable compounds that may
cause premature aging.*
Some scientific evidence suggests that
consumption of antioxidant vitamins such as Vitamin E may reduce the risk of
certain forms of cancer. However, FDA has determined that this evidence is
limited and not conclusive.
Selenium may reduce the risk of certain
cancers. Some scientific evidence suggests that consumption of selenium may
reduce the risk of certain forms of cancer. However, FDA has determined that
this evidence is limited and not conclusive.
Many factors contribute to the development of
osteoporosis including sex, race, age, and hormonal status. Even your body
type, family history, Calcium intake, and how often you exercise can have an
impact. Some populations, especially Caucasian women of northern European
ancestry and Asian women in their bone forming years (teens and young
adults) have a higher risk of developing osteoporosis. Women going through
menopause, those with a family history of the disease and the elderly are
also at a higher risk. American women of African heritage have the lowest
incidence of osteoporotic fracture. It's important to remember that everyone
loses bone mass with age. Regular exercise, a healthy diet and adequate
Calcium intake helps maintain good bone health and may reduce the high risk
of osteoporosis later in life, especially for teens and young adult
Caucasian and Asian women. A total dietary intake above 2,000 mg has no
further known benefit to bone health.
INDICATIONS
MultiLogics® for Women provides a comprehensive supplement to nutritionally
support the unique needs of women's health.*
HOW CLIENTS MAY BENEFIT
Vitamins and minerals are necessary for
growth, development, and a healthy life.*
A quick, easy, and convenient way to receive a
wide range of fruit and herb extracts traditionally used for women's unique
nutritional needs.*
Delivers an extraordinary combination of
Bioflavanoids, Ginkgo Biloba, Black Cohosh, Chasteberry, Dong Quai, Grape
Seed and many other herbs traditionally used for women's health.*
SCIENTIFIC RESEARCH
A recent review published in the journal JAMA
stated that most people do not consume an optimal amount of all vitamins by
diet alone. In fact, suboptimal intake of some vitamins, even above levels
classified as deficiency, may be unhealthy and is common in the general
population. The reviewers concluded that it is wise for all adults to take
vitamin supplements.
The National Institutes of Health, the Centers
for Disease Control, the Public Health Service and the American Medical
Women's Association advocate the use of certain nutrients for certain
populations, such as Calcium for women and young adults, Folic Acid for
women of childbearing age, and B-12 for seniors and Vegetarians.
The Departments of Health and Human Serivices
and Agriculture updated the Dietary Guidelines for Americans in 2000. This
document, published by Congressional mandate, recognizes that certain
"people need a vitamin-mineral supplement to meet specific nutrient
needs."
SUMMARY
MultiLogics® for Women is an ideal supplement for any adult female wanting to
naturally support her unique nutritional needs. Delivering vitamins and
minerals, along with a unique combination of herbal extracts, MultiLogics® for
Women is a premium quality multivitamin to support a women's natural balance. *
SUGGESTED DOSAGE
For adults, take three (3) caplets per day with meals, or follow the advice of
your health care professional. As a reminder, discuss the supplements and
medications you take with your health care providers.
REFERENCES
Agriculture Research Service. Dietary Guidelines for Americans. 2000.
Departments of Health and Human Services and Agriculture. May 30.
Anderson, R.A. Chromium glucose intolerance and
diabetes. J Am Coll Nutr. 1998. 17 (6); Dec: 548-55.
Arthur, J.R., et al. Selenium deficiency,
thyroid hormone metabolism, and thyroid hormone deiodinases. Am J Clin Nutr.
1993. 57: 236S-239S.
Baumgartner, T. et al. Trace elements in
clinical nutrition. Nutrition in Clinical Practice. 1993.
Bell, S.J., et al. A functional food product
for the management of weight. Critical Reviews in Food Sci. 2002. 42(2):
163-178. Castillo-Duran C. et al. Trace minerals in human growth and
development. J of Pediatric Endocrinology & Metabolism. 1999. 12 (5);
Sep-Oct: 589-601.
Centers for Disease Control. Use of folic
acid-containing supplements among women of childbearing age-United Sates,
1997. MMWR Weekly. 1998. 57(7); Feb 27:131-134.
Fairfield, K.M. Vitamins for chronic disease
prevention in adults. JAMA. 2002. 287(23); Jun 19: 3116-1720.
Halliwell, B. et al. Free radicals and
antioxidants in food and in vivo: What they do and how they work. Critical
Reviews in Food Science and Nutrition. 35:7-20. 1995.
National Institutes of Health. Optimum Calcium
Intake. NIH Consensus Statement. 1994. 12(4); Jun 6-8: 1-31.
Sizer, Frances et al. The vitamins. Nutrition:
Concepts and Controversies. 7th ed. 1997. 265.
Spallholz, J.E. et al. Advances in the role of
minerals in immunobiology. Biological Trace Element Research. 1989. 19:
129-151.
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MultiLogics Once Daily 30 caplets - Physiologics
Full-Spectrum
Nutritional Support*
Once Daily Formula
PRODUCT DISCUSSION
Give your body the comprehensive nutritional support it deserves. MultiLogics®
furnishes a comprehensive formulation with vitamins, fruit extracts, minerals,
bioflavonoids, and other nutrients for comprehensive nutritional support and
good health. *
STRUCTURE AND FUNCTION
Proper nutrition supplementation begins with a high quality multivitamin.
MultiLogics® provides a daily source of 22 vitamins and minerals, in addition
to fruit extracts and bioflavonoids to support many aspects of health:*
Vitamin A promotes normal growth, healthy skin and supports night and
color vision.*
The balanced B-Vitamins are essential for the synthesis of red blood cells
and the processing of amino acids to assist in energy metabolism.*
To provide immune system support, Vitamin C, Selenium, and Zinc are
included.*
Vitamin C and Copper are essential for collagen formation to help promote
healthy skin, hair, and nails.*
For bone mineralization support, Vitamin D is essential to Calcium
absorption and helps promote a healthy immune system.*
Vitamin E and Selenium, as a key component of an antioxidant enzyme, each
support cells from the harmful effects of free radicals.*
Copper assists Iron in the release of energy from cells.*
As part of a well-balanced diet that is low in saturated fat and
cholesterol, Folic Acid, Vitamin B6 and Vitamin B12 may reduce the risk of
vascular disease. FDA evaluated the above claim and found that, while it is
known that diets low in saturated fat and cholesterol reduce the risk of
heart disease and other vascular diseases, the evidence in support of the
above claim is inconclusive.
Some scientific evidence suggests that consumption of antioxidant vitamins
such as Vitamin C and Vitamin E may reduce the risk of certain forms of
cancer. However, FDA has determined that this evidence is limited and not
conclusive.
Selenium may reduce the risk of certain cancers. Some scientific evidence
suggests that consumption of selenium may reduce the risk of certain forms
of cancer. However, FDA has determined that this evidence is limited and not
conclusive.
Women who consume healthful diets with adequate folate may reduce their
risk of having a child with birth defects of the brain or spinal cord.
Folate intake should not exceed 1,000 mcg.
INDICATIONS
For your clients who are interested in nutrition supplementation,
MultiLogics® is the first step in providing additional nourishment by
furnishing a daily source of 22 vitamins and minerals plus fruit extracts for
value-added nutrition.*
HOW CLIENTS MAY BENEFIT
Vitamins and minerals are necessary for growth, development, and a healthy
life.*
Certain populations, such as maturing adults or people on restrictive
diets, may require more vitamin and mineral supplementation.*
A quick, easy, and convenient way to receive a daily source of 22 vitamins
and minerals.
B Vitamins support heart health.*
Antioxidant vitamins neutralize free radicals, unstable compounds that may
lead to DNA and cell damage.*
SCIENTIFIC RESEARCH
A recent review published in the journal JAMA stated that most people do
not consume an optimal amount of all vitamins by diet alone. In fact,
suboptimal intake of some vitamins, even above levels classified as
deficiency, may be unhealthy and is common in the general population. The
reviewers concluded that it is wise for all adults to take vitamin
supplements.
The Physician's Health Study followed almost 15,000 male physicians for up
to five years to study heart health. In this study, lower levels of
homocysteine were found in those with a healthier cardiovascular system and
longer life. In addition, researchers found that high intakes of Vitamins
B-6, B-12, and Folic Acid were correlated with lower plasma homocysteine
levels.
SUMMARY
Proper nourishment plays a role in disease prevention. While vitamin
supplementation is not an adequate substitute for a good diet, MultiLogics® is
an ideal supplement for any adult concerned about healthy nutrition. Delivering
22 vitamins and minerals, along with bioflavonoids and fruit extracts,
MultiLogics® is a premium quality multivitamin for comprehensive nutritional
support.*
SUGGESTED DOSAGE
For adults, take one (1) caplet daily, preferably with a meal, or follow the
advice of your health care professional. As a reminder, discuss the supplements
and medications you take with your health care providers.
REFERENCES
Anderson, R.A. Chromium glucose intolerance and diabetes. J Am Coll Nutr.
1998. 17 (6); Dec: 548-55.
Baumgartner, T. et al. Trace elements in clinical nutrition. Nutrition in
Clinical Practice. 1993.
Bell, S.J., et al. A functional food product for the management of weight.
Critical Reviews in Food Sci. 2002. 42(2): 163-178.
Castillo-Duran C. et al. Trace minerals in human growth and development. J
of Pediatric Endocrinology & Metabolism. 1999. 12 (5); Sep- Oct: 589-601.
DeLuca, H.F. (et. al.) Mechanisms and Functions of Vitamin D. Nutrition
Reviews. February 1998. (56)2: S4-S10
Fairfield, K.M. Vitamins for chronic disease prevention in adults. JAMA.
2002. 287(23); Jun 19: 3116-1720.
Institute of Medicine. Vitamin B6. Dietary Reference Intakes: Thiamin
Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin,
and Choline. National Academy Press. Washington D.C. 1998.
Halliwell, B. et al. Free radicals and antioxidants in food and in vivo:
What they do and how they work. Critical Reviews in Food Science and
Nutrition. 35:7-20. 1995.
Sizer, Frances et al. The vitamins. Nutrition: Concepts and Controversies.
7th ed. 1997. 265.
Spallholz, J.E. et al. Advances in the role of minerals in immunobiology.
Biological Trace Element Research. 1989. 19: 129-151.
Stampfer MJ, Malinow MR, Willett WC, Newcomer LM, Upson B, Ullmann D,
Tishler PV, Hennekens CH. A prospective study of plasma homocyst(e)ine and
risk of myocardial infarction in US physicians. JAMA. 1992 Aug
19;268(7):877-81. |
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PhyTotality Daily 120 vtabs - Physiologics
Multi
Vitamins & Minerals with Whole Food Concentrates
Also provides the naturally occurring active
constituents of whole foods includeing vitamins, minerals, trace elements,
amino acids, omega-3 and omega-6 polyunsaturates, plant enzymes and plant
pigments.
Vitamins, minerals and nutritional factors
for key areas of health*
Whole food actives like plant enzymes*
Your energy source for green nutrition*
= Vegetarian Formula
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SAMe 200mg 20 Enteric Coated Tablets - Physiologics
Supported
By Research:
• Boosts mood*
• Supports emotional well-being*
S-adenosylmethionine - SAM-e is involved in more
than 35 biochemical reactions involving enzymatic transmethylation. Methylation
is the process by which the body rids itself of compounds, synthesizes
neurotransmitters, makes components of cartilage, regulates enzyme activity
within the cell, and maintains the flexibility of cell membranes.*
• Promotes healthy joint function and comfort* |
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Vitex Chaste Tree 400mg 100 capsules - Physiologics
Supports
Menstrual & Menopausal Health*
Natural Whole Herb*
Vitex is known as a traditional herb for
women’s health and is recommended by leading herbal health experts everywhere.
Vitex gives you the holistic support you need to relieve the periodic
discomfort, mild mood changes, cramping and breast tenderness associated with
menstrual and menopause changes.*
†Physiologics' Natural Whole Herb products utilize ground plant parts to
provide the natural components in the amounts found in nature.
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L-Arginine 500mg 90 vcaps - Physiologics
For
Immune System Health*
L-Arginine is one of 20 amino acids, the
building blocks of protein.* Amino acids perform a variety of functions in the
body. L-Arginine is a precursor to nitric oxide, which helps maintain
cardiovascular health and supports the immune system.*
• Stimulates the release of nitric oxide*
• Promotes circulation throughout the body*
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L-Glutamine 500mg 90 vcaps - Physiologics
Primary
Fuel of Intestinal Cells*
L-Glutamine is one of 20 amino acids, the building blocks of protein.
Glutamine is the most highly concentrated amino acid in muscle and plays a
role in the proper functioning of the GI tract.*
Supports multiple anabolic functions in the human body
Maximizes gastrointestinal health and supports a healthy immune system*
= Vegetarian Formula
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DiaBest 2® 60 capsules - Physiologics
Supports
Sugar Metabolism*
DiaBest 2® is a blend of five powerful nutrients which provides comprehensive
support for the body’s ability to promote sugar metabolism.*
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OsteoLogic 2000 90 caplets - Physiologics
Supports Bone Health*
OsteoLogic® 2000 caplets are a source of microcrystalline hydroxyapatite
complex (MCHC) Calcium plus trace minerals that help maintain healthy bones.*
Vitamin D assists the body in absorbing Calcium, while Vitamin K plays a role in
synthesizing a key protein in bone formation.*
It's important to remember that everyone loses bone mass with age. Regular
exercise, a healthy diet and adequate Calcium intake helps maintain good bone
health and may reduce the high risk of osteoporosis later in life, especially
for teens and young adult Caucasian and Asian women. A total dietary intake
above 2,000 mg has no further known benefit to bone health.
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Wild Yam/Dong Quai Formula 90 caps - Physiologics
Supports
a Woman's Reproductive Health*
Standardized to contain:
1% lingustilides
6% saponins
5% isoflavones
The ingredients in this product have been
scientifically formulated to nutritionally support a woman's health.*
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Womens Support Formula 60caps - Physiologics
Holistic
Support During PMS and Menopausal Years*
PRODUCT DISCUSSION
PhysioLogics Women's Support Formula® is designed to provide comprehensive
nutrition for women's health needs.* It combines valuable nutrients such as
flavonoids from Chaste Tree fruit and naturally-occurring triterpene glycosides
from Black Cohosh, to help support the unique physiology of a woman.*
STRUCTURE AND FUNCTION
PhysioLogics Women's Support Formula® supplies several vital ingredients to
support women during PMS and menopausal years:*
Vitamin E helps promote metabolic functioning
to fight against free radicals and oxidative stress.*
Vitamin B6 promotes the production of red
blood cells, plays a role in energy metabolism, supports metabolism of
immune factors, and supports heart health.* It is essential for proper
hormone function.*
Folic Acid is an important B vitamin.
Magnesium is a major mineral that is essential
for cell formation and in the skeleton. It participates in every major
metabolic pathway, including nucleic acid, protein, carbohydrate, and lipid
metabolism.*
Copper is found in bones, muscles, blood and
brain.
Zinc is involved in healthy vision and smell
and acts as a cofactor for more than 300 enzymes.*
In addition to vitamins and minerals,
ingredients include Black Cohosh, a leading herb for women's health; Chaste
Tree fruit to support menstrual and menopausal health*; Dong Quai, a
traditional herb for women; and Soy Isoflavones.
CLINICAL EVIDENCE
In this randomized double-blind placebo
controlled study, 179 women were given 20 mg of agnus castus (chasteberry)
extract or placebo. Those receiving treatment experienced significant
improvements in well-being during their premenstrual phase. This study
supports the use of chasteberry for women's health and well being. (Schellenberg,
2001)
152 peri- and post-menopausal women received
either 39 mg or 127.3 mg of C. racemosae (black cohosh) preparation over a
24-week period. Both groups of women reported an increase in feelings of
health and well-being related to the transition of menopause. This study
supports the use of black cohosh to promote menopausal health. (Liske et al,
2002)
SUMMARY
PhysioLogics Women's Support Formula® offers a unique blend of vitamins,
minerals, and other ingredients to provide women with holistic support during
PMS and menopause.
SUGGESTED DOSAGE
For adults, take one (1) capsule one to two times daily, preferably with a meal,
or follow the advice of a health care professional.
WARNING: Not intended for use by pregnant or
nursing women. Patients taking any medications or planning any medical procedure
should consult a doctor before use. Product should be discontinued if any
adverse reactions occur. Not intended for use by persons under the age of 18.
REFERENCES
Diaz-Arrastia R, et al. Homocysteine and neurologic disease. Arch Neurol.
2000;57: 1422-7.
Liske E, H'nggi W, Henneicke-von Zepelin HH, et
al. Investigation of a unique extract of black cohosh (Cimicifugae racemosae
rhizome): a 6-month clinical study demonstrates no systemic estrogenic effect.
J Womens Health Gend Based Med. 2002;11:163-74.
Prasad AS. Zinc: An overview. Nutrition.
1995;11:93-9.
Schellenberg R. Treatment for the premenstrual
syndrome with agnus castus fruit extract: prospective, randomized, placebo
controlled study. BMJ. 2001;322:134-7.
Singh VN. A current perspective on nutrition
and exercise. J Nutr. 1992;122(3 Suppl):760-5.
Toto KH, Yucha CB. Magnesium: homeostasis,
imbalances, and therapeutic uses. Crit Care Nurs Clin North Am. 1994;6:767-83.
Wyatt KM, Dimmock PW, Jones PW, Shaughn O'Brien
PM. Efficacy of vitamin B-6 in the treatment of premenstrual syndrome:
systematic review. BMJ. 1999;318:1375-81.
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RejuVeinate 60 capsules - Physiologics
For
Vein Health in Legs and Lower Extremities*
PRODUCT DISCUSSION
PhysioLogics RejuVeinate™ is a specially formulated blend of herbs and fruit
extracts to promote healthy circulation and vein health in the lower
extremities.*
STRUCTURE AND FUNCTION
RejuVeinate™ supplies several active
ingredients: The ancient Horse Chestnut tree is native to northern Greece,
where its bark, leaves, and seeds were believed to have health benefits.
This unique formula contains Butcher's Broom
to support venous tone by promoting vein elasticity.* Bilberry contains over
15 naturally-occurring anthocyanosides, flavonoids that have beneficial
properties.
CLINICAL EVIDENCE
A total of 87 study subjects received tablets
standardized to contain 50 mg of aescin (the active ingredient in Horse
Chestnut extract) twice per day for 8 consecutive weeks. Leg vein health was
significantly improved at the end of the study as compared to baseline.
(Dickson et al, 2004)
In a randomized double-blind
placebo-controlled study, 148 women received either 72-75 mg dry extract of
Butcher's broom per day or placebo for 12 weeks. The subjects receiving
Butcher's broom experienced significant (p |
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Vinpocetine 10mg 90 softgels - Physiologics
Support
for Mild Memory Problems Associated with Aging and Promotes Circulation*
Vinpocetine is a chemically distinct substance
that plays a role supporting cerebral circulation and cognitive function.*
Vinpocetine is perfect for mild memory problems associated with aging.* It has
been used by European doctors for more than 10 years.
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Candistatin 90 capsules - Physiologics
Nutritional
Support for Maintaining Internal Balance*
Delivers caprylic acid
Furnishes the herb pau d’arco (5:1 extract)
containing napthoquinones
Includes goldthread, which contains a total of
10% alkaloids
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Coloklysis 30 servings - Physiologics
Fiber-rich
colon cleansing formula*
Coloklysis® furnishes both soluble and insoluble fibers, and is a powerful
colon cleansing product designed for periodic cleansing of the colon and
intestinal tract.*
• A unique fiber and herbal formula
• Formulated with both soluble and insoluble fibers to add bulk
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Detoxinal 60 capsules - Physiologics
Nutritional
Support for Cleansing*
HOW PATIENTS MAY BENEFIT
Contains ingredients traditionally used to support digestion*
PRODUCT DISCUSSION
This unique formula is designed to help cleanse the body by promoting digestion,
maintaining the health of the gastrointestinal tract, and promoting
elimination.*
STRUCTURE AND FUNCTION
Chlorella is a single-celled green algae that naturally contains the
phytonutrient chlorophyll.
Bromelain is a natural enzyme that supports digestion.* Cascara sagrada
has been traditionally used for gastrointestinal health.*
Dandelions contain unique phytochemical compounds called sesquiterpene
lactones.
CLINICAL EVIDENCE
Bromelain is the name of a family of proteolytic enzymes found in
pineapple stems and has been shown to be effective as a digestive enzyme in
the stomach and the small intestine. (Kelly, 1996)
Cascara has a long history of use in providing digestive support. (Newall
et al, 1996)
SUMMARY
PhysioLogics Detoxinol supports cleansing via multiple processes in the body.
SUGGESTED DOSAGE
For adults, take two (2) capsules daily, preferably with a meal. Product may be
taken up to three times per day or follow the advice of a health care
professional.
REFERENCES
Kelly GS. Bromelain: A literature review and discussion of its therapeutic
applications. Altern Med Rev. 1996;1:243-57.
Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for
Health-Care Professionals. London: The Pharmaceutical Press, 1996. 62. (1, 2,
4, 5, A, B, C)
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Liver Maintenance Formula 90 capsules - Physiologics
For
Healthy Liver Function*
This unique formula combines the potent herb milk
thistle, with dandelion, plus alpha lipoic acid, to help protect the liver and
maintain healthy liver function.*
Formulated with the potent
fat-and-water-soluble antioxidant, alpha lipoic acid
Fortified with standardized herbs such as milk
thistle, dandelion, picrorhiza kurroa, artichoke and boldo that protect and
promote gall bladder and liver health*
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BioFlora 60 vegetarian caplets - Physiologics
Supports
Healthy Intestinal Flora.* - 1.26 Billion Intestinal Probiotics per Caplet.***
PRODUCT IS A SYNERGYSTIC
MIXTURE OF
Fructooligosaccharides, Lactobacillus acidophilus, Bifidobacterium lactis,
Lactobacillus bulgaricus, Tumeric.
PRODUCT DISCUSSION
PhysioLogics' BioFlora® provides a unique combination of prebiotic
fructooligosaccharides and probiotic bacteria to support digestive function and
promote healthy intestinal flora. Each caplet provides 1.26 X 109 intestinal
probiotics at time of manufacture.*
STRUCTURE AND FUNCTION
The human gastrointestinal (GI) tract contains approximately 1014 bacterial
cells comprised of more than 400 species. Because some of the bacteria are
beneficial and others pose dangers to the body, it is extremely important to
maintain a healthy balance of intestinal flora. Nutrition and the amount and
type of fermentable material in the gut all influence the intestinal microbial
ecology.*
Fructooligosaccharides are non-digestible
short-chain carbohydrates that selectively promote the growth and activity of
commensal bacteria in the gut. The resultant increase in bacterial cell mass
enlarges bowel content and supports peristalsis of the alimentary tract.
Fermentation of fructooligosaccharides results in the production of beneficial
short-chain fatty acids like butyrate, the preferred substrate for energy
generation by colonic cells.*
Probiotics are symbiotic microorganisms that,
when ingested, exhibit positive influences on the health and physiology of the
host. In addition to nutrient support during fermentation, probiotics can
promote the digestibility of certain dietary nutrients. Lactobacillus
acidophilus, naturally found in foods such as yogurt, releases many enzymes into
the intestinal lumen which may support the bioavailability of proteins and fats.
Lactases produced by lactic acid bacteria are delivered to the stomach and
intestines, which may aid in lactose digestion.*
L. acidophilus can help establish a healthy GI
flora composition through a variety of mechanisms, including competition for
nutrients and attachment sites, promoting acidic pH, and production of hydrogen
peroxide and bacteriocins. L. acidophilus is a normal constituent of the vaginal
flora, where it contributes to the maintenance of a healthy acidic environment.*
INDICATIONS
Probiotics are commensal food supplements that improve the microbial composition
of the intestines and aid in digestion of nutrients. Because it is believed that
most probiotics are not permanently attached to the intestinal wall, daily
consumption of these bacteria may help maintain a supportive level. In addition,
antibiotics and certain regularly prescribed drugs may cause probiotic
depletions. Supplementing your clients' diets with BioFlora® may be desirable
to promote gastrointestinal health by ensuring a daily supply of beneficial
probiotics.*
HOW CLIENTS MAY BENEFIT
Promote balanced intestinal and vaginal flora
environments for healthy function.*
Supports digestion and a favorable balance of
intestinal flora.*
Provides a combination of three exceptional
probiotic strains.*
SUMMARY
Probiotics are live commensal food supplements that support the microbial
composition of the intestines, aiding in the digestion of nutrients.
PhysioLogics' BioFlora® provides symbiotic lactic acid bacteria and fermentable
Fructooligosaccharides for those who want to receive a daily supply of
probiotics to maintain healthy intestinal flora.*
SUGGESTED DOSAGE
For adults, take one (1) caplet up to three times per day on an empty stomach or
follow the advice of your health care professional. As a reminder, discuss the
supplements and medications you take with your health care providers.
REFERENCES
De Simone C, Ciardi A, Grassi A, Lambert Gardini S, Tzantzoglou S, Trinchieri
V, Moretti S, Jirillo E. Effect of Bifidobacterium bifidum and Lactobacillus
acidophilus on gut mucosa and peripheral blood B lymphocytes. Immunopharmacol
Immunotoxicol. 1992;14(1-2):331-40.
Kopp-Hoolihan L. Prophylactic and therapeutic
uses of probiotics: a review.J Am Diet Assoc. 2001 Feb;101(2):229-38
Marteau P, Flourie B, Pochart P, Chastang C,
Desjeux JF, Rambaud JC. Effect of the microbial lactase (EC 3.2.1.23) activity
in yoghurt on the intestinal absorption of lactose: an in vivo study in
lactase-deficient humans. Br J Nutr. 1990 Jul;64(1):71-9.
Marteau PR, de Vrese M, Cellier CJ,
Schrezenmeir J. Protection from gastrointestinal diseases with the use of
probiotics. Am J Clin Nutr. 2001 Feb;73(2 Suppl):430S-436S.
Motta L, Blancato G, Scornavacca G, De Luca M,
Vasquez E, Gismondo MR, Lo Bue A, Chisari G. [Study on the activity of a
therapeutic bacterial combination in intestinal motility disorders in the
aged] Clin Ter. 1991 Jul 15;138(1):27-35.
Murray, M. Probiotics. In: Encyclopedia of
Nutritional Supplements. Prima Publishing, 1996, 44: 359-364.
=
Vegetarian Formula
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BioFlora HP 100 capsules - Physiologics
Supports
Intestinal Health.* - 3 Billion Live Cells per Capsule.***
PRODUCT IS A SYNERGYSTIC MIXTURE OF
Lactobacillus acidophilus, L. brevis, L.
salivarius, L. helveticus, L. bulgaricus, Bifidobacterium bifidum and citrus
pectin.
PRODUCT DISCUSSION
PhysioLogics' BioFlora® HP provides a unique combination of a specially
cultured strain of Lactobacillus acidophilus, plus five additional probiotic
organisms and pectin to support digestive function and promote healthy
intestinal flora. Acidophilus promotes the health functioning of the intestinal
system. Each serving provides 9 X 109 intestinal probiotics at time of
manufacture plus 300 mg of pectin.*
STRUCTURE AND FUNCTION
The human gastrointestinal (GI) tract contains approximately 1014 bacterial
cells comprised of more than 400 species. Because some of the bacteria in the
gastrointestinal tract are friendly to the body, it is extremely important to
maintain a healthy balance of intestinal flora. Nutrition and the amount and
type of fermentable material in the gut all influence the intestinal microbial
ecology.*
Probiotics are symbiotic microorganisms that,
when ingested, exhibit positive influences on the health and physiology of the
host. In addition to nutrient support during fermentation, probiotics can
promote the digestibility of certain dietary nutrients. Lactobacillus
acidophilus, naturally found in foods such as yogurt, releases many enzymes into
the intestinal lumen which may support the bioavailability of proteins and fats.
Lactases produced by lactic acid bacteria are delivered to the stomach and
intestines, which may aid in lactose digestion. In addition, evidence suggests
that Probiotics can promote both specific and nonspecific immune responses.*
L. acidophilus can help establish a healthy
gastrointestinal flora composition through a variety of mechanisms, including
competition for nutrients and attachment sites, promoting acidic pH, production
of hydrogen peroxide and bacteriocins, immune system support and lactase
production. L. acidophilus is also a normal constituent of the vaginal flora,
where it contributes to the maintenance of a healthy acidic environment.*
INDICATIONS
Probiotics are commensal food supplements that improve the microbial composition
of the intestines and aid in digestion of nutrients. Because it is believed that
most probiotics are not permanently attached to the intestinal wall, daily
consumption of these bacteria may help maintain a supportive level. In addition,
antibiotics and certain regularly prescribed drugs may cause probiotic
depletions. Supplementing your clients' diets with BioFlora® HP may be
desirable to promote gastrointestinal health by ensuring a daily supply of
beneficial probiotics.*
HOW CLIENTS MAY BENEFIT
Promote balanced intestinal and vaginal flora
environments for healthy function.*
Supports digestion and a favorable balance of
intestinal flora.*
Provides a combination of five exceptional
probiotic strains.*
SCIENTIFIC RESEARCH
One placebo-controlled double-blind study was
conducted to study the effects of Lactobacillus acidophilus on maintaining
intestinal health and regularity. A total of 820 people traveling on
vacation in two locations to southern Turkey were assigned to receive either
2 X 109 probiotics per day or placebo. Significant support of intestinal
health was observed in one of the two destinations studied. Authors
postulate the lack of significant findings in the other location may have
been due to uneven age distribution or dissimilar microbial environments of
the localities.
SUMMARY
Probiotics are live commensal food supplements that support the microbial
composition of the intestines, aiding in the digestion of nutrients.
PhysioLogics' BioFlora® HP provides a mixture of beneficial symbiotic bacteria
and citrus pectin for those who want to receive a daily supply of probiotics to
maintain healthy intestinal flora.*
SUGGESTED DOSAGE
For adults, take two (2) capsules daily, preferably with meals, or follow the
advice of your health care professional. As a reminder, discuss the supplements
and medications you take with your health care providers.
REFERENCES
De Simone C, Ciardi A, Grassi A, Lambert Gardini S, Tzantzoglou S, Trinchieri
V, Moretti S, Jirillo E. Effect of Bifidobacterium bifidum and Lactobacillus
acidophilus on gut mucosa and peripheral blood B lymphocytes. Immunopharmacol
Immunotoxicol. 1992;14(1-2):331-40.
Kopp-Hoolihan L. Prophylactic and therapeutic
uses of probiotics: a review.J Am Diet Assoc. 2001 Feb;101(2):229-38
Marteau P, Flourie B, Pochart P, Chastang C,
Desjeux JF, Rambaud JC. Effect of the microbial lactase (EC 3.2.1.23) activity
in yogurt on the intestinal absorption of lactose: an in vivo study in
lactase-deficient humans. Br J Nutr. 1990 Jul;64(1):71-9.
Marteau PR, de Vrese M, Cellier CJ,
Schrezenmeir J. Protection from gastrointestinal diseases with the use of
probiotics. Am J Clin Nutr. 2001 Feb;73(2 Suppl):430S- 436S.
Motta L, Blancato G, Scornavacca G, De Luca M,
Vasquez E, Gismondo MR, Lo Bue A, Chisari G. [Study on the activity of a
therapeutic bacterial combination in intestinal motility disorders in the
aged] Clin Ter. 1991 Jul 15;138(1):27-35.
Murray, M. Probiotics. In: Encyclopedia of
Nutritional Supplements. Prima Publishing, 1996, 44: 359-364.
Oksanen, P.J., et al. Prevention of travelers'
diarrhea by lactobacillus GG. Ann Med. 1990. 22(1); Feb: 53-56.
=
Vegetarian Formula
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High Gamma Tocopherol 200mg 30 softgels - Physiologics
Superior
Blend of d-Gamma Tocopherols with other Vitamin E Tocopherols
100% Natural
PRODUCT IS A SYNERGISTIC
MIXTURE OF
Vitamin E (as d-Alpha Tocopherol), d-Gamma Tocopherol, d-Delta Tocopherol,
d-Beta Tocopherol, Tocotrienols
PRODUCT DISCUSSION
As the body's premier lipid-soluble antioxidant, Vitamin E functions to
stabilize cell membranes, maintain a healthy cardiovascular system, and promote
prostate health. While Alpha Tocopherol exhibits the greatest Vitamin E
activity, Gamma Tocopherol possesses distinguishing qualities that provide
health benefits. This unique formula delivers high Gamma Tocopherol content, as
well as a blend of other Tocopherols and Tocotrienols, for a more extensive
range of antioxidant activity.*
STRUCTURE AND FUNCTION
Vitamin E is the most important lipid soluble antioxidant in the human body,
where it is incorporated into the lipid phase of cell membranes and carrier
molecules to stabilize these structures from free radicals produced by heavy
metals, pollutants, drugs and radiation. By potentially minimizing lipid
oxidation, Vitamin E helps maintain healthy stable blood vessels to support
heart health. Vitamin E is actually a collective term for a group of compounds
known as Tocopherols and Tocotrienols.
Alpha-Tocopherol is widely recognized as the best
studied, most biologically active form, but recent evidence suggests Gamma-Tocopherol
may possess distinguishing qualities in some studies. Gamma-Tocopherol appears
to provide more antioxidant support against lipophilic electrophiles than Alpha-Tocopherol.
In addition, Gamma Tocopherol modifies cyclooxygenase action to facilitate
healthy immune activity.*
INDICATIONS
For your clients who wish to supplement their diets with Vitamin E, High Gamma
Tocopherol delivers a blend of Tocopherols and Tocotrienols to provide a broad
range of antioxidant activity. Vitamin E functions to stabilize cell membranes,
maintain a healthy cardiovascular system, and promote prostate health.*
HOW CLIENTS MAY BENEFIT
Vitamin E is the body's leading lipid-soluble
antioxidant.*
Helps maintain a healthy cardiovascular
system.*
Promotes prostate health.*
Receive a blend of Tocopherols and
Tocotrienols for diverse antioxidant properties.*
SCIENTIFIC RESEARCH
In the Cambridge Heart Antioxidant Study
(CHAOS), Vitamin E was shown to significantly promote cardiovascular health
compared to a placebo. As an antioxidant, Vitamin E was shown to minimize
lipid oxidation.
One study analyzed concentrations of
antioxidant micronutrients in the blood of 10,456 male subjects. A strong
association was observed between Gamma-Tocopherol levels and prostate
health.
SUMMARY
Compounds known as Tocopherols and Tocotrienols are isomers of the essential
nutrient known as Vitamin E. While Alpha Tocopherol exhibits the greatest
Vitamin E activity, Gamma Tocopherol possesses distinguishing qualities that
provide additional health benefits. Supplementing your clients' diets with
PhysioLogics' High Gamma Tocopherol will promote their cardiovascular and
prostate health, as well as provide them with a daily source of diverse Vitamin
E antioxidants.*
SUGGESTED DOSAGE
For adults, take two (2) softgels daily, preferably with meals, or follow the
advice of your health care professional. As a reminder, discuss the supplements
and medications you take with your health care providers.
REFERENCES
Brody, T. Nutritional Biochemistry. Second ed. Academic Press. 1999.
pp.628-638.
Helzlsouer, K.J., et al. Association between
alpha-tocopherol, gamma-tocopherol, selenium and subsequent prostate cancer. J
of the Natl Can Inst. 2000. 92(24); Dec 20: 2018-2023.
Huang, H., et al. Prospective study of
antioxidant micronutrients in the blood and the risk of developing prostate
cancer. 2003. Am J Epidemiol. 157(4); Feb 15: 335-344.
Institute of Medicine. Dietary Reference
Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. National Academy
Press. 2000. pp. 186-283.
Jiang, Q., et al. Gamma-tocopherol, the major
form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr.
2001. 74: 714-722.
Meydani, M. Fat-soluble vitamins: vitamin E.
Lancet. 1995. 345; Jan: 170-175.
Moyad, M.A., et al. Vitamin E, alpha- and
gamma-tocopherol, and prostate cancer. Seminars in Urologic Oncology. 1999.
17(2): 85-90.
National Research Council. Fat-soluble
vitamins. Recommended Dietary Allowances. 10th ed. 1989. 99-107.
Pryor, W.A. Vitamin E and heart disease: basic
science to clinical intervention trials. Free Rad Biol & Med. 2000. 28(1);
141-164.
Stephens, N.G. (et. al.) Randomized controlled
trial of vitamin E in patients with coronary disease: Cambridge Heart
Antioxidant Study (CHAOS) Lancet 1996; 347(9004):781-786
Swaine, R.A. et al. Therapeutic uses of vitamin
E in prevention of atherosclerosis. Altern Med Rev. 1999. 4(6); Dec: 414-423.
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Licorice GI 100 vtabs - Physiologics
Deglycyrrhizinated
Licorice Extract
Deglcyrrhizinated Licorice Extract in a
chewable vegetarian formula.
= Vegetarian Formula
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PTE Support 90 capsules - Physiologics
Supports
the Body's Immune System*
HOW PATIENTS MAY BENEFIT
Supports respiratory and digestive systems.*
Favorably modulates prostaglandin formation.*
PRODUCT DISCUSSION
PhysioLogics PTE Support™ is a scientifically-formulated supplement to support
digestion and absorption of proteins, as well as provide the body with
immune-modulating and respiratory support.* Each serving of PhysioLogics PTE
Support™ is standardized to provide 1200 Gelatin Digesting Units from 500 mg
of Bromelain (derived from pineapple) to ensure protein-digesting quality.*
Ingredients can be absorbed into the bloodstream, providing more than just
digestive support.* PTE Support™ can be used by clients who may be increasing
protein intake and need extra digestive support, or who need support of the
sinus and respiratory systems for ear, nose and throat health.*
STRUCTURE AND FUNCTION
Bromelain is a general name for a family of proteolytic enzymes obtained from
pineapple (Ananas comosus). Proteolytic enzymes help break down dietary proteins
in the digestive tract, as well as unwanted protein compounds in the
bloodstream. Bromelain's primary component is a sulfhydryl proteolytic fraction,
but bromelain also contains peroxidase, acid phosphatase, protease inhibitors,
and organic calcium.
Bromelain serves to modulate the coagulation
system by several methods. It decreases the production of Prekallikein, thereby
decreasing the production of High Molecular Weight Kinin (HMWK), and
subsequently Bradykinin. It decreases the production of Factor X, prothrombin
(II), and activates the conversion of plasminogen to plasmin. Bromelain has also
been shown to modulate the synthesis of thromboxanes and prostacyclins.
Serratiopeptidase (also known as serrapeptase) is
a proteolytic enzyme that can be absorbed into the blood to provide its
beneficial effects. It is found in nature as the enzyme produced by silkworms to
digest their cocoons. The capacity of serratiopeptidase to dissolve protein
selectively without affecting normal function makes it a great agent for a broad
spectrum of health benefits. This can be important when the body has undergone
physical stress, by helping to reduce unwanted protein compounds that can
otherwise slow recovery.*
Serratiopeptidase enzyme supports the sinus and
respiratory systems to promote ear, nose and throat health.* It seems to work by
amending the elasticity and viscosity of naturally produced mucus, without
causing mucus depletion. Serratiopeptidase has been used in Europe and Japan for
over 25 years for its health benefits.*
Bromelain and Serratiopeptides are proteolytic
enzymes that effect cellular immune functions and enhance healthy cell growth.*
CLINICAL EVIDENCE
In an open label trial, 77 subjects were given
either 200 mg or 400 mg of Bromelain every day for three months. Results
found that the group receiving 400 mg Bromelain had improved knee joint
comfort and function compared to the 200 mg group. Bromelain's positive
effect on the immune response most likely contributed to the improved
benefits. PTE Support provides 500 mg Bromelain per serving. (Walker, 2002)
Researchers from the University of Naples in
Italy conducted a multicenter, randomized, double blind study to determine
the effects of 30 mg of Serratiopeptidase on 193 subjects. Statistical
analysis revealed significant support of respiratory health in subjects
given Serratiopeptidase as compared to the placebo. (Mazzone, 1990)
In an open labeled trial researchers examined
29 subjects who received either 30 mg/day of serrapeptase or a placebo.
After 4 weeks, the group receiving serrapeptase experienced a significant
improvement in respiratory function. There was no significant change in the
control group. This study indicates that serrapeptase supports respiratory
health. (Nakamura et al, 2003)
SUMMARY
Bromelain has been clinically used in a variety of applications for more than 35
years. It has positive effects on coagulation, the kinin system, cytokine, and
prostaglandin synthesis. Bromelain also supports digestion of dietary proteins
while supporting a healthy immune response throughout the body.*
Serratiopeptidase Enzyme supports the sinus and respiratory systems to promote
ear, nose and throat health.*
SUGGESTED DOSAGE
For adults, take one (1) to two (2) capsules three times daily on an empty
stomach (1 hour before or 3 hours after a meal) or follow the advice of your
healthcare professional.
REFERENCES
Felton GE. Fibrinolytic and antithrombotic action of bromelain may eliminate
thrombosis in heart patients. Med Hypotheses. 1980;6:1123-33
Heinicke RM, et al. Effect of bromelain (Ananase)
on human platelet aggregation. Experientia. 1972;28:844-5
Livio M, et al. Effect of bromelain on
fibrinogen level, prothrombin complex factors and platelet aggregation in the
rat- A preliminary report. Drugs Expt Clin Res. 1978;4:49-53
Masson M. Bromelain in blunt injuries of the
locomotor system. A study of observed applications in general practice.
Fortschr Med. 1995;113:303-6
Mazzone A. Evaluation of serratia peptidase in
acute or chronic inflammation of otorhinolaryngology pathology: A multicentre,
double-blind, randomized trial versus placebo. J Int Med Res. 1990;18:379-288
Nakamura S, et al. Effect of the proteolytic
enzyme serrapeptase in patients with chronic airway disease. Respirology.
2003;8:316-20
Schafer AI, Adelman B. Plasmin inhibition of
platelet function and of arachidonic acid metabolism. J Clin Invest.
1985;75:456-61
Tachibana M, et al. A multi-centre,
double-blind study of serrapeptase versus placebo in post-antrotomy buccal
swelling. Pharmatherapeutica. 1984;3:526-30
Taussig SJ, Batkin S. Bromelain, the enzyme
complex of pineapple (Ananas comosus) and its clinical application. An update.
J Ethnopharmacol. 1988;22:91-203
Uhlig G, Seifert J. The effect of proteolytic
enzymes (traumanase) on posttraumatic edema. Fortschr Med. 1981;99:554-6
Walker A. Bromelain reduces mild acute knee
pain and improves well-being in a dose-dependent fashion in a open study of
otherwise healthy adults. Phytomedicine. 2002;9:681-6. |
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Zygest 180 Caps - Physiologics
Our
Best-Selling Formula for Proper Digestion*
For Enzymatic Digestion of Carbohydrates, Proteins & Fats*
PRODUCT IS A
SYNERGISTIC MIXTURE OF
Bromelain (from Pineapple), Papain (from Papaya Fruit), Protease 3.0 (from
Aspergillus niger), Amylase (from Aspergillus oryzae), Lipase (from
Aspergillus niger), Protease 4.5 (Aspergillus oryzae), Lactase (from
Aspergillus oryzae), Cellulase (from Trichoderma longibrachiatum),
Hemicellulase (from Aspergillus niger)
PRODUCT DISCUSSION
Zygest® is a registered dietary supplement with the United States Patent and
Trademark office. This specialized formulation contains a broad spectrum of
protein, carbohydrate, and fat-digesting enzymes to promote digestion of
nutrients. Zygest® is designed to offer support at various levels including
digestion occurring in the fundus and antrum of the gastric region, as well as
digestion taking place in the duodenum and other areas of the small intestine.
Enzymes are formulated to reflect activity levels as certified by a Quality
Control specialist, utilizing standards set through the Food and Chemical
Codex (FCC).*
STRUCTURE AND FUNCTION
Zygest® contains multiple enzymes designed to serve as biological catalysts
for the breakdown of macronutrients.*
Amylase is an enzyme that is naturally secreted
by pancreatic cells in-vivo. Release of this enzyme is stimulated by
carbohydrate containing foods. Once released, amylase can biochemically react
with digestion products such as starches and glycogen to form di- and
trisaccharides through hydrolysis. The amylase within Zygest® is certified in
dextrinizing units, which is defined as the quantity of alpha-amylase that
will dextrinize soluble starch in the presence of excess beta-amylase.*
Protease is an enzyme designed to assist in
protein digestion. Protein digestion begins in the gastric region when
splitting occurs at nitrogen bonds to form products such as proteoses,
peptones, and large polypeptides. Digestion continues with pancreatic enzymes
of the upper small intestine and with the epithelial cells of the small
intestinal wall. Zygest® contains Proteases standardized through both
Hemoglobin Unit of Tyrosine Basis (HUT's) and Spectrophotometric Acid Protease
Units (SAPU's), two different measures of protein digestion.*
Lipase is another naturally occurring enzyme
which helps digest fat, and can be found in-vivo in the pancreas and
epithelial cells of the small intestine. Fat digestion is a multi-level
process which includes emulsification to decrease the interfacial tension of
the fat globule surface. Once this is achieved, enzymes such as lipase can
then help split fat into monoglycerides and fatty acids. Zygest® contains
Lipase which is certified through Lipase Units, which is based on digestion of
a standard olive oil substrate.*
Lactase is a specialized enzyme designed to
split lactose disaccharides into glucose and galactose monosaccharides.
Lactase is naturally found in the microvilli of the brush border of the
epithelial cells. Once lactose digestion occurs, glucose and galactose are
immediately absorbed into the portal blood. The lactase in Zygest® is
certified through Acid Lactase Units (ALU's), which is a measure of its
ability to liberate o-nitrophenol per conditions of the assay.*
Both Bromelain and Papain are added for their
protein digestibility scores. Each is certified through Papain Units as
defined by the FCC. Papain Units measure tyrosine liberation per hour under
the specific conditions of the assay.*
Cellulase and Hemicellulase round out the
Zygest® formula. Cellulase is certified through Cellulase Units, which
measure the quantity of enzyme required to produce a relative fluidity change
of 1 in 5 minutes of a standard cellulose solution. Hemicellulase is certified
through Hemicellulase Units per FCC regulations, which is the amount of enzyme
required that will produce a relative fluidity change of 1 over a period of 5
minutes in a locust bean gum substrate under specific assay conditions.*
INDICATIONS
For clients seeking a premier digestive enzyme supplement that contains a
broad-spectrum of enzymes and activity, Zygest® is an excellent choice.*
Zygest® can be orally administered regardless of the meal composition or
nutritional plan, due to its diverse enzyme preparation.
HOW CLIENTS MAY
BENEFIT
Utilizing a form of digestive enzymes
studied in scientific gastrointestinal models and certified through FCC
standards.*
Formulated to provide gastric support for
all types of nutritional plans, whether they are low or high carbohydrate,
fat and protein.*
Multi-level support by supplying 10 distinct
digestive enzymes.*
All enzymes formulated from vegetarian
sources.*
A second digestion study was conducted by the
same research group, this time using a model that simulated conditions when
digestion would be significantly reduced. Results found that adding
digestive enzymes promoted digestion of carbohydrates and proteins compared
to digestion without enzymes. These results were obtained through samples
taken at the level of the jejunum and ileum. Based on the results of both
studies, the researchers concluded that enzymes from the National Enzyme
Company (suppliers of Zygest®) can be used to support digestion.
CLINICAL EVIDENCE
A digestion study was conducted by The Netherlands Organisation for Applied
Scientific Research. The experimental protocol was conducted with a computer
controlled dynamic gastrointestinal model (TIM). TIM is a patented technology
designed to stimulate the conditions of the human stomach and small intestine
and allows for sampling at various stages to obtain real time data. Results
found that adding digestive enzymes, as found in Zygest®, promoted digestion
of carbohydrates as compared to digestion without additional digestive
enzymes. Results also found that digestion of proteins in the ileum was
positively supported as compared to digestion without added enzymes.
SUMMARY
Zygest® is a specialized blend of digestive enzymes that can be easily
incorporated into multiple types of nutritional plans. The enzyme blend is
processed through the National Enzyme Company, which is the leader in
nutritional enzyme technology. All the digestive enzymes are labeled according
to activity units as opposed to mg amounts, and are certified by a Quality
Control specialist based on the regulations set forth in the Food and Chemical
Codex.*
SUGGESTED DOSAGE
Take one (1) to two (2) capsules up to three times daily with meals or follow
the advice of your health care professional. As a reminder, discuss the
supplements and medications you take with your health care providers.
REFERENCES
Balakrishnan, V., et al. Double-blind cross-over trial of an enzyme
preparation in pancreatic steatorrhoea. J Assoc Phys Ind. 1981. 29; Mar:
207-209.
Duskova, M., et al. Orally administered
proteases in aesthetic surgery. Aesthetic Plastic Surg. 1999. 23(1);
Jan-Feb: 41-44.
Eckert, K., et al. Effects of oral bromelain
administration on the impaired immunocytotoxicity of mononuclear cells from
mammary patients. Oncol Rep. 1999. 6(6); Nov/Dec: 1191-1199.
Havenaar, R. et al. Simulated assimilation.
Dairy Industries International. 1996. 61(9): 17-23
Krul, C. et al. Metabolism of sinigrin by the
human colonic microflora in a dynamic in vitro large-intestinal model.
Carcinogenesis. 2002. 23: 1009-1016.
Marteau, P. et al. Survival of lactic acid
bacteria in a dynamic model of the stomach and small intestine: Validation
and the effects of bile. Jrnl Dairy Sci. 1997. 80: 1031-1037
Medhekar, R. The first quantitative evidence
proving the efficacy of supplemental enzymes. TNO Nutrition and Food
Research. 2004.
Minekus, M. Development and validation of a
dynamic model of the gastrointestinal tract. PhD Thesis, University of
Utrecht. Netherlands. 1998.
Minekus, M. et al. A multi compartmental
dynamic computercontrolled model simulating the stomach and small intestine.
Alternatives to Laboratory Animals. 1995. 23:197-209.
Minekus, M. In vitro model of an in vivo
digestive tract. US Patent 5,525,305. 1996.
Venema, K. et al. TNO's in vitro large
intestinal model: an excellent screening tool for functional food and
pharmaceutical research. ErnahrungfNutrition. 2000. 24(12): 558-564.
Zeijdner, E. The fate of orally administrated
compounds during passage through the GI tract simulated in a dynamic in
vitro model (TIM). European pharmaceutical Contractor. Feb. 76-81.
Zeijnder, E. et al. Latest tool for screening
new clinical foods. A dynamic, computer-controlled model of the human
gastrointestinal tract is the most up to date technology for testing new
foods. New World Health. 1999/2000. 105.a
= Vegetarian Formula
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Blue Green Algae 500mg 90 capsules - Physiologics
Klamath
Lake Algae - Aphanizomenon flos-aquae
Blue green algae is a valuable source of many of
the nutrients that people may not get from their everyday diets.* It is one of
the most chlorophyll-rich organisms on the planet, and is unique because it
possesses characteristics of the plant and animal kingdoms.*
Delivers a range of vitamins, minerals, and
all eight essential amino acids*
Furnishes the highest concentration of
chlorophyll of any food source*
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Malic Acid+ 375mg 90 capsules - Physiologics
Supports
Muscle Health*
This formula combines malic acid, coenzyme Q10,
magnesium and potassium - nutrients that can help promote cellular energy
levels.*
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Thyroid Support Formula 60 capsules - Physiologics
Supports
Thyroid Function*
PRODUCT DISCUSSION
PhysioLogics Thyroid Support Formula® supports the thyroid gland by providing
Iodine, an essential component of thyroid hormones.* L-Tyrosine supports
synthesis of the thyroid hormones thyroxine and triiodothyronine.* In addition,
this formula delivers a unique blend of nutrients including Riboflavin, Niacin
and Vitamin B-6 to help support proper metabolic functioning, energy metabolism
and healthy skin and hair.*
STRUCTURE AND FUNCTION
Iodine is an essential component of the thyroid hormone and is therefore
essential for supporting thyroid function.* To meet the body's demand for
thyroid hormones, the thyroid gland traps iodine from the blood and incorporates
it into thyroid hormones that are stored and released into the circulation when
required.* Tyrosine is an important amino acid that forms part of the structure
of almost all proteins in the body.* The body uses Tyrosine to help synthesize
the thyroid hormones thyroxine and triiodothyronine.* B-vitamins are water
soluble and may need regular replenishment. Riboflavin and Niacin are two
B-vitamins that help support proper metabolic functioning and energy
metabolism.*
CLINICAL EVIDENCE
A cross-sectional study conducted in Denmark
examined the effect of mandatory iodization of salt on the structure and
function of the thyroid. This fortification was estimated to increase median
iodine intake to 150 mcg/day. After four years, the population studied
exhibited significant overall improvement in thyroid structure and function.
(Vejbjerg et al, 2007)
This review stated that the synthesis of
thyroid hormone requires the presence of Iodine and the amino acid
L-Tyrosine, both of which are present in PhysioLogics Thyroid Support
Formula®. (Kirsten, 2000)
SUMMARY
PhysioLogics Thyroid Support Formula® supplies several important nutrients that
support thyroid function.
SUGGESTED DOSAGE
For adults, take three (3) tablets daily, preferably with a meal, or follow the
advice of a health care professional.
REFERENCES
Kirsten D. The thyroid gland: Physiology and pathophysiology. Neonatal Netw.
2000;19:11-26. Thyroid Support Formula®
Vejbjerg P, Knudsen N, Perrild H, et al. Effect
of a mandatory iodization program on thyroid gland volume based on
individuals' age, gender, and preceding severity of dietary iodine deficiency:
A prospective, populationbased study. J Clin Endocrin Metab.
2007;92:1397-1401.
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MacuCare 60 capsules - Physiologics
Antioxidant
Protection For The Eyes*
PRODUCT DISCUSSION
The macula of the eye contains carotenoid pigments and is responsible for
supporting the health of the eye's photoreceptor cell layer. Free radicals are
unstable compounds that can occur naturally in the body. They can contribute to
oxidative stress, which in turn may contribute to the premature aging of the
cells, including those in the macula. PhysioLogics MacuCare® combines powerful
antioxidants for promoting macular health.*
STRUCTURE AND FUNCTION
The carotenoid Lutein is a yellow pigment that provides color in marigolds. The
yellow color of this macular carotenoid is crucial for the absorption of blue
light. Blue light contains a shorter wavelength in the visual spectrum,
delivering high energy to photosensitizers in the eye. Most carotenoids are
commonly found in membranes, and some may only efficiently scavenge free
radicals generated in the inner membrane. Lutein contains hydroxyl groups that
interact with the polar head groups of phospholipids, locking the molecules in a
position that spans the membrane. This property allows Lutein to react with free
radicals generated in both aqueous and membrane phases, broadening its
antioxidant capabilities.*
Alpha-lipoic acid (LA), also known as thioctic
acid, is a naturally occurring compound that is synthesized in small amounts by
plants and animals, including humans. It is endogenously synthesized and
covalently bound to specific proteins, which function as cofactors for several
important mitochondrial enzyme complexes. It supports the regeneration of
glutathione, one of body's primary antioxidants.
Taurine is the one of the most abundant free
amino acids in cardiac and skeletal muscle, platelets, and the developing
central nervous system. L-Taurine can also be found in the brain, retina of the
eyes, and skeleton.
CLINICAL EVIDENCE
A multi-center case-control study examined the
effect of dietary carotenoids and vitamins on eye health. Lutein was among
the carotenoids that were most strongly associated with macular support.
(Age-Related Eye Disease Study Research Group, 2007)
Lutein has been shown to be beneficial to
long-term visual health. Seventeen participants were randomized in a
double-blind study involving dietary supplementation with Lutein (15 mg),
alpha-tocopherol (100 mg), or placebo, three times a week for up to two
years. Visual performance, acuity and glare sensitivity were measured as
parameters of vision health. In all parameters measured, subjects who
consumed Lutein had significant improvements in vision health when compared
to the other groups. (Olmedilla et al, 2003)
SUMMARY
PhysioLogics MacuCare® combines the powerful antioxidant Lutein with Alpha-Lipoic
Acid and the amino acid Taurine for promoting macular health.*
SUGGESTED DOSAGE
Take one (1) capsule one to two times daily with meals, or follow the advice of
a health care professional.
REFERENCES
Age-Related Eye Disease Study Research Group, SanGiovanni JP, Chew EY, Clemons
TE, et al. The relationship of dietary carotenoid and vitamin A, E, and C
intake with agerelated macular degeneration in a case-control study: AREDS
Report No. 22. Arch Ophthalmol. 2007;125:1225-32.
Olmedilla B, Granado F, Blanco I, Vaquero M.
Lutein, but not alpha-tocopherol, supplementation improves visual function in
patients with age-related cataracts: a 2-y double-blind, placebo-controlled
pilot study. Nutrition. 2003;19:21-4. MacuCare®.
Seddon JM, et al. Dietary carotenoids, vitamins
A, C, and E, and advanced age-related macular degeneration. JAMA.
1994;272:1413-21.
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Ocular Defense Plus with Lutein 100 caps - Physiologics
Helps
Maintain Healthy Eye Function*
PRODUCT DISCUSSION
PhysioLogics Ocular Defense Plus delivers an extraordinary combination of
nutrients, including Lutein, Riboflavin, and Beta-Carotene for comprehensive
support of eye function and antioxidants Vitamins C, Vitamin E and Selenium for
oxidative support.*
STRUCTURE AND FUNCTION
Lutein, a yellow pigment that provides color in marigolds, is one of the most
abundant carotenoids found in the macula and supports eye health.* As an
antioxidant, Lutein serves as singlet-oxygen quencher, helping to minimize free
radical damage generated by the exposure of the eye lens to oxygen and light.*
The yellow color of macular carotenoids is crucial for the absorption of high
energy blue light. Lutein contains hydroxyl groups that interact with the polar
head groups of phospholipids, locking the molecules in a position that spans the
eye membrane and allowing it to react with free radicals generated in both
aqueous and membrane phases, thus broadening its antioxidant capabilities.*
Bilberry contains over 15 different naturally-occurring
anthocyanosides, which are phenolic compounds with beneficial effects.* The body
converts Beta-Carotene to Vitamin A, a nutrient that helps maintain the health
of the eyes and is essential for good vision.* The wide variety of antioxidants
in this product, including Vitamin C, Vitamin E, and Selenium, fight the
cell-damaging free radicals that can lead to oxidative stress.* The B Vitamin
Riboflavin helps support normal vision.*
CLINICAL EVIDENCE
Lutein has been shown to be beneficial to long-term visual
health. Seventeen participants were randomized in a double-blind study
involving dietary supplementation with Lutein (15 mg), alpha-tocopherol (100
mg), or placebo, three times a week for up to two years. Visual performance,
acuity and glare sensitivity were measured as parameters of vision health.
In all parameters measured, subjects who consumed the Lutein had significant
improvements in vision health when compared to the other groups. (Olmedilla
et al, 2003)
In a cross-sectional study conducted in India, 1,112
subjects underwent eye examinations plus evaluations for blood levels of
antioxidants. A significant inverse association was found between decline in
eye health and blood levels of lutein, vitamin C, and beta-carotene. This
study supports the use of Ocular Defense Plus, which contains these three
nutrients, for the maintenance of healthy eye function. (Dherani et al,
2008)
SUMMARY
PhysioLogics Ocular Defense Plus combines several antioxidants with key
nutrients that are associated with eye health.*
SUGGESTED DOSAGE
For adults, take four (4) capsules daily, preferably with meals or follow the
advice of a health care professional.
REFERENCES
Dherani M, Murthy GV, Gupta SK, et al. Blood levels of vitamin C, carotenoids
and retinol are inversely associated with cataract in a North Indian
population. Invest Opthalmol Vis Sci. 2008;49:3328-35.
Olmedilla B, Granado F, Blanco I, Vaquero M. Lutein, but not
alpha-tocopherol, supplementation improves visual function in patients with
age-related cataracts: a 2-y double-blind, placebo-controlled pilot study.
Nutrition. 2003;19:21-4.
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Cranberry+ 120 softgels - Physiologics
Supports
Urinary Health*
Cranberries contain the nutritional benefit of
proanthocyanidins (condensed tannins), and cranberries are known for their
ability to support urinary health.* Cranberry concentrate also contains vitamin
C, an antioxidant vitamin that plays a role in supporting immune function.* This
combination provides powerful documented support for the urinary tract and
bladder.
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Shark Cartilage 740mg 100 capsules - Physiologics
From
Pure Shark Cartilage
The pure, freeze-dried shark cartilage contained
in this product is a natural source of chondroitin sulfate, which is a key
structural component in human cartilage.*
Contains high levels of mucopolysaccharides,
such as chondroitin sulfate
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L-Lysine 500mg 90 vcaps - Physiologics
Supports
Healthy Skin & Lips*
PRODUCT DISCUSSION
PhysioLogics L-Lysine provides this essential amino acid, one of nine amino
acids that cannot be made by the body.
STRUCTURE AND FUNCTION
Amino acids are the building blocks of protein, and protein helps construct
and maintain the critical structures in the body. L-Lysine is an essential
amino acid that is used for the production of collagen and tissue maintenance
in the skin.* It also plays an important role in supporting immune system
function.*
CLINICAL EVIDENCE
Lysine has been shown to play a role in collagen crosslinking. The
enzymatic hydroxylation of lysine residues in collagen protein is required
for the stabilization and orderly formation of collagen in the body, a
necessary step in the formation of healthy connective tissue. (Robins,
2008)
A review article reports favorable results from studies examining the
effect of lysine supplementation on skin health. Proposed mechanisms by
which lysine may help support skin health are increasing the lysine/arginine
ratio in the body or possibly increasing immune response by improving
protein nutrition. (Flodin, 1997)
SUMMARY
PhysioLogics L-Lysine supplies this essential amino acid that is important for
collagen and skin health.*
SUGGESTED DOSAGE
For adults, take one (1) capsule two times daily or follow the advice of a
health care professional.
REFERENCES
Flodin NW. The metabolic roles, pharmacology, and toxicology of lysine. J Am
Coll Nutr. 1997;16:7-21.
Robins SP. Biochemistry and functional significance of collagen
cross-linking. Biochem Soc Trans. 2007;35:849-52.
= Vegetarian Formula
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CTR Support 90 capsules - Physiologics
A
Traditional Herbal Blend with Antioxidant Protection for Joints*
PRODUCT DISCUSSION
CTR Support™ combines a blend of traditional herbs, including Turmeric,
Boswellia, Devil's Claw, Ginger and Yucca, along with Bromelain and Quercetin.
This unique formula is designed to maximize the body's ability to maintain the
everyday health of joints and connective tissue.*
STRUCTURE AND FUNCTION
Turmeric, an herb used for centuries in Ayurvedic medicine, has been the subject
of many research studies. Curcumin, thought to be one of turmeric's most active
constituents, has been found in in vitro studies to reduce arachidonic acid
release from phospholipids by reducing the activity of phospholipase A2, as well
as to inhibit cycloxygenase-2 (COX-2) expression, macrophage production of
nitric oxide, and TNFa's activation of nuclear factor kappa-beta (NF-kB).*
Boswellic acids are pentacyclic triterpenes
thought to be the active ingredients of Boswellia serrata gum resin, a
traditional herb of the Ayurvedic pharmacopoeia. Boswellic acids have been found
to inhibit the 5-lipoxygenase (5-LOX) enzyme in vitro, thereby inhibiting the
synthesis of leukotrienes from arachidonic acid.* In vitro research has also
suggested that boswellia's beneficial effects are a result of its ability to
prevent the expression of VCAM-1 and ICAM-1 induced by TNFa.* Boswellia has not
been found to lead to a disturbance in glycosaminoglycan synthesis.*
Bromelain is the name given to a group of
proteolytic (proteindigesting) enzymes, derived from the stem and fruit of
pineapple. Bromelain administration in experimental animals has been found to
interfere with the arachidonic acid cascade as well as to lead to significant
reductions in concentrations of 2-series prostaglandins.* Animal research has
also found that it may not only cause reductions of substance P but also inhibit
bradykinin release; both of these molecules are chemical mediators which can
affect well-being.*
Ginger has a long history of use in both
Ayurvedic and Asian systems for health and well-being.* It naturally contains a
matrix of active constituents including gingerols, betacarotene, capsaicin,
curcumin and salicylate. In in vitro research, ginger has been found to reduce
biosynthesis of leukotrienes, nitric oxide and 2-series prostaglandins, the
latter which has also been found in a study with animals.* Ginger's unique
actions are suggested to be a reflection of it being an inhibitor of both COX
and LOX enzymes.*
Devil's claw is an herb that is native to
Southern Africa. Both the whole herb and one of its major constituents, the
iridoid harpagoside, have been studied in in vitro and animal research for their
beneficial actions.* Their ability to reduce cytokine production includes the
inhibition of NF-kB activation and its subsequent inducible expression of COX-2
and nitric oxide.*
Quercetin belongs to the flavonol family of
flavonoid phytonutrient. Not only does quercetin have strong antioxidant
activity, but results from in vitro studies suggest that it may also prevent
mast cell degranulation, reduce leukotriene synthesis, and inhibit the activity
of the NF-kB pathway; the latter mechanism may in turn decrease nitric oxide
synthase expression.*
Yucca is a plant native to the Southwestern
United States and Mexico. Yucca contains saponins as well as unique phenolics
known as yuccaols, which have been found to have significant antioxidant
activity.* Recently, researchers have identified the presence of resveratrol, as
well as resveratrol-like stilbenes, in yucca. Resveratrol is the phytonutrient
present in red wine that has been attributed with many of its health-promoting
benefits; among its other numerous actions suggested by in vitro studies,
resveratrol has been found to inhibit NF-kB activation and nitric oxide.*
INDICATIONS
CTR Support™ addresses the needs of clients looking for a natural approach to
promoting the overall health of their connective tissue and joints.* It features
a blend of botanicals and health-supportive nutrients found to reduce the
production of cytokines and eicosanoids such as prostaglandins, leukotrienes and
nitric oxide in in vitro research.* The ingredients in CTR Support™ also
provide antioxidant protection against the damaging effects of free radicals.*
HOW CLIENTS MAY BENEFIT
Supports the structure and function of
connective tissues and joints*
Reduces the generation of eicosanoids and
cytokines in in vitro studies*
Targets enzyme pathways of COX and LOX enzymes
during in vitro analysis*
Offers antioxidant protection against free
oxygen radicals*
SCIENTIFIC RESEARCH
In a double-blind, crossover study published by Deodhar et al. (1980),
administration of 1200 mg of curcumin for 2 weeks was found to improve morning
joint comfort and walking time in individuals with joint concerns. One serving
of CTR Support contains 750 mg of turmeric standardized to contain 713 mg of
curcuminoids.
A double-blind, crossover trial performed by
Kimmatkar et al. (2003) found improvements in joint comfort as well as an
increase in knee flexion and walking distance in participants who received 999
mg per day of boswellia for 8 weeks. One serving of CTR Support contains 500 mg
of boswellia. In an open, non-placebo controlled trial of healthy adults with
recently developed, mild joint concerns, Walker et al. (2002) found that those
receiving either 200 or 400 mg per day of bromelain for 30 days reported
improvements in joint comfort. One serving of CTR Support contains 250
milligrams of Bromelain.
The results of a double-blind, placebo
controlled, crossover study by Wigler et al. (2003) found that individuals
receiving 1000 mg per day of ginger extract for 60 days had improvements in
joint comfort on movement measured by a visual analog scale. One serving of CTR
Support contains 100 milligrams of ginger.
SUMMARY
The botanicals and nutrients included in CTR Support™ promote overall
connective tissue and joint health through various mechanisms.* Its botanical
and nutritional ingredients have been found to inhibit the generation of
numerous eicosanoids and cytokines when tested in-vitro.* Since it may inhibit
not only COX enzymes, but LOX enzymes as well, CTR Support™ may offer unique
benefits.*
SUGGESTED DOSAGE
Take two (2) to three (3) capsules daily, preferably on an empty stomach, or
follow the advice of your health care professional. As a reminder, discuss the
supplements and medications you take with your health care providers.
REFERENCES
Altman RD, Marcussen KC. Effects of a ginger extract on knee pain in patients
with osteoarthritis. Arthritis Rheum. 2001 Nov;44(11):2531-8.
Ammon HP, Safayhi H, Mack T, Sabieraj J.
Mechanism of antiinflammatory actions of curcumine and boswellic acids. J
Ethnopharmacol. 1993 Mar;38(2-3):113-9.
Andersen ML, Santos EH, Seabra Mde L, da Silva
AA, Tufik S. Evaluation of acute and chronic treatments with Harpagophytum
procumbens on Freund's adjuvant-induced arthritis in rats. J Ethnopharmacol.
2004 Apr;91(2-3):325-30.
Banerjee M, Tripathi LM, Srivastava VM, Puri A,
Shukla R. Modulation of inflammatory mediators by ibuprofen and curcumin
treatment during chronic inflammation in rat. Immunopharmacol Immunotoxicol.
2003 May;25(2):213-24.
Basch E, Boon H, Davies-Heerema T, Foppo I,
Hashmi S, Hasskarl J, Sollars D, Ulbricht C. Boswellia: an evidence-based
systematic review by the Natural Standard Research Collaboration. J Herb
Pharmacother. 2004;4(3):63-83.
Bingham R, Bellew BA, Bellew JG. Yucca plant
saponin in the management of arthritis. J Appl Nutr 1975;27:45-50.
Chainani-Wu N. Safety and anti-inflammatory
activity of curcumin: a component of tumeric (Curcuma longa). J Altern
Complement Med. 2003 Feb;9(1):161-8.
Comalada M, Camuesco D, Sierra S, Ballester I,
Xaus J, Galvez J, Zarzuelo A. In vivo quercitrin antiinflammatory effect
involves release of quercetin, which inhibits inflammation through
down-regulation of the NF-kappaB pathway. Eur J Immunol. 2005
Feb;35(2):584-92.
Deodhar SD, Sethi R, Srimal RC. Preliminary
study on antirheumatic activity of curcumin (diferuloyl methane). Indian J Med
Res. 1980 Apr;71:632-4.
Formica JV, Regelson W. Review of the biology
of Quercetin and related bioflavonoids. Food Chem Toxicol. 1995
Dec;33(12):1061-80.
Gagnier JJ, Chrubasik S, Manheimer E.
Harpgophytum procumbens for osteoarthritis and low back pain: a systematic
review. BMC Complement Altern Med. 2004 Sep 15;4:13.
Gaspani L, Limiroli E, Ferrario P, Bianchi M.
In vivo and in vitro effects of bromelain on PGE(2) and SP concentrations in
the inflammatory exudate in rats. Pharmacology. 2002 May;65(2):83-6.
Grzanna R, Lindmark L, Frondoza CG. Ginger - an
herbal medicinal product with broad anti-inflammatory actions. J Med Food.
2005 Summer;8(2):125-32.
Guardia T, Rotelli AE, Juarez AO, Pelzer LE.
Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin
and hesperidin on adjuvant arthritis in rat. Farmaco. 2001 Sep;56(9):683-7.
Huang TH, Tran VH, Duke RK, Tan S, Chrubasik S,
Roufogalis BD, Duke CC. Harpagoside suppresses lipopolysaccharide-induced iNOS
and COX-2 expression through inhibition of NF-kappaB activation. J
Ethnopharmacol. 2005 Sep 30; [Epub ahead of print]
Kimmatkar N, Thawani V, Hingorani L, Khiyani R.
Efficacy and tolerability of Boswellia serrata extract in treatment of
osteoarthritis of knee--a randomized double blind placebo controlled trial.
Phytomedicine. 2003 Jan;10(1):3-7.
Kumakura S, Yamashita M, Tsurufuji S. Effect of
bromelain on kaolin-induced inflammation in rats. Eur J Pharmacol. 1988 Jun
10;150(3):295-301.
Marzocco S, Piacente S, Pizza C, Oleszek W,
Stochmal A, Pinto A, Sorrentino R, Autore G. Inhibition of inducible nitric
oxide synthase expression by yuccaol C from Yucca schidigera roezl. Life Sci.
2004 Aug 6;75(12):1491-501.
Piacente S, Montoro P, Oleszek W, Pizza C.
Yucca schidigera bark: phenolic constituents and antioxidant activity. J Nat
Prod. 2004 May;67(5):882-5.
Reddy GK, Chandrakasan G, Dhar SC. Studies on
the metabolism of glycosaminoglycans under the influence of new herbal
anti-inflammatory agents. Biochem Pharmacol. 1989 Oct 15;38(20):3527-34.
Roy S, Khanna S, Shah H, Rink C, Phillips C,
Preuss H, Subbaraju GV, Trimurtulu G, Krishnaraju AV, Bagchi M, Bagchi D, Sen
CK. Human genome screen to identify the genetic basis of the anti-inflammatory
effects of Boswellia in microvascular endothelial cells. DNA Cell Biol. 2005
Apr;24(4):244-55.
Sato M, Miyazaki T, Kambe F, Maeda K, Seo H.
Quercetin, a bioflavonoid, inhibits the induction of interleukin 8 and
monocyte chemoattractant protein-1 expression by tumor necrosis factor-alpha
in cultured human synovial cells. J Rheumatol. 1997 Sep;24(9):1680-4.
Setty AR, Sigal LH. Herbal medications commonly
used in the practice of rheumatology: mechanisms of action, efficacy, and side
effects. Semin Arthritis Rheum. 2005 Jun;34(6):773-84.
Shen CL, Hong KJ, Kim SW. Comparative effects
of ginger root (Zingiber officinale Rosc.) on the production of inflammatory
mediators in normal and osteoarthrotic sow chondrocytes. J Med Food. 2005
Summer;8(2):149-53.
Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, Park
KK, Lee SS. Molecular mechanisms underlying chemopreventive activities of
anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through
suppression of NF-kappa B activation. Mutat Res. 2001 Sep 1;480-481:243-68.
Thomson M, Al-Qattan KK, Al-Sawan SM, Alnaqeeb
MA, Khan I, Ali M. The use of ginger (Zingiber officinale Rosc.) as a
potential anti-inflammatory and antithrombotic agent. Prostaglandins Leukot
Essent Fatty Acids. 2002 Dec;67(6):475-8.
Tsai SH, Lin-Shiau SY, Lin JK. Suppression of
nitric oxide synthase and the down-regulation of the activation of NFkappaB in
macrophages by resveratrol. Br J Pharmacol. 1999 Feb;126(3):673-80.
Vellini M, Desideri D, Milanese A, Omini C,
Daffonchio L, Hernandez A, Brunelli G. Possible involvement of eicosanoids in
the pharmacological action of bromelain. Arzneimittelforschung.
1986;36(1):110-2.
Walker AF, Bundy R, Hicks SM, Middleton RW.
Bromelain reduces mild acute knee pain and improves well-being in a
dose-dependent fashion in an open study of otherwise healthy adults.
Phytomedicine. 2002 Dec;9(8):681-6.
Wallace JM. Nutritional and botanical
modulation of the inflammatory cascade-eicosanoids, cyclooxygenases, and
lipoxygenases - as an adjunct in cancer therapy. Integr Cancer Ther. 2002
Mar;1(1):7-37; discussion 37.
Wigler I, Grotto I, Caspi D, Yaron M. The
effects of Zintona EC (a ginger extract) on symptomatic gonarthritis.
Osteoarthritis Cartilage. 2003 Nov;11(11):783-9.
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Resphora+ 60 capsules - Physiologics
For
the Sinus and Respiratory Systems
PRODUCT DISCUSSION
This unique formula contains herbs and vitamins designed for the respiratory
system.*
STRUCTURE AND FUNCTION
Vitamin C assists in maintaining a healthy immune system.* Picrorhizia kurroa is
a well-known traditionally used herb in the ayurvedic system of medicine.
Quercetin is a non-citrus bioflavonoid for health and wellness.
Serratiopeptidase is a proteolytic enzyme that supports health of the ear, nose,
and throat.*
CLINICAL EVIDENCE
Researchers from the University of Naples in
Italy conducted a multicenter, randomized, double blind study to determine
the effects of 30 mg of serratiopeptidase on 193 subjects. Statistical
analysis revealed significant support of respiratory health in subjects
given serratiopeptidase as compared to the placebo. (Mazzone, 1990)
In an open label trial, researchers examined
29 subjects who received either 30 mg/day of serrapeptase or a placebo.
After 4 weeks, the group receiving serrapeptase experienced a significant
improvement in respiratory function. There was no significant change in the
control group. (Nakamura et al, 2003)
>SUMMARY
This unique formula contains herbs, including Serratiopeptidase, and vitamins
designed for the respiratory system.*
SUGGESTED DOSAGE
For adults, take one (1) capsule two to four times daily, preferably with a
meal, or follow the advice of a health care professional.
REFERENCES
Mazzone A. Evaluation of serratia peptidase in acute or chronic inflammation
of otorhinolaryngology pathology: A multicentre, double-blind, randomized
trial versus placebo. J Int Med Res. 1990;18:379-288.
Nakamura S, Hashimoto Y, Mikami M, et al.
Effect of the proteolytic enzyme serrapeptase in patients with chronic airway
disease. Respirology. 2003;8:316-20.
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Cartilage Care 90 capsules - Physiologics
Nutritional
Support for Joint Health*
Support for Healthy Cartilage Formation and
Maintenance*
90 Capsules
PRODUCT IS A SYNERGISTIC
MIXTURE OF
Glucosamine Sulfate, Glucosamine Hydrochloride, Chondroitin Sulfate, Ascorbic
Acid, Manganese Amino Acid Chelate, Sea Cucumber
PRODUCT DISCUSSION
Glucosamine and chondroitin play important roles in lubricating joints,
promoting joint mobility and revitalizing the cellular components of joint
cartilage.* Both glucosamine salts (HCl and sulfate) deliver equally effective
glucosamine to joint cartilage. Cartilage Care® also contains vitamin C for
collagen formation, manganese for normal skeletal development, and sea cucumber
for an additional source of glycosaminoglycans.*
STRUCTURE AND FUNCTION
Cartilage is a fibrous, elastic connective tissue that is important as a
cushioning layer for joints. It is associated with an extracellular matrix
composed of glycosaminoglycans (GAGs) and proteoglycans, which interact with
collagen and elastic fibers to promote mobility and flexibility for range of
motion. GAGs are long, unbranched polysaccharide chains composed of repeating
disaccharide units. Proteoglycans are proteins that carry one or more GAG side
chains, and help bind components of cartilage together.*
Glucosamine, a key component of cartilage and
synovial fluid, is an aminomonosaccharide utilized as the primary substrate in
the synthesis of GAGs and proteoglycans. The amide group of Glucosamine is
required for metabolic conversion into Glucosamine-6-phosphate, which is
subsequently converted to galactosamine required for GAG assembly. Glucosamine
from food and supplements is incorporated into the metabolic pathway of
proteoglycan and GAG synthesis, promoting cartilage production and articular
function.*
Chondroitin Sulfate is a natural constituent of
cartilage, made up of repeating chains of GAGs. Chondroitin Sulfate is a highly
charged polyanion, which attracts water into the connective tissues. This ionic
attraction hydrates connective tissue, thereby promoting flexibility and
resistance to compressive forces. Composed of N-acetyl-galactosamine and
glucuronic acid, Chondroitin Sulfate provides raw materials for proteoglycans
and glycosaminoglycans.*
Manganese is an essential trace mineral involved
in many key functions in the body. It plays a role in energy production, normal
bone formation and development, and the synthesis of many vital cellular
biochemicals. Manganese is not stored in the body to any considerable extent.
Bone however can account for up to 25% of the total manganese in the body, but
bone manganese is not thought to be readily available. Manganese functions as a
constituent of enzymes and enzyme activators, including arginase, pyruvate
carboxylase, and manganese superoxide dimutase (MnSOD). Manganese is a cofactor
for the glycosyltransferases, which are required for the synthesis of
proteoglycans that are needed for the formation of healthy cartilage and bone.
Manganese is also required for the activation of prolidase, an enzyme that
functions to provide the amino acid, proline, for collagen formation in human
skin cells (Muszynska et al. 2000).
The sea cucumber (Echinodermata, Holoturoidea)
has five bundles of smooth muscles attached to its body wall. These muscles
allow the sea cucumber to alter its body length at a rapid rate. Muscle
contraction is due to an increase in cytosolic calcium ion concentration, but
unlike mammalian skeletal muscles, the sarcoplasmic reticulum is difficult to
identify. High concentrations of fucosylated chondroitin sulfate in the sea
cucumber are believed to participate in Ca2+-dependent ATPase activity. Studies
have isolated unique sulfated polysaccharides from Sea Cucumber and found them
to modulate ATPase activity.
Other studies have isolated naturally-occuring
Holothurian glycosaminoglycans. This glycosaminoglycan, extracted from the body
wall of the sea cucumber, is primarily composed of sulfated L-fucose. These
unique glycosaminoglycans complement the GAGs that are stimulated through
glucosamine supplementation and provide a unique component not found in most
joint products.*
INDICATIONS
Researchers have been studying glucosamine for several decades and now
glucosamine is recognized by rheumatologists and general practitioners. The
mixture of compounds found in Cartilage Care® provides comfort for overworked
and tired joints and contribute to the overall health of the connective tissue.*
HOW CLIENTS MAY BENEFIT
Helps maintain joints and cartilage.*
Helps to promote cartilage formation.*
Revitalizes and rejuvenates cellular
components within cartilage.*
Increases all around function and mobility of
joints.*
Provides comfort for overworked joints.*
Provides both forms of Glucosamine for
synergistic effects (HCl and Sulfate). Some researchers have speculated
sulfate attached to Glucosamine mediates many of the positive joint
benefits, while Glucosamine HCl has also been shown to be efficacious within
the literature.*
CLINICAL EVIDENCE
Many clinical trials have been conducted using glucosamine and chondroitin.
There is an overall consensus as to the efficacy of the product with regard to
joint and cartilage health. Pujalte et al. (1980) showed significant
improvements in joint comfort after 6-8 weeks supplementation of 1500mg (500mg,
3x/day) glucosamine sulfate (p |
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Cartilage Companion 90 capsules - Physiologics
Potassium
Stabilized Glucosamine and Chondroitin with MSM
Joint Health Formula*
PRODUCT IS A SYNERGISTIC
MIXTURE OF
Glucosamine Sulfate, Chondroitin Sulfate, and Methylsulfonylmethane (MSM)
PRODUCT DISCUSSION
Glucosamine is an aminomonosaccharide which promotes the production of
glycosaminoglycans (GAG's) and proteoglycans. Chondroitin promotes healthy
enzymatic metabolism of cartilage.* MSM provides a rich source of organic
sulfur, an integral component of connective tissue.* Together, these ingredients
support overall joint function, mobility, flexibility and comfort.*
STRUCTURE AND FUNCTION
Glucosamine, a key component of cartilage and synovial fluid, is an
aminomonosaccharide utilized as the primary substrate in the synthesis of GAGs
and proteoglycans. The amide group of Glucosamine is required for metabolic
conversion into Glucosamine-6-phosphate, which is subsequently converted to
galactosamine required for GAG assembly. Glucosamine from food and supplements
is incorporated into the metabolic pathway of proteoglycan and GAG synthesis,
promoting cartilage production and articular function.* Glucosamine has also
been shown to suppress platelet aggregation, release of granule constituents,
thromboxane A2 production, calcium mobilization and phosphorylation of Syk
possibly via the inhibition of ADP-binding to the receptors (Hua et al. 2004).
Chondroitin Sulfate is a natural constituent of
cartilage, made up of repeating chains of GAGs. Chondroitin Sulfate is a highly
charged polyanion, promoting water retention in the connective tissue to support
joint flexibility and cushion joints. Composed of N-acetyl-galactosamine and
glucuronic acid, Chondroitin Sulfate provides a raw material for proteoglycan
and GAG synthesis to actually help renew cartilage. Chondroitin Sulfate also
promotes healthy enzymatic metabolism of cartilage, to further maintain joint
health.*
MSM is a dietary source of sulfur and is an
odorless crystalline powder similar to the texture of sugar. MSM contains 34%
sulfur by weight and is derived by the heating of dimeythyl sulfoxide (DMSO).
Unlike DMSO, MSM however does not possess solvent properties and is completely
odorless.
Since sulfur is an integral component in
connective tissue, MSM clinical studies have focused on cartilage and joint
support. Cartilage is comprised of an extracellular matrix made of complex
proteins known as glycosaminoglycans (GAGs) and proteoglycans. Enhancement of
GAG synthesis, promotes cartilage production and articular function.* Sulfur
concentration of arthritic cartilage is one third of normal tissue (Rizzo et al.
1995).
INDICATIONS
Researchers have been studying glucosamine for several decades and now
glucosamine is recognized by rheumatologists and general practitioners. The
mixture of compounds found in Cartilage Companion® may provide joint comfort
and contribute to the overall health of the connective tissue.* For clients that
are concerned with overall joint health, including mobility, flexibility and
range of motion, Cartilage Companion is formulated based on extensive reviews of
published scientific literature.*
HOW CLIENTS MAY BENEFIT*
Promotes range of motion, mobility, and
flexibility for comfortable movement.*
Glucosamine supplies a natural component of
cartilage.*
Chondroitin Sulfate promotes water retention
to cushion joints.*
Chondroitin Sulfate promotes healthy enzymatic
metabolism of cartilage for joint maintenance.*
Helps to promote cartilage formation.*
Slows the natural breakdown of cartilage
associated with aging.*
MSM possesses antioxidant properties.*
Promotes joint and cartilage comfort.*
May provide joint comfort.*
CLINICAL EVIDENCE
Reginster et al. (2001) published a
double-blind placebocontrolled study that investigated the long-term effects
of Glucosamine Sulfate in a trial of 212 subjects. After 3 years of 1500
mg/day, the subjects that received Glucosamine maintained cartilage as
measured in the knee. Joint support was not observed in the placebo group.
In addition, Glucosamine significantly promoted joint comfort and range of
motion compared to placebo.
Qiu et al. (1998) showed that both glucosamine
sulfate and ibuprofen performed equally as well (p |
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Glucosamine Sulfate 500mg 180 capsules - Physiologics
Supports
Joint Health*
As a key ingredient in cartilage, glucosamine
plays an important role in good joint health.* Studies indicate that glucosamine
provides the building blocks for constructing cartilage.*
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Prostate Support Formula 60 capsules - Physiologics
Supports
Prostate and Reproductive Health*
Prostate Support is an ideal supplement for both
young and mature men, delivering a unique combination of Saw Palmetto, Pygeum,
Lycopene, Zinc and more. These active ingredients provide a well-balanced level
of support for prostate and reproductive health in men.*
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Saw Palmetto 160mg 60 softgels - Physiologics
Prostate
Health*
Standardized to contain: 85-95% fatty acids and biologically active sterols
PRODUCT IS ALSO
KNOWN AS
Serenoa repens, Sabal serrulata
PRODUCT DISCUSSION
Saw Palmetto has earned its clinical reputation as the leading herb for
supporting men's prostate and urinary health through the publication of multiple
trials that support its efficacy when orally administered. Physiologics
Researchers and Chemists have meticulously scrutinized the scientific literature
to develop a premier prostate supplement that separates itself from the
competition as will be evidenced within this review.*
STRUCTURE AND FUNCTION
The prostate is a sex gland in men, located at the neck of the bladder and
urethra. It is under direct control of an enzymatically altered form of male sex
hormone at the level of the prostatic androgen receptor. One of the main
functions of the prostate gland is to secrete a thin, milky fluid containing
citrate and calcium, which contributes to semen production. This fluid has a pH
range of 6.5 to 7.5 and may help to neutralize the acidic fluid of the vas
deferens.
Saw Palmetto is an extremely popular herb for
prostate health, mostly due to the breadth of scientific evidence supporting its
biochemical role in the prostate. The American Botanical Council has reported
that Saw Palmetto is one of the top 10 selling herbs in the United States. Saw
Palmetto extract consists of a dark-brown liquid which is insoluble in water and
miscible with fatty oils and fat-soluble organic solvents. Typical fatty acid
assays reveal presence of caprylic acid, capric acid, lauric acid, myristic
acid, palmitic acid, stearic acid, oleic acid, cis-linoleic acid, and linolenic
acid. Lauric, myristic and oleic acid are found in the highest amounts.
Saw Palmetto is believed to non-selectively
interact with prostate receptor cells through various sub-types. Enzymatic
interactions most likely occur within 5-alpha reductase. This mechanism of
action has been demonstrated through in-vitro experiments with human
fibroblasts. Studies with eukaryotic (baculovirus-directed insect cell)
expression system found that LESP (liposterolic extract) interacts with both
isoenzymes of 5a-reductase. The clinical USP monograph for Saw Palmetto reports
that Saw Palmetto was tested for its interaction with human prostatic a
1-adrenoceptors and [3H]prazosin binding to cloned human a 1A-and a
1B-adrenoceptors in rat-1 cells. All saw palmetto extracts had desired
interactions for radioligand binding to human alpha1-adrenoceptors in a
non-competitive, concentration-dependent manner. These biological interactions
may be the key behind the invivo reports of healthy prostate and urinary
function in men supplemented with Saw Palmetto.*
INDICATIONS
As the baby boomer generation grows older, more men will be seeking healthy
alternatives to support their prostate and urinary function. In fact, the
National Kidney and Urologic Information Clearinghouse reports that over 50% of
mature men may be viable candidates for prostate health support. Physiologics
Saw Palmetto Standardized Extract is the preferred choice for this population.
Raw materials undergo rigorous in-house testing and screening to ensure
confirmation with USP standards for fatty acid content and biologically active
sterols, and are certified by chemists in the Quality Control division. This
confirmation with clinically-defined standards is the key to promoting prostate
and urinary health as evidenced in published, human trials.*
HOW CLIENTS MAY BENEFIT
Utilizing the #1 herbal supplement, both in
terms of clinical evidence and popularity among the general public, for
prostate health.*
Promoting urinary health for men.*
Supplementing with a prostate formula that
offers a wide range of active liposterolic extracts and natural
constituents.*
The extract distinguishes itself from many
other products through in-house testing using clinically defined chemical
analysis methods for measuring and certifying fatty acid and active sterol
content, as defined by the United States Pharmacopeia. Clients can rest
assured they are receiving a premier product.
Comes in a convenient, easy to swallow softgel
that encourages compliance with dosing regimen.*
Suitable for a wide-range of clients due to
its free of status for yeast, wheat, milk or milk derivatives, lactose,
preservatives, soy, artificial color, flavor and sodium (less than 5 mg per
serving) as certified through analysis of raw material specification sheets.
CLINICAL EVIDENCE
A double-blind, placebo controlled study was
conducted in men over the age of 45 years old. Saw palmetto, standardized
for at least 85% fatty acids and sterols, was administered at daily dosages
of 320 mg. Statistical analysis, utilizing two-tailed Mann-Whitney U test
and Student's test, revealed that Saw Palmetto achieved significant effects
for prostate health scores as well as urinary health. The researchers noted
that results of the study should be applied to supplements with high quality
control standards and with standardized contents.
A double-blind, randomized trial compared the
efficacy of Saw Palmetto administered at daily dosages of 320 mg or 480 mg.
Analysis found that the lower daily dosage (the dosage supplied by
Physiologics Saw Palmetto) was as effective as the higher dosage for
prostate health.
SUMMARY
When seeking an herbal alternative which will provide first-class prostate and
urinary health for your clients, it is recommended that the supplement be backed
by clinical studies published in peer-reviewed journals, be administered in
dosages consistent with the scientific literature, consist of active ingredients
used in human trials that are backed by chemical analysis methods approved by
the highest scientific organizations, and be suitable for a wide range of
clients based on its "free of" certification from raw material
analysis. Physiologics Saw Palmetto Standardized Extract meets and/or exceeds
all of these recommendations.*
SUGGESTED DOSAGE
For adults, take one (1) softgel twice daily, preferably with a meal, or follow
the advice of your health care professional. As a reminder, discuss the
supplements and medications you take with your health care providers.
REFERENCES
Adriazola Semino M, Lozano Otega JL, Garcia C, et al. Symptomatic treatment of
benign hypertropy of the prostate. Comparative study of prazosin and Serenoa
repens. Arch Esp Urol 1992; 45: 211-3.
Authie D, Cauquil J. Evaluation of the efficacy
of permixon in daily practice. Comptes Rendus de Therap. 1987; 56; 1-9.
Bach D, Ebeling L. Long-term drug treatment of
benign prostatic hyperplasia - results of a protective 3-year multicenter
study using Sabal extract IDS 89. Phytomed 1996; 3: 105-11 (originally
published in Urologe [B]) 1995; 35: 178-83.
Boccafoschi C, Annoscia S. Confromto fra
estratto di Serenoa repens e placebo mediate prova clinica controllata in
pazienti con adenomatosi prostatica. Urologia 1983; 50: 1257-68.
Braeckman J, Denis L, de Laval J, et al. A
double-blind, placebo-controlled study of the plant extract Serenoa repens in
the treatment of benign hyperplasia of the prostate. Eur J Clin Res 1997; 9:
247-59.
Braeckman J. The extract of Serenoa repens in
the treatment of benign prostatic hyperplasia: a multicenter open study. Curr
Ther Res 1994; 55: 776-8.
Breau W, Stadler F, Hagenlocher M, et al. Der
Sabalfrucht-extrakt SG 291. Ein phytotherapeutikumzur behandlung der benignen
prostatahyperplasie. Zeitschrift fur Phytotherapie 1992; 13: 107- 15.
Brown, D. Saw palmetto extract-efficacy shown
in long-term study. Townsend Letter for Doctors & Patients. 1997: 160-161.
Carraro JC, Raynaud JP, Koch G, et al.
Comparison of phytotherapy (Permixon®) with finasteride in treatment of
benign prostate hyperplasia: a randomized international study of 1,098
patients. Prostate 1996; 29: 231-40.
Carreras JO. Experience with the hexane extract
of Serenoa repens in the treatment of benign prostate hyperplasia. Arch Esp de
Urol 1987; 40(5); 310-3.
Champault G, Patel JC, Bonnard AM. A
double-blind trial of an extract of the plant Serenoa repens in benign
prostatic hyperplasia. Br J Clin Pharmacol 1984; 18: 461-2.
Champault, G. et al. The medical treatment of
prostatic adenoma. Ann. Urol. 1984. 6:407-410.
Cukier J, Ducassou J, Le Guillou M, et al.
Permixon® versus placebo. Résultats d´une étude multicentrque. CR Ther
Pharmacol Clin 1985; 4(25): 15-21.
Dathe G, Schmid H. Phytotherapy of benign
prostatic hyperplasia (BPH) with extractum Serenoa repens. Urolog B 1991; 31;
220-3.
Delos S, et al. Inhibition of the activity of
'Basic' 5a-reductase (type 1) detected in Dells and expressed in insect cells.
J Steroid Biochem. 1994; 48(4): 347-52.
Descotes JL, Rambeaud JJ, Deschaseaux P, et al.
Placebo-controlled evaluation of the efficacy and tolerability of Permixon®in
benign prostatic hyperplasia after exclusion of placebo responders. Clin Drug
Invest 1995; 9: 291-7.
Emili E, Lo Cigno M, Petrone U. Risultati
clinici su un nuovo farmaco nella terapia dell´ipertrofia della prostata (Permixon®).
Urologia 1983; 50: 1042-8.
Fetrow, C.W. and Avila, JR, Saw palmetto.
Professional's Handbook of Complementary & Alternative Medicines. 1999.
Springhouse Corp. Springhouse, PA. 578-582.
Gerber GS, Zagaja GP, Bales GT, et al. Saw
palmetto in men with lower urinary tract symptoms: effects on urodynamic
parameters and voiding symptoms. Urology 1998; 51(6): 1003-7.
Gerber, G., et al. Randomized, double-blind,
placebo-controlled trial of saw palmetto in men with lower urinary tract
symptoms. Urology. 2001. 580(6); Dec: 960-965.
Grasso M, Montesano A, Buonaguidi A, et al.
Comparative effects of alfuzosin versus Serenoa repens in the treatment of
symptomatic benign prostatic hyperplasia. Arch Esp Urol 1995; 48: 97- 103.
Kondás J, Philipp V, Diószeghy G. Sabal
serrulata extract (Strogen forte®) in the treatment of symptomatic benign
prostatic hyperplasia. Int Urol Nephrol 1996; 28: 767-72.
Lininger, S. et al. Saw Palmetto. The Natural
Pharmacy. Prima Publishing, Rocklin, CA. 1998: 306- 307.
Lobelenz J. Extractum sabal fructus in the
therapy of benign prostatic hyperplasia (BPH). Tpk therapeutikon. 1992; 6;
34-37.
Lowe FC, Robertson C, Roehrborn C, Boyle P.
Meta analysis of clinical trials of Permixon. J Urol 1999; 159(5) Suppl: 257.
Marks LS. et al. Effects of a saw palmetto
herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol 2000
May;163(5):1451-6
Marks, L.S. et al. Saw palmetto extract: newest
(and oldest) treatment alternative for men with symptomatic benign prostatic
hyperplasia. Urology. 1999. 53: 457-461.
Wilt, T.J. Saw palmetto extracts for treatment
of benign prostatic hyperplasia. JAMA. 1998. 280 (18); Nov: 1604-1608.
Mandressi A, Tarallo U, Maggioni A, et al.
Terapia medica dell´adenoma prostatico: confronto dellaefficacia dell´estratto
di Serenoa repens (Permixon®) versus l´estratto di Pigeum africanum e
placebo. Urologia 1983; 50: 752-8.
Mattei FM, Capone M, Acconcia A, et al.
Medikamentöse therapie der benignen mit einem extrakt der Sögepalme. TW Urol
Nephrol 1990; 2(5): 346-50.
McPartland JM, Pruitt PL. Benign prostatic
hyperplasia treated with saw palmetto: a literature search and an experimental
case study. J Am Osteopath Assoc. 2000 Feb;100(2):87.
Overmyer M. Saw palmetto shown to shrink
prostatic epithelium. Urology Times 1999; 24(6):1,42.
Redecker KD, Funk P. Sabal extract WS 1473 in
benign prostatic hyperplasia. Extracta Urologica 1998; 21: 24-6.
Reese Smith H, Memon A, Smart CJ, et al. The
value of Permixon® in benign prostatic hypertrophy. Br J Urol 1986; 58:
36-40.
Silverio, F. et al. Evidence that Serenoa
repens extract displays an antiestrogenic activity in prostatic tissue of
benign prostatic hypertrophy patients. Eur. Urol. 1992. 21:309-314.
Snow, J. Serenoa repens bartram (Palmae). The
Protocol Journal of Botanical Medicine. 1996: 15-16.
Sultan, C. et al. Inhibition of androgen
metabolism and binding by a liposterolic extract of "Serenoa repens
B" in human foreskin fibroblasts. J. Steroid Biochem. 1984.
20(1):515-519.
Tasca A, Barullli M, Cavazzana A, et al.
Treatment of obstructive symptomatology in prostatic adenoma with an extract
of serenoa repens. Minerva Urologica e Nefrologica 1985; 37: 87-91.
Vahlensieck W, Völp A, Lubos W, et al. Benign
prostatic hyperplasia - treatment with Sabal fruit extract. A surveillance
study on 1334 patients. Fortschr Med 1993; 111: 323-6.
Weisser H, Behnke B, Helpap B, et al. Enzyme
activities in tissue of human benign prostatic hyperplasia after three months'
treatment with the Sabal serrulata extract IDS 89 (Strogen®) or placebo. Eur
Urol 1997; 31: 97-101.
Wilt T J, Ishan A. Stark G, et al. Saw palmetto
extracts for treatment of Benign prostatic hyperplasia. JAMA 1998; 280(18):
1804-9.
Ziegler H, Holscher U, et al. Efficacy of saw
palmetto fruit special extract WS 1473 in patients with Alken stage I-II
benign prostatic hyperplasia - open multicentre study. Jatros Uro 1998; 14:
2-7.
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Borage Oil 1300mg 90 softgels - Physiologics
For
Women's Health* - Nutritional Support For Women with PMS*
Borage oil is one of the few sources of gamma-linolenic
acid. Gamma-linolenic acid is a precursor to prostaglandins, action-specific
biomolecules that regulate many important functions in cells. Borage oil also
contains the essential fatty acid, linoleic acid (Omega-6).*
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Flax Seed Oil, High Lignan 1250 mg 90 sgels - Physiologics
Natural
Source of Omega-3 Fatty Acids
Supports Cardiovascular Health*
Organic flaxseed oil is an edible oil derived from the seeds of the flax
plant (Linum usitatissimum) and is one of the best sources of the Omega-3 fatty
acid alpha-linolenic acid. Organic flaxseed oil also provides the most
concentrated vegetarian source of Omega-3 fatty acids found in nature. Flaxseed
oil helps to balance the production of prostaglandins. The flaxseed oil that is
used in this product is produced using a unique cold processing method. The
organic flaxseeds are pressed at very cold temperatures and are processed
without solvents. In addition, the oil for our softgels is dispensed and
processed under a nitrogen blanket to safeguard it from oxygen exposure then
encased in an amber-colored gelatin shell to continue to protect the active
elements from white light. This ensures that our organic flaxseed oil retains
its integrity.
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MusclEase 60 capsules - Physiologics
Supports
Overworked Muscles*
PRODUCT IS A SYNERGISTIC
MIXTURE OF:
Valerian Extract (Valeriana officinalis), White Willow Extract (Salix alba),
Passion Flower Extract (Passiflora incarnata), Calcium Citrate, Magnesium
Aspartate
PRODUCT DISCUSSION
Muscle tension and strain can affect anyone and can be due to a variety of
physiological and psychological factors. MusclEase is a synergistic blend of
herbs and essential minerals that works on multiple neural and biochemical
levels for people experiencing occasional muscular tension related to exercise
and other physical activity.* Essential minerals are combined with the highest
quality herbal extracts for enhanced neuromuscular support.*
STRUCTURE AND FUNCTION
White Willow Extract
Willow bark has been used for therapeutic practices for approximately 2,000
years. Salicin and other salicylic derivatives have been identified as the
components responsible for Willow bark's biochemical effects. In general, total
salicylic derivatives comprise a minimum of 1.5% of the dry weight of willow
bark (American Herbal Pharmacopoeia). MusclEase standardizes Salicin to 10x this
naturallyoccurring level to help ensure the full benefits of white willow are
derived.
Willow bark constituents are believed to act
through various mechanisms. The main mechanism providing beneficial effects is
most likely through interaction with PGH-synthase. In addition, Salicin and its
derivatives may affect the functioning of neutrophils to help ease overworked
muscles.*
Magnesium
Each serving of MusclEase provides an excellent source of the essential mineral
Magnesium. Magnesium's role in proper muscle function cannot be understated as
it is involved in most if not all energy-requiring reactions.*
Adenosine Triphosphate forms a complex with
Magnesium, which is used by most or all ATP-requiring enzymes. Glycolytic
enzymes such as pyruvate kinase and phosphofructokinase require magnesium.
Magnesium is also needed at various points in the synthesis of DNA, RNA and
protein, demonstrating its importance in muscle recovery and function.* Calcium
pumps and Na,K-ATPase are usually the most sensitive to low magnesium levels,
which can affect neuromuscular activity and hence muscle
contraction/relaxation.*
Valerian
Extract
Valerian and its principle components have been extensively studied for well
over 50 years. Several natural components are believed to initiate its
relaxation effects, including valerenic acid (standardized to .8% in MusclEase).
Lab data indicates that valerenic acid and acetylvalerenic acid can inhibit GABA
transaminase, thereby prolonging GABA's effects on sedation in the central
nervous system (Reidel/82). L-hydroxypinoresinol, another natural valerian
alkaloid, has been found to possess a high affinity for the 5- HT1A receptor,
which could also play a role in Valerian's relaxing effects.*
Passion
Flower Extract
Passion flower is a traditional herb used for its neurochemical sedative
actions.* Beneficial effects attributed to passion flower include increase in
latency of reaction, increased threshold to nociceptive stimuli of heat, and
increased nervous system relaxation (Speroni/88).*
INDICATIONS
Occasional muscular tension can affect relaxation and overall quality of life.
Excessive strain from physical activity is often a leading culprit and can be
simultaneously affected by psychological stressors. MusclEase works not only at
the level of muscle contraction/relaxation, but also upstream by interacting
with the central nervous system and neuromuscular activity.*
HOW CLIENTS MAY BENEFIT*
All active ingredients are naturally-sourced
meaning no chemically-synthesized actives are utilized.
Only standardized extracts are used to ensure
consistent delivery of many of the active principles.
Delivers not one but several ingredients
implicated to play a role in neuromuscular relaxation pathways.*
Suitable for a wide-range of clients due to
its free of status for yeast, wheat, milk or milk derivatives, lactose,
sugar, preservatives, artificial color, artificial flavor, and sodium (less
than 5 mg per serving) as certified through analysis of raw material
specification sheets.
Tested to conform with USP standards for
disintegration and microbial limits, including E. Coli and Staphylococcus
screen.
CLINICAL EVIDENCE
A randomized, double-blind, placebo-controlled
study was conducted in 82 subjects. Each subject received either an active
treatment, which contained 100 mg of white willow bark in combination with
other traditional herbs (2x daily), or a matching placebo tablet. Results
measured with analysis of paired differences revealed an improvement in
comfort scores for the active treatment group as compared to the placebo
group. This effect was widely attributed to the known systemic comfort
promoting effects of the active ingredients with in white willow bark.
(Mills/96)
Valerian, propranolol, the combination of
both, or placebo were given to subjects to measure the independent and
synergistic effects on somatic and psychological activation when faced with
stressful situations. 100mg of Valerian Extract (the same amount in 2
capsules of MusclEase) was found to reduce subjective feelings of somatic
arousal. The authors reported that Valerian was able to induce thymoleptic
effects for overall well-being. This in turn could lead to a state of
relaxation in muscles and other organs affected by stress (Kohnen/88).
SUMMARY
As evidenced by laboratory and clinical investigations, ingredients within
MusclEase can affect various pathways directly tied to muscle relaxation.* Only
the highest grade extracts and ingredients are chosen to help bring about the
beneficial effects of a truly synergistic combination.*
SUGGESTED DOSAGE
Take one (1) or two (2) capsules daily as needed, or follow the advice of your
health care professional. May take up to 8 capsules daily. As a reminder,
discuss the supplements and medications you take with your health care provider.
REFERENCES
Abraham, G.E., et al. Serum and red cell magnesium levels in patients with
premenstrual tension. Am J Clin Nutr. 1981. 2364-2366.
Borenstein, D.G. Epidemology, etiology,
diagnostic evaluation and treatment of low back pain. Curr Opin Rheumatol.
2001. 13(2); Mar: 128-134.
Capasso, A. et al. Pharmacological studies on
the sedative and hypnotic effect of Kava kava and Passiflora extracts
combination. Phytomedicine. 2005 Jan;12(1-2):39-45.
Chrubasik, S. Clinical study - willow bark.
American Herbal Pharmacopoeia. Facts Sheet.
Chrubasik, S. et al. Treatment of low back pain
exacerbations with willow bark extract: a randomized double-blind study. Am J
Med. 2000. 109(1); Jul: 9-14.
Cordova, A. Changes on plasmatic and
erythrocytic magnesium levels after high-intensity exercises in men. Phys
& Behavior. 1992. 52: 819-821.
Cropley, M., et al. Effect of kava and valerian
on human physiological and psychological responses to mental stress assessed
under laboratory conditions. Phytother Res. 2002. 16(1); Feb: 23-27.
Dahle, L.O., et al. The effect of oral
magnesium on pregnancy-induced leg cramps. Am J Obs Gyn. 1995. 173: 175-180.
Fletcher, G.F., et al. Blood magnesium and
potassium alterations with maximal treadmill exercise testing: effects of _-adrenergic
blockade. Am Heart J. 1990. 121: 105-110.
Hendriks, H., Bos, R., Woerdenbag, H.J. and
Koster, A.S. Central nervous depressant activity of valerenic acid in the
mouse. Planta Medica. 51:28-31, 1985.
Kohnen, R. and Oswald, W.D. The effects of
valerian, propranolol, and their combination on activation, performance, and
mood of healthy volunteers under social stress conditions. Pharmacopsychiatry.
21:447-448, 1988.
Kuhlmann, J., et al. The influence of valerian
treatment on reaction time, alertness and concentration in volunteers.
Pharmacopsychiatry. 1999. 32(6); Nov: 235-241.
Lindahl, O. et al. Double blind study of a
valerian preparation. Pharmacol Biochem Behav. 32:1065-1066, 1989.
Mills, SY. et al. Effect of a proprietary
herbal medicine on the relief of chronic arthritic pain: a double-blind study.
Br J Rheumatol.. 1996. 35(9): 874-878.
Reidel, E. et al. Inhibition of gamma-aminobutyric
acid catabolism by valerenic acid derivatives. Planta Med. 1982. 46:219-220.
Schmid, B. et al. [Efficacy and tolerability of
standardized willow bark extract in patients with osteoarthritis: randomized,
placebo-controlled, double blind clinical trial.] Z Rheumatol. 2000. 59(5);
Oct: 314-320.
Shinomiya, K. et al. Hypnotic activities of
chamomile and passiflora extracts in sleep-disturbed rats. Biol Pharm Bull.
2005 May;28(5):808-10.
Speroni, E. et al. Neuropharmacological
Activity of Extracts from Passiflora incarnate. Planta Medica. 1988. 54(6):
488-91.
Stevinson, C., et al. Valerian for insomnia; a
systematic review of randomized clinical trials. 2000. Sleep Medicine. 1(2);
Apr: 91-99.
Upton, R., Valerian root Valeriana officinalis,
Analytical, Quality Control, and Therapeutic Monograph, in American Herbal
Pharmacopoeia and Therapeutic Compendium. 1999.
Upton, R. Willow Bark. American Herbal
Pharmacopoeia and Therapeutic Compedium. 1999. Monograph. 1-17. |
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Ester C 500mg 90 capsules - Physiologics
Unique
Gentle Form of Vitamin C
24 Hour Immune Support*
PRODUCT ALSO KNOWN AS
Calcium Ascorbate
PRODUCT DISCUSSION
PhysioLogics' Ester-C® 500 mg supplies Calcium Ascorbate, a non-acidic form of
vitamin C to provide greater bioavailability in a stomach friendly form.*
STRUCTURE AND FUNCTION
Vitamin C is a water-soluble compound whose primary function is collagen
formation, the protein essential for the formation of connective tissue in skin,
vasculature, ligaments and bones. Collagen is required in the arterial wall to
aid in expansion and contraction. By facilitating connective tissue formation,
Vitamin C is a necessary component for skin health.*
Vitamin C is an essential antioxidant that
directly influences the myeloperoxidase/hydrogen peroxide/halide system of
neutrophils. By modulating this system, Vitamin C neutralizes superoxide
production, helping to protect the eyes, lungs, and blood from free radical
damage.*
For immune system support, Vitamin C has been
shown to promote the response of lymphocytes to cytokines.* In addition, Vitamin
C enhances the phagocytic functions of polymorphonuclear (PMN) neutrophils and
supports the adherence of these cells to the vascular endothelium.*
INDICATIONS
Certain regularly prescribed drugs may cause Vitamin C depletions. PhysioLogics'
Ester-C® 500 mg may be an opportunity for individuals to obtain the antioxidant
potential of Vitamin C and support their immune system with a non-acidic
formulation that is easier on the stomach.*
HOW CLIENTS MAY BENEFIT*
Vitamin C is required for the synthesis of
collagen, to support connective tissue formation for healthy skin and
nails.*
Vitamin C scavenges harmful free radicals to
help protect the eyes, blood, and lungs from oxidative damage.*
Support the body's immune system.*
Clients with inadequate iron may benefit from
Ester-C® supplementation, as Vitamin C assists the body in absorbing non-heme
iron through a chemical reaction that adds an electron to the ferric form of
iron.*
SCIENTIFIC RESEARCH
In a 60 day study of 168 healthy participants,
subjects receiving Ester-C® had significantly fewer reports of decreased
well-being and immune system health compared to a placebo group.(Van Straten/02)
Kennes et al investigated the effects of
500mg/day supplementation of Vitamin C on the immune system in the elderly.
Vitamin C was found to promote the proliferative response of T lymphocytes
compared to the placebo.
A recent study in France investigated the
cardiovascular support potential of Vitamin C. Morel et al. found that 1000
mg of Vitamin C every day for 5 days supported endothelial tissue by
promoting healthy microparticle levels, demonstrating the importance of
antioxidants in circulatory health.
SUMMARY
Vitamin C is one of the most powerful antioxidants in the human body and has
numerous biological functions.* PhysioLogics' Ester-C® 500 mg provides a
convenient way to obtain antioxidant support and promote immune system health in
a fast-acting, absorbable and stomach friendly form.*
SUGGESTED DOSAGE
For adults, take one (1) capsule twice daily, preferably with a meal, or follow
the advice of your health care professional. As a reminder, discuss the
supplements and medications you take with your health care providers.
REFERENCES
Anderson R. Effects of ascorbate on normal and abnormal leukocyte functions.
Int J Vitam Nutr Res Suppl. 1982. 23:23-34.
Bush et al. An acute study on the relative
gastro-intestinal absorption of a novel form of calcium ascorbate. Research
Communications in Chemical Pathology and Pharmacology. 1987. 57:137-40.
Davidsson L. Approaches to improve iron
bioavailability from complementary foods. J Nutr. 2003 May;133(5 Suppl
1):1560S-2S
de la Fuente M, Ferrandez MD, Burgos MS, Soler
A, Prieto A, Miquel J.Immune function in aged women is improved by ingestion
of vitamins C and E. Can J Physiol Pharmacol. 1998 Apr;76(4):373-80.
Hughs DA. Effects of dietary antioxidants on
the immune function of middle-aged adults. Proc Nutr Soc. 1999. 58:79-84.
Hunt et al. Comparative efficacy of Inter-Cal
"Ester-C" calcium ascorbate. Results of a study prepared for Inter-
Cal Corporation by the Life Management Group, Inc. 1995.
Kennes B, Dumont I, Brohee D, Hubert C, Neve P.
Effect of vitamin C supplements on cell-mediated immunity in old people.
Gerontology. 1983;29(5):305-10.
Lazarev A, Graumlich JF, King J, Cantilena LR.
Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended
dietary allowance. Proc Natl Acad Sci U S A. 1996. 93(8):3704-9.
Levine M, Conry-Cantilena C, Wang Y, Welch RW,
Washko PW, Dhariwal KR, Park JB, Lazarev A, Graumlich JF, King J, Cantilena LR.
Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended
dietary allowance. Proc Natl Acad Sci U S A. 1996. 93(8):3704-9.
Morel O, Jesel L, Hugel B, Douchet MP, Zupan M,
Chauvin M, Freyssinet JM, Toti F. Protective effects of vitamin C on
endothelium damage and platelet activation during myocardial infarction in
patients with sustained generation of circulating microparticles. J Thromb
Haemost. 2003 Jan;1(1):171-7.
Schwartz J and Weiss S.T. Relationship between
dietary vitamin C uptake and pulmonary function in the First National Health
and Nutrition Examination Survey (NHANES I). Am J Clin Nutr. 1994. 59:110-114.
Van Straten M, Josling, P. Preventing the
common cold with a vitamin C supplement: a double-blind, placebocontrolled
survey. Adv Nat Ther. 2002. 19(3):151-9.
Wright J, Suen R, Kirk F. Comparative studies
of Ester-C versus L-ascorbic acid. Intl Clin Nutr Rev. 1990 10(1):267-70
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Chromium Picolinate 200mcg 250 vcaps - Physiologics
A
vegetarian friendly source of Chromium Picolinate
PhysioLogics offers Chromium Picolinate in a
vegetarian friendly form. Our Chromium Picolinate is specifically designed for
patients who prefer strictly non-animal sourced material to meet their
individual health and lifestyle needs.
= Vegetarian Formula
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Essential E 400IU 120 softgels - Physiologics
Superior
Antioxidant Support for Heart Health*
100% Natural Vitamin E
Essential E® contains natural vitamin E, the body’s primary fat-soluble
antioxidant. Vitamin E supports cell membranes and nerve cells from free radical
damage.*
Delivers d-alpha tocopherols – the active form of vitamin E as it occurs
in nature*
100% natural and more bioavailable than synthetic vitamin E when compared
on a milligram-to-milligram basis*
Provides dietary support for overall cellular and cardiovascular health*
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Grape Seed Extract 100mg 120 vcaps - Physiologics
Powerful
Antioxidant and Helps Support Heart Health*
Grapeseed extract contains oligomeric
proanthocyanidins (OPCs) and other polyphenolic compounds. Proanthocyanidins
are naturally occurring bioflavonoids with antioxidant properties, which help
to neutralize cell-damaging free radicals.*
= Vegetarian Formula
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MSM (Methylsulfonylmethane) 1000mg 90 Capsules - Physiologics
Promotes
Joint Comfort & Mobility*
HOW PATIENTS MAY BENEFIT
Increases mobility and range of motion*
PRODUCT DISCUSSION
PhysioLogics MSM contains Methylsulfonylmethane (MSM), an organic source of
sulfur, a mineral that is vital in the formation of collagen, connective tissue,
and healthy joint cartilage.* It is one of the top three ingredients found in
popular joint products.
STRUCTURE AND FUNCTION
Sulfur plays an important role in nutrition. It is the eighth most abundant
element, and is an integral component of more than 150 compounds in the body.
Sulfur is fundamental to the structure and integrity of certain tissues,
including hair, skin, nails, and joints.* MSM is a dietary source of sulfur that
is found widely in nature; major sources include milk, eggs, seafood, meats and
plants.
MSM clinical trials have focused on cartilage and joint support.* Cartilage
is a fibrous, elastic connective tissue that functions as a cushioning layer for
joints and is comprised of an extracellular matrix made of complex proteins
known as glycosaminoglycans (GAGs) and proteoglycans. Sulfur is used in the body
as a constituent of certain amino acids, collagen and disulfide bonds, and
provides a raw material for the production of GAGs and collagen.*
CLINICAL EVIDENCE
118 subjects participated in a clinical trial in which they received 500
mg of MSM or placebo 3 times per day for 12 weeks. Those receiving MSM
experienced a significant increase in joint comfort compared with the
placebo group. Our product provides up to 3 grams of MSM per day. (Usha and
Naidu, 2004)
40 subjects completed a clinical trial in which they received 3 g of MSM
or placebo twice per day for 12 weeks. Those receiving MSM experienced
significant improvements in joint comfort and function compared with
placebo. Our product provides up to 3 grams of MSM. (Kim et al. 2006)
SUMMARY
Sulfur is one of the building blocks of collagen and GAGs, key structural
components in cartilage.* The compounds play an important role in the integrity
and maintenance of joint cartilage.* MSM is a natural dietary source of sulfur
which helps support the health of joints and cartilage.*
SUGGESTED DOSAGE
For adults, take one (1) capsule two to three times daily (1000 mg), preferably
with meals, or follow the advice of a health care professional.
REFERENCES
Beilke MA, Collins-Lech C, Sohnle P. Effects of dimethyl sulfoxide on the
oxidative function of human neutrophils. J Lab Clin Med. 1987;110:91-6.
Jacobs B. MSM packs a sulfuric punch. Nutr Sci Rev. 1999;4:232-4.
Kim LS et al. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis
pain of the knee: a pilot clinical trial. Osteoarthritis and Cartilage. 2006.
14(3):286-294.
Oae S, Okuyama T. Organic sulfur chemistry: biochemical aspects. Boca
Raton, FL:CRC Press, 1992.
Parcell S. Sulfur in human nutrition and applications in medicine. Altern
Med Rev. 2002;7:22-44.
Sharif M, Osborne DJ, Meadows K, et al. The relevance of chondroitin and
keratan sulphate markers in normal and arthritic synovial fluid. Br J
Rheumatol. 1996;35:951-7.
Usha PR and Naidu MUR. Randomised, double-blind, parallel,
placebo-controlled study of oral glucosamine, methylsulfonylmethane and their
combination in osteoarthritis. Clinical Drug Investigation. 2004.
24(6):353-363.
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L-Carnitine 500mg 120 tabs - Physiologics
Supports
a Healthy Heart*
Assists in Fat Metabolism*
L-Carnitine plays an essential role in making
fatty acids available in muscle tissue.*
= Vegetarian Formula
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Glucosamine Sulfate 1000mg 120 capsules - Physiologics
Supports
Mobility and Flexibility in Joints*
Scientific studies indicate that Glucosamine
promotes the production of proteoglycans, supports lubrication and supports
sulfate uptake in articular cartilage.* As an chondroprotective agent,
Glucosamine nourishes joints for comfortable movement.*
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Saw Palmetto 160mg 120 softgels - Physiologics
Prostate
Health*
Standardized to contain: 85-95% fatty acids and biologically active sterols
PRODUCT IS ALSO
KNOWN AS
Serenoa repens, Sabal serrulata
PRODUCT DISCUSSION
Saw Palmetto has earned its clinical reputation as the leading herb for
supporting men's prostate and urinary health through the publication of multiple
trials that support its efficacy when orally administered. Physiologics
Researchers and Chemists have meticulously scrutinized the scientific literature
to develop a premier prostate supplement that separates itself from the
competition as will be evidenced within this review.*
STRUCTURE AND FUNCTION
The prostate is a sex gland in men, located at the neck of the bladder and
urethra. It is under direct control of an enzymatically altered form of male sex
hormone at the level of the prostatic androgen receptor. One of the main
functions of the prostate gland is to secrete a thin, milky fluid containing
citrate and calcium, which contributes to semen production. This fluid has a pH
range of 6.5 to 7.5 and may help to neutralize the acidic fluid of the vas
deferens.
Saw Palmetto is an extremely popular herb for
prostate health, mostly due to the breadth of scientific evidence supporting its
biochemical role in the prostate. The American Botanical Council has reported
that Saw Palmetto is one of the top 10 selling herbs in the United States. Saw
Palmetto extract consists of a dark-brown liquid which is insoluble in water and
miscible with fatty oils and fat-soluble organic solvents. Typical fatty acid
assays reveal presence of caprylic acid, capric acid, lauric acid, myristic
acid, palmitic acid, stearic acid, oleic acid, cis-linoleic acid, and linolenic
acid. Lauric, myristic and oleic acid are found in the highest amounts.
Saw Palmetto is believed to non-selectively
interact with prostate receptor cells through various sub-types. Enzymatic
interactions most likely occur within 5-alpha reductase. This mechanism of
action has been demonstrated through in-vitro experiments with human
fibroblasts. Studies with eukaryotic (baculovirus-directed insect cell)
expression system found that LESP (liposterolic extract) interacts with both
isoenzymes of 5a-reductase. The clinical USP monograph for Saw Palmetto reports
that Saw Palmetto was tested for its interaction with human prostatic a
1-adrenoceptors and [3H]prazosin binding to cloned human a 1A-and a
1B-adrenoceptors in rat-1 cells. All saw palmetto extracts had desired
interactions for radioligand binding to human alpha1-adrenoceptors in a
non-competitive, concentration-dependent manner. These biological interactions
may be the key behind the invivo reports of healthy prostate and urinary
function in men supplemented with Saw Palmetto.*
INDICATIONS
As the baby boomer generation grows older, more men will be seeking healthy
alternatives to support their prostate and urinary function. In fact, the
National Kidney and Urologic Information Clearinghouse reports that over 50% of
mature men may be viable candidates for prostate health support. Physiologics
Saw Palmetto Standardized Extract is the preferred choice for this population.
Raw materials undergo rigorous in-house testing and screening to ensure
confirmation with USP standards for fatty acid content and biologically active
sterols, and are certified by chemists in the Quality Control division. This
confirmation with clinically-defined standards is the key to promoting prostate
and urinary health as evidenced in published, human trials.*
HOW CLIENTS MAY BENEFIT
Utilizing the #1 herbal supplement, both in
terms of clinical evidence and popularity among the general public, for
prostate health.*
Promoting urinary health for men.*
Supplementing with a prostate formula that
offers a wide range of active liposterolic extracts and natural
constituents.*
The extract distinguishes itself from many
other products through in-house testing using clinically defined chemical
analysis methods for measuring and certifying fatty acid and active sterol
content, as defined by the United States Pharmacopeia. Clients can rest
assured they are receiving a premier product.
Comes in a convenient, easy to swallow softgel
that encourages compliance with dosing regimen.*
Suitable for a wide-range of clients due to
its free of status for yeast, wheat, milk or milk derivatives, lactose,
preservatives, soy, artificial color, flavor and sodium (less than 5 mg per
serving) as certified through analysis of raw material specification sheets.
CLINICAL EVIDENCE
A double-blind, placebo controlled study was
conducted in men over the age of 45 years old. Saw palmetto, standardized
for at least 85% fatty acids and sterols, was administered at daily dosages
of 320 mg. Statistical analysis, utilizing two-tailed Mann-Whitney U test
and Student's test, revealed that Saw Palmetto achieved significant effects
for prostate health scores as well as urinary health. The researchers noted
that results of the study should be applied to supplements with high quality
control standards and with standardized contents.
A double-blind, randomized trial compared the
efficacy of Saw Palmetto administered at daily dosages of 320 mg or 480 mg.
Analysis found that the lower daily dosage (the dosage supplied by
Physiologics Saw Palmetto) was as effective as the higher dosage for
prostate health.
SUMMARY
When seeking an herbal alternative which will provide first-class prostate and
urinary health for your clients, it is recommended that the supplement be backed
by clinical studies published in peer-reviewed journals, be administered in
dosages consistent with the scientific literature, consist of active ingredients
used in human trials that are backed by chemical analysis methods approved by
the highest scientific organizations, and be suitable for a wide range of
clients based on its "free of" certification from raw material
analysis. Physiologics Saw Palmetto Standardized Extract meets and/or exceeds
all of these recommendations.*
SUGGESTED DOSAGE
For adults, take one (1) softgel twice daily, preferably with a meal, or follow
the advice of your health care professional. As a reminder, discuss the
supplements and medications you take with your health care providers.
REFERENCES
Adriazola Semino M, Lozano Otega JL, Garcia C, et al. Symptomatic treatment of
benign hypertropy of the prostate. Comparative study of prazosin and Serenoa
repens. Arch Esp Urol 1992; 45: 211-3.
Authie D, Cauquil J. Evaluation of the efficacy
of permixon in daily practice. Comptes Rendus de Therap. 1987; 56; 1-9.
Bach D, Ebeling L. Long-term drug treatment of
benign prostatic hyperplasia - results of a protective 3-year multicenter
study using Sabal extract IDS 89. Phytomed 1996; 3: 105-11 (originally
published in Urologe [B]) 1995; 35: 178-83.
Boccafoschi C, Annoscia S. Confromto fra
estratto di Serenoa repens e placebo mediate prova clinica controllata in
pazienti con adenomatosi prostatica. Urologia 1983; 50: 1257-68.
Braeckman J, Denis L, de Laval J, et al. A
double-blind, placebo-controlled study of the plant extract Serenoa repens in
the treatment of benign hyperplasia of the prostate. Eur J Clin Res 1997; 9:
247-59.
Braeckman J. The extract of Serenoa repens in
the treatment of benign prostatic hyperplasia: a multicenter open study. Curr
Ther Res 1994; 55: 776-8.
Breau W, Stadler F, Hagenlocher M, et al. Der
Sabalfrucht-extrakt SG 291. Ein phytotherapeutikumzur behandlung der benignen
prostatahyperplasie. Zeitschrift fur Phytotherapie 1992; 13: 107- 15.
Brown, D. Saw palmetto extract-efficacy shown
in long-term study. Townsend Letter for Doctors & Patients. 1997: 160-161.
Carraro JC, Raynaud JP, Koch G, et al.
Comparison of phytotherapy (Permixon®) with finasteride in treatment of
benign prostate hyperplasia: a randomized international study of 1,098
patients. Prostate 1996; 29: 231-40.
Carreras JO. Experience with the hexane extract
of Serenoa repens in the treatment of benign prostate hyperplasia. Arch Esp de
Urol 1987; 40(5); 310-3.
Champault G, Patel JC, Bonnard AM. A
double-blind trial of an extract of the plant Serenoa repens in benign
prostatic hyperplasia. Br J Clin Pharmacol 1984; 18: 461-2.
Champault, G. et al. The medical treatment of
prostatic adenoma. Ann. Urol. 1984. 6:407-410.
Cukier J, Ducassou J, Le Guillou M, et al.
Permixon® versus placebo. Résultats d´une étude multicentrque. CR Ther
Pharmacol Clin 1985; 4(25): 15-21.
Dathe G, Schmid H. Phytotherapy of benign
prostatic hyperplasia (BPH) with extractum Serenoa repens. Urolog B 1991; 31;
220-3.
Delos S, et al. Inhibition of the activity of
'Basic' 5a-reductase (type 1) detected in Dells and expressed in insect cells.
J Steroid Biochem. 1994; 48(4): 347-52.
Descotes JL, Rambeaud JJ, Deschaseaux P, et al.
Placebo-controlled evaluation of the efficacy and tolerability of Permixon®in
benign prostatic hyperplasia after exclusion of placebo responders. Clin Drug
Invest 1995; 9: 291-7.
Emili E, Lo Cigno M, Petrone U. Risultati
clinici su un nuovo farmaco nella terapia dell´ipertrofia della prostata (Permixon®).
Urologia 1983; 50: 1042-8.
Fetrow, C.W. and Avila, JR, Saw palmetto.
Professional's Handbook of Complementary & Alternative Medicines. 1999.
Springhouse Corp. Springhouse, PA. 578-582.
Gerber GS, Zagaja GP, Bales GT, et al. Saw
palmetto in men with lower urinary tract symptoms: effects on urodynamic
parameters and voiding symptoms. Urology 1998; 51(6): 1003-7.
Gerber, G., et al. Randomized, double-blind,
placebo-controlled trial of saw palmetto in men with lower urinary tract
symptoms. Urology. 2001. 580(6); Dec: 960-965.
Grasso M, Montesano A, Buonaguidi A, et al.
Comparative effects of alfuzosin versus Serenoa repens in the treatment of
symptomatic benign prostatic hyperplasia. Arch Esp Urol 1995; 48: 97- 103.
Kondás J, Philipp V, Diószeghy G. Sabal
serrulata extract (Strogen forte®) in the treatment of symptomatic benign
prostatic hyperplasia. Int Urol Nephrol 1996; 28: 767-72.
Lininger, S. et al. Saw Palmetto. The Natural
Pharmacy. Prima Publishing, Rocklin, CA. 1998: 306- 307.
Lobelenz J. Extractum sabal fructus in the
therapy of benign prostatic hyperplasia (BPH). Tpk therapeutikon. 1992; 6;
34-37.
Lowe FC, Robertson C, Roehrborn C, Boyle P.
Meta analysis of clinical trials of Permixon. J Urol 1999; 159(5) Suppl: 257.
Marks LS. et al. Effects of a saw palmetto
herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol 2000
May;163(5):1451-6
Marks, L.S. et al. Saw palmetto extract: newest
(and oldest) treatment alternative for men with symptomatic benign prostatic
hyperplasia. Urology. 1999. 53: 457-461.
Wilt, T.J. Saw palmetto extracts for treatment
of benign prostatic hyperplasia. JAMA. 1998. 280 (18); Nov: 1604-1608.
Mandressi A, Tarallo U, Maggioni A, et al.
Terapia medica dell´adenoma prostatico: confronto dellaefficacia dell´estratto
di Serenoa repens (Permixon®) versus l´estratto di Pigeum africanum e
placebo. Urologia 1983; 50: 752-8.
Mattei FM, Capone M, Acconcia A, et al.
Medikamentöse therapie der benignen mit einem extrakt der Sögepalme. TW Urol
Nephrol 1990; 2(5): 346-50.
McPartland JM, Pruitt PL. Benign prostatic
hyperplasia treated with saw palmetto: a literature search and an experimental
case study. J Am Osteopath Assoc. 2000 Feb;100(2):87.
Overmyer M. Saw palmetto shown to shrink
prostatic epithelium. Urology Times 1999; 24(6):1,42.
Redecker KD, Funk P. Sabal extract WS 1473 in
benign prostatic hyperplasia. Extracta Urologica 1998; 21: 24-6.
Reese Smith H, Memon A, Smart CJ, et al. The
value of Permixon® in benign prostatic hypertrophy. Br J Urol 1986; 58:
36-40.
Silverio, F. et al. Evidence that Serenoa
repens extract displays an antiestrogenic activity in prostatic tissue of
benign prostatic hypertrophy patients. Eur. Urol. 1992. 21:309-314.
Snow, J. Serenoa repens bartram (Palmae). The
Protocol Journal of Botanical Medicine. 1996: 15-16.
Sultan, C. et al. Inhibition of androgen
metabolism and binding by a liposterolic extract of "Serenoa repens
B" in human foreskin fibroblasts. J. Steroid Biochem. 1984.
20(1):515-519.
Tasca A, Barullli M, Cavazzana A, et al.
Treatment of obstructive symptomatology in prostatic adenoma with an extract
of serenoa repens. Minerva Urologica e Nefrologica 1985; 37: 87-91.
Vahlensieck W, Völp A, Lubos W, et al. Benign
prostatic hyperplasia - treatment with Sabal fruit extract. A surveillance
study on 1334 patients. Fortschr Med 1993; 111: 323-6.
Weisser H, Behnke B, Helpap B, et al. Enzyme
activities in tissue of human benign prostatic hyperplasia after three months'
treatment with the Sabal serrulata extract IDS 89 (Strogen®) or placebo. Eur
Urol 1997; 31: 97-101.
Wilt T J, Ishan A. Stark G, et al. Saw palmetto
extracts for treatment of Benign prostatic hyperplasia. JAMA 1998; 280(18):
1804-9.
Ziegler H, Holscher U, et al. Efficacy of saw
palmetto fruit special extract WS 1473 in patients with Alken stage I-II
benign prostatic hyperplasia - open multicentre study. Jatros Uro 1998; 14:
2-7.
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Chondroitin Sulfate 500 mg 60 capsules - Physiologics
Promotes
Cartilage Renewal*
PRODUCT DISCUSSION
PhysioLogics Chondroitin Sulfate provides 500 mg per capsule and 1,500 mg per
day of Chondroitin, a compound that promotes healthy enzymatic metabolism of
cartilage.*
STRUCTURE AND FUNCTION
Chondroitin Sulfate is a natural constituent of cartilage, made up of repeating
chains of glycosaminoglycans (GAGs). Chondroitin Sulfate is a highly charged
polyanion, promoting water retention in the connective tissue to support joint
flexibility and cushion joints.* Composed of Nacetyl-galactosamine and
glucuronic acid, Chondroitin Sulfate provides a raw material for proteoglycan
and GAG synthesis to actually help renew cartilage.* Chondroitin Sulfate also
promotes healthy enzymatic metabolism of cartilage, to further maintain joint
health.*
CLINICAL EVIDENCE
A total of 120 subjects were given 800 mg
Chondroitin Sulfate or placebo for two, three-month periods over the course
of a year. Subjects receiving Chondroitin Sulfate had significantly improved
knee function as compared to the placebo group. (Uebelhart et al, 2004)
Another placebo-controlled study showed that
subjects consuming 1 g/day Chondroitin Sulfate had significantly improved
joint comfort and overall joint health (Lequesne's algofunctional index, AFI)
when compared to placebo. (Mazieres et al, 2001)
SUMMARY
Chondroitin Sulfate promotes healthy enzymatic metabolism of cartilage to
maintain joint health.
SUGGESTED DOSAGE
For adults, take one (1) capsule three times daily, preferably with meals, or
follow the advice of a health care professional.
REFERENCES
Bucsi L, Poor G. Efficacy and tolerability of oral chondroitin sulfate as a
symptomatic slow-acting drug for osteoarthritis (SYSADOA) in the treatment of
knee osteoarthritis. Osteoarthritis Cartilage. 1998;6 Suppl A:31-6.
Mazieres B, Combe B, Phan Van A, et al.
Chondroitin sulfate in osteoarthritis of the knee: a prospective, double
blind, placebo controlled multicenter clinical study. J Rheumatol.
2001;28:173-81.
Uebelhart D, Malaise M, Marcolongo R, et al.
Intermittent treatment of knee osteoarthritis with oral chondroitin sulfate: a
one-year, randomized, double-blind, multicenter study versus placebo.
Osteoarthritis Cartilage. 2004;12:269-76. Click
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B-12 Sublingual 5000mcg 60 vtabs - Physiologics
Promotes
Energy Metabolism and Nervous System Health*
PRODUCT DISCUSSION
Vitamin B-12 contributes to the health of the nervous system.* It plays an
important role in neurological cell integrity, DNA metabolism, and red blood
cell formation.* It is also a co-enzyme in energy reactions.* Vitamin B-12 is
exclusively synthesized in microorganisms and cannot be found in plant
sources. Foods containing Vitamin B-12 include meats, poultry, fish, and dairy
products. Vitamin B-12 may not be readily absorbable as people age.*
STRUCTURE AND FUNCTION
Vitamin B-12, or cobalamin, is a micronutrient that is essential to humans.
The two active cobalmin coenzymes in humans are methylcobalamin and
5-deoxyadenoxylcobalamin. As a co-enzyme, Vitamin B-12 is needed in the
conversion of homocysteine to methionine by methionine synthase. Vitamin B-12
is also needed in the conversion of methylmalonyl-CoA to succinyl-CoA by
methylmalonyl-CoA mutase. Succinyl- CoA may then be used as in the Kreb’s
cycle or as a substrate for heme synthesis.
B-12 is found in foods such as oysters, crab, beef, salmon, chicken, and
eggs. B-12 can be obtained from animal sources but is not found in vegetables
in any significant amount. B-12 may not be as readily absorbable (from the
digestive system) as we age.
INDICATIONS
Individuals with pernicious anemia or with gastrointestinal disorders
may benefit from a vitamin B-12 supplement.*
Older adults and vegetarians may benefit from a vitamin B-12
supplement.*
Some medications may decrease absorption of vitamin B-12. Chronic use of
those medications may result in a need for supplemental B-12.*
Pregnant women who follow strict vegetarian diets may have depleted
vitamin B-12 stores.*
HOW CLIENTS MAY BENEFIT
Vitamin B-12 is an essential nutrient and needed for overall good health and
metabolism. Vitamin B-12 is part of the B-complex which is needed for energy
metabolism and promotion of cellular health. Metabolism within the body
includes the processes of energy generation and use; including nutrition,
digestion, absorption, elimination, respiration, circulation, and temperature
regulation. Vitamin B-12 maintains proper circulatory and nerve function and
promotes healthy levels of homocysteine.* Physiologics vitamin B-12 comes in a
convenient sublingual lozenge.
CLINICAL EVIDENCE
The Oxford Healthy Aging Projects, a cohort study conducted from 1993 to 2003,
examined the relationship between serum vitamin B-12 status and cognitive
function in older adults. A significant association was found between low
levels of vitamin B-12 and the incidence and rate of cognitive decline over
the ten year period. (Clarke et al. 2007.) In a double-blind
placebo-controlled trial, 205 subjects were randomized to receive either a
combination of folic acid, vitamin B-12, and vitamin B-6, or placebo, for 6
months. At the end of the study, a significant benefit to cardiovascular
function was observed in the treatment group compared to placebo. Plasma
homocysteine levels were also significantly reduced in the treated group
compared to placebo. (Schnyder et al. 2001).
SUMMARY
PhysioLogics Sublingual Vitamin B-12 provides an important member of the
vitamin B complex. Vitamin B-12, also known as cobalamin, is necessary for the
synthesis of red blood cells and the maintenance of the nervous system.
SUGGESTED DOSAGE
For adults, take one (1) lozenge or tablet daily. Place lozenge or tablet
under the tongue for 30 seconds before swallowing, or follow the advice of a
health care professional.
REFERENCES
Clarke et al. Low Vitamin B-12 status and risk of cognitive decline in older
adults. American Journal of Clinical Nutrition. 2007 86:1384-91
Institute of Medicine. Food and Nutrition Board. Dietary Reference
Intakes: thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B-12,
pantothenic acid, biotin, and choline. Institute of Medicine. Washington,
DC:National Academy Press 1998.
Kapadia CR Vitamin B-12 in health and disease: part I -- inherited
disorders of function, absorption, and transport. Gastroenterologist.
1995;3:329-44.
Russell RM, Suter PM. Vitamin requirements of elderly people: an update.
Am J Clin Nutr. 1993;58:4-14.
Schnyder G et al. Decreased rate of coronary restenosis after lowering of
plasma homocysteine levels. New England Journal of Medicine. 2001.
345(22):1593-1600.
Shevell , Rosenblatt DS. The neurology of cobalamin. Can J Neurol Sci.
1992;19:472-86.
van Asselt DZ, van den Broek WJ, et al. Free and protein-bound cobalmin
absorption in healthy middle-aged and older subjects. J Am Geriatr Soc.
1996;44:949-53.
van Goor L, Woiski MD, Lagaay AM, et al. Review: cobalamin deficiency and
mental impairment in elderly people. Age Ageing. 1995;24:536-42.
Waldmann A, Koschizke JW, Leitzmann C, Hahn A. Homocysteine and cobalamin
status in German vegans. Public Health Nutr. 2004;7:467-72.
= Vegetarian Formula
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B-Complex 100mg 50 vcaps - Physiologics
Supports
Nervous System Health*
HOW PATIENTS MAY BENEFIT
Provides essential B Vitamins to support numerous metabolic pathways*
Promotes energy metabolism in the body*
Supplies women with the recommended folic acid dosage*
PRODUCT DISCUSSION
The B Vitamin complex is made up of several water-soluble vitamins that play
unique roles in maintaining proper metabolic functioning.* B Vitamins work
well together to support heart health and nervous system health, and provide
nourishment for the stress of daily living.* PhysioLogics B-100 Complex offers
a daily intake of the essential B Vitamins to support energy metabolism and
skin health.*
STRUCTURE AND FUNCTION
Thiamine (B-1) functions as the coenzyme thiamin pyrophosphate, assisting in
the metabolism of carbohydrates and branched-chain amino acids, as well as in
production of the neurotransmitter acetylcholine.*
Riboflavin (B-2) assists in oxidation/reduction reactions, including those
involved in energy pathways and the metabolism of carbohydrates, fats and
proteins.* It also helps maintain the skin and mucous membranes, the cornea of
the eye, and nerve sheaths.*
Niacin (B-3), also known as nicotinic acid and nicotinamide, serves as a
coenzyme in oxidation/reduction reactions as nicotinamide adenine dinucleotide
(NAD) and its phosphate form (NADP). NAD functions in intracellular
respiration and oxidation of glyceraldehydes, lactate, alcohol, and other fuel
molecules. NADP is required in reductive biosyntheses, such as fatty acid and
steroid synthesis. Niacin is needed for the metabolism of food, maintenance of
healthy skin and nerve cells, DNA replication and repair, and cell
differentiation.*
The major coenzyme forms of Pyridoxine (B-6) are pyridoxal 5'-phosphate (PLP)
and pyridoxamine (PMP), which function in the catabolism of carbohydrates and
proteins. PLP serves as a coenzyme in more than 100 reactions in amino acid
metabolism, including aminotransferases, decarboxylases, and dehydratases.
Vitamin B-6 is also used in the production of red blood cells, and is involved
in the single-carbon cycle, which produces methyl groups used in the synthesis
of other compounds. By this mechanism, Vitamin B-6 promotes healthy
homocysteine levels.*
Folic Acid, also known as folate, functions as a coenzyme essential to
virtually all biochemical reactions that use single-carbon transfers,
including purine and pyrimidine biosynthesis, generation of formate, and amino
acid interconversions, including homocysteine to methionine. Folic acid
participates in the breakdown of proteins and the formation of hemoglobin, a
compound in red blood cells that transports oxygen and carbon dioxide.
Healthful diets with adequate folate may reduce a woman's risk of having a
child with a brain or spinal cord birth defect.
Vitamin B-12 (Cobalamin) is a coenzyme in the single-carbon cycle, and,
with Vitamin B-6 and Folate, converts homocysteine to methionine. Vitamin B-12
is also required for maintenance of nerve sheaths, normal blood formation, and
DNA synthesis and repair.*
Pantothenic acid is used for the synthesis of coenzyme A and thus is
involved in many metabolic pathways, including energy metabolism.* Biotin
functions as a coenzyme in carboxylation reactions, which are also useful in
many functions of the body. Choline is a precursor for the neurotransmitter
acetylcholine.
CLINICAL EVIDENCE
In a double-blind placebo-controlled trial, 205 subjects were randomized
to receive either a combination of folic acid, vitamin B12, and vitamin
B6, or placebo, for 6 months. At the end of the study, a significant
benefit to cardiovascular function was observed in the treatment group
compared to placebo. Plasma homocysteine levels were also significantly
reduced in the treated group compared to placebo. (Schnyder et al, 2001)
A study followed 370 elderly people for three years and monitored their
cognitive function, along with serum levels of Vitamin B-12 and Folate. A
comparable pattern was found between higher levels of these vitamins and
maintenance of cognitive function. (Wang et al, 2001)
A review in the Journal of the American Medical Association stated that
most people do not consume optimal amounts of vitamins by diet alone. In
fact, suboptimal intake of some vitamins, even above levels classified as
deficiency, may be unhealthy and is common in the general population. The
reviewers concluded that it is wise for all adults to take vitamin
supplements. (Fairfield and Fletcher, 2002)
SUMMARY
The B Vitamins work individually and synergistically in a wide array of
biological functions to maintain good health and vitality.* The body needs a
daily source of the B Vitamins because B Vitamins are water-soluble.
PhysioLogics' B-100 Complex provides a convenient way to obtain all essential
B Vitamins in one easy-to-swallow capsule.*
SUGGESTED DOSAGE
For adults, take one (1) capsule daily, preferably with a meal, or follow the
advice of a health care professional.
REFERENCES
Aisen PS, Egelko S, Andrews H, et al. A pilot study of vitamins to lower
plasma homocysteine levels in Alzheimer disease. Am J Geriatr Psychiatry.
2003;11:246-9.
Centers for Disease Control and Prevention. Recommendations for the use
of folic acid to reduce the number of cases of spina bifida and other neural
tube defects. MMWR 1992. 41 (No. RR-14).
Fairfield KM, Fletcher RH. Vitamins for chronic disease prevention in
adults: scientific review. JAMA. 2002;287:3116-26.
Institute of Medicine. Dietary Reference Intakes: Thiamin, Riboflavin,
Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and
Choline. Washington, DC: National Academy Press, 1998.
Manore MM. Effect of physical activity on thiamine, riboflavin, and
vitamin B-6 requirements. Am J Clin Nutr. 2000;72(2 Suppl):598S-606S.
Nilsson K, Warkentin S, Hultberg B, et al. Treatment of cobalamin
deficiency in dementia, evaluated clinically and with cerebral blood flow
measurements. Aging (Milano). 2000;12:199-207.
Schnyder G, Roffi M, Pin R, et al. Decreased rate of coronary restenosis
after lowering of plasma homocysteine levels. N Engl J Med.
2001;345:1593-1600.
Stampfer MJ, Malinow MR, Willett WC, et al. A prospective study of plasma
homocyst(e)ine and risk of myocardial infarction in US physicians. JAMA.
1992;268:877-81.
Wang HX, Wahlin A, Basun H, et al. Vitamin B(12) and folate in relation
to the development of Alzheimer's disease. Neurology. 2001;56:1188-94.
=
Vegetarian Formula
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OsteoLogic Pro 180 tablets - Physiologics
Comprehensive
Bone Support*
OsteoLogic Pro™ combines two highly
bioavailable forms of calcium – calcium citrate and calcium hydroxyapatite –
with a blend of vitamins and minerals that are essential for proper bone
deposition.*
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DIM 100mg 60 capsules - Physiologics
Promotes
Healthy Estrogen Metabolism*
HOW PATIENTS MAY BENEFIT
Patented formulation designed to promote healthy estrogen metabolism*
Stabilized, bioavailable form of Diindolylmethane (DIM®)
PRODUCT DISCUSSION
PhysioLogics DIM (bioavailable 3,3-Diindolylmethane) is a patented, stabilized
formula that helps promote cellular health and supports the enzymatic basis of
healthy estrogen metabolism.*
STRUCTURE AND FUNCTION
The compound 3,3-Diindolylmethane is a dietary indole which occurs naturally in
Brassica vegetables. Brassica vegetables are also known as cruciferous
vegetables and include broccoli, cauliflower, cabbage, turnips, kale and
brussels sprouts. These vegetables are considered by many scientists to be among
the most metabolically healthful foods because of their unique profile of
naturally occurring biochemicals. Diindolylmethane is a stable dimer (double
molecule) of indole-3-carbinol (I3C), which is generated upon hydrolysis of
glucobrassicin, the indole glucosinolate in Brassica vegetables. Dehydration of
I3C results in a mixture of oligomeric products, including diindolylmethane.
Diindolylmethane has been shown to have beneficial enzymatic interactions in
vitro, which is believed to help mediate its positive effects on estrogen
metabolism.*
CLINICAL EVIDENCE
A randomized, double-blind, placebo controlled, clinical study analyzed
healthy estrogen metabolism in 20 postmenopausal women. Subjects were given
either 108 mg/day of Diindolylmethane as DIM® or a placebo. DIM® treated
subjects showed a significant increase in levels of 2-hydroxyestrone
(p=0.020) and diindolylmethane (p=0.045), and an increase of 47% in the
2-hydroxyestrone/16-alpha hydroxyestrone ratio (p=0.059). Based on these
results, the authors concluded that DIM® had positive effects on estrogen
metabolite ratios. (Dalessandri et al, 2004)
In a double-blind, placebo-controlled, crossover study, 33 subjects
received 60 mg of DIM® or placebo per day in four divided doses. Each study
period lasted three months. At three months, a significant positive effect
was observed on estrogen metabolism in the treatment group. No significant
effect was observed in the placebo group. (Zeligs et al, 2005)
SUMMARY
PhysioLogics DIM® utilizes BioResponse-DIM®, a bioavailable form of
Diindolylmethane, that helps promote healthy estrogen metabolism and cellular
health.*
SUGGESTED DOSAGE
For adults, take one (1) capsule with a meal up to three times daily or follow
the advice of your health care professional.
DIM® and BioResponse-DIM® are trademarks of BioResponse.
REFERENCES
Bonnesen C, Eggleston IM, Hayes JD. Dietary indoles and isothiocyanates that
are generated from cruciferous vegetables can both stimulate apoptosis and
confer protection against DNA damage in human colon cell lines. Cancer Res.
2001;61:6120-30
Bradfield CA, Bjeldanes LF. High-performance liquid chromatographic
analysis of anticarcinogen indoles in Brassica oleracea. J Agric Food Chem.
1987;35:46-9
Chen DZ, Qi M, Auborn KJ, Carter TH. Indole-3-carbinol and diindolylmethane
induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic
preneoplastic cervical epithelium. J Nutr. 2001;131:3294-302
Chen, I, et al. Indole-3-carbinol and Diindolylmethane as Arly Hydrocarbon
(Ah) Receptor Agonists and Antagonists in T47D Human Breast Cancer Cells.
Biochem Pharmacol. 1996. 51(8): 1069-1076
Chen I, McDougal A, Wang F, Safe S. Aryl hydrocarbon receptor-mediated
antiestrogenic and antitumorigenic activity of diindolylmethane.
Carcinogenesis. 1998;19:1631-9
Chintharlapalli S, Smith R 3rd, Samudio I, et al.
1,1-Bis(3'indolyl)-1-(p-substitutedphenyl)methanes induce peroxisome
proliferator-activated receptor gamma-mediated growth inhibition,
transactivation, and differentiation markers in colon cancer cells. Cancer
Res. 2004;64:5994-6001
Dalessandri KM, Firestone GL, Fitch MD, et al. Pilot study: effect of 3,3'-
diindolylmethane supplements on urinary hormone metabolites in postmenopausal
women with a history of early-stage breast cancer. Nutr Cancer. 2004;50:161-7
Firestone GL, Bjeldanes LF. Indole-3-carbinol and 3-3'-diindolylmethane
antiproliferative signaling pathways control cellcycle gene transcription in
human breast cancer cells by regulating promoter-Sp1 transcription factor
interactions. J Nutr. 2003;133(7 Suppl):2448S-2455S
Gamet-Payrastre L, Lumeau S, Gasc N, et al. Selective cytostatic and
cytotoxic effects of glucosinolates hydrolysis products on human colon cancer
cells in vitro. Anticancer Drugs. 1998;9:141-8
Ge X, Yannai S, Rennert G, et al. 3,3'-Diindolylmethane induces apoptosis
in human cancer cells. Biochem Biophys Res Commun. 1996;228:153-8
Hong C, Kim HA, Firestone GL, Bjeldanes LF. 3,3'- Diindolylmethane (DIM)
induces a G(1) cell cycle arrest in human breast cancer cells that is
accompanied by Sp1-mediated activation of p21(WAF1/CIP1) expression.
Carcinogenesis. 2002;23:1297-305
Hong C, Firestone GL, Bjeldanes LF. Bcl-2 family-mediated apoptotic effects
of 3,3'-diindolylmethane (DIM) in human breast cancer cells. Biochem Pharmacol.
2002;63:1085-97
Lee SH, Kim JS, Yamaguchi K, et al. Indole-3-carbinol and
3,3'diindolylmethane induce expression of NAG-1 in a p53-independent manner.
Biochem Biophys Res Commun. 2005;328:63-9
Leong H, Firestone GL, Bjeldanes LF. Cytostatic effects of
3,3'diindolylmethane in human endometrial cancer cells result from an estrogen
receptor-mediated increase in transforming growth factor-alpha expression.
Carcinogenesis. 2001;22:1809-17
Leong H, Riby JE, Firestone GL, Bjeldanes LF. Potent ligandindependent
estrogen receptor activation by 3,3'-diindolylmethane is mediated by cross
talk between the protein kinase A and mitogen-activated protein kinase
signaling pathways. Mol Endocrinol. 2004;18:291-302. Epub 2003 Nov 26
Lord RS, Bongiovanni B, Bralley JA. Estrogen metabolism and the diet-cancer
connection: rationale for assessing the ratio of urinary hydroxylated estrogen
metabolites. Altern Med Rev. 2002;7:112-29
Qin C, Morrow D, Stewart J, et al. A new class of peroxisome proliferator-activated
receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer
cells: 1,1-Bis(3'-indolyl)-1-(psubstituted phenyl)methanes. Mol Cancer Ther.
2004;3:247-60
Riby JE, Chang GH, Firestone GL, Bjeldanes LF. Ligand-independent
activation of estrogen receptor function by 3, 3'-diindolylmethane in human
breast cancer cells. Biochem Pharmacol. 2000;60:167-77
Staub RE, Feng C, Onisko B, et al. Fate of indole-3-carbinol in cultured
human breast tumor cells. Chem Res Toxicol. 2002;15:101-9
Sun S, Han J, Ralph WM Jr, et al. Endoplasmic reticulum stress as a
correlate of cytotoxicity in human tumor cells exposed to diindolylmethane in
vitro. Cell Stress Chaperones. 2004;9:76-87
Zeligs MA, et al. Managing cyclical mastalgia with absorbable
diindolymethane: A randomized, placebo-controlled trial. JAMA. 2005. 8(1):
5-15
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PhysioWhey Powder 840g - Physiologics
Rich Source of Whey Protein
Natural Vanilla Flavor with other Natural Flavors
PhysioWhey™ Powder is an all-natural, formulation of whey protein.
PhysioWhey™ is low in lactose, has a high biological value and a balanced
amino acid profile. This product delivers 20 grams of vanilla-flavored whey
protein per serving.*
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Cartilage Companion HP 120 tablets - Physiologics
Supports
Joint and Cartilage Maintenance*
Cartilage Companion® HP combines the top three
structural components found in popular joint support products.* Scientific
studies indicate that glucosamine helps provide the building blocks for
supporting cartilage.* Chondroitin helps to maintain joint cartilage.* MSM is an
organic source of sulfur and synergistically enhances the benefits of
Glucosamine and Chondroitin to support cartilage health.* When taken as part of
a daily supplement schedule, Cartilage Companion® HP is a formulary matrix that
helps revitalize the cellular components within the joints.*
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CMO Cetyl Myristoleate Complex 60 capsules - Physiologics
Found
in Popular Joint Products
Cetyl Myristoleate is a revolutionary new
supplement found in popular joint support products. Our Cetyl Myristoleate
Complex is made from premium ingredients and backed by extensive laboratory
testing.
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Coenzyme Q10 Q-Sorb 75mg 60 softgels - Physiologics
Supports
Cardiovascular and Antioxidant Health*
HOW PATIENTS MAY BENEFIT
Supports cells and mitochondrial DNA from the
harmful effects of reactive oxygen species*
PRODUCT DISCUSSION
PhysioLogics Coenzyme Q-10 Q-Sorb™ 75 mg provides an essential component of
the mitochondrial electron transport chain, vital for the production of
adenosine triphosphate (ATP) required for virtually all cellular processes. Co
Q-10 is a lipophilic antioxidant that neutralizes the formation of reactive
oxygen species in the mitochondria, which is important for cardiovascular
health.*
Endogenous levels of Co Q-10 may diminish with
age, strenuous exercise, and environmental stressors. In addition, certain
regularly prescribed drugs, including statins, may deplete the body's supply of
Co Q-10. (Note: Coenzyme Q-10 is not intended to serve as a replacement for
statin therapy, nor should patients discontinue taking any prescribed
medications while supplementing with Co Q-10.)
STRUCTURE AND FUNCTION
Coenzyme Q-10 is a vitamin-like molecule naturally found in the inner
mitochondrial membrane of every cell in the human body. In the mitochondrial
respiratory chain, Co Q-10 is the electron acceptor for mitochondrial complex I
and complex II, and donates electrons to complex III during oxidative
phosphorylation. Each pair of electrons in the electron transport chain must
interact with Co Q-10, the rate-limiting component of the mitochondrial
respiratory cycle.
Co Q-10 is also a component of extra-mitochondrial
redox chains, whose function is to remove excess reducing power formed during
glycolysis when mitochondrial respiration is decreased. In its reduced form, Co
Q-10 is a lipid-soluble antioxidant that readily provides electrons to
neutralize superoxide and lipid radicals. Mitochondria are the primary sources
of intracellular reactive oxygen species (ROS), which are capable of
mitochondrial DNA damage. Co Q-10 scavenges these species to support the cell
and DNA and fight oxidative stress, neutralizing both the initiation and
propagation of lipid peroxidation.
By supporting the normal physiological function
of the heart, Co Q-10 promotes healthy circulation through myocardial tissue. Co
Q-10 also has membrane stabilizing properties thought to be involved in the
phospholipid-protein interaction that aids in the metabolism of prostaglandins.
Myocardial calcium-dependent ion channels are stabilized by Co Q-10, which
supports molecules essential for ATP synthesis. In addition, Co Q-10 seems to
play a role in supporting the fluidity of membranes, important for physiological
functions of receptors, carriers and membrane-bound enzymes.
CLINICAL EVIDENCE
In a double-blind, placebo-controlled,
randomized study conducted by Berman et al, subjects consuming Co Q-10
showed significant improvement in a 6-minute walk test, breathing
parameters, New York Heart Association (NYHA) classification, and fatigue.
The administration of Co Q-10 to subjects led to a significant improvement
in functional status, and quality of life. Coenzyme Q-10 was shown to
effectively support overall well being includin heart health. (Berman et al,
2004)
In another randomized, double-blind,
controlled trial, the effects of oral treatment with Co Q-10 (120 mg/day)
were compared over one year in 144 subjects. Co Q-10 significantly increased
the level of vitamin E in the blood, supported healthy HDL levels, and
reduced molecules that cause oxidative stress. There was a significantly
lower effect in the control group. (Singh et al, 2003)
SUMMARY
Coenzyme Q-10 plays an essential role in the production of cellular ATP.* Its
role as an antioxidant supports cardiovascular tissue from oxidative damage.*
Supplementing a patient's nutritional regimen with PhysioLogics Coenzyme Q-10 Q-Sorb™
75 mg softgels will support cellular energy production and also help promote
cardiovascular health.*
SUGGESTED DOSAGE
For adults, take one (1) softgel twice daily, preferably with meals, or follow
the advice of a health care professional.
REFERENCES
Berman M, et al. Coenzyme Q10 in patients with endstage heart failure awaiting
cardiac transplantation: A randomized, placebo-controlled study. Clin Cardiol.
2004;27:295-9.
Ebadi M, et al. Ubiquinone (coenzyme Q-10) and
mitochondria in oxidative stress of Parkinson's disease. Bio Signals Recept.
2001;10:224-53.
Ernster, L, Dallner G. Biochemical,
physiological and medical aspects of ubiquinone function. Biochim Biophys Acta.
1995;1271:195-204.
Greenberg S, Frishman WH. Co-enzyme Q-10: a new
drug for cardiovascular disease. J Clin Pharmacol. 1990;30:596-608.
Kato T, et al. Reduction in blood viscosity by
treatment with coenzyme Q-10 in patients with ischemic heart disease. Int J
Clin Pharmacol Ther Toxicol. 1990;28:123-6.
Langsjoen PH, Langsjoen AM. The clinical use of
HMG CoA-reductase inhibitors and the associated depletion of coenzyme Q10. A
review of animal and human publications. Biofactors. 2003;18:101-11.
Mellors A, Tappel AL. The inhibition of
mitochondrial peroxidation by ubiquinone and ubiquinol. J Biol Chem.
1966;241:4353-6.
Mortensen SA, et al. Coenzyme Q-10: clinical
benefits with biochemical correlates suggesting a scientific breakthrough in
the management of chronic heart failure. Int J Tissue React. 1990;12:155-62.
Nair K, et al. Aging muscle. Am J Clin Nutr.
2005;81:953-63.
Nohl H, Gille L, Staniek K. The biochemical,
pathophysiological, and medical aspects of ubiquinone function. Ann N Y Acad
Sci. 1998;854:394-409.
Overvad K, et al. Coenzyme Q-10 in health and
disease. Eur J Clin Nutr. 1999;53:764-70.
Rauchova H, Drahota Z, Lenaz G. Function of
coenzyme Q in the cell: some biochemical and physiological properties. Physiol
Res. 1995;44:209-16.
Ravikumar A, et al. Isoprenoid pathway and free
radical generation and damage in neuropsychiatric disorders. Ind J Exp Biol.
2000;38:438-46.
Reis F, et al. Circadian and seasonal variation
of endogenous ubiquinone plasma level. Chronobiol Int. 2002;19:599-614.
Singh RB, et al. Effect of coenzyme Q10 on risk
of atherosclerosis in patients with recent myocardial infarction. Mol Cell
Biochem. 2003;246:75-82.
Shults CW, et al. Coenzyme Q-10 levels
correlate with the activities of complexes I and II/III in mitochondria from
parkinsonian and nonparkinsonian subjects. Ann Neurol. 1997;42:261-4.
Tran MT, et al. Role of coenzyme Q-10 in
chronic heart failure, angina, and hypertension. Pharmacotherapy.
2001;21:797-806.
Weber C, et al. Effect of dietary coenzyme Q-10
as an antioxidant in human plasma. Mol Aspects Med. 1994;15 Suppl:s97-102.
Wei YH, et al. Tandem duplications and
large-scale deletions of mitochondrial DNA are early molecular events of human
aging process. Ann N Y Acad Sci. 1996;786:82-101.
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DMAE 100mg 100 capsules - Physiologics
Popular
Ingredient Found in Skin Care Products
DMAE (Dimethylaminoethanol) can be found in fish and meats and is used as a
popular ingredient in skin care products.*
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Evening Primrose Oil 500mg 100 softgels - Physiologics
Nutrition
for Women
• 100% Natural
• Cold Processed
HOW PATIENTS MAY BENEFIT
Helps provide nutritional support to women
with PMS*
PRODUCT DISCUSSION
PhysioLogics Evening Primrose Oil (EPO) supplies 45 mg of Gamma-Linolenic Acid (GLA)
per softgel and up to 270 mg per day to help provide nutritional support for
overall health and for women with PMS.* GLA is an omega-6 fatty acid that can be
synthesized from Linoleic Acid in the body by the rate-limiting enzyme delta-6
desaturase. However, biological conversion is estimated to be less than 10% and
is affected by several factors, including aging; intake of certain nutrients
such as zinc, B6, magnesium, biotin and calcium; stress; and cholesterol levels.
GLA does not have significant food sources, so supplementation may be important.
STRUCTURE AND FUNCTION
GLA promotes cellular and metabolic health.* It is a precursor to prostaglandins,
action-specific bio-molecules that regulate many important functions in cells,
and provides nutritional support for women with PMS by modulating prostaglandin
production.* GLA also supports the immune system and can help with dry skin.*
CLINICAL EVIDENCE
Fourteen subjects were assessed for effects on
skin health after receiving capsules of evening primrose oil containing 40
mg of gamma linolenic acid (GLA) per capsule twice per day. All subjects
reported improvements in skin health, with 42.8% subjects having complete
improvement in skin health. (Yoon et al, 2002)
In a preliminary clinical trial with 68 women
who had a history of PMS, 500 mg of EPO taken twice daily led to an overall
positive effect on PMS scores, which were based on mood, mental well-being,
comfort, and fluid retention. Over 60% of the women who had poor success
with PMS previously had a reported "good" response to EPO when
compared to placebo. (Brush et al, 1984)
SUMMARY
PhysioLogics Evening Primrose Oil is a source of Gamma-Linolenic Acid and
provides nutritional support for overall health and for women with PMS.*
SUGGESTED DOSAGE
For adults, take one (1) softgel three to six times daily, preferably with
meals, or follow the advice of a health care professional.
REFERENCES
Brush MG, Watson SJ, Horrobin DF, Manku MS. Abnormal essential fatty acid
levels in plasma of women with premenstrual syndrome. Am J Obstet Gynecol.
1984;150:363-6.
Yoon S, Lee J, Lee S. The therapeutic effect of
evening primrose oil in atopic dermatitis patients with dry scaly skin lesions
is associated with the normalization of serum gamma-interferon levels. Skin
Pharmacol Appl Skin Physiol. 2002;15:20-5.
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Glucosamine Chondroitin HP 120 tablets - Physiologics
Helps
Promote Healthy Cartilage Formation and Supports Joints*
HOW PATIENTS MAY BENEFIT
Helps promote healthy cartilage and joints*
Supports range of motion, mobility,
cushioning, and flexibility for comfortable movement*
PRODUCT DISCUSSION
Physiologics Glucosamine/Chondroitin HP combines Glucosamine and Chondroitin
Sulfate, two ingredients that have been studied together in clinical trials more
than any other combination of joint ingredients. Glucosamine, an
aminomonosaccharide, provides the building blocks for constructing cartilage.*
Chondroitin promotes healthy enzymatic metabolism of cartilage.* Together, these
ingredients support overall joint function, mobility, flexibility, total joint
space and comfort.*
STRUCTURE AND FUNCTION
Glucosamine, a key component of cartilage and synovial fluid, is utilized as the
main substrate in the synthesis of glycosaminoglycans (GAG)s and proteoglycans,
the primary structural components in cartilage. Glucosamine undergoes metabolic
conversion to glucosamine-6phosphate and subsequently to galactosamine, which is
required for GAG assembly. This process promotes cartilage production and
articular function.*
Chondroitin Sulfate is a highly charged polyanion
that promotes fluid retention in the connective tissue to support joint
flexibility and cushion joints.* Composed of N-acetyl-galactosamine and
glucuronic acid, Chondroitin Sulfate provides a raw material for proteoglycan
and GAG synthesis to help renew cartilage.* Chondroitin Sulfate also promotes
healthy enzymatic metabolism of cartilage, to further maintain joint health.*
CLINICAL EVIDENCE
In this double-blind placebo/celecoxib-controlled
trial, 1583 subjects received one of the following daily for 24 weeks: 1500
mg of glucosamine HCL, 1200 mg of chondroitin sulfate, both glucosamine HCL
and chondroitin sulfate, 200 mg of celecoxib, or placebo. In the subgroup of
subjects with the most joint concerns, those receiving the combination of
glucosamine and chondroitin experienced a significant improvement in knee
function compared to placebo. (Clegg et al, 2006)
In this study, 30 subjects receiving 1500 mg
of glucosamine per day were compared with 28 subjects receiving a placebo
for 12 weeks. All participants had joint concerns at the beginning of the
study. The subjects who received the glucosamine experienced a significant
improvement in several aspects of joint comfort compared with placebo. (Usha
et al, 2004)
SUMMARY
Both Glucosamine and Chondroitin are key structural components of cartilage and
play important roles in the maintenance of joint cartilage.*
SUGGESTED DOSAGE
For adults, take three (3) tablets per day with food, or follow the advice of a
health care professional.
REFERENCES
Barclay TS, Tsourounis C, McCart GM. Glucosamine. Ann Pharmacother.
1998;32:574-9.
Bucsi L, Poor G. Efficacy and tolerability of
oral chondroitin sulfate as a symptomatic slow-acting drug for osteoarthritis
(SYSADOA) in the treatment of knee osteoarthritis. Osteoarthritis Cartilage.
1998;6 Suppl A:31-6.
Clark CC, Richards CF, Iozzo RV. Post-translational
alterations in newly synthesized cartilage proteoglycans induced by the
glutamine analogue 6-diazo-5-oxo-Lnorleucine. Time course of inhibition and
recovery. Biochem J. 1991;273:283-8.
Clegg DO, Reda DJ, Harris CL, et al.
Glucosamine, chondroitin sulfate, and the two in combination for painful knee
osteoarthritis. N Engl J Med. 2006;354:795-808.
D'Ambrosio E, Casa B, Bompani R, et al.
Glucosamine sulphate: a controlled clinical investigation in arthrosis.
Pharmatherapeutica. 1981;2:504-8.
De Camara CC, Dowless GV. Glucosamine sulfate
for osteoarthritis. Ann Pharmacother. 1998;32:580-7.
Deal CL, Moskowitz RW. Nutraceuticals as
therapeutic agents in osteoarthritis. The role of glucosamine, chondroitin
sulfate, and collagen hydrolysate. Rheum Dis Clin North Am. 1999;25:379-95.
Drovanti A, Bignamini AA, Rovati AL.
Therapeutic activity of oral glucosamine sulfate in osteoarthrosis: a
placebocontrolled double-blind investigation. Clinical Therapeutics. 1980;
3:260-72.
Giordano N, Nardi P, Senesi M, et al. The
efficacy and safety of glucosamine sulfate in the treatment of gonarthritis.
Clin Ter. 1996; 147:99-105. Italian.
Lopes Vaz A. Double-blind clinical evaluation
of the relative efficacy of ibuprofen and glucosamine sulphate in the
management of osteoarthritis of the knee in outpatients. Current Med Res Opin.
1982;8:145-9.
Mazieres B, Combe B, Phan Van A, et al.
Chondroitin sulfate in osteoarthritis of the knee: a prospective, double
blind, placebo controlled multicenter clinical study. J Rheumatol.
2001;28:173-81.
Reginster JY, Deroisy R, Rovati LC, et al.
Long-term effects of glucosamine sulphate on osteoarthritis progression: a
randomised, placebo-controlled clinical trial. Lancet. 2001;357:251-6.
Usha PR, Naidu MUR. Randomised, double-blind,
parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane
and their combination in osteoarthritis. Clin Drug Investig. 2004;24:353-63.
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MSM & Glucosamine 4oz. Cream - Physiologics
A
Soothing Emollient for the Skin and Joints
Blend of soothing emollients with
Methylsulfonylmethane for joint health.
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Mycelia Immunity Formula 60 capsules - Physiologics
Contains
Beta Glucan
Mycelia Immunity Formula is made from an extract
of Shiitake Mushrooms, which are grown aseptically on organic substrate in a
carefully controlled environment.
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IP-6 (Inositol Hexaphosphate) 120 capsules - Physiologics
Supports Cell Growth and Function*
Inositol Hexaphosphate is derived from rice bran. Inositol is an essential
component of cell membranes and plays an important role in cell growth and
function.*
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Joint Formula 120 softgels - Physiologics
Joint
Nutrition Backed by Scientific Research*
PRODUCT DISCUSSION
PhysioLogics Joint Formula utilizes Glucosamine and Chondroitin Sulfate, the
same popular joint support ingredients backed by scientific research.*
Glucosamine is an aminomonosaccharide which promotes the production of
glycosaminoglycans (GAGs) and proteoglycans. Chondroitin promotes healthy
enzymatic metabolism of cartilage. Citrus Bioflavonoids are water-soluble
pigments. This formula combines key structural components in cartilage to
support overall joint function, mobility and flexibility.*
STRUCTURE AND FUNCTION
Glucosamine, a key component of cartilage and synovial fluid, is an
aminomonosaccharide utilized as the primary substrate in the synthesis of GAGs
and proteoglycans. The amide group of Glucosamine is required for metabolic
conversion into Glucosamine-6-phosphate, which is subsequently converted to
galactosamine required for GAG assembly. Glucosamine from food and supplements
is incorporated into the metabolic pathway of proteoglycan and GAG synthesis,
promoting cartilage production and articular function.*
Chondroitin Sulfate is a natural constituent of
cartilage, made up of repeating chains of GAGs. Chondroitin Sulfate is a highly
charged polyanion, promoting water retention in the connective tissue to support
joint flexibility and cushion joints.* Composed of N-acetyl-galactosamine and
glucuronic acid, Chondroitin Sulfate provides a raw material for proteoglycan
and GAG synthesis to actually help renew cartilage.* Chondroitin Sulfate also
promotes healthy enzymatic metabolism of cartilage, to further maintain joint
health.*
CLINICAL EVIDENCE
The Lancet published a double-blind
placebo-controlled study that investigated the long-term effects of
Glucosamine Sulfate in a trial of 212 subjects. After 3 years of taking 1500
mg/day of Glucosamine or placebo, the subjects who received Glucosamine
maintained healthy joints, which was not observed in the placebo group. (Reginster
et al, 2001)
In this study, 30 subjects receiving 1500 mg
of Glucosamine per day were compared with 28 subjects receiving a placebo
for 12 weeks. All participants had joint concerns at the beginning of the
study. The subjects who received Glucosamine experienced a significant
improvement in several aspects of joint comfort compared with placebo. (Usha
et al, 2004)
A total of 120 subjects were given 800 mg
Chondroitin Sulfate or placebo for two, three-month periods over the course
of a year. Subjects receiving Chondroitin Sulfate had significantly improved
knee function as compared to the placebo group. (Uebelhart et al, 2004)
SUMMARY
PhysioLogics Joint Formula supplies Glucosamine and Chondroitin, key structural
components of cartilage that play important roles in the maintenance of joint
cartilage.*
SUGGESTED DOSAGE
For adults, take three (3) softgels daily, preferably one (1) softgel with each
meal, or follow the advice of a health care professional.
REFERENCES
Barclay TS, Tsourounis C, McCart GM. Glucosamine. Ann Pharmacother.
1998;32:574-9.
Bucsi L, Poor G. Efficacy and tolerability of
oral chondroitin sulfate as a symptomatic slow-acting drug for osteoarthritis
(SYSADOA) in the treatment of knee osteoarthritis. Osteoarthritis Cartilage.
1998;6 Suppl A:31-6.
Clark CC, et al. Post-translational alterations
in newly synthesized cartilage proteoglycans induced by the glutamine analogue
6-diazo-5-oxo-L-norleucine. Time course of inhibition and recovery. Biochem J.
1991;273(Pt 2):283-8.
da Camara CC, Dowless GV. Glucosamine sulfate
for osteoarthritis. Ann Pharmacother. 1998;32:580-7.
Deal CL, Moskowitz RW. Nutraceuticals as
therapeutic agents in osteoarthritis; the role of glucosamine, chondroitin
sulfate, and collagen hydrolysate. Rheum Dis Clin North Am. 1999;25:379-95.
Drovanti A, Bignamini AA, Rovati AL.
Therapeutic activity of oral glucosamine sulfate in osteoarthrosis: A
placebo-controlled double-blind investigation. Clin Ther. 1980;3:260-72.
Lopes Vaz A. Double-blind clinical evaluation
of the relative efficacy of ibuprofen and glucosamine sulphate in the
management of osteoarthritis of the knee in outpatients. Current Med Res Opin.
1982;8:145-149.
Mazieres B, Combe B, Phan Van A, et al.
Chondroitin sulfate in osteoarthritis of the knee: a prospective, double
blind, placebo controlled multicenter clinical study. J Rheumatol.
2001;28:173-81.
Reginster JY, Deroisy R, Rovati LC, et al.
Long-term effects of glucosamine sulphate on osteoarthritis progression: a
randomised, placebo-controlled clinical trial. Lancet. 2001;357:251-6.
Uebelhart D, Malaise M, Marcolongo R, et al.
Intermittent treatment of knee osteoarthritis with oral chondroitin sulfate: a
one-year, randomized, double-blind, multicenter study versus placebo.
Osteoarthritis Cartilage. 2004;12:269-76.
Usha PR, Naidu MUR. Randomised, double-blind,
parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane
and their combination in osteoarthritis. Clin Drug Investig. 2004;24;353-63.
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Meno-Pause Cream 4 oz (113 g) Cream - Physiologics
The
Natural Cream For Peri-Menopausal, Menopausal and Post-Menopausal Women
A cream for women in an aloe vera gel base.
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Male Performax 90 capsules - Physiologics
Supports
Sexual Health in Men*
This unique formula contains Muira puama
traditionally associated with male health.*; Korean ginseng has a long history
of use as a male tonic.* |
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MultiLogics for Men 90 caplets - Physiologics
Comprehensive
Multi for Men
PRODUCT DISCUSSION
MultiLogics® for Men delivers an exceptional combination of Saw Palmetto
extract, Green Tea extract, Ginkgo Biloba extract, Stinging Nettle, Black Cohosh,
Grape Seed extract and Tomato concentrate to provide a convenient source of
these plants and herbs traditionally used for male health.*
STRUCTURE AND FUNCTION
This formula provides a source of nutrients traditionally used for men's health.
Vitamin E is the most important lipid soluble antioxidant in the human body,
where it is incorporated into the lipid phase of cell membranes and carrier
molecules to stabilize these structures from free radical damage.* Some
scientific evidence suggests that consumption of antioxidant vitamins such as
Vitamin E may reduce the risk of certain forms of cancer. However, FDA has
determined that this evidence is limited and not conclusive.
Selenium works to recycle Vitamin E levels,
synergistically supporting its antioxidant potential. Selenium is an essential
trace mineral that functions as an antioxidant. Selenium is a cofactor for
glutathione peroxidase, the antioxidant enzyme that catalyzes the removal of
hydrogen peroxide. This enzyme functions to minimize lipid peroxidation to
cellular membranes and lipid-containing organelles. The antioxidant activity of
Selenium is believed to be responsible for its ability to support the humoral
and cellular immune systems.* Some scientific evidence suggests that consumption
of selenium may reduce the risk of certain forms of cancer. However, FDA has
determined that this evidence is limited and not conclusive.
As a cofactor for over 300 enzymes, Zinc plays a
vital role in growth and development, supporting the body's immune response,
protein formation, and men's sexual health. The precise mechanism of how Zinc
affects male reproductive health is not completely understood. Zinc is required
for spermatogenesis and aids in the formation of male sex hormone by Leydig
cells. The androgen receptor gene also contains a Zinc finger domain, necessary
for the development of male external genitalia.* Magnesium is an essential
ubiquitous cation that plays a fundamental role in more than 300 enzymatic
reactions. As a cofactor of adenosine triphosphatases, Magnesium ions play a
fundamental role in the synthesis, transfer, storage and utilization of
energy-rich compounds. Magnesium is an essential component of the muscle enzyme
creatine kinase and is a vital factor in energy production and muscle
contractions.*
Calcium is the major mineral responsible for the
health of the body's bones and teeth. Calcium intake is critical to achieving
peak bone mass, maintaining muscle contractions, nerve impulses and supporting
heart health.*
INDICATIONS
MultiLogics® for Men provides a comprehensive supplement to nutritionally
support male reproductive health.*
HOW CLIENTS MAY BENEFIT
Vitamins and minerals are necessary for
growth, development, and a healthy life.*
A quick, easy, and convenient way to receive a
wide range of fruit and herb extracts traditionally used for men's unique
nutritional needs.*
Support men's reproductive health by assisting
in sexual function and sperm production.*
Chromium is an essential mineral required for
normal metabolism of carbohydrates and lipids.*
Vitamin E neutralizes free radicals, unstable
compounds that may lead to DNA and cell damage.*
SCIENTIFIC RESEARCH
A recent review published in the journal JAMA
stated that most people do not consume an optimal amount of all vitamins by
diet alone. In fact, suboptimal intake of some vitamins, even above levels
classified as deficiency, may be unhealthy and is common in the general
population. The reviewers concluded that it is wise for all adults to take
vitamin supplements.
The National Institutes of Health, the Centers
for Disease Control and the Public Health advocate the use of certain
nutrients for certain populations, such as B-12 for seniors and Vegetarians.
The Departments of Health and Human Serivices
and Agriculture updated the Dietary Guidelines for Americans in 2000. This
document, published by Congressional mandate, recognizes that certain
"people need a vitamin-mineral supplement to meet specific nutrient
needs."
SUMMARY
MultiLogics® for Men is an ideal supplement for any adult male concerned about
overall nutritional health. Delivering vitamins and minerals, along with a
unique combination of herbal extracts, MultiLogics® is a premium quality
multivitamin for comprehensive support of men's unique nutritional needs.*
SUGGESTED DOSAGE
For adults, take three (3) caplets daily, with meals, or follow the advice of
your health care professional. As a reminder, discuss the supplements and
medications you take with your health care providers.
REFERENCES
Agriculture Research Service. Dietary Guidelines for Americans. 2000.
Departments of Health and Human Services and Agriculture. May 30.
Centers for Disease Control. Use of folic
acid-containing supplements among women of childbearing age-United Sates,
1997. MMWR Weekly. 1998. 57(7); Feb 27:131-134.
DRI for Calcium, Phosphorus, Magnesium, Vitamin
D, and Fluoride. Institute of Medicine. CH 4. Calcium. Pp71-91
Fairfield, K.M. Vitamins for chronic disease
prevention in adults. JAMA. 2002. 287(23); Jun 19: 3116-1720.
Institute of Medicine. Food and Nutrition
Board. Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D
and Fluoride. National Academy Press. Washington, DC, 1999.
Mahajan SK, Abbasi AA, Prasad AS, Rabbani P,
Briggs WA, McDonald FD. Effect of oral zinc therapy on gonadal function in
hemodialysis patients. A double-blind study. Ann Intern Med. 1982
Sep;97(3):357-61.
Matkovic V. Nutrition, genetics and skeletal
development. J Am Coll Nutr. 1996 Dec;15(6):556-69.
National Institutes of Health. Optimum Calcium
Intake. NIH Consensus Statement. 1994. 12(4); Jun 6-8: 1-31.
Prasad, A. Zinc: An overview. Nutr. 1995
Jan-Feb;11(1 Suppl):93-9.
Pryor, W.A. Vitamin E and heart disease: basic
science to clinical intervention trials. Free Rad Biol & Med. 2000. 28(1);
141-164.
Spallholz, J.E. et al. Advances in the role of
minerals in immunobiology. Biological Trace Element Research. 1989. 19:
129-151
Spallholz, J.E. et al. Advances in
understanding selenium's role in the immune system. Ann. N.Y. Acad. Sci.
587:123-139. 1990.
Swaine, R.A. et al. Therapeutic uses of vitamin
E in prevention of atherosclerosis. Altern Med Rev. 1999. 4(6); Dec: 414-423.
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Zinc Plex 60caps - Physiologics
Bioavailable
Zinc and Copper Complex*
HOW PATIENTS MAY BENEFIT
For immune, skin, and male reproductive
health*
PRODUCT DISCUSSION
PhysioLogics Zinc Plex® provides Zinc, an essential trace element required for
numerous metabolic pathways. This formula also provides copper for additional
benefits.
STRUCTURE AND FUNCTION
Zinc is a ubiquitous trace element in the human body, acting as a cofactor for
more than 300 enzymes. DNA synthesis, RNA transcription, cell division, protein
synthesis and digestion are all dependent on the presence of Zinc. The DNA
structural motif known as a Zinc finger is a site of transcriptional regulation,
with Zinc-binding proteins involved in the genetic expression of various
biological compounds.
Zinc metalloenzymes catalyze approximately 50
important biochemical reactions and are a part of all classes of enzymes,
including oxidoreductases, transferases, hydrolases, lyases, isomerases, and
ligases. They can function catalytically by the binding of the substrate
directly to Zinc or a Zinc-hydroxide ion, or structurally, with Zinc stabilizing
the quaternary structure of oligomeric holoenzymes.
The precise mechanism of how Zinc affects male
reproductive health is not completely understood. Zinc is required for
spermatogenesis and aids in the formation of male sex hormone by Leydig cells.
The androgen receptor gene also contains a Zinc finger domain, necessary for the
development of male external genitalia.*
Zinc is known to play a central role in the
immune system. As a component of collagenase, Zinc contributes to healthy skin.
Zinc is essential for cell division, assisting rapidly dividing immune cells to
support the requirements of the immune system. In addition, Zinc assists in a
wide range of specific immune functions, including Immunoglobulin G (IgG)
production in B cells and IL-2 production in CD4+ T cells.*
CLINICAL EVIDENCE
In a recent double blind human study, subjects
were given 45mg zinc/day for a period of 12 months. Subjects in the treated
group had significantly better immune function and low oxidative stress as
compared to the placebo group. (Prasad et al, 2007)
20 subjects received 10 mg of zinc aspartate
per day for about 48 days. Plasma zinc status and markers of protein
oxidation in lymphocytes were measured before and after the trial. Zinc
supplementation significantly reduced oxidative stress in cellular proteins
by maintaining the expression of protective enzymes. The results of this
study demonstrate the role of zinc as an antioxidant within the body. (Cabreiro
et al, 2008)
SUMMARY
PhysioLogics' Zinc Plex® 30 mg provides a convenient way to support the immune
system and overall health with bioavailable forms of zinc supplemented with
copper for additional support.*
SUGGESTED DOSAGE
For adults, take one (1) capsule daily with meals, or follow the advice of a
health care professional. Do not exceed one (1) capsule per day.
REFERENCES
Cabreiro F, Perichon M, Jatje J, et al. Zinc supplementation in the elderly
subjects: Effect on oxidized protein degradation and repair systems in
peripheral blood lymphocytes. Exp Gerontol. 2008;43:483-7. Epub 2007 Oct 25
Eby GA, Davis DR, Halcomb WW. Reduction in
duration of common colds by zinc gluconate lozenges in a double-blind study.
Antimicrob Agents Chemother. 1984;25:20-4
Mahajan SK, Abbasi AA, Prasad AS, et al. Effect
of oral zinc therapy on gonadal function in hemodialysis patients. A
double-blind study. Ann Intern Med. 1982;97:357-61
Prasad, A. Zinc: An overview. Nutrition.
1995;11(1 Suppl):93-9
Prasad AS, Beck FW, Bao B, et al. Zinc
supplementation decreases incidence of infections in the elderly: effect of
zinc on generation of cytokines and oxidative stress. Am J Clin Nutr.
2007;85:837-44
Sherman AR. Zinc, copper, and iron nutriture
and immunity. J Nutr. 1992;122(3 Suppl):604-9
Turner RB, Cetnarowski WE. Effect of treatment
with zinc gluconate or zinc acetate on experimental and natural colds. Clin
Infect Dis. 2000;31:1202-8. Epub 2000 Nov 06
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5-HTP Complex 100mg 120 capsules - Physiologics
Supports
Nervous System Health*
PRODUCT DISCUSSION
PhysioLogics 5-HTP 100 mg provides L-5-Hydroxytryptophan (5-HTP) along with the
B Vitamins Niacin and Vitamin B6 and the herb Valerian to promote nervous system
health.* 5-HTP is not present in significant amounts in the typical diet and is
derived from the seeds of Griffonia simplicifolia, a plant of West African
origin.
STRUCTURE AND FUNCTION
The compound 5-HTP is a precursor to serotonin, a neurotransmitter involved in
sending messages through the brain and nervous system.* It supports a calm,
relaxed mood and promotes feelings of well-being.*
Niacin (B-3), also known as nicotinic acid and
nicotinamide, helps maintain a healthy nervous system.* The major coenzyme forms
of Vitamin B-6 are Pyridoxine (B-6), pyridoxal 5'-phosphate (PLP), and
pyridoxamine (PMP). Vitamin B-6 supports brain and nervous system health.*
Valerian and its principle components have been
extensively studied for well over 50 years. Lab data indicates that valerenic
acid and acetylvalerenic acid in valerian can inhibit GABA transaminase, thereby
prolonging the effects of GABA on sedation in the central nervous system. L-hydroxypinoresinol,
another natural valerian alkaloid, has been found to possess a high affinity for
the 5-HT1A receptor, which could also play a role in Valerian's beneficial
effects.
CLINICAL EVIDENCE
In this study, 24 subjects received a one-time
dose of 200 mg 5-hydroxytryptophan (5-HTP) or placebo in a double-blinded
trial. The subjects receiving 5-HTP experienced a significantly calmer mood
than the placebo group, supporting the use of 5-HTP for feelings of
well-being. (Schruers et al, 2002)
A total of 34 subjects were given either 200
mg of 5-HTP or placebo in a double-blinded clinical trial. The results
showed a significant positive effect on feelings of calmness and well-being
in the female subjects compared with placebo. (Maron et al, 2004)
SUMMARY
PhysioLogics 5-HTP provides a unique combination of several compounds that have
effects on feelings of well-being, as well as brain and nervous system health.*
SUGGESTED DOSAGE
For adults, take one (1) capsule twice daily as needed or before bedtime, or
follow the advice of a health professional.
WARNING: Not for use by pregnant or
lactating women. Patients with heart problems or who are taking antidepressants
or weight-control drugs should avoid this product. May cause drowsiness:
Patients should not drive a motor vehicle or operate heavy machinery while using
this product.
REFERENCES
Maron E, Tőru I, Vasar V, Shlik J. The effect of 5hydroxytryptophan on
cholecystokinin-4-induced panic attacks in healthy volunteers. J
Psychopharmacol. 2004;18:194-9.
Schruers K, van Diest R, Overbeek T, Griez E.
Acute L-5hydroxytryptophan administration inhibits carbon dioxideinduced panic
in panic disorder patients. Psychiatry Res. 2002;113:237-43
Upton, R., Valerian root Valeriana officinalis,
Analytical, Quality Control, and Therapeutic Monograph, in American Herbal
Pharmacopoeia and Therapeutic Compendium. 1999. Santa Cruz, CA.
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Ginkgo Alert Formula 90 capsules - Physiologics
Supports
Cognitive Function*
This unique formula contains a blend of nutrients
and botanicals to support brain circulation, neurotransmitter activity, and
cognitive function.*
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Melatonin 1mg 90 vtabs - Physiologics
Nutritionally
Supports Sound Sleep*
PRODUCT IS ALSO KNOWN
AS:
n-Acetyl-5-Methoxytryptamine
PRODUCT DISCUSSION
Clinical trials involving orally supplemented melatonin have implicated this
indoleamine to have positive metabolic interactions on various sleep
parameters. Physiologic's supplies Melatonin at dosage levels consistent with
published research which demonstrates its ability to promote calm, restful
sleep. Melatonin may also prove to be useful for frequent travelers
experiencing jet lag.*
STRUCTURE AND FUNCTION
The pineal gland is the organ where information about light and dark is
processed and then relayed to cells throughout the body. The eyes deliver
information to the pineal gland through different routes that include the
retinohypothalamic tract and the suprachiasmatic nuclei. Norepinephrine
released from postganglionic nerve endings to the pineal gland helps control
melatonin release. This release of norepinephrine to the pinealocytes occurs
at night, which is when melatonin secretion and levels throughout the body
begin to rise.*
Melatonin, due to its considerable
lipophilicity, is able to cross any cell membrane and enter any tissue or
cellular compartment. Therefore it is likely that some of melatonin's
biochemical effects are elicited through intracellular binding sites in
addition to its interactions with membrane-bound receptors (Hardeland, 95).
Melatonin's high lipophilicity is what allows it to transmit the signal of
darkness to every cell in the body, in turn acting as the eyes for each cell,
organ and tissue. This is why melatonin levels throughout the body are so
important for promoting calm, restful sleep and a relaxed mood in the evening
by supporting natural circadian rhythms.*
In addition to its effects on sleep, Melatonin
is believed to play a major role in the biological termination of free-radical
induced redox reactions. Melatonin is reported to have a large capacity to
trap hydroxyl radicals, the free radical species with the highest relative
reactivity. Melatonin also efficiently traps peroxyl radicals and superoxide
anions. Melatonin participates in a two-step process in which it first
interacts with a hydroxyl or peroxyl radial to give a melatonyl cation
radical, which then combines with a superoxide anion to neutralize the
electrical charges and pairing electrons.*
INDICATIONS
Occasional sleeplessness can affect anyone - young or old. The National
Institutes of Health recommends to keep a regular schedule of going to bed and
waking up at the same time every day, even on weekends, to help your body
maintain a normal circadian rhythm. However, due to life's demands this is not
realistic for many people. Endogenous melatonin is an important component of
your body's circadian rhythm. Supplemental melatonin can provide circadian
rhythm support for calm, restful sleep - especially when experiencing
occasional sleeplessness or jet lag.*
HOW CLIENTS MAY
BENEFIT
Although many products and ingredients on
the market are currently sold for promoting sleep and a relaxed mood in
the evening, melatonin is the #1 product in terms of clinical testing for
efficacy in a wide variety of populations.
Those who travel often and experience jet
lag can benefit from the convenience of taking only one melatonin tablet
to promote tranquil sleep.
Participates in free-radical scavenging to
support antioxidant action in the brain and across various cellular
regions due to its high lipophilicity.
Suitable for a wide-range of clients due to
its free of status for yeast, wheat, milk or milk derivatives, lactose,
sugar, preservatives, soy, sodium (less than 5 mg per serving), and
artificial color and flavor as certified through analysis of raw material
specification sheets.
Finished product is suitable for
vegetarians.
CLINICAL EVIDENCE
The clinical effects of melatonin on sleep
latency and duration, mood, performance, oral temperature and changes in
serum melatonin levels were examined in twenty male volunteers.
Investigators employed a double blind, placebo controlled study utilizing
repeated-measures, within-subjects and a 5x5 Latin square design. Subjects
received placebo or .1, .3, 1 or 10mg of melatonin on five different
occasions. Statistical analysis revealed 1mg of melatonin to be the most
efficient dosage for the parameters studied. Subjects reported they slept
more quickly after the 1mg dose as compared to the .1mg dose. Subjects
also reported that they felt sleepier after the 1 and 10mg dosages as
compared to placebo. 1mg also decreased oral temperature more then .1mg,
which is a normal response to endogenously secreted melatonin as part of
the circadian rhythm. Melatonin at 1mg was also effective for helping
induce a relaxed mood and hypnotic-like state, which could support calm,
restful sleep. (Dollins, 94)
In a double-blinded study, healthy
volunteers were randomized to receive .3mg, 1mg or a placebo dose on three
separate occasions. It was found that the 1mg dosage decreased sleep onset
latency time and latency to stage 2 sleep - both positive findings. Sleep
efficiency was also improved relative to placebo condition. The
investigators attributed the positive findings to the acute action of
melatonin on the physiological sleep process. (Zhdanova, 96)
SUMMARY
When it comes to supporting nocturnal sleep patterns, melatonin is the #1
supplement in terms of clinical trials and efficacy. Melatonin's ability to
interact with membrane-bound receptors as well as intracellular binding sites
help translate the message of darkness and sleep to each cell in the body.
Just one tablet can be taken in the evening to help promote a relaxed mood and
restful sleep. Physiologics offers high-quality melatonin that is
vegetarian-suitable, free of substantial allergenic materials and dosed at
levels consistent with published, clinical research.*
SUGGESTED DOSAGE
For adults, take one (1) tablet daily, at bedtime as Melatonin may produce
drowsiness. Do not exceed recommended dose. As a reminder, discuss the
supplements and medications you take with your health care providers.
REFERENCES
Cardinali, D.P., et al. A multifactorial approach employing melatonin to
accelerate resynchronization of sleep - wake cycle after a 12 time-zone
westerly transmeridian flight in elite soccer athletes. J Pineal Res. 2002.
32: 41-46.
Cavallo, A. et al. Blood pressure-lowering
effect of melatonin in type 1 diabetes. J. Pineal Res. 2004.
Dollins A.B, et al. Effect of inducing
nocturnal serum melatonin concentrations in daytime on sleep, mood, body
temperature and performance. Proc Nat´l Acad Sci. 1994. 91; 1824-1828
Engstrom, J., et al. Evaluation and treatment
of orthostatic hypotension. Amer Fam Phys. 1997. 56(5): 1-8.
Girouard, H., et al. Vasorelaxant effects of
the chronic treatment with melatonin on mesenteric artery and aorta of
spontaneously hypertensive rats. J Hypertens. 2001. 19(8): 1369-77
Hardeland, R., et al. Versatile Melatonin: a
pervasive molecule serves various functions in signaling and protection.
Chronobio Int´l. 1995. 12(3):157-165
Kemp, S. et al. The value of melatonin for
sleep disorders occurring post-head injury: a pilot RCT. Brain Injury. 2004.
18(9).
Kitajima, T. The effects of oral melatonin on
the autonomic function in healthy subjects. Psychiatry Clin Neurosci. 2001.
55(3): 299-300.
Lusardi, P., et al. Effect of bedtime
melatonin ingestion on blood pressure of normotensive subjects. Blood
pressure monitoring. 1997. 2(2): 99-103.
Lusardi, P., et al. Cardiovascular effects of
melatonin in hypertensive patients well controlled by nifedipine: a 24hour
study. Brit J Clin Pharmacol. 2000. 49(5): 423-7.
Malliet, F., et al. Comparative effects of
melatonin, zolpidem and diazepam on sleep, body temperature, blood pressure
and heart rate measured by radiotelemetry in Wister rats.
Psychopharmacology. 2001. 156(4): 417-26.
Nishiyama, K., et al. Acute effects of
melatonin administration on cardiovascular autonomic regulation in healthy
men. Am Heart J. 2001. 141(5): 822.
Ray, C. Melatonin attenuates the sympathetic
nerve responses to orthostatic stress in humans. J Physiol. 2003. 551 (3):
1043-8.
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Magnesium Complex 100 vtabs - Physiologics
Helps
Maintain Bone Health*
Magnesium plays an essential role in
maintaining proper bone mineralization.* Magnesium is also involved in muscle
contractions and nerve impulses.*
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Magnesium Chelate 200mg 60 vcaplets - Physiologics
Supports
the Nervous System, Energy Cycle and Bones*
PRODUCT IS A MIXTURE OF
Magnesium Glycinate, Magnesium Oxide, Dicalcium Phosphate, Calcium Stearate
PRODUCT DISCUSSION
PhysioLogics' Magnesium Chelate provides two forms of Magnesium to support
cellular energy, promote healthy nerve function, and help maintain strong,
healthy bones.*
STRUCTURE AND FUNCTION
Magnesium is an essential ubiquitous cation that plays a fundamental role in
more than 300 enzymatic reactions. Necessary for the anatomical and functional
integrity of various subcellular organelles, it participates in every major
metabolic pathway, including nucleic acid, protein, carbohydrate, and lipid
metabolism. As a cofactor of adenosine triphosphatases, Magnesium ions play a
fundamental role in the synthesis, transfer, storage and utilization of
energy-rich compounds.*
Magnesium supports healthy nerve cell function. Its presence in adequate
amounts in the synaptic gap between neurons modulates the rate at which nerves
fire. If Magnesium levels are insufficient, neurons fire too easily, resulting
in excessive sensitivity to various stimuli. Magnesium is a component of the
muscle enzyme creatine kinase and is needed at the neuromuscular junction in
order for muscles to relax.*
Magnesium plays a key role in bone health. The human skeleton utilizes 55%
of the body's magnesium. Magnesium directly influences both matrix and mineral
metabolism in bone, and aids in the absorption of Calcium by promoting the
secretion of calcitonin, a hormone that aids in the influx of calcium into
bone. In addition, Magnesium plays a role in modulating the secretion of
parathyroid hormone, whose function is to draw Calcium out of bones and
deposit it in soft tissue.*
The importance of Magnesium in healthy cardiovascular function has long
been recognized. Epidemiological studies found that communities with
sufficient levels of Magnesium in drinking water tended to have more support
of heart health. Extracellular Magnesium ions exert important effects upon
transport and release of Calcium ions in the vascular system, supporting
healthy vascular tone.*
INDICATIONS
The National Health and Nutrition Examination Survey (NHANES III-1988-91) and
the Continuing Survey of Food Intakes of Individuals (1994 CSFII) suggest that
the diets of most adult Americans do not provide the recommended amounts of
Magnesium. In addition, certain regularly prescribed drugs may cause Magnesium
depletion. PhysioLogics' Magnesium Chelate may be a desirable dietary
supplement for clients who want to support cellular energy synthesis as well
as nerve, bone and cardiovascular health.*
HOW CLIENTS MAY BENEFIT
Maintain proper nerve function and muscle contraction.*
Magnesium aids in the absorption of calcium into bone and may promote
bone mineralization.*
Vital to the formation and release of energy to the cells as a cofactor
of adenosine triphosphatases.*
Promotes a healthy vascular system.*
SCIENTIFIC RESEARCH
A study of 12 young healthy men found that daily supplementation with
15mmol (365mg) Magnesium supports bone health, as measured by healthy
levels of resorption biochemical markers.
Magnesium can support a healthy musculature. One recent study found that
100 mg of Magnesium per day for a month promoted exercise tolerance.
In a double-blind, placebo-controlled study of Magnesium and heart
health, Rasmussen, et. al. administered 15mmol (365mg) Magnesium or
placebo to 47 patients and monitored cardiovascular health. Those who
received Magnesium had significant support of cardiac health.
SUMMARY
Magnesium is an essential nutrient for bone formation and maintenance.
PhysioLogics' Magnesium Chelate provides Magnesium Glycinate in an absorbable
form for those who want to ensure they obtain daily supply of this vital
mineral to maintain cellular energy levels and support nerve and bone health
through all stages of life.*
SUGGESTED DOSAGE
Take 1 caplet up to two times daily, preferably with meals, or follow the
advice of your health care professional. As a reminder, discuss the
supplements and medications you take with your health care providers.
REFERENCES
Abarbanel HD, Gibb L, Huerta R, Rabinovich MI. Biophysical model of synaptic
plasticity dynamics. Biol Cybern. 2003 Sep;89(3):214-26. Epub 2003 Jul 31.
Alaimo K, McDowell, M.A., Briefel, R.R, Bischlf, A.M, Caughman, C.R,
Loria, C.M, Johnson, C.L. Dietary Intake of Vitamins, Minerals, and Fiber of
Persons Ages 2 Months and Over in the United States: Third National Health
and Nutrition Examination Survey, Phase 1, 1988- 91. In: Johnson GV, ed.
Vital and Health Statistics of the Center for Disease Control and Prevention
/ National Center for Health Statistics, Hyattsville, MD 1994:1-28.
Altura BM, Zhang A, Altura BT. Magnesium, hypertensive vascular diseases,
atherogenesis, subcellular compartmentation of Ca2+ and Mg2+ and vascular
contractility. Miner Electrolyte Metab. 1993;19(4-5):323-36. Review.
Brautbar N, Carpenter C. Skeletal myopathy and magnesium depletion:
cellular mechanisms. Magnesium. 1984;3(2):57-62.
Dimai HP, Porta S, Wirnsberger G, Lindschinger M, Pamperl I, Dobnig H,
Wilders-Truschnig M, Lau KH. Daily oral magnesium supplementation suppresses
bone turnover in young adult males. J Clin Endocrinol Metab. 1998
Aug;83(8):2742-8.
Dreosti IE. Magnesium status and health. Nutr Rev. 1995 Sep;53(9 Pt
2):S23-7.
Ferment O, Touitou Y. Magnesium: metabolism and hormonal regulation in
different species. Comp Biochem Physiol A. 1985;82(4):753-8.
Institute of Medicine. Food and Nutrition Board. Dietary Reference
Intakes: Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. National
Academy Press. Washington, DC, 1999.
Matkovic V. Nutrition, genetics and skeletal development. J Am Coll Nutr.
1996. 15(6):556-69
Rasmussen HS, Aurup P, Goldstein K, McNair P, Mortensen PB, Larsen OG,
Lawaetz H. Influence of magnesium substitution therapy on blood lipid
composition in patients with ischemic heart disease. A double-blind, placebo
controlled study. Arch Intern Med. 1989 May;149(5):1050-3.
Rude RK and Olerich M. Magnesium deficiency: Possible role in
osteoporosis associated with gluten-sensitive enteropathy. Osteoporos Int
1996;6:453-61.
Sojka JE, Weaver CM. Magnesium supplementation and osteoporosis. Nutr
Rev. 1995 Mar;53(3):71-4.
Tanabe K, Yamamoto A, Suzuki N, Osada N, Yokoyama Y, Samejima H, Seki A,
Oya M, Murabayashi T, Nakayama M, Yamamoto M, Omiya K, Itoh H, Murayama M.
Efficacy of oral magnesium administration on decreased exercise tolerance in
a state of chronic sleep deprivation. Jpn Circ J. 1998 May;62(5):341-6.
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B-Complex 100mg 100 vcaps - Physiologics
Supports
Nervous System Health*
HOW PATIENTS MAY BENEFIT
Provides essential B Vitamins to support numerous metabolic pathways*
Promotes energy metabolism in the body*
Supplies women with the recommended folic acid dosage*
PRODUCT DISCUSSION
The B Vitamin complex is made up of several water-soluble vitamins that play
unique roles in maintaining proper metabolic functioning.* B Vitamins work
well together to support heart health and nervous system health, and provide
nourishment for the stress of daily living.* PhysioLogics B-100 Complex offers
a daily intake of the essential B Vitamins to support energy metabolism and
skin health.*
STRUCTURE AND FUNCTION
Thiamine (B-1) functions as the coenzyme thiamin pyrophosphate, assisting in
the metabolism of carbohydrates and branched-chain amino acids, as well as in
production of the neurotransmitter acetylcholine.*
Riboflavin (B-2) assists in oxidation/reduction reactions, including those
involved in energy pathways and the metabolism of carbohydrates, fats and
proteins.* It also helps maintain the skin and mucous membranes, the cornea of
the eye, and nerve sheaths.*
Niacin (B-3), also known as nicotinic acid and nicotinamide, serves as a
coenzyme in oxidation/reduction reactions as nicotinamide adenine dinucleotide
(NAD) and its phosphate form (NADP). NAD functions in intracellular
respiration and oxidation of glyceraldehydes, lactate, alcohol, and other fuel
molecules. NADP is required in reductive biosyntheses, such as fatty acid and
steroid synthesis. Niacin is needed for the metabolism of food, maintenance of
healthy skin and nerve cells, DNA replication and repair, and cell
differentiation.*
The major coenzyme forms of Pyridoxine (B-6) are pyridoxal 5'-phosphate (PLP)
and pyridoxamine (PMP), which function in the catabolism of carbohydrates and
proteins. PLP serves as a coenzyme in more than 100 reactions in amino acid
metabolism, including aminotransferases, decarboxylases, and dehydratases.
Vitamin B-6 is also used in the production of red blood cells, and is involved
in the single-carbon cycle, which produces methyl groups used in the synthesis
of other compounds. By this mechanism, Vitamin B-6 promotes healthy
homocysteine levels.*
Folic Acid, also known as folate, functions as a coenzyme essential to
virtually all biochemical reactions that use single-carbon transfers,
including purine and pyrimidine biosynthesis, generation of formate, and amino
acid interconversions, including homocysteine to methionine. Folic acid
participates in the breakdown of proteins and the formation of hemoglobin, a
compound in red blood cells that transports oxygen and carbon dioxide.
Healthful diets with adequate folate may reduce a woman's risk of having a
child with a brain or spinal cord birth defect.
Vitamin B-12 (Cobalamin) is a coenzyme in the single-carbon cycle, and,
with Vitamin B-6 and Folate, converts homocysteine to methionine. Vitamin B-12
is also required for maintenance of nerve sheaths, normal blood formation, and
DNA synthesis and repair.*
Pantothenic acid is used for the synthesis of coenzyme A and thus is
involved in many metabolic pathways, including energy metabolism.* Biotin
functions as a coenzyme in carboxylation reactions, which are also useful in
many functions of the body. Choline is a precursor for the neurotransmitter
acetylcholine.
CLINICAL EVIDENCE
In a double-blind placebo-controlled trial, 205 subjects were randomized
to receive either a combination of folic acid, vitamin B12, and vitamin
B6, or placebo, for 6 months. At the end of the study, a significant
benefit to cardiovascular function was observed in the treatment group
compared to placebo. Plasma homocysteine levels were also significantly
reduced in the treated group compared to placebo. (Schnyder et al, 2001)
A study followed 370 elderly people for three years and monitored their
cognitive function, along with serum levels of Vitamin B-12 and Folate. A
comparable pattern was found between higher levels of these vitamins and
maintenance of cognitive function. (Wang et al, 2001)
A review in the Journal of the American Medical Association stated that
most people do not consume optimal amounts of vitamins by diet alone. In
fact, suboptimal intake of some vitamins, even above levels classified as
deficiency, may be unhealthy and is common in the general population. The
reviewers concluded that it is wise for all adults to take vitamin
supplements. (Fairfield and Fletcher, 2002)
SUMMARY
The B Vitamins work individually and synergistically in a wide array of
biological functions to maintain good health and vitality.* The body needs a
daily source of the B Vitamins because B Vitamins are water-soluble.
PhysioLogics' B-100 Complex provides a convenient way to obtain all essential
B Vitamins in one easy-to-swallow capsule.*
SUGGESTED DOSAGE
For adults, take one (1) capsule daily, preferably with a meal, or follow the
advice of a health care professional.
REFERENCES
Aisen PS, Egelko S, Andrews H, et al. A pilot study of vitamins to lower
plasma homocysteine levels in Alzheimer disease. Am J Geriatr Psychiatry.
2003;11:246-9.
Centers for Disease Control and Prevention. Recommendations for the use
of folic acid to reduce the number of cases of spina bifida and other neural
tube defects. MMWR 1992. 41 (No. RR-14).
Fairfield KM, Fletcher RH. Vitamins for chronic disease prevention in
adults: scientific review. JAMA. 2002;287:3116-26.
Institute of Medicine. Dietary Reference Intakes: Thiamin, Riboflavin,
Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and
Choline. Washington, DC: National Academy Press, 1998.
Manore MM. Effect of physical activity on thiamine, riboflavin, and
vitamin B-6 requirements. Am J Clin Nutr. 2000;72(2 Suppl):598S-606S.
Nilsson K, Warkentin S, Hultberg B, et al. Treatment of cobalamin
deficiency in dementia, evaluated clinically and with cerebral blood flow
measurements. Aging (Milano). 2000;12:199-207.
Schnyder G, Roffi M, Pin R, et al. Decreased rate of coronary restenosis
after lowering of plasma homocysteine levels. N Engl J Med.
2001;345:1593-1600.
Stampfer MJ, Malinow MR, Willett WC, et al. A prospective study of plasma
homocyst(e)ine and risk of myocardial infarction in US physicians. JAMA.
1992;268:877-81.
Wang HX, Wahlin A, Basun H, et al. Vitamin B(12) and folate in relation
to the development of Alzheimer's disease. Neurology. 2001;56:1188-94.
=
Vegetarian Formula
B-6,
B-12, & folic acid
PhysioLogics® B-Basic™ is a blend of B-6, B-12
and folic acid, which help support brain function and promote healthy
homocysteine levels.*
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Homocysteine Formula 60 capsules - Physiologics
B-6,
B-12, & folic acid
PhysioLogics® B-Basic™ is a blend of B-6, B-12
and folic acid, which help support brain function and promote healthy
homocysteine levels.*
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DHEA 25mg 90 capsules - Physiologics
May
Help Promote Sugar Metabolism*
A clinical study published in the highly
respected Journal of the American Medical Association found that supplementation
with 50 mg of DHEA per day in mature adults helped promote sugar metabolism.*
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Ginkgo Biloba 40mg 60 Capsules - Physiologics
Ginkgo
helps maintain healthy circulation to the brain and legs*
Standardized to contain: 24% Ginkgo Flavone Glycosides
Ginkgo biloba has numerous positive effects on the cardiovascular system.* It
supports blood circulation, promotes the elasticity and strengthening of blood
vessels and provides antioxidant support against free radicals in the
bloodstream.*
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Cartilage Companion Plus 60 softgels - Physiologics
Lubricates
Joints to Promote Comfort & Flexibility*
PRODUCT IS A SYNERGISTIC
MIXTURE OF
Glucosamine Sulfate, Chondroitin Sulfate, MSM (Methylsulfonylmethane), Vitamin C
(Ascorbic Acid), Vitamin E (d-Alpha Tocopheryl Acetate), Manganese (Manganese
Aspartate), Evening Primrose Oil, Flaxseed Oil, Fish Oil
PRODUCT DISCUSSION
Cartilage Companion® + from PhysioLogics contains the three most popular
supplements to support joint health, plus essential and non-essential
polyunsaturated Omega fatty acids. Glucosamine and Chondroitin Sulfate are key
structural components of cartilage and play a role in the maintenance of joints.
MSM is an organic source of sulfur, one of the major building blocks of
glucosaminoglycans.*
STRUCTURE AND FUNCTION
Cartilage is associated with an extracellular matrix composed of
glycosaminoglycans (GAGs) and proteoglycans, which interact with collagen and
elastic fibers to cushion joints and provide range of motion. GAGs are long,
unbranched polysaccharide chains composed of repeating disaccharide units.
Proteoglycans are proteins that carry one or more GAG side chains, and help bind
components of cartilage together.
Glucosamine, a key component of cartilage, is an
aminomonosaccharide utilized in the synthesis of GAGs and proteoglycans.
Glucosamine from food and supplements is incorporated into the metabolic pathway
of proteoglycan and GAG synthesis, promoting cartilage production and articular
function.*
Chondroitin is also a natural constituent of
cartilage, made up of repeating chains of GAGs. By promoting water retention,
proteoglycan and GAG synthesis, and healthy enzymatic metabolism of cartilage,
Chondroitin supports joint flexibility and function.*
MSM supplies an organic source of sulfur. Sulfur
is used in the body as a constituent of certain amino acids, collagen and
disulfide bonds, and provides a raw material for the production of GAGs and
collagen, making MSM an important part of cartilage and joint maintenance.*
INDICATIONS
For your clients who are weekend athletes or maturing adults, Cartilage
Companion® + provides Glucosamine, Chondroitin and MSM, the three leading
ingredients to support joint and cartilage maintenance and promote range of
motion. This product also provides all three Omega polyunsaturated fatty acids
for additional health benefits.*
HOW CLIENTS MAY BENEFIT
Supports cartilage maintenance.*
Promotes range of motion.*
Glucosamine and Chondroitin Sulfate supply
natural components of cartilage.*
Glucosamine and Chondroitin Sulfate promote
proteoglycan and GAG synthesis.*
Chondroitin promotes water retention and
healthy enzymatic metabolism of cartilage.*
MSM provides sulfur, a raw material for GAG
and collagen synthesis.*
SCIENTIFIC RESEARCH
The Lancet published a double-blind
placebo-controlled study that investigated the long-term effects of
Glucosamine sulphate in a trial of 212 subjects. After 3 years of 1500
mg/day, the subjects that received Glucosamine maintained cartilage as
measured in the knee. Joint support was not observed in the placebo group.
Another double-blind study observed that
subjects given 1500 mg Glucosamine sulfate per day experienced 50% more
joint support after 3 weeks and 72% more support after 30 days, while those
with placebo reported only 36% more joint support after 30 days.
SUMMARY
Cartilage Companion® + provides the three leading ingredients to support joint
and cartilage health. Glucosamine and Chondroitin Sulfate are key structural
components of cartilage and play an important role in the maintenance of joint
cartilage. MSM provides an organic source of sulfur, one of the raw materials of
GAGs and collagen. These ingredients work synergistically to support joint
health and promote range of motion. In addition, this product provides a source
of Omega-3, Omega-6, and Omega-9 polyunsaturated fatty acids.*
SUGGESTED DOSAGE
For adults, take one (1) softgel three times daily, preferably with a meal or
follow the advice of your health care professional. As a reminder, discuss the
supplements and medications you take with your health care providers.
REFERENCES
Barclay, T.S. et al. Glucosamine. The Annals of Pharmacotherapy. 1998. 32(5);
May: 574-579.
De Camara, C.C., et al. Glucosamine sulfate for
osteoarthritis. Annals of Pharmacotherapy. 1998.
Deal, CL. et al. Nutraceuticals as therapeutic
agents in osteoarthritis; The role of Glucosamine, Chondroitin Sulfate, and
Collagen Hydrolysate. Rheum Dis Clin North Am. 1999. 25(2); May: 379-395.
Drovanti, A. et al. Therapeutic activity of
oral glucosamine sulfate in osteoarthrosis: A placebo-controlled double-blind
investigation. Clinical Therapeutics. 1980. 3: 260-272.
Reginster, J.Y. et al. Long-term effects of
glucosamine sulphate on osteoarthritis progression: a randomised,
placebo-controlled clinical trial. The Lancet. 2001. 357(9); Jan 27: 251-256.
Sizer, F. et al. Water and minerals: chloride
and sulfur. Nutrition: Concepts and Controversies. 7th ed. 1997. Wadsworth
Publishing Co. Albany, NY. 303.
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7-Keto DHEA 25MG 90 softgels - Physiologics
Natural
Metabolite of DHEA Patented Formula
DHEA has helped millions of people strengthen their immune response and fight the negative effects of aging.In 1989, researchers at the University of Wisconsin’s School of Biological Sciences discovered a potent, natural metabolite of DHEA, known as 7-Keto dehydroepiandrosterone (DHEA). Like DHEA, 7-Keto DHEA is formed naturally within the body, but will not convert into testosterone or estrogens so you don’t have to worry about its impact on sex hormones. 90 softgels 25 mg
The chemical structure of this product is found
naturally in the body. Studies indicate that levels of DHEA may decline with
age. 7-Keto DHEA (3-Acetyl-7-Oxo-Dehydroepiandrosterone) provides the benefits
of DHEA but converts at a lower rate to testosterone or estrogen. Each
stimulant-free, caffeine-free product contains 25 mg of high quality 7-Keto DHEA
in softgel form.*
Directions:
Take 1 capsule, two to four times daily or follow the advice of your health care professional.
Supplemental Facts
Serving Size 1 capsule
Amount per serving
3-beta-acetoxyarost-5-en-7
17 dione (7-Keto DHEA)**
% Daily Value
25 mg
*Daily Value not established
**7-Keto is a trademark of Humanetics Corporation
Other ingredients: Rice powder, gelatin, magnesium stearate
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Absorbable Calcium with Vitamin D 100 sgels - Physiologics
Supports
Bone Health*
Calcium is the primary mineral responsible for strong bones.* The body also
uses calcium for proper muscle contraction and nerve function - and obtains this
calcium mainly from the bones.* Because the body cannot produce calcium, a
balanced diet, regular exercise, healthy lifestyle choices and adequate intake
of calcium and vitamin D can play a role in maintaining optimal bone health.*
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Acidophilus Complex 60 Capsules - Physiologics
Specially
Selected Strains of Probiotics to Promote Healthy Intestinal Flora*
Over 4 Billion Probiotic Organisms***
Advanced Acidophilus is an advanced formula containing probiotics such as
L. acidophilus, B. lactis and S. thermophilus. Probiotics support a favorable
environment for duodenum-jejunum nutrient absorption, encourage gram-positive
Lactobacilli intestinal balance and promote healthy intestines and immune
function.* The mechanisms through which Acidophilus acts have been attributed
to factors such as production of the heat-stable protein Lactacin F,
bio-enzymatic lactic acid production, acid-resistance in the alimentary tract,
and positive effects on fecal enzyme concentrations.*
*** At time of manufacture.
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B-6 100mg 250 vtabs - Physiologics
Supports
Energy Metabolism and Nervous System Health*
Vitamin B-6 plays a role in protein and energy
metabolism and assists in the metabolism of homocysteine, an amino acid.*
= Vegetarian Formula
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B-12 Sublingual 2500mcg 100 vtabs - Physiologics
Promotes
Energy Metabolism and Nervous System Health*
PRODUCT DISCUSSION
Vitamin B-12 contributes to the health of the nervous system.* It plays an
important role in neurological cell integrity, DNA metabolism, and red blood
cell formation.* It is also a co-enzyme in energy reactions.* Vitamin B-12 is
exclusively synthesized in microorganisms and cannot be found in plant
sources. Foods containing Vitamin B-12 include meats, poultry, fish, and dairy
products. Vitamin B-12 may not be readily absorbable as people age.*
STRUCTURE AND FUNCTION
Vitamin B-12, or cobalamin, is a micronutrient that is essential to humans.
The two active cobalmin coenzymes in humans are methylcobalamin and
5-deoxyadenoxylcobalamin. As a co-enzyme, Vitamin B-12 is needed in the
conversion of homocysteine to methionine by methionine synthase. Vitamin B-12
is also needed in the conversion of methylmalonyl-CoA to succinyl-CoA by
methylmalonyl-CoA mutase. Succinyl- CoA may then be used as in the Kreb’s
cycle or as a substrate for heme synthesis.
B-12 is found in foods such as oysters, crab, beef, salmon, chicken, and
eggs. B-12 can be obtained from animal sources but is not found in vegetables
in any significant amount. B-12 may not be as readily absorbable (from the
digestive system) as we age.
INDICATIONS
Individuals with pernicious anemia or with gastrointestinal disorders
may benefit from a vitamin B-12 supplement.*
Older adults and vegetarians may benefit from a vitamin B-12
supplement.*
Some medications may decrease absorption of vitamin B-12. Chronic use of
those medications may result in a need for supplemental B-12.*
Pregnant women who follow strict vegetarian diets may have depleted
vitamin B-12 stores.*
HOW CLIENTS MAY BENEFIT
Vitamin B-12 is an essential nutrient and needed for overall good health and
metabolism. Vitamin B-12 is part of the B-complex which is needed for energy
metabolism and promotion of cellular health. Metabolism within the body
includes the processes of energy generation and use; including nutrition,
digestion, absorption, elimination, respiration, circulation, and temperature
regulation. Vitamin B-12 maintains proper circulatory and nerve function and
promotes healthy levels of homocysteine.* Physiologics vitamin B-12 comes in a
convenient sublingual lozenge.
CLINICAL EVIDENCE
The Oxford Healthy Aging Projects, a cohort study conducted from 1993 to 2003,
examined the relationship between serum vitamin B-12 status and cognitive
function in older adults. A significant association was found between low
levels of vitamin B-12 and the incidence and rate of cognitive decline over
the ten year period. (Clarke et al. 2007.) In a double-blind
placebo-controlled trial, 205 subjects were randomized to receive either a
combination of folic acid, vitamin B-12, and vitamin B-6, or placebo, for 6
months. At the end of the study, a significant benefit to cardiovascular
function was observed in the treatment group compared to placebo. Plasma
homocysteine levels were also significantly reduced in the treated group
compared to placebo. (Schnyder et al. 2001).
SUMMARY
PhysioLogics Sublingual Vitamin B-12 provides an important member of the
vitamin B complex. Vitamin B-12, also known as cobalamin, is necessary for the
synthesis of red blood cells and the maintenance of the nervous system.
SUGGESTED DOSAGE
For adults, take one (1) lozenge or tablet daily. Place lozenge or tablet
under the tongue for 30 seconds before swallowing, or follow the advice of a
health care professional.
REFERENCES
Clarke et al. Low Vitamin B-12 status and risk of cognitive decline in older
adults. American Journal of Clinical Nutrition. 2007 86:1384-91
Institute of Medicine. Food and Nutrition Board. Dietary Reference
Intakes: thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B-12,
pantothenic acid, biotin, and choline. Institute of Medicine. Washington,
DC:National Academy Press 1998.
Kapadia CR Vitamin B-12 in health and disease: part I -- inherited
disorders of function, absorption, and transport. Gastroenterologist.
1995;3:329-44.
Russell RM, Suter PM. Vitamin requirements of elderly people: an update.
Am J Clin Nutr. 1993;58:4-14.
Schnyder G et al. Decreased rate of coronary restenosis after lowering of
plasma homocysteine levels. New England Journal of Medicine. 2001.
345(22):1593-1600.
Shevell , Rosenblatt DS. The neurology of cobalamin. Can J Neurol Sci.
1992;19:472-86.
van Asselt DZ, van den Broek WJ, et al. Free and protein-bound cobalmin
absorption in healthy middle-aged and older subjects. J Am Geriatr Soc.
1996;44:949-53.
van Goor L, Woiski MD, Lagaay AM, et al. Review: cobalamin deficiency and
mental impairment in elderly people. Age Ageing. 1995;24:536-42.
Waldmann A, Koschizke JW, Leitzmann C, Hahn A. Homocysteine and cobalamin
status in German vegans. Public Health Nutr. 2004;7:467-72.
= Vegetarian Formula
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MultiLogics Iron-Free 30 caplets - Physiologics
Full-Spectrum,
Nutritional Support*
PRODUCT DISCUSSION
Give your body the comprehensive nutritional support it deserves. Iron-Free
MultiLogics® furnishes a comprehensive formulation with vitamins, fruit
extracts, minerals, bioflavonoids, and other nutrients for comprehensive
nutritional support for optimal health. The minerals in Iron-Free MultiLogics®
are chelated with amino acids for good health benefits.*
STRUCTURE AND FUNCTION
Proper nutrition supplementation begins with a high quality multivitamin.
Iron-Free MultiLogics® provides a daily source of 21 vitamins and minerals, in
addition to fruit extracts and bioflavonoids to support many aspects of health.
Because excess iron may lead to free radical formation, this formula is
iron-free for those clients that receive adequate iron from their diet.*
Vitamin A promotes normal growth, healthy skin
and supports night and color vision.*
The balanced B-Vitamins are essential for the
synthesis of red blood cells and the processing of amino acids to assist in
energy metabolism.*
To provide immune system support, Vitamin C,
Selenium, and Zinc are included.*
Vitamin C and Copper are essential for
collagen formation to help promote healthy skin, hair, and nails.*
For bone mineralization support, Vitamin D is
essential to Calcium absorption and helps promote a healthy immune system.*
Vitamin E and Selenium, as a key component of
an antioxidant enzyme, each support cells from the harmful effects of free
radicals.*
Copper assists Iron in the release of energy
from cells.*
As part of a well-balanced diet that is low in
saturated fat and cholesterol, Folic Acid, Vitamin B6 and Vitamin B12 may
reduce the risk of vascular disease. FDA evaluated the above claim and found
that, while it is known that diets low in saturated fat and cholesterol
reduce the risk of heart disease and other vascular diseases, the evidence
in support of the above claim is inconclusive.
Some scientific evidence suggests that
consumption of antioxidant vitamins such as Vitamin C and Vitamin E may
reduce the risk of certain forms of cancer. However, FDA has determined that
this evidence is limited and not conclusive.
Selenium may reduce the risk of certain
cancers. Some scientific evidence suggests that consumption of selenium may
reduce the risk of certain forms of cancer. However, FDA has determined that
this evidence is limited and not conclusive.
Women who consume healthful diets with
adequate folate may reduce their risk of having a child with birth defects
of the brain or spinal cord. Folate intake should not exceed 1,000 mcg.
INDICATIONS
For your clients who are interested in nutrition supplementation, Iron-Free
MultiLogics® is the first step in providing additional nourishment by
furnishing a daily source of 21 vitamins and minerals plus fruit extracts for
value added nutrition.*
HOW CLIENTS MAY BENEFIT
Proper nutrition plays a role in disease
prevention.*
Vitamins and minerals are necessary for
growth, development, and a healthy life.*
Certain populations, such as maturing adults
or people on restrictive diets, may require more vitamin and mineral
supplementation.*
A quick, easy, and convenient way to receive a
daily source of 21 vitamins and minerals.
B Vitamins support heart health.*
Antioxidant vitamins neutralize free radicals,
unstable compounds that may lead to DNA and cell damage.*
SCIENTIFIC RESEARCH
A recent review published in the journal JAMA
stated that most people do not consume an optimal amount of all vitamins by
diet alone. In fact, suboptimal intake of some vitamins, even above levels
classified as deficiency, may be unhealthy and is common in the general
population. The reviewers concluded that it is wise for all adults to take
vitamin supplements.
The Physician's Health Study followed almost
15,000 male physicians for up to five years to study heart health. In this
study, lower levels of homocysteine were found in those with a healthier
cardiovascular system and longer life. In addition, researchers found that
high intakes of Vitamins B-6, B-12, and Folic Acid were correlated with
lower plasma homocysteine levels.
SUMMARY
Proper nourishment plays a role in disease prevention. While vitamin
supplementation is not an adequate substitute for a good diet, Iron-Free
MultiLogics® is an ideal supplement for any adult concerned about healthy
nutrition. Delivering 21 vitamins and minerals, along with bioflavonoids and
fruit extracts, Iron-Free MultiLogics® is a premium quality multivitamin for
comprehensive nutritional support.*
SUGGESTED DOSAGE
For adults, take one (1) caplet daily, preferably with a meal, or follow the
advice of your health care professional. As a reminder, discuss the supplements
and medications you take with your health care providers.
REFERENCES
Anderson, R.A. Chromium glucose intolerance and diabetes. J Am Coll Nutr.
1998. 17 (6); Dec: 548-55.
Baumgartner, T. et al. Trace elements in
clinical nutrition. Nutrition in Clinical Practice. 1993.
Bell, S.J., et al. A functional food product
for the management of weight. Critical Reviews in Food Sci. 2002. 42(2):
163-178.
Castillo-Duran C. et al. Trace minerals in
human growth and development. J of Pediatric Endocrinology & Metabolism.
1999. 12 (5); Sep-Oct: 589-601.
DeLuca, H.F. (et. al.) Mechanisms and Functions
of Vitamin D. Nutrition Reviews. February 1998. (56)2: S4- S10
Fairfield, K.M. Vitamins for chronic disease
prevention in adults. JAMA. 2002. 287(23); Jun 19: 3116-1720.
Institute of Medicine. Vitamin B6. Dietary
Reference Intakes: Thiamin Riboflavin, Niacin, Vitamin B6, Folate, Vitamin
B12, Pantothenic Acid, Biotin, and Choline. National Academy Press. Washington
D.C. 1998.
Halliwell, B. et al. Free radicals and
antioxidants in food and in vivo: What they do and how they work. Critical
Reviews in Food Science and Nutrition. 35:7-20. 1995.
Sizer, Frances et al. The vitamins. Nutrition:
Concepts and Controversies. 7th ed. 1997. 265.
Spallholz, J.E. et al. Advances in the role of
minerals in immunobiology. Biological Trace Element Research. 1989. 19:
129-151.
Stampfer MJ, Malinow MR, Willett WC, Newcomer
LM, Upson B, Ullmann D, Tishler PV, Hennekens CH. A prospective study of
plasma homocyst(e)ine and risk of myocardial infarction in US physicians. JAMA.
1992 Aug 19;268(7):877-81.
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Acetyl L-Carnitine 250mg 60 vcaps - Physiologics
Promotes
Memory and Cognitive Function*
HOW PATIENTS MAY BENEFIT
Promotes nervous system health*
PRODUCT DISCUSSION
PhysioLogics Acetyl-L-Carnitine (ALCAR) is similar in form to the amino acid L-Carnitine.
It is synthesized in the brain, liver, and kidneys by the enzyme carnitine
acetyltransferase and plays a role in the metabolism of food into energy.* The
acetyl group of Acetyl-L-Carnitine contributes to the production of the
neurotransmitter acetylcholine, which is required for cognitive function.*
STRUCTURE AND FUNCTION
Structurally similar to the neurotransmitter acetylcholine, ALCAR serves as the
precursor to acetyl coenzyme A. Animal studies have shown that ALCAR can support
neurons in the hippocampus and prefrontal cortex, facilitating learning and
memory functioning. Additionally, ALCAR promotes healthy levels of normal
shingomyelin accumulation to promote membrane fluidity and stability.*
ALCAR also plays a key role in cellular energy metabolism, transporting
long-chain fatty acids across the mitochondrial membranes where they are
utilized for ATP production, and shuttling small-chain and medium-chain fatty
acids out of the mitochondria in order to maintain healthy coenzyme A levels.
ALCAR helps maintain complex I and complex IV activity of the electron transport
chain in aged mitochondria to further facilitate the mitochondrial energy
supply.*
Finally, ALCAR may have antioxidant tendencies, supporting cells against
peroxidation and promoting levels of reduced Glutathione and Coenzyme Q10. This
property prevents lipid, protein, and DNA oxidative damage, which may further
support brain function.*
CLINICAL EVIDENCE
Thirty subjects completed a 3-month double-blind trial in which they
received 1,000 mg of acetyl l-carnitine twice per day or an alternative
preparation. At the end of the trial, the results demonstrated significant
benefits in energy maintenance levels in those receiving acetyl lcarnitine
compared to the alternative preparation. (Tomassini et al, 2004)
Twenty subjects participated in a 4-week observational study in which they
received 1,000 mg of acetyl l-carnitine twice per day. By week 3, a
significant improvement in nervous system function was observed compared
with baseline, based on questionnaire results. (Osio et al, 2006)
SUMMARY
PhysioLogics Acetyl-L-Carnitine helps promote cognitive function, memory, and
nervous system health, and supports mitochondrial energy production.*
SUGGESTED DOSAGE
For adults, take one (1) capsule four to six times daily, preferably between
meals, or follow the advice of a health care professional.
REFERENCES
Arrigo A, Casale R, Buonocore M, Ciano C. Effects of acetyl- L-carnitine on
reaction times in patients with cerebrovascular insufficiency. Int. J Clin
Pharm Res. 1990;10:133-7.
Barnes CA, Markowska AL, Ingram DK, et al. Acetyl-1-carnitine. 2: Effects
on learning and memory performance of aged rats in simple and complex mazes.
Neurobiol Aging. 1990;11:499-506.
Calvani M, Carta A, Caruso G, et al. Action of acetyl-L-carnitine in
neurodegeneration and Alzheimer's disease. Ann N Y Acad Sci. 1992;663:483-5.
Carta A, Calvani M. Acetyl-L-carnitine: a drug able to slow the progress of
Azheimer's disease? Ann N Y Acad Sci. 1991;640:228-32.
Carta A, Calvani M, Bravi D, Bhuachalla SN. Acetyl-L-carnitine and
Alzheimer's disease: pharmacological considerations beyond the cholinergic
sphere. Ann N Y Acad Sci. 1993;695:324-6.
Feher J, Papale A, Mannino G, et al. Mitotropic compounds for the treatment
of age-related macular degeneration. Ophthalmologica. 2003;217:351-7.
Osio M, Muscia F, Zampini L, et al. Acetyl l-carnitine in the treatment of
painful antiretroviral toxic neuropathy in human immunodeficiency virus
patients: an open label study. J Peripher Nerv Syst. 2006;11:72-6.
Parnetti L, Abate G, Bartorelli L, et al. Multicentre study of
lalpha-glyceryl-phosphorylcholine vs ST200 among patients with probable senile
dementia of Alzheimer's type. Drugs Aging. 1993;3:159-64.
Spagnoli A, Lucca U, Menasce G, et al. Long-term acetyl-Lcarnitine
treatment in Alzheimer's disease. Neuro. 1991;41:1726-32.
Thal LJ, Carta A, Clarke WR, et al. A 1-year multicenter placebo-controlled
study of acetyl-L-carnitine in patients with Alzheimer's disease. Neuro.
1996;47:705-11.
Tomassini V, Pozzilli C, Onesti E, et al. Comparison of the effects of
acetyl l-carnitine and amantadine for the treatment of fatigue in multiple
sclerosis: results of a pilot, randomized, double-blind, crossover trial. J
Neurol Sci. 2004;218:103-8.
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Acetyl L-Carnitine 1000mg 30 capsules - Physiologics
Supports Memory and Brain Function*
HOW PATIENTS MAY BENEFIT
Promotes nervous system health*
PRODUCT DISCUSSION
PhysioLogics Acetyl-L-Carnitine (ALCAR) is similar in form to the amino acid L-Carnitine.
It is synthesized in the brain, liver, and kidneys by the enzyme carnitine
acetyltransferase and plays a role in the metabolism of food into energy.* The
acetyl group of Acetyl-L-Carnitine contributes to the production of the
neurotransmitter acetylcholine, which is required for cognitive function.*
STRUCTURE AND FUNCTION
Structurally similar to the neurotransmitter acetylcholine, ALCAR serves as the
precursor to acetyl coenzyme A. Animal studies have shown that ALCAR can support
neurons in the hippocampus and prefrontal cortex, facilitating learning and
memory functioning. Additionally, ALCAR promotes healthy levels of normal
shingomyelin accumulation to promote membrane fluidity and stability.*
ALCAR also plays a key role in cellular energy metabolism, transporting
long-chain fatty acids across the mitochondrial membranes where they are
utilized for ATP production, and shuttling small-chain and medium-chain fatty
acids out of the mitochondria in order to maintain healthy coenzyme A levels.
ALCAR helps maintain complex I and complex IV activity of the electron transport
chain in aged mitochondria to further facilitate the mitochondrial energy
supply.*
Finally, ALCAR may have antioxidant tendencies, supporting cells against
peroxidation and promoting levels of reduced Glutathione and Coenzyme Q10. This
property prevents lipid, protein, and DNA oxidative damage, which may further
support brain function.*
CLINICAL EVIDENCE
Thirty subjects completed a 3-month double-blind trial in which they
received 1,000 mg of acetyl l-carnitine twice per day or an alternative
preparation. At the end of the trial, the results demonstrated significant
benefits in energy maintenance levels in those receiving acetyl lcarnitine
compared to the alternative preparation. (Tomassini et al, 2004)
Twenty subjects participated in a 4-week observational study in which they
received 1,000 mg of acetyl l-carnitine twice per day. By week 3, a
significant improvement in nervous system function was observed compared
with baseline, based on questionnaire results. (Osio et al, 2006)
SUMMARY
PhysioLogics Acetyl-L-Carnitine helps promote cognitive function, memory, and
nervous system health, and supports mitochondrial energy production.*
SUGGESTED DOSAGE
For adults, take one (1) 1000 mg capsule up to two times daily, preferably with
a meal, or follow the advice of a health care professional.
REFERENCES
Arrigo A, Casale R, Buonocore M, Ciano C. Effects of acetyl- L-carnitine on
reaction times in patients with cerebrovascular insufficiency. Int. J Clin
Pharm Res. 1990;10:133-7.
Barnes CA, Markowska AL, Ingram DK, et al. Acetyl-1-carnitine. 2: Effects
on learning and memory performance of aged rats in simple and complex mazes.
Neurobiol Aging. 1990;11:499-506.
Calvani M, Carta A, Caruso G, et al. Action of acetyl-L-carnitine in
neurodegeneration and Alzheimer's disease. Ann N Y Acad Sci. 1992;663:483-5.
Carta A, Calvani M. Acetyl-L-carnitine: a drug able to slow the progress of
Azheimer's disease? Ann N Y Acad Sci. 1991;640:228-32.
Carta A, Calvani M, Bravi D, Bhuachalla SN. Acetyl-L-carnitine and
Alzheimer's disease: pharmacological considerations beyond the cholinergic
sphere. Ann N Y Acad Sci. 1993;695:324-6.
Feher J, Papale A, Mannino G, et al. Mitotropic compounds for the treatment
of age-related macular degeneration. Ophthalmologica. 2003;217:351-7.
Osio M, Muscia F, Zampini L, et al. Acetyl l-carnitine in the treatment of
painful antiretroviral toxic neuropathy in human immunodeficiency virus
patients: an open label study. J Peripher Nerv Syst. 2006;11:72-6.
Parnetti L, Abate G, Bartorelli L, et al. Multicentre study of
lalpha-glyceryl-phosphorylcholine vs ST200 among patients with probable senile
dementia of Alzheimer's type. Drugs Aging. 1993;3:159-64.
Spagnoli A, Lucca U, Menasce G, et al. Long-term acetyl-Lcarnitine
treatment in Alzheimer's disease. Neuro. 1991;41:1726-32.
Thal LJ, Carta A, Clarke WR, et al. A 1-year multicenter placebo-controlled
study of acetyl-L-carnitine in patients with Alzheimer's disease. Neuro.
1996;47:705-11.
Tomassini V, Pozzilli C, Onesti E, et al. Comparison of the effects of
acetyl l-carnitine and amantadine for the treatment of fatigue in multiple
sclerosis: results of a pilot, randomized, double-blind, crossover trial. J
Neurol Sci. 2004;218:103-8.
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Alpha Lipoic Acid 200mg 100 capsules - Physiologics
Antioxidant
Enhancer*
Alpha lipoic acid is a vitamin-like antioxidant that helps neutralize cell-damaging free radicals. Free radicals can contribute to oxidative stress, which plays a role in the premature aging of cells. Alpha lipoic acid also supports the regeneration of glutathione, one of the body's primary antioxidants.
Particularly beneficial for vision health
Small in molecular size, so it passes easily through cell membranes
= Vegetarian Formula
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Alpha Lipoic Acid 300mg 30 vsoftgels - Physiologics
Supports
Sugar Metabolism*
PRODUCT ALSO KNOWN AS
Thioctic Acid, 1,2-dithiolane-3-pentanoic acid, 1,2-dithiolane-3 valeric acid,
6,8-thioctic acid
PRODUCT DISCUSSION
Alpha Lipoic Acid 300 mg from PhysioLogics provides this remarkable universal
antioxidant that recycles Glutathione, Vitamins C and E, and Coenzyme Q10, and
supports sugar metabolism at dosages of 600 mg per day. This product can be
used as part of your diet to help maintain a healthy blood sugar level.*
STRUCTURE AND FUNCTION
The metabolic role of Alpha Lipoic Acid as a cofactor in the multi-enzyme
oxidative decarboxylation complexes of the Krebs citric acid cycle has been
established for decades. The Krebs cycle is a major biochemical process that
derives energy from carbohydrates. Pyruvate dehydrogenase and a-ketogluterate
dehydrogenase are two central enzyme complexes that require Alpha Lipoic Acid
as a coenzyme for glucose metabolism and the Krebs cycle. Pyruvate
dehydrogenase complex (PDC) converts pyruvate to acetyl-CoA, one of the two
essential substrates needed to produce citrate. A deficiency in this enzymatic
complex may limit the production of citrate. Because citrate is the first
substrate in the Krebs cycle, the process cannot proceed. Alternate metabolic
pathways may be stimulated in an attempt to produce acetyl-CoA; however, an
energy deficit remains, especially in the central nervous system.*
More recently, Alpha Lipoic Acid has received attention for its role as a
"universal antioxidant." Possessing the ability to neutralize free
radicals in both the aqueous and lipid phases of the cell, Alpha Lipoic Acid
scavenges hydroxyl radicals, hydrogen peroxide, peroxynitrite, hypochlorous
acid, singlet oxygen and nitric oxide. In addition, it regenerates NAD+ from
NADH as well as intracellular levels of Glutathione, Vitamins C and E, and
Coenzyme Q10, effectively helping to establish a cellular antioxidant network.
As an antioxidant enhancer, Alpha Lipoic Acid works to support against
oxidative stress.*
INDICATIONS
Alpha Lipoic Acid works to support against oxidative stress. In addition to
its role as an antioxidant enhancer, Alpha Lipoic Acid is intended for your
clients that want to maintain a healthy blood sugar level already within the
normal range.*
HOW CLIENTS MAY BENEFIT
Alpha Lipoic Acid helps metabolize sugar in the body.*
Involved in glucose transport.*
Promotes cellular energy production.*
Recycles intracellular Vitamin C and E, Coenzyme Q10 and Glutathione.*
Superior antioxidant support.*
SCIENTIFIC RESEARCH
In order to investigate the antioxidant support of Alpha Lipoic Acid,
Marangon et al., conducted study in which plasma, cholesterol and urine
oxidizability were measured before and after 4 months of 600 mg/day Alpha
Lipoic Acid supplementation. Compared to base line samples, Alpha Lipoic
Acid significantly promoted the lag time of oxidation of plasma and
cholesterol oxidation, and supported fewer isoprostanes in the urine,
markers of oxidative stress.*
Jacob et al., evaluated the effects of 600 mg Alpha Lipoic Acid in a
placebo-controlled double-blind study of 74 subjects. All subjects were
comparable at base line. Following 4 weeks of supplementation,
significantly more subjects experienced an increase in sensitivity to
sugar-metabolizing hormone when compared to placebo, as measured by an
isoglycemic glucose-clamp.*
SUMMARY
Alpha Lipoic Acid has steadily been receiving greater attention as an
extraordinary supplement, providing comprehensive antioxidant support against
oxidative stress. As an integral part of the Krebs cycle, Alpha Lipoic Acid
works to metabolize glucose into cellular energy.*
SUGGESTED DOSAGE
For adults, take one (1) capsule twice daily, preferably with a meal, or
follow the advice of your health care professional. As a reminder, discuss the
supplements and medications you take with your health care providers.
REFERENCES
Borcea, V., et al. Lipoic acid decreases oxidative stress even in diabetic
patients with poor glycemic control and albuminuria. Free Radical Bio &
Med. 1999. 26(11-12): 1495-1500.
Bustamante, J., et al. Lipoic acid in liver metabolism and disease. Free
Radical Bio & Med. 1998. 24(6): 1023-1039.
Jacob, S., et al. Oral administration of RAC-alpha-lipoic acid modulates
insulin sensitivity in patients with type-2 diabetes mellitus: a
placebo-controlled pilot trial. Free Radic Biol Med. 1999
Aug;27(3-4):309-14.
Jacob, S. Oral administration of RAC-alpha lipoic acid modulates insulin
sensitivity in patients with Type 2 diabetes mellitus a placebo controlled
pilot trial. Free Radical Bio & Med. 1999. 27(3-4): 309-314.
Konrad, T., et al. Alpha lipoic acid treatment decreases serum lactate
and pyruvate concentrations and improves glucose effectiveness in lean and
obese patients with Type 2 Diabetes. Diabetes care. 1999. 22(2): 280-287.
Marangon K, et al. Comparison of the effect of alphalipoic acid and
alpha-tocopherol supplementation on measures of oxidative stress. Free Radic
Biol Med. 1999 Nov;27(9-10):1114-21.
Packer, L. et al. Alpha-lipoic acid as a biological antioxidant. Free
Radical Bio & Med. 1995. 19 (2) 227-250.
Ruhnaut, K.J., et al. Effects of 3 week oral treatment with the
antioxidant thioctic acid (lipoic acid) in symptomatic diabetic
polyneuropathy. Diabetic Med: J Brit Diabetic Assoc. 1999. 16(12):
1040-1043.
Wagh, S S. Mode of action of lipoic acid in diabetes. J Biosci. 1987.
Mar. 159-74. vol.11
* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
= Vegetarian Formula
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Biotin 5mg 60 vcaps - Physiologics
Supports
Skin & Hair Health*
PRODUCT DISCUSSION
A member of the family of B-Vitamins, Biotin serves as a coenzyme in
carboxylation reactions which are useful in many of the body's functions
including gluconeogenesis, fatty acid synthesis, propionate metabolism and
leucine catabolism. Biotin promotes healthy hair, skin and nails.*
STRUCTURE AND FUNCTION
In mammals, Biotin functions as an essential coenzyme in four carboxylases which
bind the Biotin moiety. Pyruvate carboxylase, methylcrotonyl-coenzyme A (CoA)
carboxylase and propionyl-CoA carboxylase function in the mitochondria, while
the fourth, acetyl-CoA carboxylase, is found in both the mitochondria and
cytosol. These enzymes function in gluconeogenesis, fatty acid synthesis,
propionate metabolism and leucine catabolism.*
Beta-Methylcrotonyl-CoA carboxylase is essential for the catabolism of the
branch-chained amino acid leucine. Acetyl-CoA carboxylase catalyzes the
carboxylation of acetyl CoA to form malonyl CoA, a substrate for fatty acid
elongation. Pyruvate carboxylase is required for the carboxylation of pyruvate
to form oxaloacetate, an intermediate in the Krebs tricarboxylic acid (TCA)
cycle. Oxaloacetate can be converted into glucose in the liver and kidney.
Propionyl-CoA catalyzes a carboxylation reaction that ultimately leads to the
formation of succunyl-CoA, another member of the Krebs TCA cycle.
Boas conducted studies in the 1920s on rats fed proteins from several
sources. She observed that rats fed raw egg did not have the support of skin and
hair health that the other rats did. This "egg white injury" is now
known to be a result of the very tight and specific binding of Biotin by avidin,
a glycoprotein found in uncooked egg whites. There is evidence to suggest that
fatty acid metabolism secondary to Biotin-dependant carboxylases plays an
important role in the health of hair, skin and nails.*
INDICATIONS
Certain regularly prescribed drugs or other circumstances may lead to Biotin
depletions. PhysioLogics' Biotin 5 mg may be an opportune way to ensure a daily
intake of this essential B-Vitamin to support the health of your clients' hair,
skin and nails.*
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C-1000 1000mg 100 capsules - Physiologics
Superior
Antioxidant Protection* - Rapid Release
Vitamin C plays an important role in supporting immune function.* As an
antioxidant, Vitamin C helps neutralize harmful free radicals in cells.*
Bioflavonoids work with vitamin C and offer beneficial properties of their
own.*
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CardioLogics with Policosanol 60 softgels - Physiologics
Nutritional
Support for Healthy Heart Function*
PRODUCT IS A SYNERGISTIC
MIXTURE OF
Vitamin E (as d-Alpha Tocopherol), Vitamin B-6 (as Pyridoxine Hydrochloride),
Folic Acid, Vitamin B-12 (as Cyanocobalamin), Fish Oil (Eicosapentaenoic Acid
and Docosahexaenoic Acid), Policosanol (from rice wax), Coenzyme Q10
PRODUCT DISCUSSION
CardioLogics with Policosanol provides several active ingredients that
contribute to a healthy heart and cardiovascular system. Policosanol helps
maintain cholesterol levels already within the normal range, while B-6, Folate,
and B-12 help promote healthy levels of homocysteine. In addition, Fish Oil,
containing Omega-3 fatty acids, Vitamin E and Coenzyme Q10 are included for
additional health benefits.*
STRUCTURE AND FUNCTION
Policosanol is a natural mixture of high-molecular weight, aliphatic primary
alcohols obtained from the wax of plants. Numerous clinical studies confirm the
ability of Policosanol to promote heart and circulatory health. Policosanol
helps maintain cholesterol levels that are already within the normal range.*
Vitamin B-6, Folate, and Vitamin B-12 are
coenzymes in the single-carbon cycle, which produces methyl groups for the
conversion of homocysteine to methionine, helping to maintain a healthy vascular
system.* As part of a well-balanced diet that is low in saturated fat and
cholesterol, Folic Acid, Vitamin B6 and Vitamin B12 may reduce the risk of
vascular disease. FDA evaluated the above claim and found that, while it is
known that diets low in saturated fat and cholesterol reduce the risk of heart
disease and other vascular diseases, the evidence in support of the above claim
is inconclusive.
INDICATIONS
For your clients who wish to maintain a healthy cardiovascular system,
CardioLogics with Policosanol delivers several key ingredients to promote
healthy heart function. This formula also provides Fish Oil, Vitamin E and
Coenzyme Q-10 for additional health benefits.*
HOW CLIENTS MAY BENEFIT
Policosanol helps maintain cholesterol levels
that are already within the normal range.*
Promote healthy levels of homocysteine.*
Maintain healthy blood vessels.*
Receive antioxidant fortification.*
CLINICAL EVIDENCE
After 4 weeks on a diet, 55 subjects received
5 mg Policosanol per day for 5 weeks, followed by 10 mg/day for 5 weeks.
67.3% of subjects experienced cardiovascular support.
One study investigated the effects of
long-term supplementation with Policosanol and heart health. After 20 months
of supplementation, significant support was observed for exercise responses,
and overall cardiac health compared to placebo.
The Physician's Health Study followed almost
15,000 male physicians for up to five years to study heart health. In this
study, lower levels of homocysteine were found in those with a healthier
cardiovascular system. In addition, researchers found that higher serum
levels of Vitamins B-6, B-12, and Folic Acid were correlated with lower
plasma homocysteine levels.
SUMMARY
PhysioLogics knows the importance of maintaining a healthy cardiovascular
system, vital for transporting oxygen, glucose, hormones and other nourishing
fluids throughout the body. CardioLogics with Policosanol delivers a unique
blend of active ingredients to help maintain cholesterol levels already within
the normal range, promote healthy levels of homocysteine, and support blood
vessel health.*
SUGGESTED DOSAGE
For adults, take two (2) softgels daily, preferably with a meal or follow the
advice of your health care professional. As a reminder, discuss the supplements
and medications you take with your health care providers.
REFERENCES
Castano, G. et al. Comparison of the efficacy, safety and tolerability of
original policosanol versus other mixtures of higher aliphatic primary
alcohols in patients with type II hypercholesterolemia. International Journal
of Clinical Pharmacology Research. 2002. 22(2): 55-66.
Gouni-Berthold, I. Policosanol: clinical
pharmacology and therapeutic significance of a new lipid-lowering agent. Am
Heart J. 2002. 143(2):356-65.
Institute of Medicine. Thiamin. Dietary
Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin
B12, Pantothenic Acid, Biotin, and Choline. National Academy Press. Washington
D.C. 1998.
Pryor, W.A. Vitamin E and heart disease: basic
science to clinical intervention trials. Free Rad Biol & Med. 2000. 28(1);
141-164.
Stampfer MJ, Malinow MR, Willett WC, Newcomer
LM, Upson B, Ullmann D, Tishler PV, Hennekens CH. A prospective study of
plasma homocyst(e)ine and risk of myocardial infarction in US physicians. JAMA.
1992 Aug 19;268(7):877-81.
Stephens, N.G. (et. al.) Randomized controlled
trial of vitamin E in patients with coronary disease: Cambridge Heart
Antioxidant Study (CHAOS) Lancet 1996; 347(9004):781-786
Stüsser, R. et al. Long-term therapy with
policosanol improves treadmill exercise-ECG testing performance of coronary
heart disease patients. Int J Clin Pharmacol Ther. 1998. 36(9):469-73.
Swaine, R.A. et al. Therapeutic uses of vitamin
E in prevention of atherosclerosis. Altern Med Rev. 1999. 4(6); Dec: 414-423.
Taylor, J., et al. Octacosanol in human health.
Nutrition. 2003. 19(2); Feb: 192-195. |
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Coenzyme Q10 Q-Sorb 75mg 120 softgels - Physiologics
Supports
Cardiovascular and Antioxidant Health*
HOW PATIENTS MAY BENEFIT
Supports cells and mitochondrial DNA from the
harmful effects of reactive oxygen species*
PRODUCT DISCUSSION
PhysioLogics Coenzyme Q-10 Q-Sorb™ 75 mg provides an essential component of
the mitochondrial electron transport chain, vital for the production of
adenosine triphosphate (ATP) required for virtually all cellular processes. Co
Q-10 is a lipophilic antioxidant that neutralizes the formation of reactive
oxygen species in the mitochondria, which is important for cardiovascular
health.*
Endogenous levels of Co Q-10 may diminish with
age, strenuous exercise, and environmental stressors. In addition, certain
regularly prescribed drugs, including statins, may deplete the body's supply of
Co Q-10. (Note: Coenzyme Q-10 is not intended to serve as a replacement for
statin therapy, nor should patients discontinue taking any prescribed
medications while supplementing with Co Q-10.)
STRUCTURE AND FUNCTION
Coenzyme Q-10 is a vitamin-like molecule naturally found in the inner
mitochondrial membrane of every cell in the human body. In the mitochondrial
respiratory chain, Co Q-10 is the electron acceptor for mitochondrial complex I
and complex II, and donates electrons to complex III during oxidative
phosphorylation. Each pair of electrons in the electron transport chain must
interact with Co Q-10, the rate-limiting component of the mitochondrial
respiratory cycle.
Co Q-10 is also a component of extra-mitochondrial
redox chains, whose function is to remove excess reducing power formed during
glycolysis when mitochondrial respiration is decreased. In its reduced form, Co
Q-10 is a lipid-soluble antioxidant that readily provides electrons to
neutralize superoxide and lipid radicals. Mitochondria are the primary sources
of intracellular reactive oxygen species (ROS), which are capable of
mitochondrial DNA damage. Co Q-10 scavenges these species to support the cell
and DNA and fight oxidative stress, neutralizing both the initiation and
propagation of lipid peroxidation.
By supporting the normal physiological function
of the heart, Co Q-10 promotes healthy circulation through myocardial tissue. Co
Q-10 also has membrane stabilizing properties thought to be involved in the
phospholipid-protein interaction that aids in the metabolism of prostaglandins.
Myocardial calcium-dependent ion channels are stabilized by Co Q-10, which
supports molecules essential for ATP synthesis. In addition, Co Q-10 seems to
play a role in supporting the fluidity of membranes, important for physiological
functions of receptors, carriers and membrane-bound enzymes.
CLINICAL EVIDENCE
In a double-blind, placebo-controlled,
randomized study conducted by Berman et al, subjects consuming Co Q-10
showed significant improvement in a 6-minute walk test, breathing
parameters, New York Heart Association (NYHA) classification, and fatigue.
The administration of Co Q-10 to subjects led to a significant improvement
in functional status, and quality of life. Coenzyme Q-10 was shown to
effectively support overall well being includin heart health. (Berman et al,
2004)
In another randomized, double-blind,
controlled trial, the effects of oral treatment with Co Q-10 (120 mg/day)
were compared over one year in 144 subjects. Co Q-10 significantly increased
the level of vitamin E in the blood, supported healthy HDL levels, and
reduced molecules that cause oxidative stress. There was a significantly
lower effect in the control group. (Singh et al, 2003)
SUMMARY
Coenzyme Q-10 plays an essential role in the production of cellular ATP.* Its
role as an antioxidant supports cardiovascular tissue from oxidative damage.*
Supplementing a patient's nutritional regimen with PhysioLogics Coenzyme Q-10 Q-Sorb™
75 mg softgels will support cellular energy production and also help promote
cardiovascular health.*
SUGGESTED DOSAGE
For adults, take one (1) softgel twice daily, preferably with meals, or follow
the advice of a health care professional.
REFERENCES
Berman M, et al. Coenzyme Q10 in patients with endstage heart failure awaiting
cardiac transplantation: A randomized, placebo-controlled study. Clin Cardiol.
2004;27:295-9.
Ebadi M, et al. Ubiquinone (coenzyme Q-10) and
mitochondria in oxidative stress of Parkinson's disease. Bio Signals Recept.
2001;10:224-53.
Ernster, L, Dallner G. Biochemical,
physiological and medical aspects of ubiquinone function. Biochim Biophys Acta.
1995;1271:195-204.
Greenberg S, Frishman WH. Co-enzyme Q-10: a new
drug for cardiovascular disease. J Clin Pharmacol. 1990;30:596-608.
Kato T, et al. Reduction in blood viscosity by
treatment with coenzyme Q-10 in patients with ischemic heart disease. Int J
Clin Pharmacol Ther Toxicol. 1990;28:123-6.
Langsjoen PH, Langsjoen AM. The clinical use of
HMG CoA-reductase inhibitors and the associated depletion of coenzyme Q10. A
review of animal and human publications. Biofactors. 2003;18:101-11.
Mellors A, Tappel AL. The inhibition of
mitochondrial peroxidation by ubiquinone and ubiquinol. J Biol Chem.
1966;241:4353-6.
Mortensen SA, et al. Coenzyme Q-10: clinical
benefits with biochemical correlates suggesting a scientific breakthrough in
the management of chronic heart failure. Int J Tissue React. 1990;12:155-62.
Nair K, et al. Aging muscle. Am J Clin Nutr.
2005;81:953-63.
Nohl H, Gille L, Staniek K. The biochemical,
pathophysiological, and medical aspects of ubiquinone function. Ann N Y Acad
Sci. 1998;854:394-409.
Overvad K, et al. Coenzyme Q-10 in health and
disease. Eur J Clin Nutr. 1999;53:764-70.
Rauchova H, Drahota Z, Lenaz G. Function of
coenzyme Q in the cell: some biochemical and physiological properties. Physiol
Res. 1995;44:209-16.
Ravikumar A, et al. Isoprenoid pathway and free
radical generation and damage in neuropsychiatric disorders. Ind J Exp Biol.
2000;38:438-46.
Reis F, et al. Circadian and seasonal variation
of endogenous ubiquinone plasma level. Chronobiol Int. 2002;19:599-614.
Singh RB, et al. Effect of coenzyme Q10 on risk
of atherosclerosis in patients with recent myocardial infarction. Mol Cell
Biochem. 2003;246:75-82.
Shults CW, et al. Coenzyme Q-10 levels
correlate with the activities of complexes I and II/III in mitochondria from
parkinsonian and nonparkinsonian subjects. Ann Neurol. 1997;42:261-4.
Tran MT, et al. Role of coenzyme Q-10 in
chronic heart failure, angina, and hypertension. Pharmacotherapy.
2001;21:797-806.
Weber C, et al. Effect of dietary coenzyme Q-10
as an antioxidant in human plasma. Mol Aspects Med. 1994;15 Suppl:s97-102.
Wei YH, et al. Tandem duplications and
large-scale deletions of mitochondrial DNA are early molecular events of human
aging process. Ann N Y Acad Sci. 1996;786:82-101.
Click
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Coenzyme Q10 Q-Sorb 120mg 120 softgels - Physiologics
Clinically
Shown to Promote Heart Health*
Supports Antioxidant Health*
HOW PATIENTS MAY BENEFIT
Supports cells and mitochondrial DNA from the
harmful effects of reactive oxygen species*
PRODUCT DISCUSSION
PhysioLogics Coenzyme Q-10 Q-Sorb™ 120 mg provides an essential component of
the mitochondrial electron transport chain, vital for the production of
adenosine triphosphate (ATP) required for virtually all cellular processes. Co
Q-10 is a lipophilic antioxidant that neutralizes the formation of reactive
oxygen species in the mitochondria, which is important for cardiovascular
health.*
Endogenous levels of Co Q-10 may diminish with
age, strenuous exercise, and environmental stressors. In addition, certain
regularly prescribed drugs, including statins, may deplete the body's supply of
Co Q-10. (Note: Coenzyme Q-10 is not intended to serve as a replacement for
statin therapy, nor should patients discontinue taking any prescribed
medications while supplementing with Coenzyme Q-10.)
STRUCTURE AND FUNCTION
Coenzyme Q-10 is a vitamin-like molecule naturally found in the inner
mitochondrial membrane of every cell in the human body. In the mitochondrial
respiratory chain, Co Q-10 is the electron acceptor for mitochondrial complex I
and complex II, and donates electrons to complex III during oxidative
phosphorylation. Each pair of electrons in the electron transport chain must
interact with Co Q-10, the rate-limiting component of the mitochondrial
respiratory cycle.
Co Q-10 is also a component of extra-mitochondrial
redox chains, whose function is to remove excess reducing power formed during
glycolysis when mitochondrial respiration is decreased. In its reduced form, Co
Q-10 is a lipid-soluble antioxidant that readily provides electrons to
neutralize superoxide and lipid radicals. Mitochondria are the primary sources
of intracellular reactive oxygen species (ROS), which are capable of
mitochondrial DNA damage. Co Q-10 scavenges these species to support the cell
and DNA and fight oxidative stress, neutralizing both the initiation and
propagation of lipid peroxidation.
By supporting the normal physiological function
of the heart, Co Q-10 promotes healthy circulation through myocardial tissue. Co
Q-10 also has membrane stabilizing properties thought to be involved in the
phospholipid-protein interaction that aids in the metabolism of prostaglandins.
Myocardial calcium-dependent ion channels are stabilized by Co Q-10, which
supports molecules essential for ATP synthesis. In addition, Co Q-10 seems to
play a role in supporting the fluidity of membranes, important for physiological
functions of receptors, carriers and membrane-bound enzymes.
CLINICAL EVIDENCE
In a double-blind, placebo-controlled, randomized study, subjects consuming Co
Q-10 showed significant improvement in a 6-minute walk test, in breathing
parameters, New York Heart Association (NYHA) classification, and fatigue. The
administration of Co Q-10 to subjects led to a significant improvement in
functional status, and quality of life. Coenzyme Q-10 was shown to effectively
support overall well being including heart health. (Berman et al, 2004) In
another randomized, double-blind, controlled trial, the effects of oral
treatment with Co Q-10 (120 mg/day) were compared over one year in 144 subjects.
Co Q-10 significantly increased the level of vitamin E in the blood, supported
healthy HDL levels, and reduced molecules that cause oxidative stress. There was
a significantly lower effect in the control group. (Singh et al, 2003)
SUMMARY
Coenzyme Q-10 plays an essential role in the production of cellular ATP.* Its
role as an antioxidant supports cardiovascular tissue from oxidative damage.*
Supplementing a patient's nutritional regimen with PhysioLogics Coenzyme Q-10 Q-Sorb™
120 mg softgels will help support cellular energy production and also help
promote cardiovascular health.*
SUGGESTED DOSAGE
For adults, take one (1) softgel daily, preferably with a meal, or follow the
advice of a health care professional.
REFERENCES
Berman M, et al. Coenzyme Q10 in patients with endstage heart failure awaiting
cardiac transplantation: A randomized, placebo-controlled study. Clin Cardiol.
2004;27:295-9.
Ebadi M, et al. Ubiquinone (coenzyme Q-10) and
mitochondria in oxidative stress of Parkinson's disease. Bio Signals Recept.
2001;10:224-53.
Ernster, L, Dallner G. Biochemical,
physiological and medical aspects of ubiquinone function. Biochim Biophys Acta.
1995;1271:195-204.
Greenberg S, Frishman WH. Co-enzyme Q-10: a new
drug for cardiovascular disease. J Clin Pharmacol. 1990;30:596-608.
Kato T, et al. Reduction in blood viscosity by
treatment with coenzyme Q-10 in patients with ischemic heart disease. Int J
Clin Pharmacol Ther Toxicol. 1990;28:123-6.
Langsjoen PH, Langsjoen AM. The clinical use of
HMG CoA-reductase inhibitors and the associated depletion of coenzyme Q10. A
review of animal and human publications. Biofactors. 2003;18:101-11.
Mellors A, Tappel AL. The inhibition of
mitochondrial peroxidation by ubiquinone and ubiquinol. J Biol Chem.
1966;241:4353-6.
Mortensen SA, et al. Coenzyme Q-10: clinical
benefits with biochemical correlates suggesting a scientific breakthrough in
the management of chronic heart failure. Int J Tissue React. 1990;12:155-62.
Nair K, et al. Aging muscle. Am J Clin Nutr.
2005;81:953-63.
Nohl H, Gille L, Staniek K. The biochemical,
pathophysiological, and medical aspects of ubiquinone function. Ann N Y Acad
Sci. 1998;854:394-409.
Overvad K, et al. Coenzyme Q-10 in health and
disease. Eur J Clin Nutr. 1999;53:764-70.
Rauchova H, Drahota Z, Lenaz G. Function of
coenzyme Q in the cell: some biochemical and physiological properties. Physiol
Res. 1995;44:209-16.
Ravikumar A, et al. Isoprenoid pathway and free
radical generation and damage in neuropsychiatric disorders. Ind J Exp Biol.
2000;38:438-46.
Reis F, et al. Circadian and seasonal variation
of endogenous ubiquinone plasma level. Chronobiol Int. 2002;19:599-614.
Singh RB, et al. Effect of coenzyme Q10 on risk
of atherosclerosis in patients with recent myocardial infarction. Mol Cell
Biochem. 2003;246:75-82.
Shults CW, et al. Coenzyme Q-10 levels
correlate with the activities of complexes I and II/III in mitochondria from
parkinsonian and nonparkinsonian subjects. Ann Neurol. 1997;42:261-4.
Tran MT, et al. Role of coenzyme Q-10 in
chronic heart failure, angina, and hypertension. Pharmacotherapy.
2001;21:797-806.
Weber C, et al. Effect of dietary coenzyme Q-10
as an antioxidant in human plasma. Mol Aspects Med. 1994;15 Suppl:s97-102.
Wei YH, et al. Tandem duplications and
large-scale deletions of mitochondrial DNA are early molecular events of human
aging process. Ann N Y Acad Sci. 1996;786:82- 101.
Click
here for Label Information in PDF format
Close PDF window to return to store |
79.90 |
View |
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Coenzyme Q10 Q-Sorb 200mg 60 softgels - Physiologics
Supports
Cardiovascular and Antioxidant Health*
HOW PATIENTS MAY BENEFIT
Supports cells and mitochondrial DNA from the
harmful effects of reactive oxygen species*
PRODUCT DISCUSSION
PhysioLogics Coenzyme Q-10 Q-Sorb™ 200 mg provides an essential component of
the mitochondrial electron transport chain, vital for the production of
adenosine triphosphate (ATP) required for virtually all cellular processes. Co
Q-10 is a lipophilic antioxidant that neutralizes the formation of reactive
oxygen species in the mitochondria, which is important for cardiovascular
health.*
Endogenous levels of Co Q-10 may diminish with
age, strenuous exercise, and environmental stressors. In addition, certain
regularly prescribed drugs, including statins, may deplete the body's supply of
Co Q-10. (Note: Coenzyme Q-10 is not intended to serve as a replacement for
statin therapy, nor should patients discontinue taking any prescribed
medications while supplementing with Coenzyme Q-10.)
STRUCTURE AND FUNCTION
Coenzyme Q-10 is a vitamin-like molecule naturally found in the inner
mitochondrial membrane of every cell in the human body. In the mitochondrial
respiratory chain, Co Q-10 is the electron acceptor for mitochondrial complex I
and complex II, and donates electrons to complex III during oxidative
phosphorylation. Each pair of electrons in the electron transport chain must
interact with Co Q-10, the rate-limiting component of the mitochondrial
respiratory cycle.
Co Q-10 is also a component of extra-mitochondrial
redox chains, whose function is to remove excess reducing power formed during
glycolysis when mitochondrial respiration is decreased. In its reduced form, Co
Q-10 is a lipid-soluble antioxidant that readily provides electrons to
neutralize superoxide and lipid radicals. Mitochondria are the primary sources
of intracellular reactive oxygen species (ROS), which are capable of
mitochondrial DNA damage. Co Q-10 scavenges these species to support the cell
and DNA and fight oxidative stress, neutralizing both the initiation and
propagation of lipid peroxidation.
By supporting the normal physiological function
of the heart, Co Q-10 promotes healthy circulation through myocardial tissue. Co
Q-10 also has membrane stabilizing properties thought to be involved in the
phospholipidprotein interaction that aids in the metabolism of prostaglandins.
Myocardial calcium-dependent ion channels are stabilized by Co Q-10, which
supports molecules essential for ATP synthesis. In addition, Co Q-10 seems to
play a role in supporting the fluidity of membranes, important for physiological
functions of receptors, carriers and membrane-bound enzymes.
CLINICAL EVIDENCE
In a double-blind, placebo-controlled,
randomized study conducted by Berman et al, subjects consuming Co Q-10
showed significant improvement in a 6-minute walk test, in breathing
parameters, New York Heart Association (NYHA) classification, and fatigue.
The administration of Co Q-10 to subjects led to a significant improvement
in functional status, and quality of life. Coenzyme Q-10 was shown to
effectively support overall well being including heart health. (Berman et
al, 2004)
In another randomized, double-blind,
controlled trial, the effects of oral treatment with Co Q-10 (120 mg/day)
were compared over one year in 144 subjects. Co Q-10 significantly increased
the level of vitamin E in the blood, supported healthy HDL levels, and
reduced molecules that cause oxidative stress. There was a significantly
lower effect in the control group. (Singh et al, 2003)
SUMMARY
Coenzyme Q-10 plays an essential role in the production of cellular ATP.* Its
role as an antioxidant supports cardiovascular tissue from oxidative damage.*
Supplementing a patient's nutritional regimen with PhysioLogics Coenzyme Q-10 Q-Sorb™
200 mg softgels will support their cellular energy production and also help
promote cardiovascular health.
SUGGESTED DOSAGE
For adults, take one (1) softgel daily, preferably with a meal, or follow the
advice of a health care professional.
REFERENCES
Berman M et al. Coenzyme Q10 in patients with end-stage heart failure awaiting
cardiac transplantation: A randomized, placebo-controlled study. Clin Cardiol.
2004;27:295-9. Ebadi M, et al. Ubiquinone (coenzyme Q-10) and mitochondria in
oxidative stress of Parkinson's disease. Bio Signals Recept. 2001;10:224-53.
Ernster, L, Dallner G. Biochemical,
physiological and medical aspects of ubiquinone function. Biochim Biophys Acta.
1995;1271:195-204.
Greenberg S, Frishman WH. Co-enzyme Q-10: a new
drug for cardiovascular disease. J Clin Pharmacol. 1990;30:596-608.
Kato T, et al. Reduction in blood viscosity by
treatment with coenzyme Q-10 in patients with ischemic heart disease. Int J
Clin Pharmacol Ther Toxicol. 1990;28:123-6.
Langsjoen PH, Langsjoen AM. The clinical use of
HMG CoAreductase inhibitors and the associated depletion of coenzyme Q10. A
review of animal and human publications. Biofactors. 2003;18:101-11.
Mellors A, Tappel AL. The inhibition of
mitochondrial peroxidation by ubiquinone and ubiquinol. J Biol Chem.
1966;241:4353-6.
Mortensen SA, et al. Coenzyme Q-10: clinical
benefits with biochemical correlates suggesting a scientific breakthrough in
the management of chronic heart failure. Int J Tissue React. 1990;12:155-62.
Nair K, et al. Aging muscle. Am J Clin Nutr.
2005;81:953-63.
Nohl H, Gille L, Staniek K. The biochemical,
pathophysiological, and medical aspects of ubiquinone function. Ann N Y Acad
Sci. 1998;854:394-409.
Overvad K, et al. Coenzyme Q-10 in health and
disease. Eur J Clin Nutr. 1999;53:764-70.
Rauchova H, Drahota Z, Lenaz G. Function of
coenzyme Q in the cell: some biochemical and physiological properties. Physiol
Res. 1995;44:209-16.
Ravikumar A, et al. Isoprenoid pathway and free
radical generation and damage in neuropsychiatric disorders. Ind J Exp Biol.
2000;38:438-46.
Reis F, et al. Circadian and seasonal variation
of endogenous ubiquinone plasma level. Chronobiol Int. 2002;19:599-614.
Singh RB, et al. Effect of coenzyme Q10 on risk
of atherosclerosis in patients with recent myocardial infarction. Mol Cell
Biochem. 2003;246:75-82.
Shults CW, et al. Coenzyme Q-10 levels
correlate with the activities of complexes I and II/III in mitochondria from
parkinsonian and nonparkinsonian subjects. Ann Neurol. 1997;42:261-4.
Tran MT, et al. Role of coenzyme Q-10 in
chronic heart failure, angina, and hypertension. Pharmacotherapy.
2001;21:797-806.
Weber C, et al. Effect of dietary coenzyme Q-10
as an antioxidant in human plasma. Mol Aspects Med. 1994;15 Suppl:s97-102.
Wei YH, et al. Tandem duplications and
large-scale deletions of mitochondrial DNA are early molecular events of human
aging process. Ann N Y Acad Sci. 1996;786:82-101.
Click
here for Label Information in PDF format
Close PDF window to return to store |
71.90 |
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Coenzyme Q10 400mg 30 softgels - Physiologics
Supports
Cardiovascular Health and Helps Promote Metabolic Functions*
HOW PATIENTS MAY BENEFIT
Supports cells and mitochondrial DNA from the
harmful effects of reactive oxygen species*
PRODUCT DISCUSSION
PhysioLogics Coenzyme Q-10 Q-Sorb® 400 mg provides an essential component of
the mitochondrial electron transport chain, vital for the production of
adenosine triphosphate (ATP) required for virtually all cellular processes. Co
Q-10 is a lipophilic antioxidant that neutralizes the formation of reactive
oxygen species in the mitochondria, which is important for cardiovascular
health.*
Endogenous levels of Co Q-10 may diminish with
age, strenuous exercise, and environmental stressors. In addition, certain
regularly prescribed drugs, including statins, may deplete the body's supply of
Co Q-10. (Note: Coenzyme Q-10 is not intended to serve as a replacement for
statin therapy, nor should patients discontinue taking any prescribed
medications while supplementing with Coenzyme Q-10.)
STRUCTURE AND FUNCTION
Coenzyme Q-10 is a vitamin-like molecule naturally found in the inner
mitochondrial membrane of every cell in the human body. In the mitochondrial
respiratory chain, Co Q-10 is the electron acceptor for mitochondrial complex I
and complex II, and donates electrons to complex III during oxidative
phosphorylation. Each pair of electrons in the electron transport chain must
interact with Co Q-10, the rate-limiting component of the mitochondrial
respiratory cycle.
Co Q-10 is also a component of extra-mitochondrial
redox chains, whose function is to remove excess reducing power formed during
glycolysis when mitochondrial respiration is decreased. In its reduced form, Co
Q-10 is a lipid-soluble antioxidant that readily provides electrons to
neutralize superoxide and lipid radicals. Mitochondria are the primary sources
of intracellular reactive oxygen species (ROS), which are capable of
mitochondrial DNA damage. Co Q-10 scavenges these species to support the cell
and DNA and fight oxidative stress, neutralizing both the initiation and
propagation of lipid peroxidation.
By supporting the normal physiological function
of the heart, Co Q-10 promotes healthy circulation through myocardial tissue. Co
Q-10 also has membrane stabilizing properties thought to be involved in the
phospholipid-protein interaction that aids in the metabolism of prostaglandins.
Myocardial calcium-dependent ion channels are stabilized by Co Q-10, which
supports molecules essential for ATP synthesis. In addition, Co Q-10 seems to
play a role in supporting the fluidity of membranes, important for physiological
functions of receptors, carriers and membrane-bound enzymes.
CLINICAL EVIDENCE
In a double-blind, placebo-controlled,
randomized study subjects consuming Co Q-10 showed significant improvement
in a 6-minute walk test, in breathing parameters, New York Heart Association
(NYHA) classification, and fatigue. The administration of Co Q-10 to
subjects led to a significant improvement in functional status, and quality
of life. Coenzyme Q-10 was shown to effectively support overall well being
including heart health. (Berman et al, 2004)
In another randomized, double-blind,
controlled trial, the effects of oral treatment with Co Q-10 (120 mg/day)
were compared over one year in 144 subjects. Co Q-10 significantly increased
the level of vitamin E in the blood, supported healthy HDL levels, and
reduced molecules that cause oxidative stress, with a significantly lower
effect in the control group. (Singh et al, 2003)
SUMMARY
Coenzyme Q-10 plays an essential role in the production of cellular ATP.* Its
role as an antioxidant supports cardiovascular tissue from oxidative damage.*
Supplementing a patient's nutritional regimen with PhysioLogics Coenzyme Q-10 Q-Sorb®
400 mg softgels will help support cellular energy production and also help
promote cardiovascular health.*
SUGGESTED DOSAGE
For adults, take one (1) softgel daily, preferably with a meal, or follow the
advice of a health care professional.
REFERENCES
Berman M, et al. Coenzyme Q10 in patients with end-stage heart failure
awaiting cardiac transplantation: A randomized, placebo-controlled study. Clin
Cardiol. 2004;27:295-9.
Ebadi M, et al. Ubiquinone (coenzyme Q-10) and
mitochondria in oxidative stress of Parkinson's disease. Bio Signals Recept.
2001;10:224-53.
Ernster, L, Dallner G. Biochemical,
physiological and medical aspects of ubiquinone function. Biochim Biophys Acta.
1995;1271:195-204.
Greenberg S, Frishman WH. Co-enzyme Q-10: a new
drug for cardiovascular disease. J Clin Pharmacol. 1990;30:596-608.
Kato T, et al. Reduction in blood viscosity by
treatment with coenzyme Q-10 in patients with ischemic heart disease. Int J
Clin Pharmacol Ther Toxicol. 1990;28:123-6.
Langsjoen PH, Langsjoen AM. The clinical use of
HMG CoAreductase inhibitors and the associated depletion of coenzyme Q10. A
review of animal and human publications. Biofactors. 2003;18:101-11.
Mellors A, Tappel AL. The inhibition of
mitochondrial peroxidation by ubiquinone and ubiquinol. J Biol Chem.
1966;241:4353-6.
Mortensen SA, et al. Coenzyme Q-10: clinical
benefits with biochemical correlates suggesting a scientific breakthrough in
the management of chronic heart failure. Int J Tissue React. 1990;12:155-62.
Nair K, et al. Aging muscle. Am J Clin Nutr.
2005;81:953-63.
Nohl H, Gille L, Staniek K. The biochemical,
pathophysiological, and medical aspects of ubiquinone function. Ann N Y Acad
Sci. 1998;854:394-409.
Overvad K, et al. Coenzyme Q-10 in health and
disease. Eur J Clin Nutr. 1999;53:764-70.
Rauchova H, Drahota Z, Lenaz G. Function of
coenzyme Q in the cell: some biochemical and physiological properties. Physiol
Res. 1995;44:209-16.
Ravikumar A, et al. Isoprenoid pathway and free
radical generation and damage in neuropsychiatric disorders. Ind J Exp Biol.
2000;38:438-46.
Reis F, et al. Circadian and seasonal variation
of endogenous ubiquinone plasma level. Chronobiol Int. 2002;19:599-614.
Singh RB, et al. Effect of coenzyme Q10 on risk
of atherosclerosis in patients with recent myocardial infarction. Mol Cell
Biochem. 2003;246:75-82.
Shults CW, et al. Coenzyme Q-10 levels
correlate with the activities of complexes I and II/III in mitochondria from
parkinsonian and nonparkinsonian subjects. Ann Neurol. 1997;42:261-4.
Tran MT, et al. Role of coenzyme Q-10 in
chronic heart failure, angina, and hypertension. Pharmacotherapy.
2001;21:797-806.
Weber C, et al. Effect of dietary coenzyme Q-10
as an antioxidant in human plasma. Mol Aspects Med. 1994;15 Suppl:S97- 102.
Wei YH, et al. Tandem duplications and
large-scale deletions of mitochondrial DNA are early molecular events of human
aging process. Ann N Y Acad Sci. 1996;786:82-101.
Click
here for Label Information in PDF format
Close PDF window to return to store |
79.12 |
View |
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CoQ-10 50 mg & L-Carnitine 250 mg - Physiologics
Dual Support for Heart Health &
Energy Production*
PRODUCT IS A SYNERGISTIC MIXTURE OF
Coenzyme Q-10, L-Carnitine (as L-Carnitine Fumarate), Gamma Tocopherol, Vitamin
E (as d-Alpha Tocopherol), Vitamin C (as Ascorbyl Palmitate)
PRODUCT DISCUSSION
Physiologics' Coenzyme Q-10 & L-Carnitine softgels provide two powerful
ingredients to support heart health. CoQ-10 is an essential component of the
mitochondrial electron transport chain, vital for the production of adenosine
triphosphate (ATP) required for virtually every cellular process. By supporting
the normal physiology of the heart, CoQ-10 promotes healthy circulation through
myocardial tissue. L-Carnitine plays a role in fatty acid metabolism and
supports muscle tissue. Together, these ingredients provide natural support for
cardiovascular health.*
STRUCTURE AND FUNCTION
Coenzyme Q-10 is naturally found in the inner mitochondrial membrane of every
cell in the human body and plays a fundamental role in the production of ATP. In
the mitochondrial respiratory chain, CoQ-10 is the electron acceptor for
mitochondrial complex I and complex II, and donates electrons to complex III
during oxidative phosphorylation. Each pair of electrons in the electron
transport chain must interact with CoQ-10, the rate-limiting component of the
mitochondrial respiratory cycle.*
CoQ-10 is also a component of extra-mitochondrial redox chains, whose
function is to remove excess reducing power formed during glycolysis when
mitochondrial respiration is decreased. In its reduced form, CoQ-10 is a
lipid-soluble antioxidant that readily provides electrons to neutralize
superoxide and lipid radicals. Mitochondria are involved in the production of
reactive oxygen species, and CoQ-10 scavenges these species to support the cell
from oxidative stress that can lead to cell and DNA damage and premature aging.*
In addition, CoQ-10 has membrane stabilizing properties thought to be
involved in the phospholipids-protein interaction that aids in the metabolism of
prostaglandins. Myocardial calcium-dependent ion channels are stabilized by
CoQ-10, which prevents depletion of molecules essential for ATP synthesis.
CoQ-10 supports healthy blood flow to cardiac muscle.*
L-Carnitine is synthesized in the liver and kidneys from lysine and
methionine, two essential amino acids. Of primary importance is L-Carnitine's
obligate role in mitochondrial fatty acid metabolism and energy production. L-Carnitine
shuttles long-chain fatty acids across the inner mitochondrial membrane in
liver, heart, and skeletal muscle where they are oxidized for the release of
free energy. The heart in particular is reliant on L-Carnitine for the
production of energy from fat.
INDICATIONS
CoQ-10 is a normal component of the mitochondrial electron transport chain and
supports a healthy cardiovascular system. Endogenous levels of CoQ-10 may
diminish with age, strenuous exercise, and environmental stressors. In addition,
certain regularly prescribed drugs may cause CoQ-10 depletions. L-Carnitine is a
conditionally essential nutrient important for the heart. Supplementing your
clients' diets with Coenzyme Q-10 & L-Carnitine may be an opportunity to
receive a daily supply of these important molecules for heart health.*
HOW CLIENTS MAY BENEFIT
Increase myocardial CoQ-10 levels for cardiovascular health support.*
Support cellular levels of ATP, the energy source for all biological
processes.*
CoQ-10 is a powerful antioxidant that fortifies cells from the harmful
effects of free radicals.*
Maintain oxidative phosphorylation for exercise support.*
L-Carnitine promotes fatty acid metabolism for cellular energy
production.*
CLINICAL EVIDENCE
In one double-blind trial, Tran et al. administered daily doses of 100 mg
of CoQ-10 to 80 patients for 17 weeks. Eighty-nine percent experienced
support of cardiovascular function, respiratory function and muscle strength
support. These benefits lasted during the entire course of treatment.
In a long-term study, Langsjoen et al. treated 424 patients with CoQ-10 in
addition to their normal health regimes and monitored their heart health for
eight years. Fifty-eight percent experienced promotion by one New York Heart
Association (NYHA) class, 28% by two classes, and 1.2% by three classes.
In one double blind trial investigating the role of a modified form of
Carnitine called propionyl-L-Carnitine (PC) in heart health, 500 mg PC daily
was found to promote exercise tolerance by 26% after six months.
SUMMARY
Coenzyme Q-10 plays an essential role in the production of cellular ATP and
cardiovascular health maintenance. Its role as an antioxidant supports tissue
from oxidative damage. L-Carnitine transports fatty acids into mitochondria to
promote cellular energy production. Supplementing your clients' nutritional
regimes with PhysioLogics' Coenzyme Q-10 & L-Carnitine will support their
cellular energy levels, to promote cardiovascular health.*
SUGGESTED DOSAGE
For adults, take one (1) softgel two to four times daily, preferably with meals,
or follow the advice of your health care professional. As a reminder, discuss
the supplements and medications you take with your health care providers.
REFERENCES
Brass, E.P. Supplemental carnitine and exercise. Am J Clin Nutr. 2000.
71(suppl): 618S-623S.
Carter, A.L., et al. Biosynthesis and metabolism of carnitine. J Child.
Neurol. 10(Suppl 2):S3-S7, 1995.
Center, S.A., et al. The clinical and metabolic effects of rapid weight
loss in obese pet cats and the influence of supplemental oral L-carnitine. J
Vet Intern Med. 2000. 14(6); Nov-Dec: 598-608.
Folkers K. Relevance of the biosynthesis of coenzyme Q-10 and the four
bases of DNA as a rationale for the molecular causes of cancer and a therapy.
Biochem Biophys Res Commun 1996;224:358-61.
Frei B, Kim MC, Ames BN.Ubiquinol-10 is an effective lipid-soluble
antioxidant at physiological concentrations. Proc Natl Acad Sci U S A. 1990
Jun;87(12):4879-83.
Greenberg S, Frishman WH. Co-enzyme Q-10: a new drug for cardiovascular
disease. J Clin Pharmacol. 1990 Jul;30(7):596-608
Kato T, Yoneda S, Kako T, Koketsu M, Hayano I, Fujinami T. Reduction in
blood viscosity by treatment with coenzyme Q-10 in patients with ischemic
heart disease. Int J Clin Pharmacol Ther Toxicol. 1990 Mar;28(3):123-6.
Langsjoen H, Langsjoen P, Langsjoen P, Willis R, Folkers K. Usefulness of
coenzyme Q-10 in clinical cardiology: a long-term study. Mol Aspects Med.
1994;15 Suppl:s165-75.
Mancini M, Rengo F, Lingetti M, Sorrentino GP, Nolfe G. Controlled study on
the therapeutic efficacy of propionyl-Lcarnitine in patients with congestive
heart failure. Arzneimittelforschung. 1992 Sep;42(9):1101-4.
Mellors A, Tappel AL.The inhibition of mitochondrial peroxidation by
ubiquinone and ubiquinol. J Biol Chem. 1966 Oct 10;241(19):4353-6
Mortensen SA, Vadhanavikit S, Muratsu K, Folkers K. Coenzyme Q-10: clinical
benefits with biochemical correlates suggesting a scientific breakthrough in
the management of chronic heart failure. Int J Tissue React.
1990;12(3):155-62.
Nohl H, Gille L, Staniek K.The biochemical, pathophysiological, and medical
aspects of ubiquinone function. Ann N Y Acad Sci. 1998 Nov 20;854:394-409.
Overvad K, Diamant B, Holm L, Holmer G, Mortensen SA, Stender S. Coenzyme
Q-10 in health and disease. Eur J Clin Nutr. 1999 Oct;53(10):764-70.
Rauchova H, Drahota Z, Lenaz G. Function of coenzyme Q in the cell: some
biochemical and physiological properties. Physiol Res. 1995;44(4):209-16
Reis F, Hermida RC, Souza I, Maldonado J, Tavares P, Fontes- Ribeiro CA,
Teixeira HM, Alcobia T, Almeida L, Teixeira F. Circadian and seasonal
variation of endogenous ubiquinone plasma level. Chronobiol Int. 2002
May;19(3):599-614.
Tran MT, Mitchell TM, Kennedy DT, Giles JT. Role of Coenzyme Q-10 in
Chronic Heart Failure, Angina, and Hypertension. Pharmacotherapy
21(7):797-806, 2001.
Weber C, Jakobsen TS, Mortensen SA, Paulsen G, Holmer G. Effect of dietary
coenzyme Q-10 as an antioxidant in human plasma. Mol Aspects Med. 1994;15
Suppl:s97-102.
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Coral Calcium Complex 120 capsules - Physiologics
Supports
Heart, Nerve and Muscle Functions*
Calcium is the major mineral responsible for the
health of the body's bones and teeth.* Calcium intake is critical to achieving
peak bone mass, maintaining muscle contractions, nerve impulses, and supporting
heart health.* This unique formula also provides Magnesium, and Vitamin D to aid
in the absorption of Calcium and promote bone mineralization.* This Coral
Calcium is mined, not collected, from an above ground source - making it
environmentally friendly as it prevents damaging coral reefs.
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Cranberry+ Triple Strength 100 sgels - Physiologics
Supports
Urinary and Immune System Health*
PRODUCT ALSO KNOWN AS
Vaccinium macrocarpon
PRODUCT DISCUSSION
Cranberry has been traditionally used for hundreds of years to support urinary
tract health.* The pro-anthocyanidins found in Cranberry fruit help promote a
free bladder wall surface to support healthy urinary function. Each Cranberry+
Triple Strength softgel provides 420 mg Cranberry Concentrate, equivalent to
5,040 mg fresh Cranberries. Cranberry+ Triple Strength also contains Vitamin C
to support immune system health.*
STRUCTURE AND FUNCTION
Cranberry (Vaccinium macrocarpon) is a relative of the Bilberry and Blueberry
family of fruits and has been traditionally used in Europe to promote urinary
tract health. German researchers began investigating the connection between the
European variety of Cranberry and urinary tract health in the 1840s. They
discovered that the urine of people who consumed Cranberries contained a
substance known as hippuric acid. U.S. researchers later speculated that this
substance might acidify urine, providing a potential mechanism of action. By the
1960s, however, investigators found that Cranberry's effects on urine pH were
transient, leading them to delineate an alternative mechanism of action.*
The urine of certain individuals contains a natural substance known as
Tamms-Horfall glycoprotein, a molecule that is associated with a healthy urinary
tract. This glycoprotein has the ability to compete with mucosal surfaces for
the attachment of certain cells, thus promoting a free bladder surface.
Scientific research has shown that Cranberry displays a similar activity. Sobota
conducted a study on mice and humans given Cranberry juice in diet and 15 oz.
per day, respectively, or water serving as a control. Following ingestion of one
of these samples, the urine from those consuming the Cranberry preparations
significantly promoted the isolation of uroepithelial cells from competing
cells. Pre-incubation with the competing cells, but not the epithelial cells,
with Cranberry juice, strongly promoted isolation in attachment assays. In
addition, when epithelial cells were pre-attached to competing cells, Cranberry
juice promoted the rapid release of cells, showing that a constituent of
Cranberry juice has an affinity for a component of the competing cells.*
Cranberries contain a number of components that may have a positive effect on
urinary tract health. While the presence of benzoic acid was initially believed
to provide the most support, the flavonoid components known as pro-anthocyanidins
(condensed tannins) have been shown to be the major factor, followed by
flavonols and benzoic acid.*
Cranberry Fruit Extract also contains 100 mg Vitamin C in each softgel. For
immune system support, Vitamin C has been shown to promote the response of
lymphocytes to cytokines.* In addition, Vitamin C enhances the phagocytic
functions of polymorphonuclear (PMN) neutrophils and supports the adherence of
these cells to the vascular endothelium.*
INDICATIONS
Designed to promote urinary tract health, PhysioLogics' Cranberry Fruit Extract
softgels provide 420 mg Cranberry Concentrate, equivalent to 5,040 mg fresh
Cranberries. Clients should drink adequate amounts of water to further support
urinary tract health.*
HOW CLIENTS MAY BENEFIT*
Cranberry helps support/promote urinary tract health.*
Cranberries contain the nutritional benefit of proanthocyanidins.*
Cranberry Concentrate also contains vitamin C, an antioxidant vitamin that
plays a role in supporting immune function.*
SCIENTIFIC RESEARCH
Walker et al. conducted a placebo-controlled, doubleblind study to
investigate the effects of Cranberry on urinary tract health. Nineteen women
were asked to consume two 400 mg capsules of Cranberry extract or placebo
daily for 3 months, followed with opposite supplementation for an additional
3 months. Nine women were lost from the study due to pregnancy. The
Cranberry extract was significantly associated with promotion of urinary
tract health compared to placebo.
Stothers evaluated the effects of Cranberry supplements versus Cranberry
juice in a placebo-controlled, double-blind trial of one year's duration.
One hundred fifty women between the ages of 21 through 72 years were
randomized to one of three supplementation groups: placebo juice + placebo
tablets, placebo juice + Cranberry tablets, or Cranberry juice + placebo
tablets. Tablets were taken 400 mg, twice daily, juice 250 ml three times
daily. While both Cranberry juice and Cranberry tablets significantly
promoted urinary tract health compared to placebo, the investigator
determined that Cranberry tablets were much more cost effective, The annual
cost of Cranberry juice and Cranberry tablets being $1,400 and $624,
respectively.
SUMMARY
Cranberry+ Triple Strength from PhysioLogics provides the nutritional benefit of
pro-anthocyanidins.* These molecules compete with the mucosal surfaces for
attachment by other cells, helping to promote an uninhibited bladder wall.*
Cranberry+ Triple Strength can be used as part of your diet to promote a healthy
urinary tract.*
SUGGESTED DOSAGE
For adults take one (1) softgel two times daily, preferably with a meal or
follow the advice of your health care professional. As a reminder, discuss the
supplements and medications you take with your health care providers.
REFERENCES
American Botanical Council. Vaccinium macrocarpon. Cranberry Fruit. American
Botanical Council. 1997. Austin, TX. 17.
Avorn, J., et al. Reduction of bacteriuria and pyuria after ingestion of
cranberry juice. JAMA. 1994. 271(10); Mar 9: 751-754.
Barney, D. P. The Cranberry cure. Herbs for Health.1996. Nov/Dec: 45-47.
Gibson, L., et al. Effectiveness of cranberry juice in preventing urinary
tract infections in long-term care facility patients. J Naturopathic Med.
1991. 2 (1):45-47.
Habash, M.B., et al. The effect of water, ascorbic acid, and cranberry
derived supplementation on human urine and uropathogen adhesion to silicone
rubber. Can J Microbio. 1999. 45(8); Aug: 691-694.
Henig, Y.S., et al. Cranberry juice and urinary-tract health: science
supports folklore. Nutr. 2000. 16(7/8); Jul- Aug: 684-687.
Lininger, S., et al. Cranberry. Natural Pharmacy. Prima Publishing,
Rocklin, CA. 1998. 249-250.
Marwan, A.G., et al. Microbial Inhibitors of Cranberries. J Food Sci. 1986.
51: 1009-1013.
Ofek, I., et al. Anti-Escherichia coli adhesion activity of cranberry and
blueberry juices. N Engl J Med. 1991. 324:1599.
Siciliano, Arthur A. Cranberry. Herbal Gram. 51-54, 1995.
Sobota, A.E. Inhibition of bacterial adherence by cranberry juice:
potential use for the treatment of urinary tract infections. J Urology. 1984.
131; May: 1013-1016.
Sothers, L. A randomized trial to evaluate effectiveness and cost
effectiveness of naturopathic cranberry products as prophylaxis against
urinary tract infection in women. Can J Urol. 2002. 9(3):1558-62
Walker, E.B., et al. Cranberry concentrate: UTI prophylaxis. J Farm Pract.
1997. 45(2); Aug: 167-168.
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Flax Seed Oil, Organic 1250 mg 90 sgels - Physiologics
Natural
Source of Omega-3 Fatty Acids
Supports Cardiovascular Health*
PRODUCT ALSO KNOWN AS
Flaxseed Oil, a-Linolenic Acid (ALA), Linoleic Acid, Oleic Acid.
PRODUCT DISCUSSION
PhysioLogics' Organic Flaxseed Oil 1250 mg provides an excellent plant source of
Omega-3, Omega-6 and Omega-9 fatty acids in one convenient softgel. The Flaxseed
Oil used in this product is prepared using a unique cold processing method
without the use of solvents. The oil is dispensed and processed under a nitrogen
blanket to safeguard it from oxygen exposure, then encased in an amber-colored
gelatin shell to continue to protect the active ingredients from white light.
STRUCTURE AND FUNCTION
Flaxseed Oil contains all three polyunsaturated fatty acids, the Omega-3,
Omega-6, and Omega-9 fatty acids. The parent essential fatty acid (EFA)
molecules are the Omega-6 Linoleic Acid and the Omega-3 a-Linolenic Acid (ALA).
Because mammals cannot synthesize the primary EFAs, humans depend on dietary
sources to meet their EFA requirements. Both parent EFAs can be desaturated and
elongated in the body to form longer chain polyunsaturated fatty acids required
by the body.*
EFAs are an integral part of the structure of the
membranes of every cell in the body and are precursors to a wide range of
biologically important molecules such as eicosanoids, prostaglandins, and
leukotrienes, which are required in the regulation of virtually every process in
the body.*
Flaxseed Oil contains the most concentrated
source of the parent Omega-3 ALA in nature. Studies have shown that Flaxseed
Oil-based diets promote a healthy immune system and support healthy cell
proliferation. Once ingested, ALA may be converted in the liver to the Omega-3
fatty acids Eicosapentaenoic Acid and Docosahexaenoic Acid, the forms readily
used by the body. Omega-3 fatty acids are especially abundant in brain
phospholipids and are essential for the development of brain and retina. In
addition, Omega-3s are vital for cardiovascular health and circulation.
Flaxseed Oil also contains Oleic Acid, the parent
Omega-9 fatty acid. Oleic Acid is a ubiquitous component of tissue glycerolipids,
especially enriched in the myelin sheath. It is the precursor to nervonic acid,
the most characteristic monounsaturated fatty acid in myelin, and longer fatty
acids characteristic of myelin sphingolipids. Lignans are hormone-like
phytochemicals found in Flaxseed Oil that may support women's health. By
promoting the synthesis of sex hormone binding globulin (SHBG), lignans help
maintain healthy circulating levels of women's sex hormones, which may support
women during PMS and menopause.*
INDICATIONS
Flaxseed Oil provides an excellent plant source of all three polyunsaturated
fatty acids, the Omega-3, Omega- 6, and Omega-9 fatty acids. The parent Omega-3
and Omega-6 molecules are essential fatty acids not synthesized by the body and
consequently must be supplied by diet. Consumption of Omega-3 fatty acids may
reduce the risk of coronary heart disease. FDA evaluated the data and determined
that, although there is scientific evidence supporting the claim, the evidence
is not conclusive PhysioLogics' Organic Flaxseed Oil 1250 mg is a dietary
supplement for individuals who want to receive a daily supply of essential and
nonessential polyunsaturated acids.*
HOW CLIENTS MAY BENEFIT
Delivers more Flaxseed Oil than most Flaxseed
Oil supplements.
Receive essential components of cell membranes
for healthy cell growth.*
Promotes healthy membrane phospholipids
composition to support membrane fluidity and function.*
Obtain a source of lignans, phytochemicals to
support women's health during PMS and menopause.*
Obtain a source of all three parent
polyunsaturated fatty acids.
Supplies nature's richest plant source of
Omega-3 fatty acids, for heart and nervous system health.*
SCIENTIFIC RESEARCH
The Physician's Health Study followed
apparently healthy men for up to 17 years. Analysis of the blood indicated
that higher levels of Omega-3 fatty acids were found in those with a
healthier cardiovascular system and quality of life.
Researchers at the Harvard School of Public
Health followed over 5,100 women for up to 16 years and found that diets
with a higher consumption of Omega- 3 fatty acids were associated with heart
health maintenance and quality of life.
The Cardiovascular Health Study investigated
plasma phospholipids concentrations of ALA in 5,201 people >65 years old.
Results suggest that higher dietary intake of ALA is associated with heart
health maintenance.
A food-frequency questionnaire completed by
76,283 found that diets with a higher dietary intake of ALA supported
cardiac health.
SUMMARY
The parent Omega-3 and Omega-6 polyunsaturated fatty acids are essential
nutrients not produced by the human body and consequently must be supplied by
diet. Supplementing your clients' diets with PhysioLogics' Organic Flaxseed Oil
will provide them with the essential and non-essential fatty acids to help
support their cardiovascular and nervous systems, as well as overall health.
SUGGESTED DOSAGE
For adults, take one (1) softgel two to three times daily, preferably with a
meal, or follow the advice of your health care professional. As a reminder,
discuss the supplements and medications you take with your health care
providers.
REFERENCES
Albert CM, Campos H, Stampfer MJ, Ridker PM, Manson JE, Willet WC, Ma J. Blood
levels of long-chain n-3 fatty acids and the risk of sudden death. N Engl J
Med. 2002. 346(15):1113-8.
Carroll D, Roth M. Evidence for the
cardioprotective effects of Omega-3 fatty acids. Ann Pharmacther.2002.
36(12):1950-6.
Chen J, Stavro PM, Thompson LU. Dietary
flaxseed inhibits human breast cancer growth and metastasis and downregulates
expression of insulin-like growth factor and epidermal growth factor receptor.
Nutr Cancer. 2002;43(2):187-92.
DeLuca P, Rothman D, Zurier R. Marine and
botanical lipids as immunomodulatory and therapeutic agents in the treatment
of rheumatoid arthritis. Rheumatic disease clinics of North America. 1995.
21(3):759-77
Health benefits of flaxseed. Flaxseed ? Health,
Nutrition and Functionality. Chapter 4. 27-35. No authors listed.
Hu FB, Stampfer MJ, Manson JE, Rimm EB, Wolk A,
Colditz GA, Hennekens CH, Willett WC. Dietary intake of alphalinolenic acid
and risk of fatal ischemic heart disease among women. Am J Clin Nutr. 1999
May;69(5):890-7.
Lemaitre, R.N., et al. n-3 polyunsaturated
fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction
in older adults: the cardiovascular health study. Am J Clin Nutr. 2003. 77(2);
Feb: 319-325.
Linder, M.C. Functions: nutrition and
metabolism: functions of fats in the human organism. Nutritional Biochemistry
and Metabolism. 2nd Ed. Appleton & Lange, Norwalk, CT. 55-58.
Martinez, M. Tissue levels of polyunsaturated
fatty acids during early human development. J of Pediatrics. 1992.
Onogi, N. et al. Suppressing effect of perilla
oil on azoxymethane-induced foci of colonic aberrant crypts in rats.
Carnicogenesis. 1996. 17(6): 1291-1296.
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Ginkgo Biloba 60mg 50 softgels - Physiologics
Ginkgo
helps maintain healthy circulation to the brain and legs*
Standardized to contain: 24% Ginkgo Flavoglycosides
Ginkgo Biloba is the most scientifically
researched plant extract for the nutritional support of cerebral function.*
Ginkgo leaf extracts augment the vasoregulating activity of arteries,
capillaries, and veins to maintain healthy circulation to the brain and
extremities.* Enhanced cerebral circulation improves intellectual functions
such as concentration, memory, and alertness.*
= Vegetarian Formula
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Glucosamine Sulfate 500mg 90 capsules - Physiologics
Supports
Joint Health*
As a key ingredient in cartilage, glucosamine
plays an important role in good joint health.* Studies indicate that glucosamine
provides the building blocks for constructing cartilage.*
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Hyaluronic Acid 50mg 90 capsules - Physiologics
Natural
Component of the Body*
Hyaluronic Acid is a polymer made of repeating units of glucuronic acid and
N-acetylglucosamine.* The glucuronic acid and N-acetylglucosamine within
Hyaluronic Acid are connected through Beta 1-3 and Beta 1-4 linkages.*
Hyaluronic Acid is found in all the connective tissues of the body, including
the ligaments and tendons, where it plays a role in lubrication.*
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L-Theanine 100mg 60 capsules - Physiologics
Supports
Mood Centers in the Brain*
Theanine is a natural phytochemical found in
Japanese green tea. PhysioLogics L-Theanine provides the L-isomer of this unique
amino acid that is related to the amino acid glutamate.
STRUCTURE AND FUNCTION
L-Theanine is a nonessential amino acid that can support the mood centers in the
brain.* It is a non-protein amino acid, found only in tea and the rare mushroom
xerocomus badius, that has been shown by electroencephalography (EEG) to affect
alpha-band activity in the brain.*
CLINICAL EVIDENCE
In a double-blind, placebo-controlled,
crossover trial, 12 subjects were given a mental arithmetic task designed to
induce an acute stress response. The feelings of the subjects were measured
after taking 200 mg of L-Theanine at the start of the task, 200 mg of L-Theanine
midway through the task, placebo, or nothing. Both L-Theanine treatments
resulted in an equally significant calming effect compared to the two
control groups. This study supports the use of 200 mg of L-Theanine, the
recommended daily dose for PhysioLogics L-Theanine, for relaxation. (Kimura
et al, 2007)
A total of 35 subjects received either 50 mg
of L-Theanine or placebo before having brain activity assessed by EEG at
rest and at 45, 60, 75, 90 and 105 minutes. Researchers observed a
significantly greater increase in alpha brain wave activity over time in the
treatment group compared with the control group. Alpha-band activity is
associated with a relaxed yet alert mental state. (Nobre et al, 2008)
SUMMARY
L-Theanine, a unique amino acid found in tea, helps support a healthy mood.* L-Theanine
enhances alpha brain wave activity, which is considered indicative of
relaxation.*
SUGGESTED DOSAGE
For adults, take one (1) capsule, two to three times daily, preferably with
meals, or follow the advice of a health care professional.
REFERENCES
Gomez-Ramirez M, Higgins BA, Rycroft JA, et al. The deployment of intersensory
selective attention: a highdensity electrical mapping study of the effects of
theanine. Clin Neuropharmacol. 2007;30:25-38.
Juneja LR, Chu D-C, Okubo T, et al. L-theanine
- a unique amino acid of green tea and its relaxation effect in humans. Trends
Food Sci Technol. 1999;10:199-204.
Kimura K, Ozeki M, Juneja LR, Ohira H. L-theanine
reduces psychological and physiological stress responses. Biol Psychol.
2007;74:39-45.
Nobre AC, Rao A, Owen GN. L-theanine, a natural
constituent in tea, and its effect on mental state. Asia Pac J Clin Nutr.
2008;17(Suppl 1):167-8.
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Lutein 20mg 60 softgels - Physiologics
For
Eye Health*
Natural Carotenoid
Lutein is one of a few carotenoids selectively accumulated by the retina of
the eye.* Lutein is considered a dietary xanthophyll that helps promote the
health of photoreceptors in the eye to support visual health.*
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Melatonin 3mg 120 vtabs - Physiologics
Nutritionally
Supports Sound Sleep*
PRODUCT IS ALSO KNOWN
AS:
n-Acetyl-5-Methoxytryptamine
PRODUCT DISCUSSION
Clinical trials involving orally supplemented melatonin have implicated this
indoleamine to have positive metabolic interactions on various sleep
parameters. Physiologic's supplies Melatonin at dosage levels consistent with
published research which demonstrates its ability to promote calm, restful
sleep. Melatonin may also prove to be useful for frequent travelers
experiencing jet lag.*
STRUCTURE AND FUNCTION
The pineal gland is the organ where information about light and dark is
processed and then relayed to cells throughout the body. The eyes deliver
information to the pineal gland through different routes that include the
retinohypothalamic tract and the suprachiasmatic nuclei. Norepinephrine
released from postganglionic nerve endings to the pineal gland helps control
melatonin release. This release of norepinephrine to the pinealocytes occurs
at night, which is when melatonin secretion and levels throughout the body
begin to rise.*
Melatonin, due to its considerable
lipophilicity, is able to cross any cell membrane and enter any tissue or
cellular compartment. Therefore it is likely that some of melatonin's
biochemical effects are elicited through intracellular binding sites in
addition to its interactions with membrane-bound receptors (Hardeland, 95).
Melatonin's high lipophilicity is what allows it to transmit the signal of
darkness to every cell in the body, in turn acting as the eyes for each cell,
organ and tissue. This is why melatonin levels throughout the body are so
important for promoting calm, restful sleep and a relaxed mood in the evening
by supporting natural circadian rhythms.*
In addition to its effects on sleep, Melatonin
is believed to play a major role in the biological termination of free-radical
induced redox reactions. Melatonin is reported to have a large capacity to
trap hydroxyl radicals, the free radical species with the highest relative
reactivity. Melatonin also efficiently traps peroxyl radicals and superoxide
anions. Melatonin participates in a two-step process in which it first
interacts with a hydroxyl or peroxyl radial to give a melatonyl cation
radical, which then combines with a superoxide anion to neutralize the
electrical charges and pairing electrons.*
INDICATIONS
Occasional sleeplessness can affect anyone - young or old. The National
Institutes of Health recommends to keep a regular schedule of going to bed and
waking up at the same time every day, even on weekends, to help your body
maintain a normal circadian rhythm. However, due to life's demands this is not
realistic for many people. Endogenous melatonin is an important component of
your body's circadian rhythm. Supplemental melatonin can provide circadian
rhythm support for calm, restful sleep - especially when experiencing
occasional sleeplessness or jet lag.*
HOW CLIENTS MAY
BENEFIT
Although many products and ingredients on
the market are currently sold for promoting sleep and a relaxed mood in
the evening, melatonin is the #1 product in terms of clinical testing for
efficacy in a wide variety of populations.
Those who travel often and experience jet
lag can benefit from the convenience of taking only one melatonin tablet
to promote tranquil sleep.
Participates in free-radical scavenging to
support antioxidant action in the brain and across various cellular
regions due to its high lipophilicity.
Suitable for a wide-range of clients due to
its free of status for yeast, wheat, milk or milk derivatives, lactose,
sugar, preservatives, soy, sodium (less than 5 mg per serving), and
artificial color and flavor as certified through analysis of raw material
specification sheets.
Finished product is suitable for
vegetarians.
CLINICAL EVIDENCE
The clinical effects of melatonin on sleep
latency and duration, mood, performance, oral temperature and changes in
serum melatonin levels were examined in twenty male volunteers.
Investigators employed a double blind, placebo controlled study utilizing
repeated-measures, within-subjects and a 5x5 Latin square design. Subjects
received placebo or .1, .3, 1 or 10mg of melatonin on five different
occasions. Statistical analysis revealed 1mg of melatonin to be the most
efficient dosage for the parameters studied. Subjects reported they slept
more quickly after the 1mg dose as compared to the .1mg dose. Subjects
also reported that they felt sleepier after the 1 and 10mg dosages as
compared to placebo. 1mg also decreased oral temperature more then .1mg,
which is a normal response to endogenously secreted melatonin as part of
the circadian rhythm. Melatonin at 1mg was also effective for helping
induce a relaxed mood and hypnotic-like state, which could support calm,
restful sleep. (Dollins, 94)
In a double-blinded study, healthy
volunteers were randomized to receive .3mg, 1mg or a placebo dose on three
separate occasions. It was found that the 1mg dosage decreased sleep onset
latency time and latency to stage 2 sleep - both positive findings. Sleep
efficiency was also improved relative to placebo condition. The
investigators attributed the positive findings to the acute action of
melatonin on the physiological sleep process. (Zhdanova, 96)
SUMMARY
When it comes to supporting nocturnal sleep patterns, melatonin is the #1
supplement in terms of clinical trials and efficacy. Melatonin's ability to
interact with membrane-bound receptors as well as intracellular binding sites
help translate the message of darkness and sleep to each cell in the body.
Just one tablet can be taken in the evening to help promote a relaxed mood and
restful sleep. Physiologics offers high-quality melatonin that is
vegetarian-suitable, free of substantial allergenic materials and dosed at
levels consistent with published, clinical research.*
SUGGESTED DOSAGE
For adults, take one (1) tablet daily, at bedtime as Melatonin may produce
drowsiness. Do not exceed recommended dose. As a reminder, discuss the
supplements and medications you take with your health care providers.
REFERENCES
Cardinali, D.P., et al. A multifactorial approach employing melatonin to
accelerate resynchronization of sleep - wake cycle after a 12 time-zone
westerly transmeridian flight in elite soccer athletes. J Pineal Res. 2002.
32: 41-46.
Cavallo, A. et al. Blood pressure-lowering
effect of melatonin in type 1 diabetes. J. Pineal Res. 2004.
Dollins A.B, et al. Effect of inducing
nocturnal serum melatonin concentrations in daytime on sleep, mood, body
temperature and performance. Proc Nat´l Acad Sci. 1994. 91; 1824-1828
Engstrom, J., et al. Evaluation and treatment
of orthostatic hypotension. Amer Fam Phys. 1997. 56(5): 1-8.
Girouard, H., et al. Vasorelaxant effects of
the chronic treatment with melatonin on mesenteric artery and aorta of
spontaneously hypertensive rats. J Hypertens. 2001. 19(8): 1369-77
Hardeland, R., et al. Versatile Melatonin: a
pervasive molecule serves various functions in signaling and protection.
Chronobio Int´l. 1995. 12(3):157-165
Kemp, S. et al. The value of melatonin for
sleep disorders occurring post-head injury: a pilot RCT. Brain Injury. 2004.
18(9).
Kitajima, T. The effects of oral melatonin on
the autonomic function in healthy subjects. Psychiatry Clin Neurosci. 2001.
55(3): 299-300.
Lusardi, P., et al. Effect of bedtime
melatonin ingestion on blood pressure of normotensive subjects. Blood
pressure monitoring. 1997. 2(2): 99-103.
Lusardi, P., et al. Cardiovascular effects of
melatonin in hypertensive patients well controlled by nifedipine: a 24hour
study. Brit J Clin Pharmacol. 2000. 49(5): 423-7.
Malliet, F., et al. Comparative effects of
melatonin, zolpidem and diazepam on sleep, body temperature, blood pressure
and heart rate measured by radiotelemetry in Wister rats.
Psychopharmacology. 2001. 156(4): 417-26.
Nishiyama, K., et al. Acute effects of
melatonin administration on cardiovascular autonomic regulation in healthy
men. Am Heart J. 2001. 141(5): 822.
Ray, C. Melatonin attenuates the sympathetic
nerve responses to orthostatic stress in humans. J Physiol. 2003. 551 (3):
1043-8.
= Vegetarian Formula
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Milk Thistle 250mg 60 capsules - Physiologics
Standardized to contain: 80% Silymarin
Coloklysis® furnishes both soluble and insoluble fibers, and is a powerful
colon cleansing product designed for periodic cleansing of the colon and
intestinal tract.*
A unique fiber and herbal formula
Formulated with both soluble and insoluble fibers to add bulk
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MultiLogics Once Daily 60 caplets - Physiologics
Full-Spectrum
Nutritional Support*
Once Daily Formula
PRODUCT DISCUSSION
Give your body the comprehensive nutritional support it deserves. MultiLogics®
furnishes a comprehensive formulation with vitamins, fruit extracts, minerals,
bioflavonoids, and other nutrients for comprehensive nutritional support and
good health.*
STRUCTURE AND FUNCTION
Proper nutrition supplementation begins with a high quality multivitamin.
MultiLogics® provides a daily source of 22 vitamins and minerals, in addition
to fruit extracts and bioflavonoids to support many aspects of health:*
Vitamin A promotes normal growth, healthy skin
and supports night and color vision.*
The balanced B-Vitamins are essential for the
synthesis of red blood cells and the processing of amino acids to assist in
energy metabolism.*
To provide immune system support, Vitamin C,
Selenium, and Zinc are included.*
Vitamin C and Copper are essential for
collagen formation to help promote healthy skin, hair, and nails.*
For bone mineralization support, Vitamin D is
essential to Calcium absorption and helps promote a healthy immune system.*
Vitamin E and Selenium, as a key component of
an antioxidant enzyme, each support cells from the harmful effects of free
radicals.*
Copper assists Iron in the release of energy
from cells.*
As part of a well-balanced diet that is low in
saturated fat and cholesterol, Folic Acid, Vitamin B6 and Vitamin B12 may
reduce the risk of vascular disease. FDA evaluated the above claim and found
that, while it is known that diets low in saturated fat and cholesterol
reduce the risk of heart disease and other vascular diseases, the evidence
in support of the above claim is inconclusive.
Some scientific evidence suggests that
consumption of antioxidant vitamins such as Vitamin C and Vitamin E may
reduce the risk of certain forms of cancer. However, FDA has determined that
this evidence is limited and not conclusive.
Selenium may reduce the risk of certain
cancers. Some scientific evidence suggests that consumption of selenium may
reduce the risk of certain forms of cancer. However, FDA has determined that
this evidence is limited and not conclusive.
Women who consume healthful diets with
adequate folate may reduce their risk of having a child with birth defects
of the brain or spinal cord. Folate intake should not exceed 1,000 mcg.
INDICATIONS
For your clients who are interested in nutrition supplementation, MultiLogics®
is the first step in providing additional nourishment by furnishing a daily
source of 22 vitamins and minerals plus fruit extracts for value-added
nutrition.*
HOW CLIENTS MAY BENEFIT
Vitamins and minerals are necessary for
growth, development, and a healthy life.*
Certain populations, such as maturing adults
or people on restrictive diets, may require more vitamin and mineral
supplementation.*
A quick, easy, and convenient way to receive a
daily source of 22 vitamins and minerals.
B Vitamins support heart health.*
Antioxidant vitamins neutralize free radicals,
unstable compounds that may lead to DNA and cell damage.*
SCIENTIFIC RESEARCH
A recent review published in the journal JAMA
stated that most people do not consume an optimal amount of all vitamins by
diet alone. In fact, suboptimal intake of some vitamins, even above levels
classified as deficiency, may be unhealthy and is common in the general
population. The reviewers concluded that it is wise for all adults to take
vitamin supplements.
The Physician's Health Study followed almost
15,000 male physicians for up to five years to study heart health. In this
study, lower levels of homocysteine were found in those with a healthier
cardiovascular system and longer life. In addition, researchers found that
high intakes of Vitamins B-6, B-12, and Folic Acid were correlated with
lower plasma homocysteine levels.
SUMMARY
Proper nourishment plays a role in disease prevention. While vitamin
supplementation is not an adequate substitute for a good diet, MultiLogics® is
an ideal supplement for any adult concerned about healthy nutrition. Delivering
22 vitamins and minerals, along with bioflavOnoids and fruit extracts,
MultiLogics® is a premium quality multivitamin for comprehensive nutritional
support.*
SUGGESTED DOSAGE
For adults, take one (1) caplet daily, preferably with a meal, or follow the
advice of your health care professional. As a reminder, discuss the supplements
and medications you take with your health care providers.
REFERENCES
Anderson, R.A. Chromium glucose intolerance and diabetes. J Am Coll Nutr.
1998. 17 (6); Dec: 548-55.
Baumgartner, T. et al. Trace elements in
clinical nutrition. Nutrition in Clinical Practice. 1993.
Bell, S.J., et al. A functional food product
for the management of weight. Critical Reviews in Food Sci. 2002. 42(2):
163-178.
Castillo-Duran C. et al. Trace minerals in
human growth and development. J of Pediatric Endocrinology & Metabolism.
1999. 12 (5); Sep- Oct: 589-601.
DeLuca, H.F. (et. al.) Mechanisms and Functions
of Vitamin D. Nutrition Reviews. February 1998. (56)2: S4-S10
Fairfield, K.M. Vitamins for chronic disease
prevention in adults. JAMA. 2002. 287(23); Jun 19: 3116-1720.
Institute of Medicine. Vitamin B6. Dietary
Reference Intakes: Thiamin Riboflavin, Niacin, Vitamin B6, Folate, Vitamin
B12, Pantothenic Acid, Biotin, and Choline. National Academy Press. Washington
D.C. 1998.
Halliwell, B. et al. Free radicals and
antioxidants in food and in vivo: What they do and how they work. Critical
Reviews in Food Science and Nutrition. 35:7-20. 1995.
Sizer, Frances et al. The vitamins. Nutrition:
Concepts and Controversies. 7th ed. 1997. 265.
Spallholz, J.E. et al. Advances in the role of
minerals in immunobiology. Biological Trace Element Research. 1989. 19:
129-151.
Stampfer MJ, Malinow MR, Willett WC, Newcomer
LM, Upson B, Ullmann D, Tishler PV, Hennekens CH. A prospective study of
plasma homocyst(e)ine and risk of myocardial infarction in US physicians. JAMA.
1992 Aug 19;268(7):877-81.
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N-Acetyl L-Cysteine 600mg 90 capsules - Physiologics
Promotes
Antioxidant Support In The Body*
NAC is an important precursor to Glutathione, one
of the body’s most important endogenous antioxidants.* It also supports
Vitamin C’s ability to support the immune system.
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Red Yeast Rice 600mg 120 vcaps - Physiologics
Staple
food of the traditional Chinese diet
PRODUCT DISCUSSION
Red Yeast Rice has been a part of the traditional Chinese diet for centuries.
It is created by fermenting cooked rice with Monascus purpureus yeast at
carefully controlled temperatures. Red yeast rice contains natural pigments,
starch, fatty acids, phytosterols and isoflavones along with a group of fungal
metabolites. Red yeast rice supports overall health benefits.*
SUGGESTED DOSAGE
For adults, take two (2) capsules daily, preferably with a meal. Do not exceed
four (4) capsules in a 24-hour period, or follow the advice of your health
care professional.
REFERENCES
National Nutritional Foods Association. NNFA Backgrounder:
Red Yeast Rice. September 2003.
= Vegetarian Formula
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MesoVision 30 softgels - Physiologics
Promotes
Photoreceptor Health in the Eye*
PRODUCT ALSO KNOWN AS
Lutein Plus proprietary blend, a mixture of Lutein, Meso-Zeaxanthin, Zeaxanthin
PRODUCT DISCUSSION
MesoVision, a proprietary blend offered by PhysioLogics, combines three of the
most renowned carotenoids for promoting visual acuity. Lutein, Meso-Zeaxanthin
and Zeaxanthin are dietary carotenoids that help promote the health of
photoreceptors in the eye to support vision maintenance. This formula is
designed to provide similar ratios of these pigments found in the human retina.*
STRUCTURE AND FUNCTION
Lutein, Meso-Zeaxanthin and Zeaxanthin are a special class of higher plant
carotenoids known as xanthophylls. These molecules serve as photoprotectants for
the plants and leaves under environmental stress. In primates, these molecules
are specifically taken up by the macula of the eye. These antioxidants serve as
singlet-oxygen quenchers, helping to minimize free radical damage generated by
the exposure of the lens to oxygen and light.*
Lutein and Zeaxanthin are yellow pigments that
provide color in marigolds and corn, respectively. The yellow color of the
macular carotenoids is crucial for the absorption of blue light. Blue light
contains a shorter wavelength in the visual spectrum, consequently delivering
high energy to photosensitizers in the eye.
The natural functions of carotenoids are
dependant on the individual physical and chemical structures of the molecules.
Most carotenoids are commonly found in membranes, and some may only efficiently
scavenge free radicals generated in the inner membrane. Lutein and Zeaxanthin,
however, contain hydroxyl groups that interact with the polar head groups of
phospholipids, locking the molecules in a position that spans the membrane. This
property allows these molecules to react with free radicals generated in both
aqueous and membrane phases, which broadens their antioxidant capabilities.*
Meso-Zeaxanthin is a third carotenoid found in
the macula. Unlike the more familiar Lutein and Zeaxanthin, Meso-Zeaxanthin is
not commonly present in the diet, making supplementation the only practical
source outside of the body.
INDICATIONS
MesoVision is a proprietary blend of carotenoids, which provides antioxidant
support for the eye. MesoVision may be a desirable dietary supplement for those
who wish to nutritionally support visual acuity and macular health.*
HOW CLIENTS MAY BENEFIT
Supports eye health.*
Helps absorb high-energy blue light in the
macula.*
Provides antioxidant support for the retina
and macula.*
Promotes visual acuity.*
SCIENTIFIC RESEARCH
One study found that oral supplementation with
10 mg Lutein per day for 12 weeks significantly promoted macular density.
A multi-center study investigating the association
between carotenoids and eye health found that mature adults who ate more dark
green leafy vegetables had 43% better support of macular health. Among
specific carotenoids, Lutein and Zeaxanthin were most strongly associated with
macular support.
SUMMARY
The eyes are the most acutely developed senses, and PhysioLogics knows the
important role proper nutrition plays in supporting eye health. MesoVision
delivers a proprietary blend of carotenoids specifically taken up by the macula
of the eye. Together Lutein, Meso- Zeaxanthin and Zeaxanthin provide antioxidant
support and promote blue light absorption to support the macula and lens and
help maintain visual acuity.*
SUGGESTED DOSAGE
For adults, take one (1) softgel one to two times daily, preferably with a meal,
or follow the advice of your health care professional. As a reminder, discuss
the supplements and medications you take with your health care providers.
REFERENCES
Berendschot, T.T., et al. Influence of lutein supplementation on Macular
pigment, assessed with two objective techniques. Investigative Opthalmology
& Visual Science. 200. 41:3322-3326.
Britton, G. Structure and properties of
carotenoids in relation to function. The FASEB Journal. 9:1551-1558, 1995.
Gonzalez J. Supplement may help increase
macular pigment density, developers say. Ocular Surgery News. Oct. 15,
2003.42-43.
Landrum, John T. et al. A one year study of the
macular pigment: the effect of 140 days of a lutein supplement. Experimental
Eye Research. 1997. 65:57-62.
Olson, J.A. et al. Introduction: the colorful,
fascinating world of the carotenoids: important physiologic modulators. The
FASEB Journal. 1995. 9:1547-1550.
Schalch, W. et al. Vitamins and carotenoids-a
promising approach to reducing the risk of coronary heart disease, cancer and
eye diseases. In: Free Radicals in Diagnostic Medicine. Edited by, Armstrong,
D. Plenum Press, 1994, pp: 335-350.
Seddon , J.M. et al. Dietary carotenoids,
vitamins A, C, and E, and advanced age-related macular degeneration. JAMA,
1994. 272 (18): 1413-1421.
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Alpha Lipoic Acid 600MG 60 Capsules - Physiologics
Supports
Sugar Metabolism*
HOW PATIENTS MAY BENEFIT
Superior antioxidant support*
Promotes cellular energy production*
Supports healthy nerve function*
BACKGROUND
Alpha Lipoic Acid (ALA) plays a role in antioxidant synergism to fight oxidative
stress and free radical formation.* As a coenzyme, ALA is needed to break down
glucose for energy production.* ALA helps metabolize sugar in the body,
especially in muscles, where it promotes energy.*
PRODUCT DISCUSSION
PhysioLogics higher potency ALA 600 mg supplies this universal antioxidant that
recycles Glutathione, Coenzyme Q-10, and Vitamins C and E to help establish a
cellular antioxidant network.* Alpha Lipoic Acid also supports sugar metabolism
to help maintain healthy blood sugar level already within a normal range.*
STRUCTURE AND FUNCTION
ALA is a cofactor in the Krebs cycle, a major biochemical process that derives
energy from carbohydrates. Two central enzyme complexes, pyruvate dehydrogenase
and alpha-ketogluterate dehydrogenase, require ALA to generate citrate. Because
citrate is the first substrate in the Krebs cycle, the process cannot proceed
without adequate ALA. Alternate metabolic pathways may be stimulated in an
attempt to produce acetyl-CoA; however, an energy deficit remains, especially in
the central nervous system.
The body generates free radicals as natural
by-products of metabolism. Free radicals can contribute to oxidative stress,
which in turn may contribute to the premature aging of the cells. ALA is a
"universal antioxidant" that helps neutralize cell-damaging free
radicals in both the water-soluble and fat-soluble compartments of body cells.*
In addition, it regenerates NADt from NADH as well as intracellular levels of
Glutathione, Vitamins C and E, and Coenzyme Q-10.*
CLINICAL EVIDENCE
A double-blind placebo controlled study with
33 men examined the relationship between alpha-lipoic acid, glutathione
status and immune function. The subjects received either alpha-lipoic acid,
300 mg 3 times a day, or a placebo for 6 months. Blood glutathione levels
increased significantly in the treatment group compared with placebo (p=
0.04). Proliferation of lymphocytes was significantly enhanced in the
treatment group compared to declining levels in the placebo group. This
study indicates that alpha-lipoic acid can support immune function via
maintenance of glutathione status. (Jariwala et al, 2008)
This randomized double-blind placebo
controlled trial involved 181 participants receiving either 600 mg, 1,200
mg, 1,800 mg of alpha-lipoic acid or placebo for 5 weeks to determine its
effect on nerve health. Participants in all 3 dosage groups experienced
significant improvement in nerve health compared to placebo (p |
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B-100 Complex 100 capsules - Physiologics
Supports
Nervous System Health*
B-100 Complex provides an excellent source of B
vitamins to help promote a sufficient daily intake. The B-Complex is essential
for the maintenance of a healthy nervous system.* The B-Complex also plays a
role in energy metain the body.* Choline and Inositol are essential components
of cell membranes.*
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B-2 Riboflavin 100MG 100 vtabs - Physiologics
Promotes
Energy Metabolism and Nervous System Health*
Vitamin B-2 (Riboflavin) is necessary for red
blood cell formation, antibody production, cell respiration, and growth. It also
aids in the metabolism of carbohydrates, fats, and proteins.*
= Vegetarian Formula
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B-1 with Thiamine 250 mg 100 vtabs - Physiologics
Supports
Sugar Metabolism*
Thiamin serves as a cofactor for the enzymes pyruvate dehydrogenase,
alpha-ketoglutarate dehydrogenase, BCKA dehydrogenase and transketolase - all
factors involved in energy metabolism. Additionally, Thiamin serves an important
role in nervous system health and sugar metabolism.*
=
Vegetarian Formula
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Betaine HCL 400MG 90 vtabs - Physiologics
Supports
Digestive Health*
Betaine Hydrochloride contributes to stomach acid
in the body. Betaine Hydrochloride is a digestive aid and can be used to promote
enzymatic digestion.*
=
Vegetarian Formula
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Bilberry Extract 60MG 120 vcaps - Physiologics
Standardized
to contain: 25% Anthocyanidins - Supports Healthy Eye Function*
Bilberry’s active constituents are its
anthocyanoside compounds which help strengthen the structural integrity of the
tiny capillaries that deliver nutrients to the eyes, promote immunity, and help
prevent free radical damage within the eye. Bilberry also maximizes the eye’s
ability to adapt to darkness by helping accelerate the regeneration of retinal
purple.*
=
Vegetarian Formula
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Caprylic Acid 350MG 90 vtabs - Physiologics
For
Internal Wellness*
Also known as octanoic acid, Caprylic Acid is a
medium chain fatty acid found naturally in coconuts. Caprylic Acid is
traditionally used for internal wellness.*
= Vegetarian Formula
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Cinnamon with Chromium Picolinate 1000MG 60 Capsules - Physiologics
Promotes Sugar &
Fat Metabolism*
PRODUCT IS A SYNERGISTIC MIXTURE OF:
Cinnamon and Chromium Picolinate
PRODUCT DISCUSSION
Cinnamon and Chromium Picolinate are two clinically studied ingredients for
support of sugar and fat metabolism.* In a lab study involving 50 different
herbs and spices, Cinnamon was found to be the most bioactive ingredient
tested.* Chromium is involved with proper receptor functioning necessary for
nutrient metabolism.*
STRUCTURE AND FUNCTION
Cinnamon is an ancient herb mentioned in Chinese texts as long ago as 4,000
years, and has an expansive range of historical uses in many different cultures.
It contains the important compounds eugenol and cinnamaldehyde, and has been
traditionally used for wellness. Cinnamon has been shown to enhance in vitro
glucose uptake and glycogen synthesis and to increase phosphorylation of the
insulin receptor; moreover, cinnamon extracts are likely to aid in triggering
the insulin cascade system.*
Research indicates that as a supplement, Cinnamon helps support sugar and fat
metabolism in the body.* It also helps to maintain a healthy metabolism of
nutrients, making it an excellent choice for an herbal addition to your health
program.*
Chromium is an essential trace element essential to humans for proper
carbohydrate and lipid metabolism.* Chromium exists in several valence states,
of which the trivalent (III) and hexavalent states are the most common. Most
chromium in the food supply is in the trivalent state. Chromium picolinate
consists of organic trivalent chromium and picolinic acid, a natural derivative
of tryptophan.
A naturally-occurring oligopeptide, low-molecularweight Chromium-binding
substance (LMWCr), binds four Chromium ions and is capable of binding to sugar
metabolism receptors, promoting receptor kinase activity. It acts in a similar
manner as Calmodulin does with Calcium, and hence is named Chromodulin.*
Chromium is also part of the Glucose Tolerance Factor, composed of chromic ion,
nicotinic acid, and amino acids glycine, glutamic acid and cysteine.*
INDICATIONS
Glucose metabolism can be a concern for people of all ages and ethnic
backgrounds. In baked goods, levels of cinnamon can range from 1.3-1.4%. In
contrast, our Cinnamon supplement provides 1000 mg of Cinnamon per capsule, and
1 gram of Cinnamon per daily serving. Taking advantage of the benefits of
Cinnamon in supplement form may be a more practical choice than just relying on
the small amounts you may eat in foods.
The National Research Council estimates that chromium intake in the U.S. is
25-33 mcg/day, with more than 90% of persons having a suboptimal daily intake of
less than 50mcg/day. Supplementing with chromium in an absorbable complex with
picolinic acid is an easy and affordable way to support the metabolism of
glucose and other dietary macronutrients.*
HOW CLIENTS MAY BENEFIT
Helping to ensure an adequate daily Chromium and Cinnamon intake which may
be at sub-optimal levels in many individuals.
By supporting sugar, fat and protein metabolism all in one convenient
supplement.*
Using a dietary supplement with ingredients backed by scientific research
and testing.
Suitable for a wide-range of clients due to its free of status for yeast,
wheat, milk or milk derivatives, lactose, sugar, preservatives, soy, sodium
(less than 5mg per serving), and artificial color and flavor as certified
through analysis of raw material specification sheets.
CLINICAL EVIDENCE
In a randomized placebo-controlled, clinical trial, 60 men and women were
given 1, 3, or 6 g of cinnamon daily or matching placebo for 40 days. After
40 days, those in the cinnamon group had significantly improved scores in
glucose, triglyceride, and cholesterol metabolic parameters. There were no
changes seen in the placebo group. This trial demonstrated that all three
doses of cinnamon effectively supported sugar and fat metabolism, which can
have implications in heart health.
50 subjects were studied in a double-blind, placebo controlled, crossover
fashion to determine the metabolic interaction of Chromium and
carbohydrates. Chromium supplementation markedly elevated serum Chromium
levels and promoted sugar metabolism at a Pvalue of .001. (Ghosh/02)
SUMMARY
Research indicates that as a supplement, Cinnamon helps support sugar and fat
metabolism in the body.* It also helps to maintain a healthy metabolism of
nutrients, making it an excellent choice for an herbal addition to your health
program.* Chromium, in the clinically-studied and absorbable from of chromium
picolinate, is recommended for anyone looking to support glucose metabolism and
the metabolism of other dietary macronutrients. One tablet can be taken daily to
help promote sugar and fat metabolism.* Physiologics offers a high-quality
formula that is free of milk and soy allergens and dosed at levels consistent
with published, clinical research.*
SUGGESTED DOSAGE
For adults, take one (1) capsule daily, preferably with a meal or follow the
advice of your health care professional. Capsules can be opened and the contents
added to your favorite beverage or food. As a reminder, discuss the supplements
and medications you take with your health care providers.
REFERENCES
Prevalence of total diabetes in the United States, all ages - United States,
2002. http://www.diabetes.org/diabetes-statistics/national-diabetes-fact-sheet.jsp
Agricultural Research Service. Dr. Duke's Phytochemical and Ethnobotanical
Databases. Available at: www.arsgrin.gov/duke/.
Onderoglu S, Sozer S, Erbil KM, et al. The evaluation of long-term effects
of cinnamon bark and olive leaf on toxicity induced by streptozotocin
administration to rats. J Pharm Pharmacol 1999;51:1305-12.
Lee, NA. et al. Beneficial effect of chromium supplementation on serum
triglyceride levels in NIDDM. Diabetes Care. 1994, 17(12); Dec: 1449-1452.
Press, R.I., et al. The effect of chromium picolinate on serum cholesterol
and apolipoprotein fractions in human subjects. West J Med. 1990. 152:41-45
Ghosh, D., et al. Role of chromium supplementation in Indians with type 2
diabetes mellitus. J Nutr Biochem. 2002. 13(11); Nov: 690-697.
Anderson RA, Broadhurst CL, Polansky MM, et al. Isolation and
Characterization of Polyphenol Type-A Polymers from Cinnamon with Insulin-like
Biological Activity. J Agric Food Chem 2004;52:65-70.
Jarvill-Taylor KJ, Anderson RA, Graves DJ. A hydroxychalcone derived from
cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. J Am Coll
Nutr 2001;20:327-36.
Lamson D.S. & Plaza S.M. (2002) The safety and efficacy of high-dose
chromium. Altern Med Rev. 7(3):218-35.
Lee, N.A. & Reasner, C.A. (1994) Beneficial effect of chromium
supplementation on serum triglyceride levels in NIDDM. Diabetes Care.
17(12):1449-52.
Morris, B.W. et al. (1993) The inter-relationship between insulin and
chromium in hyperinsulinaemic euglycaemic clamps in healthy volunteers. J
Endocrinol. 139(2):339-45.
Morris, B.W. et al. (1998) Enhancement in insulin sensitivity in healthy
volunteers following supplementation with chromium picolinate. Med Biochem.
1:65-72.
Morris, B.W. et al. (1999) Chromium homeostasis in patients with type II (NIDDM)
diabetes. J Trace Elem Med Biol. 13(1-2):57-61.
Press, R.I et al. (1990) The effect of chromium picolinate pn serum
cholesterol and apolipoprotein fractions in human subjects. West J Med.
152:41-45.
Schawarz, K. & Merz, W. (1957) A glucose tolerance factor and its
differentiation from factor 3. Arch Biochem Biophys. 72:515-518.
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Tonalin® CLA 1000MG 60 Softgels - Physiologics
Scientifically
Formulated to Support a Healthy Body Composition*
HOW PATIENTS MAY BENEFIT
Use with a reduced calorie diet and regular exercise program
Helps support metabolism of dietary lipids, carbohydrates, and proteins
for patients with diverse eating patterns and meal compositions*
PRODUCT DISCUSSION
PhysioLogics Tonalin® CLA provides multi-level diet support by working through
distinct enzymatic and metabolic pathways. The patented, active ingredients have
been used in a variety of in-vivo human trials. This product has been
scientifically formulated to help support a healthy body composition.* Use with
a reduced calorie diet and regular exercise program.
STRUCTURE AND FUNCTION
PhysioLogics Tonalin® CLA contains Conjugated Linoleic Acid (CLA), which exists
as several isomers of the essential polyunsaturated fatty acid Linoleic Acid.
Bioactive isomers include the cis-9, trans-11 isomer and trans-10, cis-12
isomer. Stereoisomers have seemingly different biological effects, making a
precise mechanism of action difficult to discern. CLA has been shown to promote
certain enzymes responsible for fatty acid betaoxidation and mobilization, such
as hormone sensitive lipoprotein lipase. Preliminary evidence suggests that CLA
promotes activation of peroxisome proliferatoractivated receptor alpha (PPARa),
a regulator of lipid homeostasis. Other mechanisms discussed in the scientific
literature include CLA's positive effects on total carnitine
palmitoyl-transferase activity, promoting fatty acyl CoA transfer from the
cytosol into the mitochondrial matrix. Uncoupling protein gene expression, as
evidenced in murine models, may also be partially responsible for the metabolic
effects of CLA at the level of ATP formation.*
CLINICAL EVIDENCE
In a double-blinded trial, 60 male and female subjects who met the
inclusion criteria of BMI>25 were randomized to receive one of four doses
of Tonalin® CLA or matching placebo. Statistical analysis using Dunnett's
test to make pair-wise comparisons of CLA vs. placebo revealed significant
differences in body composition even at the lowest dose of 1.7g CLA per day.
(Blankson et al, 2000)
A double-blinded trial randomized 20 males and females to receive placebo
or 1.8g per day of CLA from Tonalin®. Body composition was found to be
significantly improved at 4, 8, and 12 week measures within CLA subjects and
as compared to placebo subjects. (Thom et al, 2001)
SUMMARY
PhysioLogics Tonalin® CLA contains scientifically tested ingredients for
helping to inhibit triglyceride accumulation within adipocyte cells while
simultaneously supporting metabolism of all of the major macronutrients.*
Studies show that CLA can help support a healthy body composition.* Use with a
reduced calorie diet and regular exercise program.
SUGGESTED DOSAGE
For adults, take one (1) softgel three times daily, with a meal, or follow the
advice of a health care professional.
REFERENCES
Azain MJ, Hausman DB, Sisk MB, et al. Dietary conjugated linoleic acid reduces
rat adipose tissue cell size rather than cell number. J Nutr.
2000;130:1548-54.
Blankson H, Stakkestad JA, Fagertun H, et al. Conjugated linoleic acid
reduces body fat mass in overweight and obese humans. J Nutr. 2000;130:2943-8.
Fremann D, Linseisen J, Wolfram G. Dietary conjugated linoleic acid (CLA)
intake assessment and possible biomarkers of CLA intake in young women. Public
Health Nutr. 2002;5:73-80.
Gaullier J, Halse J, H'ye K, et al. Conjugated linoleic acid
supplementation for 1 y reduces body fat mass in healthy overweight humans. Am
J Clin Nutr. 2004;79:1118-25.
Ghosh D, Bhattacharya B, Mukherjee B, et al. Role of chromium
supplementation in Indians with type 2 diabetes mellitus. J Nutr Biochem.
2002;13:690-7.
Kaats GR, et al. Effects of chromium picolinate supplementation on body
composition: a randomized, double-masked placebo controlled study. Current
Thera Res. 1996;57:747-56.
Kamphuis MM, Lejeune MP, Saris WH, Westerterp- Plantenga MS. The effect of
conjugated linoleic acid supplementation after weight loss on body weight
regain, body composition, and resting metabolic rate in overweight subjects.
Int J Obes Relat Metab Disord. 2003;27:840-7.
Kreider RB, Ferreira MP, Greenwood M, et al. Effects on conjugated linoleic
acid supplementation during resistance training on body composition, bone
density, strength and selected hematological markers. J Strength Cond Res.
2002;16:325-34.
Lee NA, Reasner CA. Beneficial effect of chromium supplementation on serum
triglyceride levels in NIDDM. Diabetes Care. 1994;17:1449-52.
Mougios V, Matsakas A, Petridou A, et al. Effect of supplementation with
conjugated linoleic acid on human lipids and body fat. J Nutr Biochem.
2001;12:585-94.
Ohnuki K, Haramizu S, Oki K, et al. A single oral administration of
conjugated linoleic acid enhanced energy metabolism in mice. Lipids.
2001;37:583-7.
Park Y, Storkson JM, Albright KJ, et al. Evidence that the trans-10 cis-12
isomer of conjugated linoleic acid induces body composition changes in mice.
Lipids. 1999;34:235-41.
Press RI, Geller J, Evans GW. The effect of chromium picolinate on serum
cholesterol and apolipoprotein fractions in human subjects. West J Med.
1990;152:41-5.
Smedman A, Vessby B. Conjugated linoleic acid supplementation in humans®
metabolic effects. Lipids. 2001;36:773-81.
Thom E, Wadstein J, Gudmundsen O. Conjugated linoleic acid reduces body fat
in healthy exercising humans. J Int Med Res. 2001;29:392-6.
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Coenzyme Q-10 120MG 60 Softgels - Physiologics
Clinically
Shown to Promote Hearth Health*
Supports Antioxidant Health*
HOW PATIENTS MAY BENEFIT
Supports cells and mitochondrial DNA from the harmful effects of reactive
oxygen species*
PRODUCT DISCUSSION
PhysioLogics Coenzyme Q-10 Q-Sorb™ 120 mg provides an essential component of
the mitochondrial electron transport chain, vital for the production of
adenosine triphosphate (ATP) required for virtually all cellular processes. Co
Q-10 is a lipophilic antioxidant that neutralizes the formation of reactive
oxygen species in the mitochondria, which is important for cardiovascular
health.*
Endogenous levels of Co Q-10 may diminish with age, strenuous exercise, and
environmental stressors. In addition, certain regularly prescribed drugs,
including statins, may deplete the body's supply of Co Q-10. (Note: Coenzyme
Q-10 is not intended to serve as a replacement for statin therapy, nor should
patients discontinue taking any prescribed medications while supplementing with
Coenzyme Q-10.)
STRUCTURE AND FUNCTION
Coenzyme Q-10 is a vitamin-like molecule naturally found in the inner
mitochondrial membrane of every cell in the human body. In the mitochondrial
respiratory chain, Co Q-10 is the electron acceptor for mitochondrial complex I
and complex II, and donates electrons to complex III during oxidative
phosphorylation. Each pair of electrons in the electron transport chain must
interact with Co Q-10, the rate-limiting component of the mitochondrial
respiratory cycle.
Co Q-10 is also a component of extra-mitochondrial redox chains, whose
function is to remove excess reducing power formed during glycolysis when
mitochondrial respiration is decreased. In its reduced form, Co Q-10 is a
lipid-soluble antioxidant that readily provides electrons to neutralize
superoxide and lipid radicals. Mitochondria are the primary sources of
intracellular reactive oxygen species (ROS), which are capable of mitochondrial
DNA damage. Co Q-10 scavenges these species to support the cell and DNA and
fight oxidative stress, neutralizing both the initiation and propagation of
lipid peroxidation.
By supporting the normal physiological function of the heart, Co Q-10
promotes healthy circulation through myocardial tissue. Co Q-10 also has
membrane stabilizing properties thought to be involved in the phospholipid-protein
interaction that aids in the metabolism of prostaglandins. Myocardial
calcium-dependent ion channels are stabilized by Co Q-10, which supports
molecules essential for ATP synthesis. In addition, Co Q-10 seems to play a role
in supporting the fluidity of membranes, important for physiological functions
of receptors, carriers and membrane-bound enzymes.
CLINICAL EVIDENCE
In a double-blind, placebo-controlled, randomized study, subjects consuming Co
Q-10 showed significant improvement in a 6-minute walk test, in breathing
parameters, New York Heart Association (NYHA) classification, and fatigue. The
administration of Co Q-10 to subjects led to a significant improvement in
functional status, and quality of life. Coenzyme Q-10 was shown to effectively
support overall well being including heart health. (Berman et al, 2004) In
another randomized, double-blind, controlled trial, the effects of oral
treatment with Co Q-10 (120 mg/day) were compared over one year in 144 subjects.
Co Q-10 significantly increased the level of vitamin E in the blood, supported
healthy HDL levels, and reduced molecules that cause oxidative stress. There was
a significantly lower effect in the control group. (Singh et al, 2003)
SUMMARY
Coenzyme Q-10 plays an essential role in the production of cellular ATP.* Its
role as an antioxidant supports cardiovascular tissue from oxidative damage.*
Supplementing a patient's nutritional regimen with PhysioLogics Coenzyme Q-10 Q-Sorb™
120 mg softgels will help support cellular energy production and also help
promote cardiovascular health.*
SUGGESTED DOSAGE
For adults, take one (1) softgel daily, preferably with a meal, or follow the
advice of a health care professional.
REFERENCES
Berman M, et al. Coenzyme Q10 in patients with endstage heart failure awaiting
cardiac transplantation: A randomized, placebo-controlled study. Clin Cardiol.
2004;27:295-9.
Ebadi M, et al. Ubiquinone (coenzyme Q-10) and mitochondria in oxidative
stress of Parkinson's disease. Bio Signals Recept. 2001;10:224-53.
Ernster, L, Dallner G. Biochemical, physiological and medical aspects of
ubiquinone function. Biochim Biophys Acta. 1995;1271:195-204.
Greenberg S, Frishman WH. Co-enzyme Q-10: a new drug for cardiovascular
disease. J Clin Pharmacol. 1990;30:596-608.
Kato T, et al. Reduction in blood viscosity by treatment with coenzyme Q-10
in patients with ischemic heart disease. Int J Clin Pharmacol Ther Toxicol.
1990;28:123-6.
Langsjoen PH, Langsjoen AM. The clinical use of HMG CoA-reductase
inhibitors and the associated depletion of coenzyme Q10. A review of animal
and human publications. Biofactors. 2003;18:101-11.
Mellors A, Tappel AL. The inhibition of mitochondrial peroxidation by
ubiquinone and ubiquinol. J Biol Chem. 1966;241:4353-6.
Mortensen SA, et al. Coenzyme Q-10: clinical benefits with biochemical
correlates suggesting a scientific breakthrough in the management of chronic
heart failure. Int J Tissue React. 1990;12:155-62.
Nair K, et al. Aging muscle. Am J Clin Nutr. 2005;81:953-63.
Nohl H, Gille L, Staniek K. The biochemical, pathophysiological, and
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