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For
Healthy Joint Cartilage*
HOW PATIENTS MAY BENEFIT
- Promotes joint and cartilage comfort*
- Increases mobility and range of motion*
PRODUCT DISCUSSION
PhysioLogics MSM contains Methylsulfonylmethane (MSM), an organic source of
sulfur, a mineral that is vital in the formation of collagen, connective tissue,
and healthy joint cartilage.* It is one of the top three ingredients found in
popular joint products.
STRUCTURE AND FUNCTION
Sulfur plays an important role in nutrition. It is the eighth most abundant
element, and is an integral component of more than 150 compounds in the body.
Sulfur is fundamental to the structure and integrity of certain tissues,
including hair, skin, nails, and joints.* MSM is a dietary source of sulfur that
is found widely in nature; major sources include milk, eggs, seafood, meats and
plants.
MSM clinical trials have focused on cartilage and
joint support.* Cartilage is a fibrous, elastic connective tissue that functions
as a cushioning layer for joints and is comprised of an extracellular matrix
made of complex proteins known as glycosaminoglycans (GAGs) and proteoglycans.
Sulfur is used in the body as a constituent of certain amino acids, collagen and
disulfide bonds, and provides a raw material for the production of GAGs and
collagen.*
CLINICAL EVIDENCE
- 118 subjects participated in a clinical trial
in which they received 500 mg of MSM or placebo 3 times per day for 12
weeks. Those receiving MSM experienced a significant increase in joint
comfort compared with the placebo group. Our product provides up to 3 grams
of MSM per day. (Usha and Naidu, 2004)
- 40 subjects completed a clinical trial in
which they received 3 g of MSM or placebo twice per day for 12 weeks. Those
receiving MSM experienced significant improvements in joint comfort and
function compared with placebo. Our product provides up to 3 grams of MSM.
(Kim et al. 2006)
SUMMARY
Sulfur is one of the building blocks of collagen and GAGs, key structural
components in cartilage.* The compounds play an important role in the integrity
and maintenance of joint cartilage.* MSM is a natural dietary source of sulfur
which helps support the health of joints and cartilage.*
SUGGESTED DOSAGE
For adults, take one (1) capsule two to three times daily (1000 mg) or four to
six times daily (500 mg), preferably with meals, or follow the advice of a
health care professional.
REFERENCES
Beilke MA, Collins-Lech C, Sohnle P. Effects of dimethyl sulfoxide on the
oxidative function of human neutrophils. J Lab Clin Med. 1987;110:91-6.
Jacobs B. MSM packs a sulfuric punch. Nutr Sci
Rev. 1999;4:232-4.
Kim LS et al. Efficacy of methylsulfonylmethane
(MSM) in osteoarthritis pain of the knee: a pilot clinical trial.
Osteoarthritis and Cartilage. 2006. 14(3):286-294.
Oae S, Okuyama T. Organic sulfur chemistry:
biochemical aspects. Boca Raton, FL:CRC Press, 1992.
Parcell S. Sulfur in human nutrition and
applications in medicine. Altern Med Rev. 2002;7:22-44.
Sharif M, Osborne DJ, Meadows K, et al. The
relevance of chondroitin and keratan sulphate markers in normal and arthritic
synovial fluid. Br J Rheumatol. 1996;35:951-7.
Usha PR and Naidu MUR. Randomised,
double-blind, parallel, placebo-controlled study of oral glucosamine,
methylsulfonylmethane and their combination in osteoarthritis. Clinical Drug
Investigation. 2004. 24(6):353-363.
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