Selenium 200 mcg 100 vtabs - Physiologics

Helps Support the Immune System*

PRODUCT DISCUSSION
Selenium is an obligatory nutrient which provides nutritional support for multiple biological functions.* Clinical evidence supports selenium's role in cellular antioxidant function, thyroid hormone activity and various immune parameters.*

STRUCTURE AND FUNCTION
Thyroxin (T4), the major hormone product of the thyroid gland, is converted by 5 (outer ring) deiodination to the more biologically active hormone triiodothyronine (3,5,3triiodothyronine, T3). This conversion is induced by type I and type II iodothyronine deiodinases enzymes. Selenium plays an integral part in enzyme bio-activity for healthy thyroid functioning.*

Glutathione Peroxidase, one of the major intracellular antioxidants in the human body, is a well-characterized selenoprotein. Selenium-containing peroxidases help protect the lipophilic membrane and soluble fractions of cells from free radical induced redox reactions.*

Free radicals such as hydrogen peroxide can influence lymphocyte activity depending on cellular concentration. Selenium supports glutathione's role in helping neutralize hydrogen peroxide, which in turn may positively influences lymphocyte levels for immune support.*

Some scientific evidence suggests that consumption of selenium may reduce the risk of certain forms of cancer. However, FDA has determined that this evidence is limited and not conclusive.

INDICATIONS
Selenium content within soil can widely vary depending on geographical location, affecting the levels within plant foods. This in turn can affect selenium levels within animals feeding off of these plants. Supplementation is an easy way to promote adequate selenium levels. It is often recommended that older individuals and vegetarians supplement with selenium as well (meat is one of the better natural sources of selenium).

HOW CLIENTS MAY BENEFIT

• Provides selenium in a form often used in scientific research.
• Excellent supplement for promoting immune function.*
• Essential component of Glutathione Peroxidase for antioxidant support.*
• Critical component of T4-T3 conversion for thyroid support.*
• Can be used as part of a healthy-aging program.*

CLINICAL EVIDENCE

• 22 older subjects were given 100 mcg/d of selenium yeast or placebo in a double-blinded trial. Subjects receiving selenium demonstrated a significant response for immune-promoting properties.
• Over 100 euthyroid subjects were randomized to receive selenium or placebo in a double-blinded trial. Results found that selenium status positively influenced healthy thyroid hormone levels.
• In a double-blinded study, selenium supplementation was found to promote both selenium and glutathione peroxidase levels.
Subjects receiving parenteral nutrition were given 200 mcg/d of selenium and had immune parameters analyzed. Results found selenium to have a positive impact on lymphocyte and mitogen response.

SUMMARY
Selenium is an essential nutrient for biological health, backed by peer-reviewed, clinical evidence.* Research supports its ability to impact the infrastructure of key systems, including immune, thyroid and antioxidant complexes.*

SUGGESTED DOSAGE
For adults, take one (1) tablet daily, preferably with a meal, or follow the advice of your health care professional. As a reminder, discuss the supplements and medications you take with your health care providers.

REFERENCES
Al-Taie, OH. et al. Selenium supplementation enhances low selenium levels and stimulates glutathione peroxidase activity. Nutr Cncr. 2003;46(2):125-30.

Arthur, J.R., et al. Selenium deficiency, thyroid hormone metabolism, and thyroid hormone deiodinases. Am J Clin Nutr. 1993. 57: 236S-239S.

Brooks, J.D., et al. Plasma selenium levels. J Urology. 2001. 166; Dec: 2034-2038.

Clark, LC. Et al. Effects of selenium supplementation. JAMA. 1996. 276(24): Dec 25: 1957-1963.

Fox, T. et al. Bioavailability of selenium from fish, yeast and selenate: comparative study in humans using stable isotopes. European J of Clin Nutr.. 2004. 58: 343-349.

Olivieri, O. et al. Low selenium status in the elderly influences thyroid hormones. Clinical Science. 1995. 89(6): 637-642.

Peretz, A. et al. Effects of selenium supplementation on immune parameters in patients on home parenteral nutrition. Nutrition. 1991 May-Jun;7(3):215-21.

Peretz, A., et al. Lymphocyte response is enhanced by supplementation of elderly subjects with seleniumenriched yeast. Am J Clin Nutr. 1991. 53; May: 1323-8

  =  Vegetarian Formula

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